References
References are noted in square brackets '[' ']' and contain section number and reference number.
Example:
[2.1] is reference in section 2 "Diabetes" number 1 => "The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats"
Quotes from the reference are placed in double quote marks " ... ".
My comments are in brackets (...) or just plain text without quote marks.
Time is noted as [mm:ss] or [hh:mm:ss] where: hh is hours, mm is minutes, ss is seconds
Example:
[2.1] is reference in section 2 "Diabetes" number 1 => "The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats"
Quotes from the reference are placed in double quote marks " ... ".
My comments are in brackets (...) or just plain text without quote marks.
Time is noted as [mm:ss] or [hh:mm:ss] where: hh is hours, mm is minutes, ss is seconds
1. Cancer
1.1. Prostate Cancer, Nutrition, and Dietary Supplements
(EGCG) "no-observed-adverse-effect–level was greater than 600 mg/kg/day" (in dogs)
"Polyphenon E containing a dose range of 200 to 1200 mg EGCG was well tolerated"
"In a 2003 study, patients with androgen-independent metastatic prostate cancer consumed 6 g of green tea daily for up to 4 months. Among 42 participants, 1 patient exhibited a 50% decrease in serum PSA level compared to baseline, but this response was not sustained beyond 2 months. Green tea was well tolerated by most study participants. However, six episodes of grade 3 toxicity occurred, involving insomnia, confusion, and fatigue. These results suggest that, in patients with advanced prostate cancer, green tea may have limited benefits."
Note: Eat Green Tea
1.2. Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues.
"EGCG plateaued between 500 and 2000 mg/kg" (in mice)
1.3. Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals
"We conclude that it is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8–16 cups of green tea once a day or in divided doses twice a day for 4 weeks. There is a >60% increase in the systemic availability of free EGCG after chronic green tea polyphenol administration at a high daily bolus dose (800 mg EGCG or Polyphenon E once daily)."
1.4. EGCG - potent extract of green tea
Atherosclerosis, Cancer, Bladder cancer, Breast cancer, Colorectal cancer, Lung cancer, Pancreatic cancer, Prostate cancer,
Skin cancer, Stomach cancer, Skin health, Joint health, Inflammatory bowel disease (IBD), Diabetes, Liver disease, Antioxidant properties, Weight loss
1.5. Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo.
" Tumor size in xenograft mice treated with 120 mg/kg of rutin was significantly smaller than that in the untreated-control group. These novel findings indicate that rutin inhibits tumor growth in a xenograft animal model. Rutin may be useful in treating leukemia but certainly much more research is needed."
1.6. Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.
"10 g quercetin/kg diet" ( see [4.1, 4.2, 4.3])
"In conclusion, quercetin, but not rutin, at a high dose reduced colorectal carcinogenesis in AOM-treated rats, which was not reflected by changes in ACF-parameters. The lack of protection by rutin is probably due to its low bioavailability."
1.7. Apoptosis by dietary factors: the suicide solution for delaying cancer growth
"Various studies indicate that dietary constituents, particularly phytochemicals, can modulate the complex multistage process of carcinogenesis (6,7). The promising dietary chemopreventive compounds with demonstrated effects in more than one tumor model include (–)-EGCG in green tea; resveratrol in grapes; lupeol in fruits like mango, strawberry and grape; delphinidin in pigmented fruits like pomegranate and strawberry; curcumin in turmeric; sulforaphane and other isothiocyanates in cruciferous vegetables; organosulfur compounds in garlic; lycopene in tomato; quercetin in onion and tomato; silymarin in milk thistle and genistein in soybeans among many others (8). Table I shows various dietary agents that have been reported to induce apoptosis of cancer cells."
1.8. Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase
"In recent years, many dietary compounds have been recognized as anticancer agents and previous studies indicate that resveratrol suppresses growth of pancreatic cancer cells. However, the molecular mechanisms underlying the effect of resveratrol are unknown. Our results herein show a role for resveratrol as a chemo-preventive and chemotherapeutic agent against pancreatic cancer and strongly suggest that LTA4H is an important target."
"our results indicated that promotion of pancreatic cancer could be delayed or suppressed by resveratrol"
1.9. The Influence of Quercetin on Exercise Performance and Muscle Mitochondria
"quercetin supplementation at doses of 1,000 mg/day"
"Food sources of quercetin include elderberries (42 mg/100 grams), red onions (33 mg/100 grams), hot peppers (15 mg/100 grams), apples (4.7 mg/100 grams), and kale (7.7 mg/100 grams)."
"In vitro animal and human epidemiologic studies suggest a long list of desirable effects result from consuming quercetin in the diet. These include antioxidative, anti-inflammatory, antibacterial, immunomodulatory, anticarcinogenic, and cardioprotective actions. High quercetin intake via diet is associated with decreased rates of colorectal, kidney, pancreatic, prostate, and lung cancer; cardiovascular disease; and diabetes."
"Measurements of long-term supplementation with quercetin yield a wide variance in absorption rates. A 12-week study of 1,000 subjects who received either placebo or 500 mg or 1,000 mg of quercetin per day yielded a range of unpredictable responses in plasma levels. A study of ileostomy patients given single 100 mg doses of quercetin found a mean absorption rate of 24%. Another study found a 52% absorption when the quercetin was administered as a serving of fried onions. Polymorphisms in intestinal enzymes, transporters, and liver enzymes, and effects of coadministered foods (dietary compounds), may explain some of these variances."
"In rat studies, omega-3 fats, vitamin C, vitamin E, and green tea extracts have a synergistic effect on quercetin’s action."
"combination of quercetin, green tea, and fish oil. Quercetin (1,000 mg/day), ... (EGCG; 120 mg), isoquercetin (400 mg), and EPA-DHA (400 mg)
... Plasma quercetin levels of those who took the supplement combination were almost twice as high as in those who took quercetin alone."
"A January 2010 study reports red onion, an excellent source of quercetin, enhances absorption of EGCG from green tea."
"Quercetin’s action of increasing mitochondria may warrant clinical trials to study using it for fatigue associated with cancer treatment. It may increase stamina in these patients while at the same time having anticancer action."
1.10. Quercetin
"Pregnant and breastfeeding women and people with kidney disease should avoid quercetin.
At high doses (greater than 1 g per day), there are some reports of damage to the kidneys."
"Chemotherapy -- Test tube and animal studies suggest that quercetin may enhance the effects of doxorubicin and cisplatin, chemotherapy medications used to treat cancer. In addition, some doctors believe taking antioxidants at the same time as chemotherapy can be harmful, while others believe it can be helpful."
1.11. Curcumin 2000x
Content: 300mg curcumin, 100mg Cayenne pepper, 90IU Vit. E
1.12. Standard Curcumin 95% (low cost)
1.13. Curcumin solubility
(poor absorption when taken orally)
"Solubility:
Soluble in ethanol (10 mg/ml),
DMSO (25 mg/ml), ...
water (< 0.1 mg/ml) ..."
1.14. Sabinsa weighs into curcumin bioavailability debate
5mg - piperine will not enhance the absorption of toxins and drugs
more than 20mg - piperine will enhance absorption of toxins and drugs.
Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice.
"cotreatment with piperine resulted in a C(max) = 31.60 +/- 15.08 nmol/g at 90 min, and levels were maintained
above 20 nmol/g until 180 min. This resulted in a significant increase in the small intestine EGCG AUC
(4621.80 +/- 1958.72 vs. 1686.50 +/- 757.07 (nmol/g.min))."
1.15. Testimony from a news group (Melanoma):
"When I started I was using life extension and yes, it almost bankrupted us. But, I changed brands and started capping my own black pepper to go with it, the protocol continues to work as well. Here is where I get mine, it is much more affordable. http://turmeric-curcumin.com/
I buy 12 bottles at a time, which really brings the cost down. I buy bulk organic black pepper and cap it in 00 caps which I take with it.
Dosage always starts at 1 gram a day for a week, then it raises to 2 grams a day for the next week, then 3 grams a day, etc. This is called ramping up. Just starting in taking 4 grams a day will make most people violently ill. After ramping up to 8 grams a day, I felt really tired and fragile, but it was worth it. The moles began to disintegrate, just falling off my skin. When I dropped my dosage to a gram a day, I noticed the moles on my face that did not fall off, but turned pink again, started to go dark. So I raised my dose to 2 grams a day and I appear to be doing really good at this level."
1.16. The amazing healing powers of cayenne pepper (capsicum)
"Christopher has even documented cases where he helped patients come out of heart attacks using only a teaspoon of cayenne powder in a cup of warm water. He isn't alone; there are several anecdotes of people recovering from serious heart attacks by downing cayenne teas or tinctures."
"Dr. Christopher liked to use warm purified or distilled water to mix in the fine cayenne powder. One-half to a full cup of water can be used for to mix a half or full teaspoon of cayenne that can be quickly gulped. Allowing the heat to permeate is part of cayenne's therapeutic value, which a reason why Dr. Schulze disdains cayenne capsules."
"It is also a valuable aid for digestion and elimination which can ultimately help heal hemorrhoids and ulcers. Both Dr. Christopher and Dr. Schulze assert that ingesting cayenne powder will boost the potency of the other herbs and supplements you're taking.
In cayenne studies, scientists have demonstrated an 80% reduction with prostate cancers in mice and in human prostate cancer cells in cultures. The capsaicin in cayenne actually creates accelerated cancer cell apoptosis, or cellular self destruction.
Cayenne pepper contains many beneficial phytochemicals, extremely bio-available vitamins C & E, and minerals, including the vital heart-health mineral magnesium. It cleans the blood, allowing hormonal signals to make their way unimpeded through your system and enhancing the immune system."
1.17. BCM95 - High bioavailability Curcumin
1.18. Meriva - High bioavailability Curcumin
1.19. Turmeric
"Cancer Prevention
...
Inhibits Cancer Cell Growth and Metastases
...
Turmeric and Onions May Help Prevent Colon Cancer
... cancer in the lower intestine. Similarly, quercetin, an anti-oxidant flavonoid found in a variety of foods including onions, green tea and red wine, has been shown to inhibit growth of colon cancer cell lines in humans and abnormal colorectal cells in animals.
In this study, a decrease in polyp number was observed in four of five patients at three months and four of four patients at six months.
Each patient received curcumin (480 mg) and quercetin (20 mg) orally 3 times a day for 6 months. Although the amount of quercetin was similar to what many people consume daily, the curcumin consumed was more than would be provided in a typical diet because turmeric only contains on average 3-5 % curcumin by weight.
...this research clearly demonstrates that liberal use of turmeric and onions can play a protective role against the development of colorectal cancer. And turmeric doesn't have to only be used in curries. This spice is delicious on healthy sautéed apples, and healthy steamed cauliflower and/or green beans and onions. Or, for a flavor-rich, low-calorie dip, try adding some turmeric and dried onion to creamy yogurt.
...
Turmeric Teams Up with Cauliflower to Halt Prostate Cancer
...
curcumin, along with phenethyl isothiocyanates, a phytochemical abundant in cruciferous vegetables including cauliflower, cabbage, broccoli, Brussels sprouts, kale, kohlrabi and turnips.
... when combined, they significantly reduced both tumor growth and the ability of the prostate cancer cells to spread (metastasize) in the test animals.
...
Reduce Risk of Childhood Leukemia
...
Improved Liver Function"
1.20. Turmeric - A detailed description
"Curcumin also was shown by Mahady et al to inhibit the growth of Helicobacterpylori, a group 1 carcinogen, as a possible explaining mechanism for its role in prevention of gastric and colon cancers in rodents.
Curcumin was administered orally for three months with doses ranging from 500 to 12,000 mg/d. Curcumin was found to be non-toxic in doses of up to 8,000 mg/d orally for three months. The results also showed that one of four patients with C1N and one of seven patients with oral leucoplakia developed frank malignancies in spite of treatment with curcumin. However, histological improvement was seen in one of two patients with bladder cancer, two of seven patients with leucoplakia, one of six patients with intestinal metaplasia, one of four patients with C1N, and two of six patients with Bowen's disease.
Turmeric should be avoided in patients allergic to turmeric or any of its constituents (including curcumin), yellow food colorings, or other members of the Zingiberaceae (ginger) family. It should be avoided in patients with bile duct obstruction or cholelithiasis, and gastric or duodenal ulcers or other hyperacidity disorders. [Reviewer’s note: whole turmeric, not the isolated curcurmin, is in fact, recommended in small amounts in these conditions.]
Turmeric is considered safe for pregnant and lactating women when used as a spice in foods. Turmeric should not be taken in large amounts during pregnancy as it might stimulate menstrual flow and uterine contraction. Animal studies have not shown any teratogenicity. There is insufficient evidence of safety to support use of large amounts of turmeric during lactation. "
1.21. Resveratrol - many actions against cancer
"Resveratrol increased longevity by stimulating the survival defence enzyme Sir, which in turn stimulates the
production of sirtuins , survival defence hormones produced when animals are on restricted calorie diets. And in turn,
this improved insulin sensitivity and reduced IGF-1 levels, increased mitochondrial numbers and activity, and
improved motor function. Moreover it negated the detrimental effects of a high-calorie diet at a genetic level.
However the doseage used was 24 mgs per kilogram of body weight equivalent to 1000 bottles per day of red wine!
Not surprisingly there are also scientific studies that show a restriction of calories can stop tumour growth. Drugs
based on resveratrol are being studied for both anti-ageing and type-2 diabetes.
In a study of gliomas (Brain tumours) using rats (Clin Cancer Res. 2004; Mar) a concentration of resveratrol at
40 mgs per kilogram of body weight per day increased survival rate, by exerting an anti-tumour effect and an anti-
vascular effect. It was concluded that the natural compound is a potent chemotherapy agent."
Resveratrol (Linus Pauling Institute)
"At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on
such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens.
... Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-
sensitive cancers, such as breast, ovarian, and uterine cancers, should avoid resveratrol supplements"
1.22. Taurine & Cancer
"Taking up to 3,000 mg of taurine daily is considered safe"
1.23. Taurine enhances anticancer activity of cisplatin in human cervical cancer cells.
"the results indicated that co-treatment of cisplatin with taurine was more effective than single treatment of cisplatin."
1.24. The Forgotten Longevity Benefits of Taurine
Taurine Prevents Obesity
Taurine Promotes Glucose Control—and Treats Diabetes
Taurine Reverses Cardiovascular Disease Factors
Taurine Provides Potent Retina Protection
Taurine Helps Reverse Tinnitus
Solution for Seizures
Taurine Prevents and Treats Liver Disease
1.25. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.
2 [oz] of Aloe gel increases Vit.C and Vit.E absorption apprximately 3..4 times.
"500 mg of ascorbic acid or 420 mg of vitamin E acetate alone (control), or combined with 2 oz of two different Aloe preparations (a whole leaf extract, or an inner fillet gel)."
"For comparative purposes the control area was 100%. The Aloe Gel area was 304%, and Aloe Whole Leaf 80%. Only Aloe Gel caused a significant increase in plasma ascorbate after 8 and 24 h. For vitamin E, the results for the relative areas were control 100%, Gel 369%, and Leaf (198%). Only the Aloes produced a significant increase in plasma tocopherol after 6 and 8 h. Both Aloes were significantly different from the control after 8 h. Aloe Gel was significantly different from the baseline after 24 h. The Aloes slowed down the absorption of both vitamins with maximum concentrations 2-4 h later than the control. There was no difference between the two types of Aloe. The results indicate that the Aloes improve the absorption of both vitamins C and E. The absorption is slower and the vitamins last longer in the plasma with the Aloes. Aloe is the only known supplement to increase the absorption of both of these vitamins and should be considered as a complement to them."
1.26. pycnogenol side effects, pycnogenol benefits
"Studies have shown that these compounds may have benefits on inflammation, asthma, cancer (tumor), vascular disorders, retinopathy, Alzheimer's disease, diabetes, cholesterol, erectile dysfunction, sperm quality, wound healing, dymenorrhea and aging."
"maximum 200 mg/day"
"50 mg x 3/day for 2 months"
CANCER
"In conclusion, pycnogenol selectively induced death in human mammary cancer cells (MCF-7) and not in normal human mammary MCF-10 cells."
"Pycnogenol benefits - on RETINOPATHY
They also consider that pycnogenol is known to increase capillary resistance. They reviewed couples of old study reports in French and German and found that Pycnogenol retains progression of retinopathy and partly recovers visual acuity. Pycnogenol was shown to improve capillary resistance and reduce leakages into the retina.
With pycnogenol-treatment, the retinal function stopped to deteriorate and visual acuity significantly recovered. They both thought that the mechanism might be related to its free radical (FR) scavenging, anti-inflammatory and capillary protective activities. They considered that pycnogenol might bind to the blood vessel wall proteins and mucopolysaccharides and produce a capillary 'sealing' effect, leading to a reduced capillary permeability and oedema formation."
"the side effect was found to be mild and it was confined to gastric discomfort. While in another study of 58 patients suffered from hypertension (hight blood pressure), the side effects included gastrointestinal problems, vertigo, headache and nausea."
1.27. Pycnogenol
Detailed secription and effect of Pycnogenol on various illnesses.
1.28. New Research Shows Combination Of Pycnogenol®, Vitamin C And Zinc To Be An Effective Natural Approach To Relieve Common Cold Duration And Symptoms
"The trio (100mg Pycnogenol® + 200mg Vitamin C + 30mg Gluconate Zn per day) showed the most success in significantly shortening the duration of symptoms to four days, as compared to the average of seven days."
1.29. Effect of pycnogenol on ascorbic acid (vitamin C)
"Among all of the flavonoids tested in this experiment, which included myricetin, polyphenon and theaflavin, pycnogenol had the greatest effect."
1.30. Living Proof Vitamin C Miracle Cure 60 Minutes Video 3 News
H1N1, Leukemia, coma
[7:00] - IV Vit.C - 2 days - 25,000 [mg/day]
[14:30] - Lypo-spheric Vit. C - 6,000 [mg/day]
1.31. William Li: Can we eat to starve cancer?
Angiogenesis
[3:10] (Excessive Angiogenesis) Cancer, Blinding diseases, Psoriasis, Arthritis, Endometriosis, AIDS Kaposi-Sarcoma, Alzheimer, Obesity, MS, Cerebral malaria, Rosacea
[3:50] - every type of cancer
[6:45] Antiangiogenic therapy - targets only cancer cells
[7:10] Glioma (brain tumor) - 4 weeks treatment
[7:20] Breast cancer - 4 weeks
[7:50] (dog) - malignant neurofibroma - spread to lungs (doctor gave him 3 months to live)
applied mixture in food and cream for topical treatment. - 7 weeks
[8:20] - 60% response rate
[8:40] - (dolphin) - Squamous cells cancer; applied paste on tongue 3 times a week; - 7 months
[9:00] - (horse) angio-sarcoma; applied creme and oral cocktail; - 6 months
[9:45] - drugs that are based on antiangiogenic treatment
[9:55] - patient survival data
[11:30] - 35% of cancer is due to diet
[12:30] - Resveratrol - 60% reduced angiogenesis
Strawberries - very potent
Soy bean extract - very potent
[12:55] - list of foods
some of them are - berries, citrus fruits, red grape, red wine, bok choy, kale, turmeric, lavender, parsley,
licorice, garlic, tomato, olive oil, grape seed oil, dark chocolate
[13:40] - tea combination (food synergy); food list vs drugs
[15:10] - cooked tomatoes (lycopene) - 2..3 servings per week - 50% less risk for cancer
[16:45] - obesity
1.32. Cancer Smart Bomb, Part I: An Idea from Ancient Chinese Medicine
(dogs) Osteosarcoma ... five days of treatment the dog was able to walk normally
lymphosarcoma - immediate reduction in tumor size. In all these canine cases, an iron supplement was used.
Prostate Cancer
Pancreatic Cancer
Brain Tumors
Tongue Tumor
"5 cm tongue tumor, being fed through a feeding tube, had her tumor disappear and the feeding tube removed in less than two weeks on artemether."
Breast Cancer
"A woman with stage IV metastatic breast cancer has returned to work after four months of treatment with artemether."
"47-year-old woman with stage-IV breast cancer with metastases to her spine, causing significant pain and limping. Various alternative therapies gave her some symptom relief, but no change was registered on her CT scan until a course of artemisinin was instituted. The other breast cancer case he writes of is a large, oozing cancer that cleared up in a month on artemisinin derivatives."
Lymphoma
"egg-sized tumor on the left side of the man's head, which spontaneously cleared up two weeks after a two-week course of artemisinin derivatives."
Types of Cancers Responding
leukemia, colon cancer, melanoma, breast, ovarian, prostate, renal and central nervous system cancers such as glioblastoma and neuroblastoma.
"the fat-soluble form has superior absorption into the brain."
"Artemether is a semi-synthetic, more fat-soluble form that is the longest lasting in the blood stream. Due to the fat-soluble nature of this compound, it passes more readily through the blood brain barrier. It is also metabolized fairly rapidly to dihydroartemisinin (DHA), and blood tests show that after 6 hours the DHA metabolite has higher plasma concentrations than the parent compound artemether. (see:: www.arenco.be/docu11.htm)"
Various Oral Dosages Used
"1 to 2 mg/kg, once or twice a day."
"3 to 4 mg/kg"
"Higher dosages may be neurotoxic after long-term use or may cause heart problems (read toxicity info below)."
"... combination of a 100 mg capsule of artemisinin, a 60 mg capsule of artesunate and a 40 mg capsule of artemether once a day at bedtime with a glass of milk. He also writes that the correct dosage for a specific person needs to be determined on an individual basis."
artemether - take 2 times a day.
On an Empty Stomach
"need to be taken on an empty stomach away from food, so that it will not interact with the iron in the food. In the evening this would mean at least two or more hours after the last meal."
"take it with a glass of milk "
"take it with cod liver oil and conjugated linoleic acid."
"intestine builds up resistance to absorbing oral artemisinin compounds very quickly, within several days. Resistance is demonstrated by a drop to >30% of the original rate of absorption. Research indicates that this resistance can be overcome very quickly by discontinuing use of the artemisinin compounds for several days to a week; when resumed, their absorption will be at the previous higher level."
"Supplemental antioxidants may be contraindicated with the use of artemisinin though. The nature of the action of artemisinin compounds in the body is the creation of free radicals through interaction with iron in the cancer cell. Anything that protects against that free radical damage may be counterproductive to the effectiveness of the action of the artemisinin derivatives."
1.33. Cancer Smart Bomb: Part II Artemisinin Follow-Up
"dosages from 100 to 600 mg/day"
"brain cancer ... came out of his coma after 21 days of injections of artemether"
"70% reduction in tumor size within a week ... on day one with an oral capsule containing 150 mg of ferrous sulfate along with folic acid (0.5), and from day 1 to day 15, a 60 mg injection (IM) of artesunate was given every evening. Starting on day 16, the patient was switched to an evening oral tablet of artesunate (50 mg), which is being continued on a daily basis."
1.34. ARTEMISININ UPDATE
"American College for Advancement in Medicine, (ACAM list of doctors: 1-888-439-6891 or www.acam.org/dr_search/) who do alternative therapies, usually IV therapies for chelation. They might also be familiar with artemisinin and/or other nutritional support protocols for cancer."
Artemisinin and Cancer
"Dr. Singh reports that a combination of the forms may be the very best treatment due to these different properties
(based on a lab experiment). Thus, he feels the best preparation will contain artemisinin and artemether to provide a
dose of 0.5 – 2 mg/Kg of each form once daily before bed (away from an residual iron left in the stomach after the
evening meal). Dr. Hoang reports that 500 mg twice daily of oral artemisinin by itself is the dosage he has been using
with great success.
The product is best taken on an empty stomach with some natural fat to enhance absorption. Any iron present from
residual food may neutralize the peroxides. Mile is one of the few foods with minimal iron. Whole milk, cottage
cheese or yogurt have ample fat to enhance absorption. Additionally, I believe simultaneous administration of cod
liver oil (for its omega-3 and vitamin D) and conjugated linoleic acid (CLA) will assist absorption, while providing
therapeutic benefits. To date, with the exception of patients very near death, taking artemisinin or derivatives have
stabilized, improved, or remitted every cancer patient I have followed."
Artemisinin And Canine Cancer
Recommended treatment:
1mg/kg Artemether. Calculate Artemix supplement (combination of the 3 types) based on the Artemether content.
Give with Butyrate and Vit.D3. Small quantities of antioxidants can be given (250mg Vit.C, 200IU Vit.E but not given
at the same time as artemisinin). No iron supplements are necessary.
Continue treatment for 8 weeks (every day). If condition improves, start pulsing the Artemisinin and continue for
3..4 months. If condition is not improved change the therapy.
Synergic effects of artemisinin and resveratrol in cancer cells.
Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.
"... artemisinin-type compounds are able to kill cell lines of many different tumor types, e.g. leukemia, lymphoma,
melanoma, brain tumors, carcinoma of the colon, breast, ovary, lung, kidney, and many others...
... Artemisia annuaL. preparations (Luparte®) were obtained from Lupovet GmbH (Müllheim/Baden, Germany).
Using a semiautomated device 450 or 150 mg of the 1:30 extracted and pulverized Herba A. annuae were for
technical reasons enriched with 50 or 17 mg Inulin and enclosed in capsules size “O” or “4”, respectively.
... One female and two male dogs as well as one male cat between 10 and 13 years were diagnosed with
hemangioendothelial sarcoma or fibrosarcoma at the Veterinary Clinic, Müllheim. All four animals suffered from
a grade 3 or 4 tumor at diagnosis ...
... iron was given p.o. b.i.d or intramuscularly every 3 days to mark the iron affine malignant cells. The initial “blind”
dose of orally given iron (e.g. Ferrosanol® capsules 100 mg) was about 100 mg/30 kg b.i.d. or about 100 mg/10 kg
weight Ursoferran i.m. two times a week. The iron application was continued for the entire treatment time, and was
attuned to maintain the iron level at 250 ± 30 µg/dL.
From the fourth day onward, the animals were treated p.o. two to three times daily with one capsule (150 mg in the
cat, 450 mg in the dogs) of Herba A. annuae simultaneously."
Differential Effect of Artemisinin Against Cancer Cell Lines
"The tumor volume increase linearly and significantly in control mice between day 0 and day 6 to reach 1.7 ± 0.08 cm3
compared to the treated animals (1 ± 0.08 cm3). After the 6th day, tumor volumes of untreated mice continue to
growth, which reached at day 20 a mean volume of 2.2 ± 0.1 cm3. Thus, tumor-bearing mice died from progressive
tumors. However, in treated animals, tumor volume began to decrease to attaint 0.26 ± 0.06 cm3 at day 10, and close
to regression (0.003 ± 0.06 cm3) at day 14. This difference was found to be significant between the control and treated
groups (P < 0.05). The tumor volumes of treated animals remained constant between the 14th and 20th day,
suggesting an inhibition of cell growth during this period.
... artemisinin ... at a concentrations able to induce a cytotoxic activity against tumor cells (P815 and BSR), no
cytotoxicity effect on normal cells was observed.
... Furthermore, artesunate, another derivative of artemisinin, was proved to decrease tumor microvessel
density and subsequently reduced tumor growth with no apparent toxicity to the animals at 50 and 100 mg/kg/day,
respectively. The authors described the anti-angiogenic effect of artemisinin analogues ..."
1.35. Garlic Proven to Kill Brain Cancer Cells, Prevent Future Growth
"brain cancer cells, specifically glioblastoma,"
"peel open garlic cloves and exposes them to air for 15 minutes or so to release those compounds. Some even say crush them for more exposure, then consume them raw to get the full benefits."
1.36. The Use of Bee Pollen as a Superfood
"Delay in the Appearance of Palpable Mammary Tumors in C3H Mice Following the Ingestion of PolIenized Food"
"twenty-five women suffering from inoperable uterine cancer. Because surgery was impossible, the women were treated with chemotherapy. The lucky women given bee pollen with their food quickly exhibited a higher concentration of cancer-fighting immune-system cells, increased antibody production, and a markedly improved level of infection-fighting and oxygen carrying red blood cells (hemoglobin). These women suffered less from the awful side effects of chemotherapy as well. Bee pollen lessened the terrible nausea that commonly accompanies the treatment and helped keep hair loss to a minimum. The women also slept better at night."
1.37. How to Take Bee Pollen
"Begin by placing a single granule or a small dosage of the bee pollen supplement on the tip of your tongue. If you are allergic to this product, you will begin to experience an allergic reaction within minutes of the pollen being absorbed by the mucus membranes of your tongue. Any signs of a runny nose, itchy eyes, nose or throat, shortness of breath, hives or other skin problems, or swelling will indicate an allergy to bee pollen."
"Slowly increase your dose every day to make sure that you don't experience an allergic reaction with larger doses. If you begin to experience any side effects with a larger dose, reduce the quantity of bee pollen that you are consuming daily and maintain that smaller quantity for a few weeks. After time has passed, you can begin increasing your dosage once again."
"Most individuals limit themselves to 1 or 2 tablespoons of bee pollen granules each day."
I have sleep improvement at 1/2 teaspoon/day after 2 days. Another site was saying 1 to 6 teaspoons/day.
1.38. MAPLE LEAF HIFU
HIFU - ALTERNATIVE PROSTATE CANCER TREATMENT
info for US patients
1.39. Author Ann Cameron cured her stage 4 cancer with carrot juice, nothing else.
2012, June 6 - surgery for a newly diagnosed Stage 3 colon cancer
November 6 - Stage 4 colon cancer metastasized to the lungs
November 17 - started drinking the juice 5 lbs of carrots / day. No other diet change.
2 weeks after starting the carrots, there was no improvement.
8 weeks after starting the carrots, the tumors had stopped growing and were shrinking.
4 months after starting the carrots, all the lymph nodes in my lungs had returned to normal.
8 months after starting, there was no sign of cancer anywhere in my body.
1.40. Vitamin D Might Be Able to Slash Your Breast Cancer Risk by 90 Percent
sun exposure - 40 percent of your body for approximately 20 minutes between 10 am and 2 pm
oral supplement - D3 - 8,000 [IU] to 10,000 [IU]
K2 - 150 to 200 [micro grams] "Vitamin K2 deficiency is actually what produces the symptoms of vitamin D
toxicity, which includes inappropriate calcification that can lead to hardening of your arteries."
Test Values and Treatment for Vitamin D Deficiency
"50-70[ng/ml] optimal, 70-100[ng/ml] maximum to treat cancer and heart desease."
"multiply by 2.5 to convert to [nmol/L]"
1.41. Questions and Answers About High-Dose Vitamin C
"The anticancer effect of vitamin C in different types of cancer cells involves a chemical reaction that makes hydrogen peroxide, which may kill cancer cells."
"Treatment with high-dose vitamin C slowed the growth and spread of prostate, pancreatic, liver, colon, malignant mesothelioma, neuroblastoma, and other types of cancer cells."
"Combining high-dose vitamin C with certain types of chemotherapy may be more effective than chemotherapy alone."
"Combining dehydroascorbic acid, a particular form of vitamin C, with chemotherapy made it less effective in killing some kinds of cancer cells."
"The study found that patients who received IV vitamin C had better quality of life and fewer side effects than those who did not."
"Vitamin C was shown to be a safe and effective therapy to improve quality of life in these patients, including physical, mental, and emotional functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss."
1.42. Hydrogen peroxide marshals immune system
"the body uses hydrogen peroxide to sound the alarm when a tissue has been injured. As a direct result of this hydrogen-peroxide red alert, white blood cells come to the aid of the wounded site."
"white blood cells *needed* hydrogen peroxide to sense the wound, and move towards it"
1.43. 35% Hydrogen Peroxide Treats cancer
Beat cancer with 35% hydrogen peroxide
Hydrogen Peroxide Cancer Treatment
Alternatives in Cancer Therapy - Hydrogen Peroxide
The One-Minute Cure: The Secret to Healing Virtually All Diseases
Notes:
can be taken in a bath (preferred) or orally.
must use food grade 35%.
if taken orally:
- there must be 3 to 4 hour window of no food and water before taking it.
- must be taken with lots of water (1 to 2 glasses of water).
- dose must be build up slowly.
- maximum dose depends on how you feel!
I know a person (he did not have cancer) who managed to reach 25 drops/day.
Side effect - severe diarrhea, feel sick for a while after drinking it.
He felt very good at 15 drops (excluding the side effects). He did not loose weight despite the diarrhea.
Recommendations if you take it orally:
take probiotics. Hydrogen peroxide will kill good and bad microbes in your intestines.
take vitamins and minerals.
take 1/2 teaspoon/day of naturally dried sea salt or Himalayan salt.
1.44. Nutritional Supplements and Cancer Risk Evidence from Human Trials
[6:15] Vitamin E types:
low dose Alpha is OK; Less than 100[IU] (recommended 60[IU])
Gamma is OK; Gamma is better for Cancer; Alpha suppresses Gamma;
Natural is better than synthetic;
Better when taken with Selenium, CoQ 10 and Vit. C;
[16:45] Beta carotene {from supplements (my comment)} maybe bad for lung cancer.
[17:45] Beta carotene increases the risk of bladder cancer slightly.
[18:00] Astaxanthin instead of Beta carotene.
[25:20] Don't take iron supplements (unless you need it).
[25:45] Curcumin:
[26:30] Curcumin is effective for many diseases; Impact on every stage of cancer;
[27:15] Patient with liver {"pancreatic" on image (my comment)} cancer (failed chemo and radiation):
Curcumin {standard 95% (my comment)} 8,000[mg/day] - cat-scan shows 73% reduction in 2 months.
[29:40] Curcumin supplements and absorption levels:
Meriva - free curcumin not detected in plasma;
detected curcumin break down products (good for inflammation, arthritis);
For Alzheimer's disease you need free curcumin - i.e. Meriva is not good.
BCM-95 - confusing published data
[35:00]
Longvida - the only one that has human trials with good results.
2,000[mg] Longvida supplement reaches 32[ng/ml] (used in the cancer study above with 8,000[mg])
builds up in fatty tissues (including the Brain)
- need 1 [capsule/day] (80[mg] curcumin in 400 [mg] capsule)
- effect after 1 month (to improve brain function).
[39:30] Longvida used for Alzheimer detection via retina scans (visible difference from Dimentia);
shows that Longvida is absorbed and crosses blood brain, blood retina barrier, and binds to the amyloid plaques.
[40:60] Vitamin D; [56:55] - minimum 1,500 [IU/day]
1.45. Antioxidant-Bashing Study is 'Nonsense,' Says Top Doc
"For one thing, all of these types of studies use dl-alpha tocopheryl," he says. Dl-alpha tocopheryl is a synthetic form of vitamin E made from petrochemicals and is not identical to the natural form.
“It's cheaper than d-alpha tocopherol – the natural form. Research has shown that natural vitamin E is twice as effective as synthetic. It's the worst form of vitamin E to use."
"most important failure of the study is that the sick rodents were given just a single antioxidant."
"Studies show that if you give a person or animal a single nutrient like vitamin E, it will oxidize. It is no longer an antioxidant – it becomes an oxidant. You are adding to the oxidant burden, not reducing it," he said.
"Numerous studies have shown that certain antioxidants, such as curcumin, quercetin, resveratrol, and ellagic acid are powerful suppressors of cancer growth and invasion," says Dr. Blaylock.
"I've treated cancer patients with flavonoids and antioxidants for over 20 years and I've never seen them make a cancer grow faster.
1.46. Influence of ellagic acid on prostate cancer cell proliferation: a caspase-dependent pathway.
" It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer."
1.47. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells.
"synergistic interaction for the combinations of ellagic acid with resveratrol and quercetin with resveratrol"
"confirming a synergistic interaction with a combination index of 0.64 for the combination of ellagic acid and resveratrol and 0.68 for quercetin and resveratrol."
"Results indicate that the anticarcinogenic potential of foods containing polyphenols may not be based on the effects of individual compounds, but may involve a synergistic enhancement of the anticancer effects."
1.48. Ellagic acid inhibits migration and invasion by prostate cancer cell lines.
1.49. The Truth About Ellagic Acid and Red Raspberries
"one cup of red raspberries per day (40 mg of ellagitannins)"
"In pure form, ellagic acid is highly insoluble and biologically unavailable...ellagic acid, as it is biosynthesized in plants, occurs in combination with glucose as ellagitannins. These compounds are quite water soluble and biologically available. This means that relatively small amounts of ellagitannins may be more effective in the human diet than large doses of ellagic acid,"
"What is interesting to note is the superior efficacy of eating red raspberries as opposed to taking the individual phytochemicals in the form of dietary supplements. Though we do not yet fully comprehend why this is so, it is clear the nutraceutical whole is greater than the sum of its parts."
"synthetic ellagic acid is too harsh for the human body to accept, and has some potentially serious side effects"
"ellagic acid itself is not naturally present in plants"
"pomegranate. Although not proven in clinical studies, the anecdotal evidence is extremely strong – and the concentration of ellagitannins is much higher in pomegranate than raspberries."
"over 70% of the ellagitannins present in the Meeker red raspberry are found in the seeds."
"One gram of red raspberry seed powder, taken twice a day, provides 40 mg of ellagitannins – equivalent to the amount of ellagitannins found in one cup of fresh red raspberries."
1.50. Alternative and Complementary Therapies in Oncology Care
"Currently, the most interesting results from laboratory and clinical studies involve phytochemicals from fruits and vegetables and berries.
Our group is currently researching the effects of ellagic acid, a simple polyphenol compound—probably a natural insecticide—that is found in raspberries, figs, and red grapes.
Pomegranates, for some reason, have the highest level of ellagic acid we have determined in the laboratory.
We are currently using raspberries as our test substance. Our group studied healthy patients in a clinical research unit and fed them raspberries to determine how much ellagic acid they absorbed; the peak absorption is approximately 5 hours.
We therefore examined ellagic acid and DNA synthesis in our laboratory. For example, DNA synthesis in untreated cervical cancer cells increases rapidly. When we exposed these cancerous cells to ellagic acid in the amount that one gets from eating a cup of raspberries, DNA synthesis basically stops for a period of time, and in our study, a very profound apoptotic cell death occurred among human cervical cancer cells approximately 36 hours after being exposed to ellagic acid.
Our group is currently studying a number of patients, each of whom has been eating 1 cup of raspberries once a day; they are allowing us to perform biopsies of their colons every 3 months. We are using KR67 assays in this study to determine whether the dose of ellagic acid in 1 cup of raspberries returns the rate of cell proliferation back toward normal in patients with hyperactive colon mucosa, colon polyps, and patients who have had colon cancer. "
1.51. Part 2 - Beat Your Own Cancer - Ketogenic Kills Cancer
[1:00] Brain cancer - calorie restricted ketogenic diet
[4:00] tumors cannot metabolize ketones for energy.
(mice test) 40% calorie restriction, 3 days - 65% to 90% tumor reduction
powerful anti-angiogenic effect; pro-apoptonic (kills cancer cells).
[7:15] standard vs ketogenic diet; Fat to (protein + carbohydrates) ratio of 4 to 1.
must be calorie restricted to have therapeutic effect!
added 2-DG (glucolysis inhibitor) - synergy between diet and drug.
[10:00] human study
after standard treatment, 3 days fast, ketogenic diet; tumor disappear completely;
patent gets off ketogenic diet; tumor appears after 2 months;
patent then goes on avastin (chemo drug that actually enhances tumor); patient died;
1.52. Starving Cancer: Ketogenic Diet a Key to Recovery
[0:30] recovery from bone cancer (doctors gave him 3 months to live; 3 different doctors told him that)
cancer disappeared and patent is still OK after 1 year.
[2:00] metabolic therapy.
cancer cells can only survive on glucose; normal cells can use glucose or ketones;
fat and cholesterol are OK, it is sugar that is bad.
[5:45] woman with cancer on salivary gland - went on ketogenic diet and it is OK.
[6:10] ketogenic diet for children with epilepsy; from 100 seizures cured by ketogenic diet;
[7:00] must be high fat
[9:00] MSG comments
[10:00] ketogenic diet makes you loose weight
1.53. The new science of healing, Louis Kuhne (1835 - 1901)
Louis Kuhne: The Origin Of The Detox Bath Method
Main goals:
normalize digestion (no diarrhea or constipation)
restore perspiration (according to him, most sick people don't sweat)
Treatment consist of:
cold water sitting bath (only cooling down the hip/abdomen);
rubbing stomach area with a cloth during the bath;
heat chambers - heating the body (but not the head)
indirect light sunbaths
mostly vegetarian diet (I think milk was OK); solid food (no soup);
patient is left by himself after dinner;
Multiple cases described of people healing themselves using these simple techniques.
Explanations of how the body works and why this treatment helps don't make sense (book is written in 19th century, so
no surprise there). However I do believe that there were people that were healed using his method.
Definitely worth a read or skim through the book skipping his ideas on body physiology.
My opinion on his treatment is:
- cold water sit baths - no idea yet how this could help, but it would have effect on all internal organs and some
lymph nodes. The temperature of the water is ~22 .. 25[oC].
Hypothermia has weakening effect on the immune system. However, when combined with hyperthermia it
appears to strengthen the immune system instead [Ref.1.131].
- rubbing the stomach area with a cloth during the baths:
he describes that sores appear usually (but not always) at the rubbed area.
Sometimes the sores appear at other areas instead (previously injured/ill sites).
I think this is stimulating the immune system.
In addition H2O2 is released when the body is injured stimulating immune response [Ref.1.42], so
I wonder if H2O2 has also direct affect on the cancer, or it is just the immune system.
Also, when the body has constant inflammation due to the sores, it will have raised temperature.
In "The fourfold path to healing" the author is saying that some times tumors shrink if the patient gets
infectious disease and has fever.
- heat chambers - I guess it has general beneficial effect:
restore perspiration/detox;
increased body temperature - "whole body hyperthermia" [Ref.1.109];
also heat is used to treat depression [Ref.3.5], so it should have positive effect hormone and
neurotransmitters balance.
The cooling of the body after the hyperthermia session promotes relaxation and sleep (link).
- relaxing outside on indirect sunlight:
extra Vit. D (?);
some bright light to boost the mood;
relaxation;
- mostly vegetarian diet and non spicy meals; solid food:
This (according to Kuhne) is to maintain proper digestion.
Also, considering the book was written about 100 years ago, everything was organic and pesticide free.
I wonder how many calories/day the patients were taking ... on vegetarian diet, probably not what we take
today. Reduced calories can have effect on cancer (along melatonin and ketogenic diet) [Ref1.68, 1.51].
- patient left alone after dinner:
Again, >100 years ago ... no electric lights, TVs, computers to keep you up at night with bright screens...
This had to boost the melatonin production a lot [Ref.1.68]:
"Food restriction may be related to an increase in melatonin secretion, while blindness leads to the
appearance of free rhythms and a strong melatonin signal. This increase seems to be related to an
improvement in the natural defense mechanisms of the organism. In rats developing breast cancer after
exposure to the carcinogen DMBA, ... afternoon melatonin administration decreased (development of
cancer)."
In addition, for bipolar disorder, many people have positive effects from Darkness Therapy (14..16 hours
(later can be reduced to 8..12) of darkness a day to balance/calm their mood). It was discovered that
actually the blue light is the worst, so if the patent wears yellow glasses the effect is almost the same as
total darkness. I think that probably the effect is related to direct (via the eyes) brain stimulation
(actually lack of stimulation), and also due to stimulating melatonin secretion.
1.54. Aloe
"One study in Italy of 240 patients reported in 2009. It tested aloe vera alongside chemotherapy for people with lung cancer, bowel cancer, or stomach cancer that had spread. Half the patients took aloe arborescens as a liquid 3 times a day during standard chemotherapy treatment. In this study the cancer was controlled or shrank for a time in 67% of patients who had the combined aloe and chemotherapy treatment and in 50% of patients who had chemotherapy alone. In this study the researchers said that patients taking the aloe vera had a better quality of life and that they had fewer chemotherapy side effects such as numb fingers and fatigue.
The researchers also said that there were no ill effects from the aloe vera. More patients who had the aloe vera survived for 3 years than patients who just had chemotherapy."
1.55. The Effect of Curcumin on Breast Cancer Cells
"Moreover, curcumin decreases the toxic effect of mitomycin C"
"Furthermore, curcumin enhanced the efficacy of chemotherapy"
1.56. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-?B and Src protein kinase signaling pathways.
1.57. Fantastic Chemo Response - Was it the Curcumin?
"She was then started on Paclitaxel/Carboplatin (PC) chemo; we persuaded her oncologist to sanction our use of Curcumin at the same time (having read great things about this ingredient of the curry spice, Turmeric, on the internet).
After three rounds of PC a scan showed significant improvement but the remaining tumour was still considered inoperable, so the next 3 rounds of chemo was scheduled to be followed by a one-year course of Avastin. Another scan was taken at the end of the chemo and the Avastin treatment was started.
It turned out that the scan at the end of the 6th chemo showed a remarkable change, so the oncologist got back to the surgical team and they scheduled an operation for optimal debulking and possible bowel resection. They had to wait 6 weeks after the last of the Avastin was given and the surgery took place last week.
A 12 inch section of the colon had to be removed because of damage previously caused by the cancer... but there was no active disease visible on it or anywhere else in the abdomen - even the spleen was completely normal in appearence!
The cancer surgeon told us that he has no doubt that the PC chemo regime, Curcumin & subsequent Avastin have together somehow brought about this fantastic reversal of our situation. "
1.58. Insulin Potentiation Therapy:
from post in a news group:
">if the insulin therapy works for cancer?
Disclosure: I'm on the Advisory Board of BestAnswerForCancer.org, a nonprofit educational integrative cancer
organization that has traditionally focused on IPT.
Insulin potentiation therapy (IPT)/insulin potentiation targeted low dose (IPTLD) is a highly effective cancer
treatment when used by a well-trained IPT doctor on cancers for which it's indicated (as part of an integrative
cancer treatment protocol). It's a strategy for administering a small dose of chemo (or other cancer treatment)
and delivering it to the cancer cells in a concentrated manner. (The ketogenic diet works in a completely different
manner--starving the cancer cells to death by depriving them of sugar over a long period of time; it can also be
very effective.)
>only for some cancers or for all?
IPT is usually most effective w/lymphoma (though high doses are often needed), melanoma, ovarian, breast,
prostate, stomach, small-cell lung cancer (SCLC). It’s also often effective with non-small-cell lung cancer (NSCLC),
colorectal, esophageal, pancreatic, cervical, and uterine cancer, as well as other cancers that are sensitive to chemo.
It’s usually ineffective w/brain cancer, slow-growing/low-grade/indolent cancers, subcutaneous metastases, and
cancers that are resistant to chemo. If the cancer lights up on a PET scan, that may indicate that IPT will be effective.
The Greek chemo-sensitivity test (www.rgcc-genlab.com) adds insulin in their chemo-sensitivity testing, which
assesses the effectiveness of IPT.
Our directory of doctors trained in IPT is at
http://www.ioicp.com/directory
For more info on IPT,
www.ioicp.com (or http://IPTforCancer.com)"
">Some are called German chemo-sensitivity test ... Biofocus (“German Test”)
www.biofocus.de/de/onkologie/ueberblick/ueberblick
>is there any difference?
Yes, it's similar to but (I believe) not as good (and doesn't test as many natural substances) as the Greek test (RGCC)."
Other sources of info on IPT:
Low-dose chemotherapy with insulin (insulin potentiation therapy) in combination with hormone therapy for
treatment of castration-resistant prostate cancer.
Insulin, chemotherapy, and the mechanisms of malignancy: the design and the demise of cancer
IPTLD – Insulin Potentiation Therapy Low Dose for Cancer
DMSO Potentiation Therapy (DPT) DMSO – The Magic Bullet For Cancer (used with IPT)
The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells
Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and
colonic cancer cells.
1.59. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.
"The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia,
sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary
adenocarcinoma."
"With the exception of MB-F10 melanoma, all other tumor-bearing animals had a significantly increased survival
index after bromelain treatment. The largest increase ( approximately 318 %) was attained in mice bearing EAT
ascites and receiving 12.5 mg/kg of bromelain."
1.60. Bromelain
Uses:
- Surgery, Sprains and Strains, and Tendinitis
- Wounds and Burns
- Sinusitis (Sinus inflammation)
- Arthritis
- Infection
How to Take It:
- Don’t give bromelain to a child.
- Adults: 80 - 320 mg 2 - 3 times per day. For specific conditions, higher doses may be prescribed:
Digestive aid: 500 mg per day in divided doses with meals
Injuries: 500 mg 4 times a day on an empty stomach
Arthritis: 500 - 2,000 mg a day in two divided doses
Bromelain is generally recommended for no longer than 8 - 10 days in a row.
Pregnant women, people with bleeding disorders, high blood pressure, liver or kidney disease should not take
bromelain.
Bromelain may increase the risk of bleeding during and after surgery.
You should stop taking bromelain at least 2 weeks before surgery.
Side effects: nausea, vomiting, diarrhea, and excessive menstrual bleeding.
Possible Interactions
- Antibiotics
- Blood-thinners
- Sedatives
- Anti-seizure medications
- Barbiturates
- Benzodiazepines
- Drugs to treat insomnia
- Tricyclic antidepressants
- Alcohol
- herbs with a sedating effect, such as valerian, kava, and catnip.
1.61. Bitter melon extract may have potential to fight head, neck cancer
"In this study, the bitter melon extract treatment suppressed the head and neck cancer cell growth in the mouse model,
reducing the growth of the tumor."
"Ray's initial research found that treatment with this natural substance halted the breast and prostate cancer cell growth,
eventually stopping them from spreading."
1.62. Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells.
"Bitter melon juice (BMJ) against pancreatic carcinoma cells both in culture and nude mice. "
"Results showed that BMJ (2-5% v/v) decreases cell viability in all four pancreatic carcinoma cell lines by inducing
strong apoptotic death. "
"In vivo, oral administration of lyophilized BMJ (5mg in 100 µl water/day/mouse) for 6 weeks inhibited MiaPaCa-2
tumor xenograft growth by 60% (P < 0.01) without noticeable toxicity in nude mice."
1.63. Simple plant kills up to 98% of cancer cells - and stops diabetes
"Bitter melon juice diluted to just 5% in water showed remarkable potency in severely damaging all four pancreatic cancer cell lines researchers tested. The bitter melon reduced the viability of two cancer cell lines by 90%, while it knocked off the other two lines by a staggering 98%. And it did so after just 72 hours of treatment!"
"it also activated a pathway, which shows that it knocks out the cancer cells' metabolism of glucose. In other words, it literally starved them of the sugar they need to survive."
"The animals had a 64% reduction in pancreatic tumor size without side effects! This level of effectiveness beat the most commonly used chemo drugs for this lethal cancer."
"The dose used in mice translates to 6 grams of powder for an average-sized adult (75 kg)."
1.64. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck.
"In 23 cases of carcinoma of the head and neck, the combined use of Somatostatin and/or its analogue Octreotide, prolactin inhibitors, Melatonin, Retinoids, Vitamin E, Vitamin D3, Vitamin C, Calcium, chondroitin-sulphate, and minimal oral doses of cyclophosphamide (50-100 mg/day) led to a decided increase in survival with respect to the median values reported in the literature for the same tumours and stages, together with an evident improvement in the quality of life, partial or complete objective responses and, in some cases, complete and stable cure with functional recovery.
The rationale and the mechanisms of molecular biology of the treatment are discussed, showing that the treatment has a differentiating, apoptotic, antiproliferative, antiangiogenic and antimetastatic effect, and, unlike chemo- and/or radiotherapy, preserves and enhances the trophism and functionality of organs, tissues and immunitary and antitumoral homeostasis.
This result, achieved without toxicity, demonstrates the efficacy of this biological multitherapy (Prof. Luigi Di Bella's method or DBM) and is in agreement with the positive results already published on the use of the DBM in various neoplastic diseases."
1.65. The Di Bella Method (DBM) in the treatment of prostate cancer: a preliminary retrospective study of 16 patients and a review of the literature.
"To evaluate the objective clinical response and the safety of the combined administration of somatostatin, melatonin, retinoids, vitamin D3, dopamine subtype 2 receptor (D2R) agonists and low doses of cyclophosphamide, associated with androgen ablation, in patients with a histological diagnosis of prostate adenocarcinoma (Pac).
16 patients ... Median age: 64 years. Disease stages: 8 patients (50%) were in Stage II. For advanced stages (Stage IV), secondary lesions were located in the bones and lymph nodes.
Taken together, an overall objective response (OR) [Complete response (CR) + Partial Response (PR)] was achieved in 69% of the patients, with 88% of objective clinical benefit [CR+PR+SD]. For local Prostate Cancer group, an OR was achieved in 87.5% of patients (7 cases; 53-98; 95% CI), with CR in 62.5% (5 cases, 31-86; 95% CI). In metastatic disease, the OR was 50% (4 cases; 21-78; 95% CI), with a 20% of CR (2 cases; 7-59; 95% CI) and 75% of clinical benefit.
Conclusions: This preliminary study shows that patients with early and advanced forms of prostate cancer, not previously treated by surgery and/or chemo-radiotherapy, can achieve a more than positive clinical benefit with the protocol foreseen by the Di Bella Method. Further clinical investigations are strongly recommended."
1.66. Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report.
"The current strategies for the treatment of breast cancer are essentially based on surgery, preceded and/or followed by chemotherapy often supplemented by radiotherapy and/or the administration of hormonal therapy and monoclonal antibodies. Their combined use has made it possible to increase an overall survival but they are still penalized by adverse effects and toxicity.
The marked anti-cancer effects of biological molecule such as somatostatin, melatonin, retinoid, vitamin D3 and prolactin inhibitors have been studied and documented for several decades. Their integrated and synergic action have been demonstrated, but only a few studies have as yet been carried out on their combined application in humans. The aim of the present investigation was to evaluate both the objective clinical response and toxicity of the biological multimodal treatment named Di Bella Method (DBM).
... 20 women with a certified diagnosis of breast cancer,defined disease stage, and who independently decided to follow the DBM as first-line treatment, were retrospectively reviewed.
The mean age of the patients was 51 years (min 30; max 73). Twelve (12) patients (60%) presented an early stage disease, while the other 40% had a locally advanced/metastatic stage. An overall clinical benefit was achieved in 75% of cases, with 55% of complete response and 20% of partial response. For metastatic patients, the overall survival rate was 71%. The main toxicity effects included leukopenia, gastrointestinal phenomena and drowsiness.
The preliminary results of this report confirm the positive action of the biological treatment in terms of efficacy and survival, showing a more than favorable profile of tolerability."
Recurrent Glioblastoma Multiforme (grade IV - WHO 2007): a case of complete objective response - concomitant
administration of Somatostatin / Octreotide, Retinoids, Vit E, Vit D3, Vit C, Melatonin, D2 R agonists (Di Bella Method.
1.67. Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells.
"Therefore, we suggest that melatonin is a potential chemotherapeutic agent for treatment of colon cancer, the effects of which are mediated by regulation of both cell death and senescence in cancerous cells with minimized cardiotoxicity."
1.68. Melatonin and Cancer
Therapeutic applications of melatonin
"Many studies have shown that melatonin inhibits the growth of breast cancer cells, cervical cancer cells and ovarian cancer cells."
"In rats, having been exposed to the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA), blindness and food restriction prevent the appearance of breast adenocarcinoma, this result being dependent on the presence of the pineal [Bartsch et al. 1995]. Food restriction may be related to an increase in melatonin secretion, while blindness leads to the appearance of free rhythms and a strong melatonin signal. This increase seems to be related to an improvement in the natural defense mechanisms of the organism. In rats developing breast cancer after exposure to the carcinogen DMBA, pinealectomy increased the frequency of cancer development while afternoon melatonin administration decreased it."
"melatonin was administered along with tamoxifen in women with metastatic breast cancer, which had progressed despite the administration of tamoxifen. It was found that the simultaneous administration of melatonin and tamoxifen may contribute to the objective regression of cancer in women with metastatic breast cancer not responding to tamoxifen alone"
"melatonin with interleukin 2 in patients with distant metastases in non-small cell lung carcinoma, liver carcinoma, bowel carcinoma, stomach carcinoma, pancreatic carcinoma and breast cancer contributes to cancer regression and disease stabilization"
"melatonin was investigated in a group of 1440 patients with progressive solid cancer who received supportive therapy with or without melatonin ...
The objective response of patients to therapy was significantly greater in patients receiving melatonin and chemotherapy than those receiving only chemotherapy. Melatonin decreased the frequency of cachexia, thrombocytopenia, stomatitis, cardiotoxicity and neurotoxicity due to chemotherapy."
"melatonin has been proved to decrease the oxidative damage induced by ionizing radiation. Data show that melatonin may be used as a radioprotective agent in patients with cancer either alone for cancer inhibition or in combination with traditional radiotherapy with the aim of a better effectiveness/toxicity ratio"
"These studies show that melatonin may be used successfully in clinical oncology as supportive therapy in patients with progressive cancer and for the prevention of toxicity induced by chemotherapy and radiotherapy"
"Melatonin is a hormone with multiple actions. It is involved in the regulation of biological rhythms, in sleep regulation, it has potent antioxidant action and protects the organism from carcinogenesis and neurodegenerative disorders. The hormone possesses immune-enhancing activity. Therapeutically, it may be used for the management of insomnia, jet lag, the resynchronization of circadian rhythms, as an adjuvant in cancer therapy and in the inhibition of disease progression in Alzheimer's disease and other neurodegenerative disorders."
1.69. Melatonin - Overview
"melatonin is taken in doses from 0.2 to 20.0 mg"
1.70. Melatonin
"In a study that included a small number of women with breast cancer, melatonin (given 7 days before beginning chemotherapy) prevented the lowering of platelets in the blood. This is a common complication of chemotherapy that can lead to bleeding.
In another small study of women who were taking tamoxifen for breast cancer but seeing no improvement, adding melatonin caused tumors to modestly shrink in more than 28% of the women."
"Studies show that men with prostate cancer have lower melatonin levels than men without the disease. In test tube studies, melatonin blocks the growth of prostate cancer cells. In one small-scale study, melatonin -- combined with conventional medical treatment -- improved survival rates in 9 out of 14 men with metastatic prostate cancer. Interestingly, since meditation may cause melatonin levels to rise it appears to be a valuable addition to the treatment of prostate cancer."
"our bodies normally produce (< 0.3 mg per day)"
Interactions:
Antidepressant medications
In an animal study, melatonin supplements reduced the antidepressant effects of desipramine and fluoxetine (Prozac).
In addition, fluoxetine (a member of a class of drugs called selective serotonin reuptake inhibitors, or SSRIs) can
cause low levels of melatonin in people.
Antipsychotic medications
A common side effect of antipsychotic medications used to treat schizophrenia is a condition called tardive dyskinesia,
which causes involuntary movements. In a study of 22 people with schizophrenia and tardive dyskinesia caused by
antipsychotic medications, those who took melatonin supplements had fewer symptoms compared to those who did
not take the supplements.
Benzodiazepines
The combination of melatonin and triazolam (Halcion) improved sleep quality in one study.
In addition, a few reports have suggested that melatonin supplements may help people stop using long-term
benzodiazepine therapy.
Blood pressure medications
Melatonin may make blood pressure medications like methoxamine (Vasoxyl) and clonidine (Catopres) less effective.
Beta-blockers may lower melatonin levels in the body
Blood-thinning medications
Melatonin may increase the risk of bleeding from anticoagulant medications such as warfarin
Interleukin-2
In one study of 80 cancer patients, use of melatonin along with interleukin-2 led to more tumor regression and
better survival rates than treatment with interleukin-2 alone.
Nonsteroidal anti-inflammatory drugs (Advil, Motrin) may lower levels of melatonin in the blood
Steroids and immunosuppressant medications
Melatonin may cause these medication to lose their effectiveness.
Tamoxifen
Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and melatonin may
benefit some people with breast and other cancers.
1.71. Clinical evaluation of "immunoaugmentative therapy (IAT)": an unconventional cancer treatment.
"No indication of toxicity or effectiveness was found in an uncontrolled, consecutively selected series of 46 cancer patients undergoing IAT treatment. In addition, the therapy did not appear to contribute to improved quality of life in most patients. This study does not justify its continued use."
1.72. Cesium Chloride
Clinical effects of cesium intake.
"total cesium intakes of 6 g/day have been found to produce severe hypokalemia, hypomagnesemia, prolonged QTc interval, episodes of polymorphic ventricular tachycardia, with or without torsade de pointes, and even acute heart arrest."
Life-threatening Torsades de Pointes resulting from "natural" cancer treatment.
Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts.
"CsCl may have a therapeutic effect against prostate cancer, but one cannot overlook the acute toxicities also described."
Fatal cesium chloride toxicity after alternative cancer treatment.
"CsCl is sold as an alternative treatment for cancer. There is no demonstrable efficacy, and clear evidence shows life-threatening toxicity. Reported here is a case of fatal CsCl toxicity after attempted intratumoral injection."
1.73. Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
"administration of AKBA alone (100 mg/kg) significantly inhibited the tumor growth; this activity was enhanced by gemcitabine"
"Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets."
1.74. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.
"BS significantly reduced cerebral edema measured by MRI in the study population. BS could potentially be steroid-sparing for patients receiving brain irradiation."
1.75. Boswellia, Boswellic Acid, Frankincense
Boswellia (Boswellic Acids)
"3000[mg]"
Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By
Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.
"frankincense oil to induce bladder cancer cell death"
Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer
"aroma hand massage on each hand for 5 min for 7 days with blended oil-a mixture of Bergamot, Lavender, and
Frankincense in the ratio of 1:1:1, which was diluted 1.5% with sweet almond carrier oil 50 ml. ...
The aroma hand massage experimental group showed more significant differences in the changes of pain score
and depression than the control group."
A lipoxygenase inhibitor in breast cancer brain metastases.
"The complication of multiple brain metastases in breast cancer patients is a life threatening condition with
limited success following standard therapies. ...
Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were
successfully reversed using this method in a breast cancer patient who had not shown improvement after
standard therapy."
Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.
Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells.
"The aim of the study was to investigate the antitumor and/or preventive effect of BC-4, an isomeric compound
isolated from the plant Boswellia carteri Birdw. containing alpha- and beta-boswellic acid acetate in 1:1,
MW 498.3. ...
In conclusion, if it turns out that BC-4 is a well tolerated substance, exhibiting no significant toxicity or side
effects, being evaluated currently in China, BC-4 is a good candidate for the prevention of primary tumor,
invasion and metastasis."
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.
"Boswellic acids from frankincense ... exert antiproliferative activity toward a variety of malignant cells. ...
tested ... on five leukemia ... and two brain tumor ... The Boswellia serrata extract induced dose-dependent
antiproliferative effects on all human malignant cells tested ..."
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
"Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring
triterpenoids, beta-boswellic acid and its structural related derivatives, has been used as a traditional medicine
for the treatment of inflammatory and arthritic diseases. Topical application of BE to the backs of mice markedly
inhibited ... and tumor promotion in ... mice. Feeding 0.2% of BE in the diet to CF-1 mice for 10-24 weeks reduced
the accumulation of parametrial fat pad weight under the abdomen, ... "
Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human
pancreatic cancer cell death in cultures and in a xenograft murine model
"Both frankincense chemical extracts and essential oil prepared from Boswellia species gum resins exhibit
anti-neoplastic activity, and have been investigated as potential anti-cancer agents....All fractions of frankincense
essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human
pancreatic cancer cell lines.
frankincense ... anti-tumor activity. ... induces apoptosis and prolong survival in a rat glioma model ... inhibits
abnormal skin cell proliferation ... and tumor promotion ... in a mouse ... In a human clinical study ... reduce
cerebral edema and potential anti-cancer activity in patients irradiated for brain tumors ... cultured human
bladder and breast cancer cells are more sensitive to frankincense essential oils prepared from both Boswellia
carteri and Boswellia sacra than their normal counterparts with suppressed proliferation and increased apoptosis
... frankincense essential oil overcomes multicellular resistant and invasive phenotypes of human breast cancer
cells."
Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from
Boswellia serrata.
Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate
cancer cells.
1.76. Brain Tumor
https://www.lef.org/protocols/cancer/brain_tumor_01.htm
Brain tumors and conventional medicine
Brain Tumor Nutritional Protocol
Hormones and Brain Tumors
Vitamin D:
Melatonin:
https://www.lef.org/protocols/cancer/brain_tumor_02.htm
Botanical or Herbal Extracts
Berberine:
Boswellia:
Curcumin:
Quercetin:
Resveratrol:
Green Tea and Coffee:
Sulforaphane:
https://www.lef.org/protocols/cancer/brain_tumor_03.htm
A Diet for Brain Cancer
The Ketogenic Diet:
Caloric Restriction:
1.77. Berberine
Diabetes; Lipids; Liver; Heart; Transplants; Cancer; Mental health; Intestinal Disorders; HIV
1.78. Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
"Cancer cells become resistant to different therapies over time; thus, it is necessary to target multiple signaling points for effective therapy. We have determined that MSM can inhibit STAT3/VEGF and STAT5b/IGF-1R pathways, thereby suppressing the growth of solid tumors. "
"Anti-angiogenic therapy appears to be a too narrow approach for treating patients with cancer. Cancer cells may find compensatory pathways for survival and metastasis. A combinatorial approach should produce better results under such conditions. MSM was found to have high levels of cytotoxic activity (Fig. 8) and anti-angiogenic activity by suppressing VEGF. This compound can halt tumor progression by blocking STAT5b and IGF-1R."
"MSM is an edible natural organic compound present in many food items and is not associated with any toxic effect even at higher concentration [33], [34]. Because of this, we used high concentration of the drug (300 mM) for further studies."
"These results were similar to the ones from a study by Caron et al. on a metastatic murine melanoma cell line. In their report, the authors state that 200 mM MSM exhibits anti-metastatic and anti-cancer activity. This finding was the first report on metastatic anti-cancer effect of MSM [40]. In addition to this, MSM may have dual function with anti-oncogenic effects and active-tumor suppressing effects in the nuclear level of cancer cells (Fig. 4C)."
"Triple-negative hormone receptors are very important in human breast cancer because they can make tumors sensitive or resistant to chemotherapy [15]. The mortality rate of patients with triple-negative breast cancer is very high [55]. These hormonal receptors are usually overexpressed in human breast cancers [56]. Therapy is usually designed based on the receptors responsible for the malignancy. The remarkable ability of MSM is that this compound can manage all types of malignancies associated with hormone receptors. Western blotting studies on hormone responsive breast cancer cells showed that MSM had the ability to down-regulate the expression of triple-negative hormone receptors (Fig. 2)."
1.79. Topical application of curcumin - news group post:
"5 years ago, mom was dissuaded form getting surgery because the tumor was at the base of her tongue and it would disfigured her and we were sure she wouldn't survive it. Besides, we prayed and discerned about it and felt convicted to go natural instead.
Recently we stopped the massive doses of vitamin c. We noticed it made her weaker throughout the six months she had been taking it. Instead we are now trying a turmeric and virgin coconut oil paste on her tongue. It is now the fourth day and there is a tremendous difference in her tongue. Whereas before she had brown, black areas and even green spots on her tongue now they have turned pink and the halitosis has been obliterated. The fight is far from over but we will proceed and hope for the best."
1.80. Alternative Cancer Treatment Clinics in Germany - news group post:
"> My husband who had prostate cancer went to St Georg Klinik in Bad Aibling
> for intraprostate hyperthermia / IV vit C etc.
> Huge success rate – very nice. Intra-prostate hyperthermia was what I was
> after – they take care of many others too –
> They do give chemo when needed yet really focus on nutrition
> etc too.
> My husband psa dropped down to nothing, it was virtually painless & easy
> quick treatments. Absolutely no palp
> Tumors – which is how it was discover. It is soft & pliable – pees like
> a young man. Absolutely no side effects.
> Is coverable by re-imbursement for insurance though really have to chase
> the money. Was total cost around $12k
> for 3 of us to fly there, 2 hospital rooms (son stayed in one) meals, and
> fun things. Total medical costs were around
> $8k. He keeps his manhood and can be repeated. Crazy it isn’t a 1st line
> treatment vs cut & burn methods we offer
> In US. Better than HIFU & other methods we highly researched in my book.
> On supplements alone, his psa began dropping before we went, but I have
> peace of mind knowing it is gone for now.
> Drs here were angry we were going this route – now they are shocked and
> following him closely.
> http://www.klinik-st-georg.de/en/
> I've known many people who've gone to Germany. There are many excellent
> alt. and integrative cancer hospitals there. Overall, my 1st choice would
> be Hufeland Klinik for Holistic Immunotherapy
> Loffeisteizer Str. 1-3, D-97980 Bad Mergentheim, Germany
> 49-7931-7082 or 7931-5360; Fax: 49 7931-8185 or 7931-46244;
> [email protected]_ (mailto:[email protected])
> _www.hufeland.com/english/index.html_
> (http://www.hufeland.com/english/index.html)
> http://germancancerclinics.com/clinics-german-cancer-treatment/hufeland-klinik
> _www.GermanCancerBreakthrough.com_
> (http://www.germancancerbreakthrough.com/)
> Most effective w/melanoma; sarcomas; and brain (particularly GBM), breast,
> prostate, colon, & kidney cancers. Also effective w/ovarian cancer. Least
> effective w/pancreatic cancer.
> "mistletoe...PDT...local and full-body hyperthermia [sometimes w/IPT],
> fever therapy [Coley’s toxins]”, Issels, IV vitamins, autohemotherapy,
> Carnivora, electrogalvanic electricity, pneumatron, autohormone therapy
> (AHT), eumetabolic therapy, light therapy, thyroid peptides, thymus, enzymes,
> oxygen multistep therapy (OMT) (ozone, peroxide), serums, antigens, interferon,
> detox, mind-body therapies, surgery, (rarely) radiation. NFAM.org (2001)
> thought it was the best clinic in Germany--"best protocol, least
> expensive."
> "Moss.... found that [Hufeland]...had excellent documentation to prove
> [their] success with advanced... cancer." "have visited Hufeland clinic
> four times and each time…favorable impression… orientation is the patient’s
> welfare...fees…reasonable…staff keep good records…We rarely hear any
> complaints about [Hufeland]" (Ralph Moss, 2008). Only $3500/wk inpatient (outpatient
> option available)."
1.81. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
"Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. "
"Cell death in 10 cancer and 4 normal cell types was measured by using 1-h exposures. Normal cells were unaffected by 20 mM ascorbate, whereas 5 cancer lines had EC50 values of <4 mM, a concentration easily achievable i.v. Human lymphoma cells were studied in detail because of their sensitivity to ascorbate (EC50 of 0.5 mM) and suitability for addressing mechanisms. Extracellular but not intracellular ascorbate mediated cell death, which occurred by apoptosis and pyknosis/necrosis. Cell death was independent of metal chelators and absolutely dependent on H2O2 formation. Cell death from H2O2 added to cells was identical to that found when H2O2 was generated by ascorbate treatment. H2O2 generation was dependent on ascorbate concentration, incubation time, and the presence of 0.5-10% serum, and displayed a linear relationship with ascorbate radical formation. Although ascorbate addition to medium generated H2O2, ascorbate addition to blood generated no detectable H2O2 and only trace detectable ascorbate radical. Taken together, these data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H2O2, and that blood can be a delivery system of the pro-drug to tissues. These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H2O2 may be beneficial."
"Ascorbic acid (vitamin C, ascorbate) has a controversial history in cancer treatment (1). Observational reports described ascorbate, given in pharmacologic doses of 10 g daily, as effective in treating some cancers and in improving patient well-being (2-4). Subsequently, the same dose had no effect on patient well-being and survival in two double-blind placebo-controlled trials, and ascorbate was discarded as a treatment modality (5, 6). Recent clinical evidence, however, indicates that the role of ascorbate in cancer treatment should be examined anew (7). The originally reported observational studies used i.v. and oral ascorbate, but the subsequent double-blind placebo-controlled studies used only oral ascorbate. It was not recognized that the route of ascorbate administration might produce large differences in plasma concentrations. Recent pharmacokinetics studies in men and women show that 10 g of ascorbate given i.v. is expected to produce plasma concentrations of nearly 6 mM, which are >25-fold higher than those concentrations from the same oral dose (7-9). As much as a 70-fold difference in plasma concentrations is expected between oral and i.v. administration, depending on dose. Despite inconsistencies, some in vitro studies showed that ascorbate killed cancer cells, although mechanisms and physiologic relevance were unclear (10-12). Complementary and alternative medicine practitioners worldwide currently use ascorbate i.v. in some patients, in part because there is no apparent harm (13-15)."
"For five of the nine cancer cell lines, ascorbate concentrations causing a 50% decrease in cell survival (EC50 values) were less than 5 mM, a concentration easily achievable from i.v. infusion (7). All tested normal cells were insensitive to 20 mM ascorbate."
"Ascorbate is transported into cells as such by sodium-dependent transporters, whereas dehydroascorbic acid is transported into cells by glucose transporters and then immediately reduced internally to ascorbate (29). By using either external ascorbate or external dehydroascorbic acid, lymphoma cells were loaded to equal internal concentrations of ascorbate over 1 h (data not shown). Despite similar intracellular ascorbate concentrations under both conditions, cells died only when ascorbate was present externally (Fig. 2D )."
"Because these data implicated H2O2 in cell killing, we added H2O2 to lymphoma cells and studied death patterns using nuclear staining (19, 28). The death patterns found with exogenous H2O2 exposure were similar to those found with ascorbate. For both ascorbate and H2O2, death changed from apoptosis to pyknosis/necrosis as concentrations increased (Fig. 3B )."
"H2O2 generated by ascorbate oxidation and exogenously added H2O2 produced cell death curves that were indistinguishable (Fig. 3C )."
"Ascorbate administered i.v. is likely to be safe in most patients, with virtually no toxicity compared to most currently available cancer chemotherapeutic agents. The occurrence of one predicted complication, oxalate kidney stones, is controversial (13). In patients with glucose-6-phosphate dehydrogenase deficiency, i.v. ascorbate is contraindicated because it causes intravascular hemolysis (13)."
"Old observational animal experiments, although uncontrolled, suggest that i.v. ascorbate is effective in some viral infections (56, 57). This finding is also consistent with in vitro experiments, in which H2O2 is toxic to hepatitis C (58). Use of ascorbate as an H2O2-delivery system against sensitive pathogens, viral or bacterial, has substantial clinical implications that deserve rapid exploration."
1.82. A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy
"At the conclusion of the 12 week treatment period, PSAV decreased and PSADT increased in 13 of 17 patients (p = 0.05). There were no dose-limiting adverse effects. Of the 15 patients who continued on Apatone after 12 weeks, only 1 death occurred after 14 months of treatment.
Apatone showed promise in delaying biochemical progression in this group of end stage prostate cancer patients."
"When VC and VK3 were combined in a ratio of 100:1 (Apatone) and administered to human tumor cell lines, including androgen independent prostate cancer cells (DU145), they exhibited a synergistic inhibition of cell growth and induced cell death by apoptosis at concentrations that were 10 to 50 times lower than for the individual vitamins."
"All patients were treated with Vitamin C: K3 (5,000 mg. of VC and 50 mg. of VK3 each day, Apatone) for a total of 12 weeks."
1.83. Autoschizis: a new cell death induced found in tumour cells induced by oxidative stress mechanism
"One summarizes in this contribution some of the main cytotoxic changes observed in those cancer cells obtained as a result of treatments by VC alone, VK3 alone, combined VC+VK3 [23] as well as in vivo studies in the aim to support the use of this
vitamins’ combination as adjuvant therapy or treatment strategy against some forms cancers [24]. As shown in the
report those vitamins, used against cancer cells, were able to trigger and induce characteristic cell injuries that lead
toward a new form of cell death we have called autoschizic cell death or death by autoschizis, different tham necrotic or
oncotic cell death or apoptotic cell death"
"bladder, prostate, ovarian, etc and other carcinoma cell lines"
1.84. Mistletoe based treatment described in The Fourfold Path to Healing
also check (http://alternativecancertreatmentgerson.com/iscador-therapy/) for more info and instructions
here they combine it with IV vit.C and Gerson Therapy)
---------------------------------------
Phase 1 (6 months minimum, 1..3 years if it has positive effect):
1. Iscador (Weleda - mistletoe extract) treatment according to recommendations
2. measure vitamin D in blood and increment D3 supplement by 1,000IU until blood test reaches 40..60;
Brand used: Carlson;
use calcium lactate (6 tablets/day)
3. Mediherb ganoderma/shiitake - 1 tablet 2..3 times/day
4. Immuplex (by Standard Process) - 1 capsule, 3 times/day
specific protomorphogen of the tissue type from which the cancer originated.
For example - breast cancer - mammary PMG - 1 tablet 3 times/day.
5. individualized herbal therapy:
digestive complaints - turmeric extract (I guess he means curcumin), burdock root, milk thistle
cancers with hormonal implications (breast, prostate) - licorice, saw palmetto
usually add also: poke root extract
-----------------------------------------
Phase 2 (if phase 1 does not stop the cancer growth after 6 months).
In addition to all in Phase 1 add:
1. Melatonin - 20mg
2. Wobezym dygestive enzymes - 3..10 tablets 3..4 times a day between meals
3. Essiac - 2..4 tablets 2..3 times a day
4. specific herbs:
for gastro-intestinal cancer: aloe vera (Mediherb) 1 tablespoon 2 times a day
for melanoma and kidney cancer - Echinacea permium (Mediherb) - 1 tablet 3 times a day
or Astragalus Complex (Mediherb) - 1 tablet 3 times per day
--------------------------------------------
Phase 3:
1. Iscador Special, Mali for women, Quercus for men
-------------------------------------------
Phase 4:
1. IL-2 therapy after stopping Iscador. Dose - 3 million units/day 6 out of 7 days, 4 weeks
-------------------------------------------
In addition he recommend 20,000IU/day vit A from cod liver oil, balanced diet, fermented vegetables (beets),
coconut oil, animal fat, flax seeds/oil, special exercises, meditation.
Specifically says to avoid extreme diets such as all-raw vegetarian
1.85. Mistletoe treatment articles:
The case for mistletoe in the treatment of laryngeal cancer.
"case of a patient with laryngeal carcinoma who made a full recovery following mistletoe therapy, despite failing to
respond to chemoradiotherapy and salvage laryngectomy"
Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines.
"It was concluded that VA extracts have a cytotoxic effect on SCC9 and SCC25 cell lines, but while SCC9 cell line was
more resistant to the action of the drugs, Iscador Qu Spezial and Iscador M have higher cytotoxic potential in both
cell lines compared to Iscador P."
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.
"ISCADOR Q, showing multiple positive effects in the treatment of glioblastoma, may be a candidate for concomitant
treatment of this cancer."
Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two
Case Reports.
"The lymphoma regressed over a period of 12 and 8 months, respectively, and after administration of a cumulative
dose of 12.98 g and 4.63 g mistletoe extract, respectively. The patients are in remission to date, 3.5 years after
commencement of treatment. Neither patient received conventional cancer treatment during the entire observation
period."
Suzanne Somer's Cancer Battle
Mistletoe Extract: Cancer Therapy?
The majority of the mistletoe extracts that are used to treat cancer in patients originate from Europe; they have a
variety of brand names: Iscador (Iscar), Eurixor, Helixor, Isorel (Vysorel), Iscucin, Lektinol (Plenosol) and Abnoba-
viscum.
German researchers performed a meta-analysis in which they reviewed the effects of Iscador, a commonly used form
of mistletoe extract, on survival of cancer patients. The researchers reported that the data they examined showed a
lower risk of mortality.
In a review of randomized and non-randomized control trials, the efficacy of a type of mistletoe extract called Viscum
album was assessed to determine whether or not it improved on quality-of-life parameters in patients with cancer.
The researchers reported that the plant improved on quality-of-life measures such as sleep, exhaustion, depression
and anxiety; it also reduced the side effects of chemotherapy and radiation therapy.
In targeted nutritional program for my patients, I focus on several areas:
- Nutrients that lower the 3 main cancer promoters: AP-1, NF-kappa-B, and IGF.
- Nutrients that inhibit the main cancer promoting enzymes; tyrosine kinase, m-TOR, akt and COX-2.
- Nutrients that convert hormones that promote cancer to hormones that protect against cancer.
- Angio-preventative nutrients that inhibit angiogenesis.
- Anti-inflammatory nutrients.
- Reversing hyperinsulinemia through nutrition.
- Nutrients that facilitate apoptosis or programmed cell death, a process which cancer cells have lost.
- Detoxifying cancer-causing toxins with nutrients.
Glutathione, glycine, taurine, black raspberry, garlic, omega-3 and -9 fatty acids, fermented soy products,
isohumalones from hops, and phytosterols are just a few of the nutrients which data show are essential for the above
areas.
1.86. Oligomeric Proanthocyanidins (OPCs)
(Grape Seed Extract, Pine Bark Extract, Procyanidolic Oligomers (PCOs), Pycnogenol)
"Several food sources contain similar chemicals: red wine, cranberries, blueberries, bilberries, tea (green and black),
black currant, onions, legumes, parsley, and the herb hawthorn . However, most OPC supplements are made from
either grape seed or the bark of the maritime pine."
"For the treatment of specific medical conditions, studies have used doses of 150 to 300 mg daily."
Edema After Surgery or Injury:
"Breast cancer surgery often leads to swelling of the arm. A double-blind, placebo-controlled study of 63 post-
operative breast cancer patients found that 600 mg of grape seed OPCs daily for 6 months reduced edema, pain, and
peculiar sensations known as paresthesias. 32 Also, in a double-blind, placebo-controlled study of 32 people who had
received facial surgery, edema disappeared much faster in the group treated with grape seed OPCs. 33"
"Another 10-day, double-blind, placebo-controlled study enrolling 50 participants found that grape seed OPCs
improved the rate at which edema disappeared following sports injuries . 34"
Safety Issues:
"OPCs may have some anticoagulant properties when taken in high doses, and therefore should be used only under
medical supervision by individuals on blood-thinner drugs, such as warfarin (Coumadin), heparin, clopidogrel
(Plavix), ticlopidine (Ticlid), pentoxifylline (Trental), or aspirin."
1.87. Bromelain
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
"However, the viability of MUC1 expressing pancreatic and breast cancer cells are adversely affected by bromelain.
Further, the efficacy of cisplatin and 5-FU are enhanced by adjuvant treatment with bromelain, indicating that the
barrier function of MUC1 may be affected. Other studies have also indicated that there is a greater accumulation of 5-
FU in the cell compartment on treatment with 5-FU and bromelain. Malignant peritoneal mesothelioma (MPM)
expresses MUC1 and initial studies have shown that the viability of MPM cells is adversely affected by exposure to
bromelain. Further, bromelain in combination with either 5-FU or cisplatin, the efficacy of the chemotherapeutic drug
is enhanced. Hence, current evidence indicates that bromelain may have the potential of being developed into an
effective anticancer agent for MPM."
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis.
"we describe its anti-proliferative, anti-inflammatory and subsequent anti-cancer effects in vitro, against human
epidermoid carcinoma-A431 and melanoma-A375 cells. Bromelain exhibited reduction in proliferation of both these
cell-lines and suppressed their potential for anchorage-independent growth. ... Bromelain afforded substantial anti-
cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agent besides only an
additive in chemotherapy."
Bromelain-induced apoptosis in GI-101A breast cancer cells.
"Bromelain has been reported to promote apoptosis, particularly in breast cancer cells"
"Our results indicate an increase in apoptosis-related cell death in breast cancer cells with increasing concentrations
of bromelain."
1.88. Avemar (commercial) / Rejuvelac (home made)
Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases.
"Avemar can inhibit metastatic tumor dissemination and proliferation during and after chemotherapy, surgery, or
radiation. Benefits of Avemar treatment have been shown in various human cancers, in cultures of in vitro grown
cancer cells, in the prevention of chemical carcinogenesis, and also in some autoimmune conditions."
Avemar (wheat germ extract) in cancer prevention and treatment.
"The wide range of biological activity of Avemar probably cannot be explained by only one active ingredient. Since
there are numerous experimental data and the clinical benefit repeatedly confirmed Avemar can be one of the most
potent and best researched food supplements available for cancer patients."
Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of
its activity.
"We found that FWGE (fermented wheat germ extract) exhibited significant antiproliferative effects against 12 human
OVCA cell lines and potentiated cisplatin-induced apoptosis. ... Our findings confirm the value of FWGE as a natural
product with anticancer properties that may also enhance the activity of existing therapeutic agents."
Fermented wheat germ extract--nutritional supplement or anticancer drug?
"FWGE interacts synergistically with a variety of different anticancer drugs and exerted antimetastatic properties in
mouse models. ... Data in the F-344 rat model provide evidence for a colon cancer preventing effect of FWGE.
Clinical data from a randomized phase II trial in melanoma patients indicate a significant benefit for patients treated
with dacarbazine in combination with FWGE in terms of progression free survival (PFS) and overall survival (OS).
Similarly, data from studies in colorectal cancer suggested a benefit of FWGE treatment. Besides extension of OS and
PFS, FWGE improved the quality of life in several studies.
CONCLUSION:
In conclusion, available data so far, justify the use of FWGE as a non-prescription medical nutriment for cancer
patients. Further randomized, controlled and large scale clinical studies are mandatory, to further clarify the value of
FWGE as a drug component of future chemotherapy regimens.
Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines.
Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-
resistant H9 human lymphoma cells through induction of apoptosis.
Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma
patients: a randomized, pilot, phase II clinical study with a 7-year follow-up.
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human
HL-60 promyelocytic leukemia cells.
How to make Rejuvelac (fermented wheat germ juice)
Rejuvelac
"We recommend drinking one quart (1 liter) of rejuvelac per day"
"1. Rinse, then soak in filtered water 3/4 cup of dry grains for 8-12 hours in a jar with a screen tied over the opening.
2. Drain and discard the soak water from the grains, then rinse the grains. Keep the jar upside down at a 45 degree
angle to fully drain and for sprouting.
3. Sprout the grains for 24-36 hours. Rinse the grains two to three times during sprouting.
4. Blend the one cup of sprouted grains with two cups of purified water for about 5 seconds.
Pour contents from the blender into a one gallon container and add enough water to make one gallon.
5. Place a screen on top of the one gallon container and let the rejuvelac ferment for 24 hours in a room temperature
of 68-80 degrees F. Ferment longer if a stronger rejuvelac is desired.
6. Pour rejuvelac through a strainer to strain out the grains and sediment that forms on the bottom.
Discard or compost the grains and sediment."
1.89. Positive thinking
Is there Power in Positive Thinking?
[31:00] starts describing techniques:
MBSR (Mindfulness based stress reduction)
Combined Positive Affect and Self Affirmation Intervention
Cognitive behavioral stress management
Coping effectiveness training
BREATHE:
B - take a deep Breath; be present in the moment; accept what it is; be non judgmental
R - Realistic goals; celebrate when achieving your goals;
E - notice positive moments in Everyday life; recognize when things go right; share with others;
A - Acts of kindness
T - Turn it around; reframe the negative into positive;
H - Honor strengths; acknowledge your strengths;
E - Each day with gratitude; note positive steps and all you are thankful for;
Positive Emotion in the Midst of Stress (similar to "Is there power in Positive thinking")
[37:00] starts describing techniques
The Art of Living Every Minute of Your Life
[31:30] at the end of the day, reflect on your day going backwards (3 times) and ask yourself 1 question:
1. "What surprised me today?"
2. "What touched my heart today?"
3. "What inspired me today?"
write down the 3 answers in your diary.
1.90. Exercises
Healing Through Dance
I think the title is misleading. The main idea is to increase the range of motion and apply mindfulness during the
movement. Pay attention at pain and limitations of the body. Try to avoid (control) pain.
She mention that this can be helpful after surgery.
Demonstration starts at [42:00].
Similar exercises are described in [Ref.1.84].
1.91. Topical Yunnan Baiyao administration as an adjunctive therapy for bleeding complications in adolescents with advanced cancer.
"YNB may be an efficacious agent for uncontrolled bleeding in conjunction with conventional hemostatic agents in
adolescents with advanced cancer. It is well accepted by patients. YNB may be especially valuable in the outpatient
setting to prevent the recurrence of hemorrhage."
In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines.
Yunnan Baiyao and cancer for dogs
The efficacy of Yunnan Baiyao on haemostasis and antiulcer: a systematic review and meta-analysis of randomized
controlled trials.
http://csuvets.colostate.edu/pain/Articlespdf/YunnanPaiyao111206.pdf
1.92. Licorice
The anti-angiogenic activities of glycyrrhizic acid in tumor progression.
" Glycyrrhizic acid (GA) is the bioactive compound of licorice and has been used as a herbal medicine because of its
anti-viral, anti-cancer, and anti-inflammatory properties.
We observed that GA inhibited tumor growth and angiogenesis in mice.
Considering that angiogenesis is highly stimulated in the majority of cancers, GA could offer a potent therapeutic
agent for cancer."
Inhibition of tumor progression by naturally occurring terpenoids.
"Literature survey revealed that triterpenoids, such as glycyrrhizic acid, ursolic acid, oleanolic acid, and nomilin, the
diterpene andrographolide, and the monoterpenoids like limonene and perillic acid had shown immunomodulatory
and antitumor activities. All of them could induce apoptosis in various cancer cells by activating various proapoptotic
signaling cascades. Many of these terpenoids found to inhibit metastatic progression and tumor-induced
angiogenesis."
Licorice - general information
"Licorice is LIKELY SAFE for most people when consumed in amounts found in foods.
It is POSSIBLY SAFE when consumed in larger amounts use as medicine, short-term.
However, it is POSSIBLY UNSAFE when used in large amounts for more than four weeks.
Consuming 30 grams or more of licorice daily for several weeks can cause severe side effects including high
blood pressure, low potassium in the blood, weakness, paralysis, and occasionally brain damage in otherwise
healthy people. In people who eat a lot of salt or have heart disease, kidney disease, or high blood pressure, as
little as 5 grams per day can cause these problems.
Other side effects of licorice use include tiredness, absence of a menstrual period in women, headache, water and
sodium retention, and decreased sexual interest and function in men.
Special precautions & warnings:
Don’t use licorice if you are pregnant or breast-feeding.
Don’t consume large amounts of it if you have high blood pressure.
Don’t consume licorice if you have heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine
fibroids: Licorice might act like estrogen in the body. If you have any condition that might be made worse by exposure
to estrogen, don’t use licorice.
A muscle condition caused by nerve problems (hypertonia): Licorice can cause the level of potassium to drop in the
blood. This can make hypertonia worse. Avoid licorice if you have hypertonia.
Low potassium levels in the blood (hypokalemia): Licorice can lower potassium in the blood. If your potassium is
already low, licorice might make it too low. Don’t use licorice if you have this condition.
Sexual problems in men: Licorice can lower a man’s interest in sex and also worsen erectile dysfunction (ED) by
lowering levels of a hormone called testosterone.
Kidney disease: Overuse of licorice could make kidney disease worse. Don’t use it.
Surgery: Licorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2
weeks before a scheduled surgery."
1.93. Aloe
Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo.
"Aloin (AL), an natural compound derived from Aloe barbadensis Miller leaves, has been shown to possess anti-cancer
potential activities. ...
Our studies provided the first evidence that AL may inhibit tumor angiogenesis and growth via blocking STAT3
activation, with the potential of a drug candidate for cancer therapy."
Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human
U87 malignant glioma cells by aloe emodin.
"Aloe emodin, one of the active compounds found in Aloe vera leaves, plays an important role in the regulation of cell
growth and death. It has been reported to promote the anti-cancer effects in various cancer cells by inducing
apoptosis. ...
Aloe emodin showed a time- and dose-dependent inhibition of U87 cells proliferation and decreased the percentage of
viable U87 cells via the induction of apoptosis."
Reduction of intestinal polyp formation in min mice fed a high-fat diet with aloe vera gel extract.
"Aloe vera gel supercritical CO2 extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat
accumulation, and influence the metabolism of glucose and lipids in animal model experiments.
These results indicate that HAVGE (high dose AVGE = 12.5mg/kg) reduced large-sized intestinal polyps and
ameliorated reduction in plasma HMW adiponectin levels in Min mice fed HFD."
Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial.
"To evaluate an Aloe vera lotion for prevention of radiation-induced dermatitis, all patients with a prescription of
radiotherapy to a minimum dose of 40 Gy were eligible provided that their treatment area could be divided into two
symmetrical halves. Patients were given a lotion of Aloe vera to use on one half of the irradiated area, with no
medication to be used on the other half. ...
Based on these results, we conclude that the prophylactic use of Aloe vera reduces the intensity of radiationinduced
dermatitis."
1.94. Medicinal plants used for cancer treatment
Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.
"The plants that were cited at a higher frequency were Aloe vera, Euphorbia tirucalli, and Tabebuia impetiginosa. ...
We found the following molecules to be the most studied in vitro and in vivo: silibinin, ß-lapachone, plumbagin and
capsaicin."
Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of
ERK1/2-mediated apoptosis.
"Taken together, these findings suggest that euphol selectively induced gastric cancer cells apoptosis by modulation
of ERK signaling, and could thus be of value for cancer therapy."
Preventive and therapeutic euphol treatment attenuates experimental colitis in mice.
"The tetracyclic triterpene euphol is the main constituent found in the sap of Euphorbia tirucalli. This plant is widely
known in Brazilian traditional medicine for its use in the treatment of several kinds of cancer, including leukaemia,
prostate and breast cancers. Here, we investigated the effect of euphol on experimental models of colitis and the
underlying mechanisms involved in its action. ...
Together, these results clearly demonstrated that orally-administered euphol, both preventive or therapeutic
treatment were effective in reducing the severity of colitis in two models of chemically-induced mouse colitis and
suggest this plant-derived compound might be a potential molecule in the management of inflammatory bowel
diseases."
Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya.
"Most commonly cited plant species were Spathodea campanulata P. Beauv. ssp. nilotica (Seem), Microglossa pyrifolia
(Lam.) Kuntze, Harungana madagascariensis Lam. ex poir, Prunus africana (Hook. f.) kalkman, Cyphostemma serpens
(A. Rich), Catharanthus roseus (L.) G. Don and Aloe volkensii Engl."
Complementary and alternative medicine use in patients with chronic lymphocytic leukemia: an Italian multicentric
survey.
"The most common Complementary and alternative medicine therapies were green tea, aloe formulations and high
dose vitamins."
Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer(2).
"The herbs that are traditionally used for anti-cancer treatment and that are anti-angiogenic through multiple
interdependent processes (including effects on gene expression, signal processing, and enzyme activities) include
Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (curcumin), Scutellaria
baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese
magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinalis (ginger),
Panax ginseng, Rabdosia rubescens hora (Rabdosia), and Chinese destagnation herbs."
Botanical medicine and cancer: a review of the safety and efficacy.
"Current evidence suggests that Asian ginseng, garlic, green tea, tomatoes and soy intake as part of the diet may be
useful in preventing various cancers; additional research is needed in order to determine the efficacy of essiac,
evening primrose oil, mistletoe, reishi, shiitake and turmeric as cancer treatments; and ginger may be effective in
treating chemotherapy-induced nausea and vomiting."
Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants
from the island Soqotra.
"Notable cancer cell growth inhibition ... Ballochia atro-virgata, Eureiandra balfourii and Hypoestes pubescens,
... The methanol extracts of Acanthospermum hispidum, Boswellia dioscorides, Boswellia socotrana, Commiphora
ornifolia and Euphorbia socotrana also showed noticeable antiproliferative potency ....
The greatest antimicrobial activity was exhibited by extracts from Acacia pennivenia, Boswellia dioscorides,
Boswellia socotrana, Commiphora ornifolia, Euclea divinorum, Euphorbia socotrana, Leucas samhaensis, Leucas
virgata, Rhus thyrsiflora, and Teucrium sokotranum ...
In addition, the methanolic extracts of Acacia pennivenia, Boswellia dioscorides, Boswellia socotrana and
Commiphora ornifolia showed good antioxidant potential at low concentrations ..."
1.95. Astragalus
Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.
"Astragalus memebranaceus is a traditional Chinese herbal medicine used in treatment of common cold, diarrhea,
fatigue, anorexia and cardiac diseases. Recently, there are growing evidences that Astragalus extract may be a
potential anti-tumorigenic agent. Some research showed that the total saponins obtained from Astragalus
membranaceus possess significant antitumorigenic activity. ...
Total Astragalus saponins inhibited human gastric cancer cell growth, decreased the invasion ability and induced the
apoptosis. "
Does the Couse of Astragalus-Containing Chinese Herbal Prescriptions and Radiotherapy Benefit to Non-Small-Cell
Lung Cancer Treatment: A Meta-Analysis of Randomized Trials.
"Couse of Astragalus-containing Chinese herbal prescriptions and radiotherapy may benefit the patients with non-
small-cell lung cancer via increasing the therapeutic effectiveness and reducing the toxicity of radiotherapy."
Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice.
"In the present study, we investigated the antitumor and immunomodulatory activity of Astragalus membranaceus
polysaccharide (AMP) on liver cancer using murine H22 hepatocarcinoma model. The results showed that AMP (100
and 400 mg/kg) could effectively inhibit the solid tumor growth of H22 hepatocarcinoma transplanted in BALB/c
mice. ...
Taken together, these findings indicate that AMP has antitumor activity in vivo at least partly via improving immune
responses of host organism, and seems to be safe and effective for the use of anti-tumor therapy."
Astragalus
"Medicinal Uses and Indications
Astragalus has been used for the following:
Adaptogen -- protects the body from stress and disease
Anemia -- may improve blood counts in people with aplastic anemia.
Diabetes -- Astragalus appears to lower blood sugar.
Fatigue or lack of appetite from chemotherapy -- Some studies suggest astragalus may help reduce side effects
from chemotherapy.
Hepatitis -- A few studies have used a combination of herbs containing astragalus to treat hepatitis.
Kidney disease -- Preliminary research suggests astragalus may help protect the kidneys and may help treat
kidney disease.
Seasonal allergies -- One study found that astragalus may help reduce symptoms in people who have allergic
rhinitis or hayfever.
How to Take It
Dosage depends on condition being treated, age, and weight. Work with your physician to determine the safest and
most effective dosage for you. Higher doses may suppress the immune system. For best results, use a standardized
astragalus supplement. Recommended doses are as follows:
Standardized extract: 250 - 500 mg, 3 - 4 times a day standardized to 0.4% 4-hydroxy-3-methoxy isoflavone 7-sug.
Decoction (strong boiled tea): 3 - 6 g of dried root per 12 oz water, 3 times per day
Fluid extract (1:1) in 25% ethanol: 2 - 4 mL, 3 times a day
Powdered root: 250 - 500 mg, 3 - 4 times per day
Ointment: 10% astragalus applied to surface of wound. Do not apply to open wound without your doctor's supervision.
Tincture (1:5) in 30% ethanol: 20 - 60 drops, 3 times a day
Possible Interactions
Drugs that suppress the immune system -- Astragalus may interfere with these drugs. If you have an autoimmune
disease such as rheumatoid arthritis or lupus, or take cyclophosphamide, a medication used to reduce the chances of
rejection in transplant recipients, or corticosteroids, do not take astragalus.
Lithium -- Astragalus can make it harder for the body to get rid of lithium, so dangerously high levels of the drug could
build up."
1.96. Integrating Dietary Supplements Into Cancer Care
Curcumin
Curcumin also acts as a chemosensitizer and radiosensitizer for tumors in some cases. Curcumin has also been shown
to protect normal organs such as liver, kidney, oral mucosa, and heart from chemotherapy- and radiotherapy-induced
toxicity.
The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, familial polyposis,
pancreatic cancer, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma,
lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets.
Glutamine
In various cancer patients undergoing chemotherapy and radiation, when glutamine was added to their treatment,
there was decreased rates and severity of mucositis, neuropathy, and intestinal toxicity. Additional benefit was
observed in decreased use of pain medication in patients suffering from stomatitis, with improved nutrition, as a result
of this intervention.
It is commonly used in the powder form to produce oral solution, the dosage in that form is 10 g TID (range = 5-30
g/d).
Vitamin D
Subsequent studies have supported the finding that lower serum 25-hydroxyvitamin D levels are associated with
increased risks of breast and prostate as well as colorectal and possibly other cancers, although the data are considered
inconclusive. An increasing body of evidence suggests that lower serum levels are also related with poorer prognoses in
patients diagnosed with various malignancies.
Maitake Mushrooms
When Maitake D-fraction was given to patients receiving chemotherapy for a number of different cancers, response
rates reportedly increased from 12% to 28%.67 Various chemotherapy side effects were also said to be ameliorated in
patients receiving Maitake D-fraction. In the absence of toxicities, it is felt to be a useful adjuvant to chemotherapy.
There are also reports of synergy when used with vitamin C as suggested by in vitro and animal model studies. A recent
study suggests a direct antitumor effect of Maitake D-fraction with induction of apoptosis observed in breast cancer
cell lines.
Fish Oil
Recent studies in patients with earlier stage cancers, especially those receiving chemotherapy or chemoradiation, have
shown beneficial effects on body weight and quality of life.
Fish oil may increase apoptosis and decrease resistance by suppressing NF-?B.82 Higher rates of response and clinical
benefit with a tendency toward longer survival were observed in lung cancer patients supplemented with fish oil during
chemotherapy, with no increase in dose-limiting toxicities.83 Fish oil improved neutrophil number and function during
chemotherapy, and reduced weight loss.84
Finally, fish oil is used as perioperative immunonutrition—enteral supplements containing fish oil with arginine and
other nutrients have been found to reduce hospital stays and postoperative complications.
Green Tea
Clinical trials in prostate cancer suggest that green tea may be more effective in early than later-stage conditions9;
short-term administration before prostatectomy suggests favorable chemopreventive effects.
Premalignant oral lesions are suppressed by green tea supplements.
Positive effects were shown for a topical preparation in human papilloma virus–infected cervical lesions. Breast cancer
patients drinking green tea had improved high-density lipoprotein cholesterol and nonsignificant improvements in
insulin resistance and weight. Asymptomatic early stage patients with chronic lymphocytic leukemia received high-
dose Polyphenon E in a phase I trial; improvements in absolute lymphocyte count and adenopathy as well as one partial
remission were observed.
Liver enzymes should be monitored in patients taking high-dose green tea supplements.
Milk Thistle
Clinical trials of silymarin have been conducted primarily in patients with either hepatitis or cirrhosis.109 Silymarin is
the only known drug effective in protection from Amanita phalloides toxin, which targets the liver.110,111
Three case reports,112-114 3 pharmacokinetic studies,115-117 and 2 double-blind randomized trials118,119 have been
conducted with varying degrees of scientific rigor. In the only report describing the use of silymarin (450 mg/d) for the
treatment of hepatocellular carcinoma, the authors reported spontaneous regression of the tumor in the absence of
initiation of anticancer therapy.112 In a double-blind, placebo-controlled randomized trial, 50 children who were
undergoing treatment for acute lymphoblastic leukemia and who had chemotherapy-related hepatotoxicity were given
silymarin (80-360 mg/d) for a 30-day period.118 The treatment group had a significantly lower aspartate
aminotransferase and a trend toward a significantly lower alanine aminotransferase. Vidlar et al119 explored the effect
of milk thistle (570 mg) in combination with selenium on quality of life, lipid profile, oxidative stress, and testosterone
levels. Thirty-seven men who underwent radical prostatectomy were randomized to milk thistle and selenium or
placebo for a 6-month period. The authors reported significant improvements in quality of life and lipid panel (total
cholesterol and low-density lipoproteins); however, no effect was observed on measures of oxidative stress or
testosterone levels. No adverse events were reported.
Daily doses ranging from 2 to 13 g are safe.
Astragalus membranaceus
It is used as a supportive agent during cancer treatment, and data from clinical studies suggest that it may be beneficial
when used in conjunction with chemotherapy.1
They also increase phagocytosis and demonstrate hepatoprotective effects on chemical-induced liver injury in
vitro125 and in vivo.126
Astragalus has been reported to have direct anticancer effects: Astragalus extracts inhibit tumor growth,124 delay
chemical-induced hepatocarcinogenesis in rats,126 have antiangiogenic property,127 and may also enhance the effects
of platinum-based chemotherapy.
Melatonin
Probiotics
Chemotherapy relief: Good bugs from probiotics can ease side-effects
Cancer breakthrough: Probiotics may save patients from deadly chemotherapy; antibiotics may cause chemo to be fatal
Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy.
1.97. Diindolilmethane (DIM)
DIM is a phytonutrient (plant nutrient) found in cruciferous vegetables. These include cabbage, broccoli, bok choy,
Brussels sprouts, cauliflower, kale, kohlrabi, mustard, rutabaga, and turnip.
Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects.
200[mg] - maximum effective single dose.
DIM
"Since pure DIM must be provided in an absorption-enhancing formulation, the dose for DIM sometimes specifies the
weight of the absorbable formulation, which is only one-fourth, or 25 percent DIM. In the book, All About DIM, the
suggested dose of 100 to 200 mg per day for women and 200 to 400 mg of DIM per day for men refers to milligrams
of such an absorbable formulation.(15) This dose range for hormonal balance corresponds to 25 to 50 mg per day of
actual DIM for women and 50 to 100 mg of actual DIM for men."
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.
"We report that administration of DIM in a multidose schedule protected rodents against lethal doses of total body
irradiation up to 13 Gy, whether DIM dosing was initiated before or up to 24 h after radiation.
In contrast, DIM did not protect human breast cancer xenograft tumors against radiation under the conditions
tested."
1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a
metastasis model.
Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -
independent prostate cancer cells.
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth.
3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.
Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3'-
diindolylmethene in human breast epithelial cell lines.
3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells.
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic
reticulum stress-dependent upregulation of DR5.
1.98. Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver
metastases via modulating matrix metalloproteinase-9 and E-cadherin expression.
1.99. In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4)
in liver of rats injected with DEN.
"Moreover, curcumin has the potential to be used in a therapy for liver cancer."
Potential therapeutic efficacy of curcumin in liver cancer.
"It is found that Curcumin dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis.
Moreover, Curcumin delayed the growth of liver cancer in a dose-dependent manner in nude mice."
1.100 Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.
"Curcuma aromatica and Polygonum cuspidatum are one of the commonly used paired-herbs for liver cancer
treatment. Curcumin and resveratrol are the major anticancer constituents of Curcuma aromatica and Polygonum
cuspidatum, respectively. Curcumin and resveratrol have been found to exhibit a synergistic anticancer effect in
colon cancer. ...
Combination of curcumin and resveratrol upregulated intracellular reactive oxygen species (ROS) levels in Hepa1-6
cells. The ROS scavenger, NAC, partially attenuated the apoptosis and caspase activation induced by the
combination treatment of curcumin and resveratrol. In addition, the combination of curcumin and resveratrol
downregulated XIAP and survivin expression. These data suggest that the combination treatment of curcumin and
resveratrol is a promising novel anticancer strategy for liver cancer."
Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN
knockout mice.
1.101 Potential impact of curcumin and taurine on human hepatoma cells using Huh-7 cell line.
"Curcumin/taurine in combination formula is better treatment than single therapy ...
Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with
consequent induction of CD8 T-cell responses to lyse tumor cells."
1.102 Integrating Nutrition and Selected Controversial Nutritional Supplements into a Cancer Treatment Program
An excellent article. Some bullet points:
- detoxification; proper digestion; regular bowel movements;
sulforaphane (broccoli sprouts extract) - liver detoxification
- macrobiotic diet; positive results for pancreatic, prostate cancer;
avoid: sugar, white flower, alcohol, caffeine, fluoridated/chlorinated water, food containing bromine,
hydrogenated fats, trans fatty acids, artificial chemicals in food (sweeteners, colors, flavors, preservatives)
GMO, fish with mercury, gluten
non dietary items to avoid: tobacco, recreational drugs, amalgam fillings, exposure to toxic chemicals,
synthetic hair dyes, aluminum containing antiperspirants, cell phones/microwave ovens,
nuclear plants, high voltage transmission power lines (my comment),
tight fitting clothing (bras) which cuts off lymphatic circulation
diet: whole foods, mostly plant based, organic, grass fed animals, juicing vegetables, low glycemic index foods
eat slowly, don't skip breakfast, do not skip meals, avoid malnutrition
boil/poach/stew; avoid frying/broiling/roasting/microwave
- Curcumin, EPA, Vitamin D3, Melatonin, Vit. A, Boswellic acid - affect up to 15 mechanisms of cancer
supplements are about 30 times less potent than drugs and about 21 times less toxic,
supplements work better in combinations
do not interfere and actually enhance chemotherapy and radiation; decrease side effects;
- Jaakkola study supplements:
Retinol Palmitate (Vit.A) - 15,000 .. 40,000[IU]
Beta Carotene - 10,000 .. 20,000[IU]
Vit.E - 300 .. 800[IU]
Thiamin (Vit. B1) - 150 .. 750 [mg]
Vit. B6 - 200 .. 1,140[mg]
Vit. B12 - 30 .. 1,600[ug]
Vit. D - 400 .. 1,000[IU]
Vit. C - 2,000 .. 5,000[mg]
Vit. B5 - 50 .. 300 [mg]
Biotin - 300 .. 1,000[ug]
Essential Fatty Acids - 5 .. 65[g]
Calcium
Magnesium
Zinc
Manganese
Selenium
Copper
Chromium
Vanadium
- The Hoffer protocol
improved diet (see above)
Vit.C - 10 .. 40[g]
Vit.B3 - 300 .. 3,000[mg]
Vit.B6 - 200 .. 300 [mg]
Folic acid - 1 .. 30[mg]
Vit.E - 400 .. 1,200[IU]
mixed carotenoids (such as carrot juice)
multi vitamins and minerals
Co Q10 - 300 .. 600[mg]
Selenium - 200 .. 1,000[ug]
Zinc - 25 .. 10[mg] (with some copper)
Calcium and Magnesium - 2:1 ratio
most supplements given in divided doses 2 .. 3 times daily
- IV Vit.C - 10 .. 120[g]
not giving IV glutathione on the same day as IV Vit.C
typical IV Vit.C includes:
60[g] Vit.C,
10[cc] Calcium Gluconate,
4[cc] Magnesium Chloride,
500[cc] sterile water,
administered over 2 hours
- Iodine - used in Gerson therapy and Hoxsey formula
12.5 .. 50[mg] (about 400 times higher than RDA)
fibrocystic breast disease - could be reversed with 5[mg]; good results with 50[mg] for 3 months
Japanese diet - 13[mg] from seaweed
thyroid gland - iodide form of iodine
breast/ovaries - elemental form of iodine
Lugol (Iodoral) contain both forms
dose must be no more than the body can tolerate in terms of detoxification.
Take with lots of water, unrefined salt, selenium, magnesium and Vit.C
- Mirko Beljanski Products - extracts from Pao Pereira and Rauwolfia Vomitoria
liver, thyroid, brain and breast cancer
- proteolytic enzymes
Vir. D3, Vit. K, Vit. A, phytonutrients (sulforaphane), resveratrol, curcumin, pre/pro biotics
- Salvestrols (resveratrol - max 30[mg])
1.103 Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from
Golden Spice
- anti-inflammatory [3], hypoglycemic [4,5], antioxidant [6], wound healing [7], and antimicrobial activities [8]. It has
been shown to possess chemosensitization, chemotherapeutic and radiosensitization activities as well [9]. Curcumin
has been studied for its chemopreventive potential in a wide variety of cancers, in both preclinical studies and in
clinical trials [10].
1. Oral delivery
Curcumin showed beneficial effects in several types of cancer in patients. Recently it has been reported that oral
curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients
[19]. In animal model oral administration of curcumin inhibited cancer of lung [20], skin [21], head and neck [22],
oral [23], hepatocellular carcinoma [24], mammary tumors, lymphomas, leukemias [25], and familial adenomatous
polyposis [26]. Oral treatment of curcumin found to effective in diabetic condtion. It attenuated high fat diet-
induced glucose intolerance and elevations of oxidative stress in the skeletal muscle [27]. Curcumin also enhanced
wound repair in diabetic impaired healing in mice [28]. Curcumin improves the peripheral neuropathy of R98C mice
by alleviating endoplasmic reticulum stress, reducing the activation of unfolded protein response and promoting
Schwann cell differentiation [29]. It also protects against the pulmonary and cardiovascular effects in mice [30].
2. Subcutaneous delivery
It has been also shown that the microparticle formulation of curcumin showed marked anticancer efficacy in nude
mice
3. Intraperitoneal (IP) delivery
Curcumin, delivered intraperitoneally, has shown inhibitory effect against lipopolysaccharide induced cardiac
hypertrophy in rodents [33]. It also reduced volume of glioma tumor implanted in nude mice, and prolonged the
survival of animals [34]. Another study showed that IP injection of curcumin inhibited tumorigenicity and tumor
growth, decreased the percentages of myeloid-derived suppressor cells in the spleen, blood, and tumor tissues,
reduced IL-6 levels in the serum and tumor tissues in a human gastric cancer xenograft model and a mouse colon
cancer allograft model [35]. It has been also shown that curcumin ameliorates intracerebral hemorrhage damage by
preventing matrix metalloproteinase-mediated blood-brain barrier damage and brain edema, which might provide
therapeutic potential for intracerebral hemorrhage [36]. Beside these, curcumin acts against asthma. ...
Curcumin administered IP inhibited human oral squamous cell carcinoma xenograft tumor in mice, indicating its
therapeutic efficacy in vivo [23]. Interestingly, it has been shown that oral curcumin treatment showed no effect on
important measures of bleomycin-induced injury in mice, whereas IP curcumin administration effectively inhibited
inflammation and collagen deposition along with a trend toward improved survival of animals. IP curcumin also
reduced fibrotic progression even when administered after the acute bleomycin-induced inflammation had subsided.
Intravenous Delivery
Numerous reports have been shown that intravenous injection of curcumin exhibits anticancer property in animal
model. Kim et al. [39] has shown that in curcumin has in antitumor effects in xenograft mouse model of colorectal
cancer. They have also shown that curcumin loaded human serum albumin (HSA) nanoparticles has greater
therapeutic effect than curcumin without inducing toxicity [39]. Several other studies reported that liposomal
curcumin inhibited different type of tumor growth in mouse models. It inhibited the growth of head and neck
squamous cell carcinoma in xenograft mouse .... Liposomal formulation of curcumin also enhanced the effect of
radio and chemotherapy. Shi et al. [41] showed that liposomal curcumin when combined with radiation enhanced
the
inhibition of tumor growth in a murine lung carcinoma (LL/2) model. It has been also reported that intravenous
treatment of liposomal curcumin in combination of cisplatin significantly enhances growth inhibition of xenograft
head and neck tumors in mice.
Another derivative of curcumin conjugated with luteinizing hormone releasing hormone, [DLys(6)]-LHRH-curcumin,
when given intravenously caused a reduction in tumor weights and volumes, and free curcumin given by gavage at an
equal dose failed to cause a significant reduction in tumor weights and volumes in the nude mouse pancreatic cancer
model. This bioconjugate enhanced apoptosis in tumor tissue [43]. The encapsulated curcumin with monomethoxy
poly (ethylene glycol)-poly(e-caprolactone) (MPEG-PCL) micelles also showed stronger anticancer effect than that of
free curcumin. When curcumin/MPEG-PCL micelle applied intravenously inhibited the growth of subcutaneous C-26
colon carcinoma in vivo [44]. The intravenous administration of another curcumin derivative, curcumin-loaded HSA
nanoparticles also showed greater therapeutic effect than curcumin in tumor xenograft HCT116 models without
inducing toxicity [39].
1. Topical delivery
Curcumin has been used topically to study its effect mostly on inflammation on target organ, wound healing, skin
cancer and other.
Beside these when curcumin applied as a noninvasive topical paste to the head and neck squamous cell carcinoma
(HNSCC) xenografts tumors in mice, resulted in inhibition of its growth. Thus, it can be used as an adjuvant or
chemopreventive agent in several cancer [48].
2. Nasal delivery
To increase the bioavailability and also direct nose-to-brain drug transport, nasal delivery of curcumin has been used.
In a study, the pharmacokinetics results showed that the absolute bioavailability of curcumin in the microemulsion-
based in situ ion-sensitive gelling system was 55.82% by intranasal administration. And the distribution of curcumin
in brain versus blood following intranasal administration was higher than that following intravenous administration
[49]. Another study also showed that the drug-targeting efficiencies of the curcumin in the cerebrum, cerebellum,
hippocampus and olfactory bulb after intranasal administration of the curcumin hydrogel were 1.82, 2.05, 2.07, and
1.51 times higher than intravenous administration of the curcumin solution injection, respectively, indicating that the
hydrogel and intranasal administration significantly increased the distribution of curcumin into the rat brain tissue.
In another study intranasal curcumin has been detected in plasma of mice after 15 minutes to 3 hours at
pharmacological dose (5 mg/kg), which has shown antiasthmatic potential by inhibiting bronchoconstriction and
inflammatory cell recruitment to the lungs. Thus, this study indicates that intranasal treatment of curcumin prevents
airway inflammations and bronchoconstrictions in asthma without any side effect [51].
Bioavailability of Curcumin
1. Unformulated curcumin
2. Nanocurcumin
3. Polylactic-co-glycolic acid (PLGA)
4. Liposomal encapsulation
5. Cyclodextrin (CD)
6. Piperine
Biological Activities of Formulated Curcumin
Curcumin liposomes of dimyristoyl phosphatidyl choline and cholesterol inhibit proliferation of prostate cancer cell 10
times more than curcumin [67].
Absorption of Curcumin in Blood, Liver, Brain, Kidney, and Other Organs
Metabolism of Curcumin
1.104 Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C.
"Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available,
the unsatisfactory outcomes demand establishing more effective interventions. D-fraction (PDF), a bioactive
proteoglucan of Maitake mushroom, demonstrates anticancer and immunomodulatory activities, which are also
shown to be potentiated by vitamin C (VC). ...
The present study demonstrates that the combination of PDF and VC can become highly cytotoxic, inducing severe
cell death in ACHN cells. ... Therefore, as PDF and VC may work synergistically to induce apoptotic cell death, they
may have clinical implications in an alternative, improved therapeutic modality for advanced RCC."
1.105 Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells.
"Treatment of cells with liposomal curcumin (5-10 microM) for 24-48 h at 37 degrees C resulted in at least 70-80%
inhibition of cellular proliferation without affecting their viability. On the other hand, free curcumin exhibited similar
inhibition only at 10-fold higher doses (>50 microM). ... We are currently developing liposome formulations with
targeting ability to further improve the efficacy of curcumin in vivo."
Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and
angiogenesis.
"In xenograft tumors in nude mice, liposomal curcumin at 20 mg/kg i.p. three-times a week for four weeks induced
42% suppression of tumor growth compared to untreated controls. ...
These data clearly establish the efficacy of liposomal curcumin in reducing human pancreatic cancer growth in the
examined model. The therapeutic curcumin-based effects, with no limiting side-effects, suggest that liposomal
curcumin may be beneficial in patients with pancreatic cancer."
Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications
Role of Curcumin in Cancer Therapy
1.106. ALA/N Protocol
"The purpose of the program was 3-fold: (1) nutritional support especially through specific antioxidant agents, (2)
comfort and palliation, and (3) immune system modulation via biological response modification. The major
therapeutic agents were intravenous (IV) a-lipoic acid (ALA), 300 to 600 mg, 2 days per week, and low-dose
naltrexone (LDN), 4.5 mg by mouth at bedtime. In addition, a triple antioxidant regimen consisting of oral ALA(600
mg per day), selenium (200 mcg twice daily), and silymarin (300 mg 4 times a day) was started. JA was also placed
on a generally accepted as healthy diet and lifestyle program."
The Long-term Survival of a Patient With Pancreatic Cancer With Metastases to the Liver After Treatment With the
Intravenous Alpha Lipoic Acid/Low-Dose Naltrexone Protocol
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic
pancreatic cancer: a report of 3 new cases.
Alpha-Lipoic Acid Plus Low-Dose Naltrexone Reviewed for Cancer Treatment
"Dr. Berkson reported success using ALA to repair liver damage in patients from mushroom poisoning or chronic
infections with hepatitis C virus. He also cited a number of research articles in European medical journals showing
ALA’s beneficial effects on cancer. ...
successful therapy with LDN of both the patient’s cancer and rheumatoid arthritis ...
Dr. Berkson reported uniformly positive responses and low toxicity from the ALA/ LDN regimen for each of the
seven cancer patients ...
Dr. Donahue presented findings from use of LDN in both human ovarian cancer cell cultures and for treating human
ovarian tumors grafted into mice. ...
The Penn State lab has found similar positive responses to LDN in other human cancer cell lines and mouse studies,
including for pancreatic cancer ...
Dr. Donahue has also studied the effects of LDN or OGF in combination with common chemotherapy agents for
cancer, such as taxol and cisplatin. She reported that LDN did not interfere with the tumor reduction effects of those
drugs and, in one case, seemed to enhance the drug’s effect."
Integrative Medical Center of New Mexico
from a post in a news group (cancer type - not specified):
"My recipe for my cancer remission is LDN, ALA, liposomal vitamin C, DCA and fasting two days a week. This
brought me back from hospice in December of 2011."
Dichloroacetate: University of Alberta Doctors Discover A Cure For Cancer
Metabolic treatment of cancer: intermediate results of a prospective case series.
"... lipoic acid at 600 mg i.v. (Thioctacid), hydroxycitrate at 500 mg t.i.d. (Solgar) and low-dose naltrexone at
5 mg (Revia) at bedtime."
Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone and vitamin D3--a case report.
"...These included oral dichloroacetate [14-16] (apoptosis inducer/metabolic therapy), low dose naltrexone,
ammonium tetrathiomolybdate [17-20] (copper chelator / angiogenesis inhibitor), and combination therapy
with radiation. Risks and benefits were discussed.
He was reluctant to have radiotherapy and was interested in medication with low side effects, so LDN was selected.
High dose vitamin D was also added (10,000 IU per day of oral liquid vitamin D3) since it can act as a differentiating
agent, thus potentially enhancing the cancer therapy [21-24]. The target blood level of 25-hydroxy vitamin D was the
upper end of the normal range, as specified by the patient’s local blood lab. The patient was also asked to moderate his
alcohol consumption.
LDN was started at a dose of 3mg orally once a day at bedtime. This reduced dose was selected to ensure that sleep was
not disrupted by insomnia or vivid dreams (known side effects of LDN). Since the LDN was well-tolerated, the dose
was increased to 4 mg daily at bedtime. The patient also added oral vitamin C 2000mg daily for the first 3 months of
therapy.
The patient felt improvement in symptoms with LDN therapy, and decided to continue under the direction of his
family doctor, with periodic re-assessment from his otolaryngologist at the regional cancer hospital. After 3 months
of therapy, blood tests were repeated and demonstrated normalization of most values (Table 2). After one year of
therapy, the 25-hydroxy vitamin D was 268nmol/L (normal range 75-250 nmol/L). Vitamin D was reduced to 5,000 IU
daily. The patient felt well and had no further symptoms from his cancer. Therapy was continued with no dose
changes, and after a total of 2 years of LDN and vitamin D, the MRI was repeated.
There were no complications from the LDN or high dose vitamin D, and no conventional therapy was ever introduced."
Other articles on LDN:
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
"fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. ... anti-inflammatory agent in
the central nervous system, via action on microglial cells.... As a daily oral therapy, LDN is inexpensive and well-
tolerated."
Low-dose naltrexone therapy improves active Crohn's disease.
1.107 Milk Thistle (Silymarin)
Silymarin in the prevention and treatment of liver diseases and primary liver cancer.
"The chemopreventive effect of silymarin on HCC has been established in several studies using in vitro and in vivo
methods; it can exert a beneficial effect on the balance of cell survival and apoptosis by interfering cytokines. In
addition to this, anti-inflammatory activity and inhibitory effect of silymarin on the development of metastases
have also been detected. In some neoplastic diseases silymarin can be administered as adjuvant therapy as well."
1.108 Tea Tree Oil
Tea tree oil might combat melanoma.
"TTO proved to be capable of inhibiting the growth of melanoma cells and of overcoming multidrug resistance
(MDR), as we reported in our previous study. ... The results reported herein indicate that TTO and its main active
component, terpinen-4-ol, can also interfere with the migration and invasion processes of drug-sensitive and drug-
resistant melanoma cells."
Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil.
"Four, daily, topical treatments of 10% TTO/DMSO regressed subcutaneous AE17 mesotheliomas in mice for a
period of 10 days and significantly retarded the growth of subcutaneous B16-F10 melanomas. The antitumour effect
of topical 10% TTO/DMSO was accompanied by skin irritation similar to other topical chemotherapeutic agents, but
unlike other approved topical agents, quickly and completely resolved. Furthermore, we show that topical 10%
TTO/DMSO caused an influx of neutrophils and other immune effector cells in the treated area, with no evidence of
systemic toxicity.
TTO combined with an effective carrier significantly inhibited the growth of aggressive, subcutaneous, chemo-
resistant tumours in immunocompetent mice. Taken together, these findings highlight the potential of topical TTO
as an alternative topical antitumour treatment."
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.
"Melaleuca alternifolia (tea tree) oil (TTO) applied topically in a dilute (10%) dimethyl sulphoxide (DMSO)
formulation exerts a rapid anti-cancer effect after a short treatment protocol. Tumour clearance is associated with
skin irritation mediated by neutrophils which quickly and completely resolves upon treatment cessation. ...
Although topical application of 10% TTO/DMSO appears to activate an immune response, anti-tumour efficacy is
mediated by a direct effect on tumour cells in vivo. The direct cytotoxicity of TTO in vivo appears to be associated
with TTO penetration."
Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and
terpinen-4-ol.
"PURPOSE: To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil (TTO), and its major
active terpene component, terpinen-4-ol, against two aggressive murine tumour cell lines, AE17 mesothelioma and
B16 melanoma.
CONCLUSION: TTO and terpinen-4-ol had significant anti-proliferative activity against two tumour cell lines."
A review of the toxicity of Melaleuca alternifolia (tea tree) oil.
"Anecdotal evidence from almost 80 years of use suggests that the topical use of the oil is relatively safe, and that
adverse events are minor, self-limiting and occasional. Published data indicate that TTO is toxic if ingested in
higher doses and can also cause skin irritation at higher concentrations. Allergic reactions to TTO occur in
predisposed individuals and may be due to the various oxidation products that are formed by exposure of the oil to
light and/or air. Adverse reactions may be minimised by avoiding ingestion, applying only diluted oil topically and
using oil that has been stored correctly. Data from individual components suggest that TTO has the potential to be
developmentally toxic if ingested at higher doses, however, TTO and its components are not genotoxic."
DMSO
The Human Toxicology Of Dimethyl Sulfoxide
"80% DMSO gel at 1 g/kg"
WebMD link
DMSO - living naturally web site
1.109 Hyperthermia
Hyperthermia in Cancer Treatment
Research in hyperthermia treatments
Whole Body Hyperthermia at 43.5-44°C: Dreams or Reality?
Note: Extreme application under general anesthesia.
HYPERTHERMIA at home with Michael and Trish
1.110 Selenium
Super Selenium Complex
contains all 3 forms: Sodium selenite, L-selenomethionine, Selenium-methyl L-selenocysteine
Selenium: What Forms Protect Against Cancer?
The New Recommendations for Dietary Antioxidants
"We also suggest daily supplements of 200 mg of natural vitamin E and 100-200 mcg of selenium, especially for men
at increased risk of prostate cancer. Vitamin E and selenium supplements should not exceed 1,000 mg/day and 400
mcg/day, respectively.
Beta-carotene supplementation is not advisable.
Even very large doses of vitamin C do not exert any adverse health effects."
Dietary selenium supplementation modifies breast tumor growth and metastasis.
"The primary tumor growth, the numbers of cancer cells present in lungs, hearts, livers, kidneys and femurs and
several proinflammatory cytokines were measured. We found that inorganic selenite supplementation provided
only short-term delay of tumor growth, whereas the two organic SeMet and MSA supplements provided more
potent growth inhibition. These diets also affected cancer metastasis differently. Mice fed selenite developed the
most extensive metastasis and had an increased incidence of kidney and bone metastasis. On the other hand, mice
fed the SeMet diet showed the least amount of cancer growth at metastatic sites."
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-
treated colorectal cancer cells.
"Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including
leukemia, prostate cancer and colorectal cancer (CRC) cells."
Selenite enhances and prolongs the efficacy of cisplatin treatment of human ovarian tumor xenografts.
"Selenite increased and prolonged the efficacy of multiple cisplatin treatments, although selenite was not an
effective inhibitor by itself. In the absence of selenite, the effectiveness of cisplatin decreased."
Selenium (University of Maryland)
Selenium (National Institute of Health)
1.111 Hemp Oil
Phoenix tears - Rick Simpson
RUN FROM THE CURE: The Rick Simpson Story
PROOF CANNABIS CURES CANCER - VARIOUS NEWS SOURCES
Hemp oil effectively kills cancer cells
Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows
Spain study confirms hemp oil cures cancer without side effects
Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
"This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the
Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation
therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions
provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally
to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia
chromosome mutation and indications of dose-dependent disease control.
...
These results cannot be explained by any other therapies, as the child was under palliative care and was solely on
cannabinoid treatment when the response was documented by the SickKids Hospital. The toxicology reports ruled
out chemotherapeutic agents, and only showed her to be positive for THC (tetrahydrocannabinol) when she had a
recent massive decrease of WBC from 350,000 to 0.3’ inducing tumor lysis syndrome, as reported by the primary
hematologist/oncologist at the SickKids Hospital."
Me and Cancer-The Cannabis Oil Cure
Case of terminal liver and bowel cancer.
Repositioning therapy for thyroid cancer: new insights on established medications.
"For instance, the derivatives of cannabis and an anti-diabetic agent, metformin, are both able to inhibit extracellular
signal-regulated protein kinase (ERK), which is commonly activated in thyroid cancer cells. We present here several
examples of well-known medications that have the potential to become new therapeutics for patients with thyroid
cancer."
Towards the use of non-psychoactive cannabinoids for prostate cancer.
"... present comprehensive evidence that plant-derived cannabinoids, especially cannabidiol, are potent inhibitors of
prostate carcinoma viability in vitro. They also showed that the extract was active in vivo, either alone or when
administered with drugs commonly used to treat prostate cancer ..."
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and
underlying mechanisms.
"Cannabidiol (CBD) significantly inhibited cell viability."
Cannabinoid-associated cell death mechanisms in tumor models (review).
"Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the
ability of these compounds to induce different pathways of cell death has been highlighted."
1.112 Essiac
Remission of hormone-refractory prostate cancer attributed to Essiac.
"We describe here the case of a 64-year-old man whose hormone-refractory prostate cancer responded well
to Essiac tea."
Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
"Essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a
matter of debate. ...
Essiac effectively scavenged hydroxyl, up to 84% reduction in radical signal at the 50% tea preparation
concentration, and superoxide radicals, up to 82% reduction in radical signal also at the 50% tea preparation
concentration, as well as prevented hydroxyl radical-induced DNA damage. In addition, Essiac inhibited hydroxyl
radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that
Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-
cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac."
Inhibition of prostate cancer-cell proliferation by Essiac.
1.113 Curcumin
Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway.
"In the present study, we found that cell mortality and curcumin concentration were dose dependent. Curcumin of
low concentrations (10 µM) could reduce the level of reactive oxygen species (ROS) in tumor cells, while curcumin
of high concentrations (80 µM) was able to significantly increase the content of ROS. In addition, Western blotting
detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of
Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently
slowing the curcumin-induced apoptosis. Taken together, curcumin further activates the mitochondrial apoptotic
pathway by inducing cells to generate ROS and ultimately promotes the apoptosis of tumor cells."
Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis.
"Through FACS analysis and activated caspase-3 labeling we demonstrate that CUR induces apoptosis of
rabdomyosarcoma and osteosarcoma cells and that this effect is potentiated when CUR is combined with RES or
DADS."
Cytotoxic effects of curcumin on osteosarcoma cell lines.
"In the current study we examined the cytotoxic effect of curcumin on seven osteosarcoma (OS) cell lines with
varying degrees of in vivo metastatic potential. Curcumin inhibited the growth of all OS cell lines tested with half-
maximal inhibitory concentration values ranging from 14.4 to 24.6 microM."
The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro.
"Cisplatin (0.1, 1.0, 10.0 microM) and curcumin (0.1, 1.0, 10.0 microM) induced significant dose-dependent
inhibition in both cell growth as well as cell proliferation. Genistein and quercetin (1.0, 10.0, 100.0 microM) had
biphasic effect, depending on their concentrations, on cell growth as well as cell proliferation. Based on these
findings, it is concluded that curcumin is considerably more potent than genistein and quercetin, but cisplatin is
five fold more potent than curcumin in inhibition of growth and DNA synthesis in SCC-25."
Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
"The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to
curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin
treatment. Therefore, this study showed that at the right concentrations (5 µM to 25 µM), curcumin, along with a
proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells."
Curcumin - The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention
and Treatment
"can act synergistically with ... radiotherapy, chemotherapy and hormonotherapy
... synergistic effect with genistein
... When combined, they are able to reduce the proliferation of the human breast MCF-7 oestrogen-positive cells
induced by environmental pesticides [192].
... curcumin ... D3 (calcitrol) ...
... curcumin and omega-3 fatty acids (fish oil diet) leads to the prevention and treatment of pancreatic tumor ...
... curcumin with embellin, a natural benzoquinone derived from Embelia ribes berries, ... hepatocarcinogenesis
... human prostate cancer PC-3 ... curcumin and b-phenylethyl isothiocyanate (PEITC), a natural compound
issued from cruciferous vegetables.
... curcumin and resveratrol ... colon cancer
... curcumin with epigallocatechin-3-gallate (EGCG), ... premalignant and malignant human oral epithelial cells
... chronic lymphocytic leukemia cells (CLL), synergism between EGCG and curcumin allows to overcome the
stromal-mediated protection of the CLL cells in the case of sequential therapy. By this way, EGCG sensitizes the
cells to curcumin effects and is able to increase strongly cell death in leukemic cells [172].
Curcumin ... piperine, an alkaloid from black pepper, inhibits breast stem cell self-renewal without inducing
toxicity to differentiated cells. This inhibitory effect is mediated by the inhibition of mammosphere formation
and Wnt signaling pathway, but without causing toxicity to differentiated cells [91].
... curcumin with quercetin, ... adenomas in patients with familial adenomatous polyposis without
appreciable toxicity ...
5.2. Synergism with conventional therapy
... curcumin with radiation enhances significantly ...
Curcumin was shown to potentiate the effect of Taxol / paclitaxel-mediated chemotherapy in advanced breast
cancer in vitro and in vivo and is able to inhibit lung metastasis. Such a sensitization of taxol-induced cell death
by curcumin was also observed in cervical HeLa cancer cells.
... enhance ... vinorelbine for the treatment of advanced non-small lung H520 carcinoma cells [204] and of
celecoxib, ..., in pancreatic adenocarcinoma cells
human colon cancer ... curcumin is associated with the antimetabolite 5-fluorouracil (5-FU) chemotherapeutic
agent
... curcumin ... 5-FU associated with oxaliplatin or oxoplatin
... curcumin is also able to circumvent chemoresistance ... platinium (Pt) drugs such as cisplatin and oxaliplatin
... thalidomide and bortezomib ... gemcitabine ... capecitabine
... attenuate the myocardial toxicity usually observed after adriamycin/doxorubicin
... docetaxel, ... highly potent in mice with multidrug-resistant tumors
... sensitize prostate cancer cells for TRAIL-mediated immunotherapy...
6. The “Dark Side” of Curcumin
Moreover, several studies also pointed out that curcumin can exhibit toxicity and carcinogenic effects [12].
In a 2-year study performed on rodents fed with curcumin, an equivocal evidence of curcumin carcinogenic
activity was reported as they observed an increased incidence of hepatocellular and clitoral gland adenoma as
well as carcinomas of the small intestine, due to curcumin ingestion [227]. Curcumin also appeared responsible
for the promotion of lung tumor multiplicity
... curcumin inhibits camptothecin-, mechlorethamine-, and doxorubicin"
The dark side of curcumin
This is the article cited above.
NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component
79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
this is the article referenced in the above one. The test was using turmeric oleoresin with curcumin content up to
85%. Doses were equivalent to ~15,000 to 400,000[mg] (for 70kg person) for the duration of 2 years. Results were
different for male and female rats (maybe indicating effect on hormones). Assuming 10 times lower doses should be
OK, this means that below 2,000[mg] should be OK for long term use.
Curcumin (general info)
Theracurcumin (nano-particles formulation) - 10 to 30 times better effectiveness and ~13 (instead of 6) hours
half-life.
Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
"Curcumin, a dietary pigment from the plant Curcuma longa, inhibits cell proliferation and induces apoptosis in
different cell lines. The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral
application. Therefore, great efforts were undertaken to enhance the effectiveness of curcumin. Recently, it was
demonstrated that curcumin offers the described effects also at low concentrations (0.2–1 µg/ml) when applied in
combination with UVA or visible light."
Curry Compound Fights Cancer in the Clinic
Spicy approach to cancer treatment
1.114 Diallyl Disulphide; Garlic Oil
Diallyl disulphide, a beneficial component of garlic oil, causes a redistribution of cell-cycle growth phases, induces
apoptosis, and enhances butyrate-induced apoptosis in colorectal adenocarcinoma cells (HT-29).
"Garlic oil is a prominent dietary constituent that prevents the development of colorectal cancer. This effect is
believed to be mainly due to diallyl disulphide (DADS), which selectively induces redox stress in cancerous (rather
than normal) cells that leads to apoptotic cell death. ...
Short-chain fatty acids (SCFAs), particularly butyrate (abundantly produced in the gut by bacterial fermentation of
dietary polysaccharides), enhance colonic cell integrity but, in contrast, inhibit colonic cancer cell growth.
Combining DADS with butyrate augmented the apoptotic effect of butyrate on HT-29 cells. These results suggest
that the anticancerous properties of DADS afford greater benefit when supplied with other favorable dietary factors
(short chain fatty acids/polysaccharides) that likewise reduce colonic tumor development."
1.115 Research finds combo of plant nutrients kills breast cancer cells
"The research team tested ten known protective chemical nutrients found in foods like broccoli, grapes, apples,
tofu, and turmeric root (a spice used in Indian curry) before settling upon six – Curcumin known as tumeric,
Isoflavone from soybeans, Indo-3-Carbinol from cruciferous plants, C-phycocyanin from spirulina, Reservatrol
from grapes, and Quercetin, a flavonoid present in fruits, vegetables, and tea.
The researchers administered these six at bioavailable levels to both breast cancer and control cells. They tested
the compounds individually and in combination. They found that the compounds were ineffective individually.
When combined, though, the super cocktail suppressed breast cancer cell growth by more than 80%, inhibited
migration and invasion, caused cell cycle arrest, and triggered the process leading to cell death resulting in the death
of 100% of the breast cancer cells in the sample. The researchers observed no harmful effects on the control cells.
Further analysis also identified several key genes, which could serve as markers to follow the progress of therapy.
Although the cocktail was not tested against BRCA1 and BRAC2, previous studies have shown that they are
molecular targets of four of the six compounds. The researchers also earlier demonstrated that two of the
compounds synergize effectively to kill ovarian cancer cells."
Simultaneous Inhibition of Cell-Cycle, Proliferation, Survival, Metastatic Pathways and Induction of Apoptosis
in Breast Cancer Cells by a Phytochemical Super-Cocktail: Genes That Underpin Its Mode of Action
"The anti-cancer effect of Curcumin ... results from its ability to inhibit tumor growth and metastasis.
Isoflavone (Genistein), a naturally occurring chemical in soybeans, has a protective effect against localized
prostate cancer, non-small cell lung cancer, and estrogen and progesterone receptor positive (ER+, PR+)
breast tumors
Indol-3-Carbinol (I3C), extracted from cruciferous plants, plays an important role in inhibiting carcinogenesis
by protecting cells from oxidative stress ... The chemical derivative of I3C, 1-Benzyl-indole-3-carbinol has a
1000 fold higher activity than I3C in inhibiting the growth of both estrogen-dependent and -independent breast
tumors 20. I3C also plays an important role in sensitizing BC cells to the chemotherapeutic drug tamoxifen 20.
In MDA-MB-231 BC cell line, another member of I3C, 3'-diindolylmethane (DIM) induced apoptosis and
inhibited angiogenesis by suppressing the activity of the Akt/NF-?B signaling pathway. I3C was shown to inhibit
bone metastasis of MDA-MB-231 breast cancer cells in a SCID mouse model.
In a recent study, extract from the blue green algae Spirulina platensis, combined with selenium (an element with
anti-cancer activity), was shown to inhibit the growth of MCF7 BC cell line. ... The active compound of these
extracts, C-phycocyanin (C-PC) is a water-soluble biliprotein that has anti-inflammatory and anti-oxidant effects
and has been reported to induce apoptosis in MCF7 breast cancer cells. Our previous studies have demonstrated
that spirulina inhibited rat liver toxicity and carcinogenesis induced by dibutyl nitrosamine (DMB) precursors
Grape seed extract contains Resveratrol (RE) that inhibits cancer cell proliferation ... induces apoptosis ...
synergizes with Indole 3 Carbinol to inhibit proliferation and survival of ovarian cancer cells
Quercetin induces cell apoptosis
(Curcumin) CUR: 2.25 µg/ml
(Isoflavone / Genistein) GA: 3 µg/ml
(Indol-3-Carbinol) I3C: 4 µg/ml
(C-phycocyanin) PC: 50 µg/ml
(Resveratrol) RE: 0.5 µg/ml
(Quercetin) Qurc:1.5 µg/ml
A moderate effect was observed for each of I3C and Quercetin on MCF7 cell ...
In contrast to the results observed for the individual compounds, a moderate, yet significant decrease of cellular
proliferation was observed in the presence of the combination treatment on the first day of treatment. This effect
continued throughout the treatment reaching maximum level of inhibition by day six with an 8-fold decrease of
cell proliferation.
Similarly, the treatment of MDA-MB-231 metastatic BC cell line with each phytochemical individually resulted
in no detectable effect on the proliferation of the treated cells throughout the course of the experiment, with the
exception of a moderate inhibition with I3C by the third day of treatment. Similar to what was observed with the
MCF7 cells, treatment with the 6-combination on the MDA-MB-231 cells showed a significant suppression in the
number of proliferating cells by day six
When the cells were exposed to the phytochemical combination for 8 days, all the cells were found to detach,
float up and were lost. These data suggest a synergistic mode of action of the individual phytochemicals in the
6-combination treatment for affecting the proliferation of BC cells.
Interestingly, treatment of MCF7 cells with the six phytochemical combination greatly restored the expression
of Wt p53. This induction of Wt p53 would sensitize the primary BC cells for chemotherapy
However previous studies 46-48 have shown that BRCA1 and BRCA2 are molecular targets for four of the six
compounds (Indole-3-carbinol, Resveratrol, Genistein and Curcumin) used in this phytochemical cocktail.
Further, we previously demonstrated that I3C and RE synergize to effectively kill ovarian cancer cells 27, thus
making this super cocktail effective against this cancer also."
1.116 Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
here is the pdf version of the full article.
"1. Indole-3-carbinol (I3C) and diindolylmethane (DIM)
Administered doses of I3C have ranged from 200 to 500mg/day (~ 6-7mg/kg) ...
800 mg/day did not provide additional benefits over 400 mg/day ...
DIM in plasma (2.5µM max at 2 hours, gradually decreasing by 12 hours) or in urine following oral administration
of I3C...
I3C was not detected in plasma or serum following oral doses of 400-1200mg ...
enhanced absorption DIM (BioResponse DIM ®; 108mg/day ...
BioResponse DIM resulted in levels approximately 50% higher than those obtained with unformulated DIM...
I3C was rapidly absorbed and cleared from blood and tissues within an hour, while DIM peaked slightly later and
was more persistent...
assumptions that I3C is not absorbed, but undergoes complete acid-condensation in the stomach. Several studies
have revealed distinct responses to I3C and DIM in animal models [22-26]. Therefore, the in vivo activity of
dietary I3C cannot be attributed completely to the production of DIM, although response due partially to DIM
conversion is probable. ...
I3C dose given to mice would equate to a 20mg/kg dose in humans (1200 mg/day), which yielded the maximal
serum concentration 2.5µM DIM (2 hours), with no I3C detectable after 1 hour ...
BioResponse DIM resulting in 50% higher bioavailability. The dose of BioResponse DIM used in humans was
108mg (~ 1.3-1.9mg/kg) [6], which might be expected to give levels in the range 3-30µM....
Both I3C and DIM clearly inhibit tumour cell growth in vivo in a range of animal models ...
mammary tumours ... liver, small intestine and lungs ...
1.6. Evidence for I3C or DIM acting synergistically/ antagonistically
... melanoma ... in combination with vinblastine
DIM (45µM) increased the drug content of cells by 50% ...
DIM (25µM) plus genistein (5µM) ...
I3C (50 or 100µM) has been shown to cooperate with tamoxifen (1µM) in vitro ...
I3C acid-condensation mixture also enhanced the efficacy of vinblastine in mouse melanoma cells (see above),
while I3C itself had no effect ...
I3C, together with crambene ...
2. Curcumin
8 g/day ... 3.6 g/day ... 10 nM range
3.6 g/day for one week. In the only human study to examine colorectal tissue to date, this oral dose resulted in
levels in the 10 µM range ...
Significant levels of curcumin may also be achieved locally when administered topically to the skin or within the
oral cavity, but the exact dose achieved in these scenarios remains to be confirmed. ...
liposomal preparation of curcumin ... nano-particle ..
Anti-cancer effects of curcumin have been demonstrated in multiple cell types, at concentrations between 5 and
50 µM ...
pancreatic cancer ... gastrointestinal tract, including breast [95], prostate [96], lung [97] and liver ...
2.6. Evidence for curcumin acting synergistically/ antagonistically
curcumin (10 µM) and genistein (25 µM) ...
Curcumin also synergistically potentiated the inhibitory effect of celecoxib on pancreatic carcinoma cells ...
colorectal cancer with celecoxib ...
oral cancer, EGCG ... curcumin ... only the combination decreased the proliferation index of squamous cell
carcinoma ...
prostate cancer cells ... TRAIL (20 ng/ml) ... curcumin (10 µM) ...
colorectal carcinoma lines, ... curcumin ... oxaliplatin ...
curcumin ... gemcitabine and paclitaxel in bladder cancer ... gemcitabine in an orthotopic model of pancreatic
cancer ...
Antagonistic interactions have also been demonstrated, however, with curcumin shown to inhibit chemotherapy-
induced apoptosis in breast tumour lines. Camptothecin-, mechlorethamine-, and doxorubicin-induced apoptosis
in MCF7, MDA-MB-231 and BT-474 cells was inhibited by as much as 70%, following 3h exposure to as little as
1 µM curcumin.
3. Epigallocatechin-3-gallate (EGCG)
Bioavailability in two early studies found plasma levels at 0.2 to 2% of the ingested amount of EGCG (up to 4µM),
but higher plasma concentrations have since been reported in fasting subjects compared to those who consumed
catechins with food ...
topical application to skin of an ointment containing 10% EGCG ...
holding a green tea solution (1.2g/200ml water) in the mouth for one min resulted in salivary EGCG concentrations
(mean) of 27µM, with values up to 48µM recorded, several fold higher than achieved through normal drinking,
and many more times greater than plasma concentrations [114, 115]. But holding the tea in the mouth for 5 min
resulted in salivary concentrations four to five times higher, whilst taking tea solids in capsules resulted in no
detectable salivary catechin levels. ...
liposomes for local (injection) delivery of EGCG, found that a liposomal cocktail containing deoxycholic acid and
ethanol greatly increased the tumour uptake of EGCG, in both melanoma and colon murine tumour models.
However, liposomal delivery was not superior following topical application. ...
piperine from black pepper enhanced the bioavailability of EGCG in mice. Small intestinal levels following
EGCG administration alone resulted in a Cmax of 37.5 ± 2.5 nmol/g at 60 min, decreasing to 5.1 ± 1.7nmol/g
at 90min. Following cotreatment with piperine, the Cmax was 31.6 ± 15.1nmol/g at 90 min, with levels still
above 20nmol/g at 180min. Appearance of EGCG in the colon and faeces was slower in the co-treated mice. ...
bioavailability of EGCG, whether administered as tea or pure compound, is in the range of 0.1-7µM in humans,
with concentrations over 100µM observed in saliva ...
Green tea polyphenols inhibited growth of 4T1 breast cancer cells and their metastasis to lungs in BALB/c mice ...
Topical application of EGCG to SKH-1 hairless mice ... decreased the multiplicity of skin tumours by 44-72%
and increased the apoptotic index by 56-92%,...
liposomal delivery of EGCG resulted in increased tumour uptake, ... increased antiproliferative activity in basal
carcinoma cells in vitro, ...
When green tea extract (400-500mg/cup, 5 cups/day) ...
0.6% green tea inhibited DMBA-induced oral tumour...
green tea in drinking water (1.25% containing 708µg/ml EGCG, giving plasma levels of 0.1 - 0.3µM) ...
EGCG may be a useful in vivo inhibitor of angiogenesis ...
prostate intraepithelial neoplasia, ... 600mg/day green tea compounds in (oral) capsule form,
3.6 Evidence for EGCG acting synergistically/ antagonistically
epicatechin significantly enhanced uptake of labelled EGCG into human lung PC-9 cells ...
whole green tea was a better preventive agent than EGCG alone ...
EGCG were also increased by tamoxifen or sulindac ...
prostate cancer ... 10µM EGCG only resulted in a 12-21% inhibition in cell viability, the addition of 10µM NS-398 ...
EGCG, at 0.1µg/ml (equivalent to serum concentrations), markedly enhanced the growth inhibitory effects of
5-fluorouracil in head and neck squamous carcinoma cells ...
EGCG enhanced the sensitivity of HNSCC (0.1µg/ml) and breast (1.0µg/ml) cells to taxol ...
white tea (1.5%) and sulindac (80ppm),... intestinal tumours ...
EGCG and sulindac was also found to be efficacious in preventing azoxymethane-induced colon cancer in rat ...
4. Resveratrol
0.3-2.4µM following single oral doses of 0.5-5g ...
10-25mg pure resveratrol/70kg ... 1.83-2.06µM at 30 minutes post dose, returning to baseline by 4 hours ...
Aqueous solubility of resveratrol is low ...
The presence of fatty acids increases binding to serum albumin, ... for the delivery of resveratrol to cell
membranes and thus, signalling events. ...
20mg/kg gave a maximal resveratrol plasma content of 3µM, falling to <0.1µM after 1 hour [140], with a
5mg/kg dose showing maximal plasma levels of 1.5µM ...
anti-cancer potential over a range of doses and in a wide variety of tissues, including breast, colon, pancreas,
stomach, prostate, head and neck, ovary, liver, lung and cervix ...
300ml of red wine over a 30 minute period, blood taken up to 2 hours post dose showed significantly raised
serum antioxidant capacity ...
Daily i.p injections of 40mg/kg resveratrol (estimated serum level of 25µM) reduced neuroblastoma growth in
rats and increased survival by 70%. ...
100/mg/kg/day prolonged survival time for rats with intracerebral tumours generated from RT-2 glioma cell ...
4.6. Evidence for resveratrol acting synergistically/antagonistically
Resveratrol sensitized colon cancer cells to CD95 and TRAIL ... sensitized HT29 cells to cisplatin ...
Resveratrol cooperatively enhanced doxorubicin, cytarabine, actinomycin D, taxol and methotrexate ...
neuroblastoma cells [173], and enhanced TRAIL ...
paclitaxel in A549, EBC-1 and Lu65 lung cancer cell lines [175], and of cisplatin and doxorubicin in OVCAR-3
and Ishikawa cells respectively ...
Resveratrol has been used in combination with other phytochemicals such as beta-siterol ...
quercetin/ellagic acid with resveratrol resulted in a synergistic effect ...
resveratrol (0.5µM) or I3C (50µM) to induce non-steroidal anti-inflammatory drug-activated-gene (NAG-1), a
TGF-ß superfamily gene associated with pro-apoptotic and anti-tumorigenic activity. However, when used in
combination, the doses could be reduced to 0.025µM and 1µM respectively. ..."
1.117 Oil Pulling Therapy
"Oil pulling therapy simply consists in thoroughly sloshing certain types of commonly found oil in the mouth for up
to 20 minutes (for details see Instructions: how oil pulling is done). This practice is said to draw toxins & destroy
natural mouth germs while stimulating the body's eliminatory system and increasing metabolism, thus leading to
improved health and the conquering of disease.
In fact, thanks to this double action, oil pulling therapy is claimed (according to Dr. Karach MD as well as others)
to have healed illnesses and complaints as diverse as bronchitis, tooth pain, diseased teeth, headaches & migraines,
eczema, thrombosis, chronic sleeplessness, arthritis & related illnesses, diseases of stomach & intestines (such as
ulcers, gastro-enteritis, peritonitis), kidney, liver, lung and heart disease, blood disorders (such as chronic blood
diseases like leukemia), women’s diseases & hormonal disorders and diseases affecting the nervous system (such
as encephalitis, meningitis, neuro-physiological paralysis). It is also said to prevent the growth of malignant tumors,
to cut and heal them, to be a heart attack preventative, to cure diseases brought on by toxic drugs, and it is credited
with the cure of diabetes.
Additionally, “in terminal diseases such as cancer, Aids and chronic infections, this treatment method has been
shown to successfully replace all others. ... a wide variety of symptoms have unquestionably disappeared without
any side effects
Interestingly, oil pulling is also part of the daily morning routine prescribed in conventional and alternative cancer
treatment researcher Lothar Hirneise’s new cancer treatment center in Germany.
... man who had his saliva tested for eight industrial toxins in the laboratory after oil pulling with sunflower oil.
While the sunflower oil itself (before oil pulling) contained infinitesimal amounts of environmental toxins such as
Lindan, PCB 138, PCB 153, PCB 180, HCB, DDE etc., the saliva-cum-oil-mix contained up to 27 times as much and
even contained toxins that had no detectable levels in the oil prior to pulling. In other words, the body had excreted
these toxins in the process of oil pulling.
... pulling with water (or herbal tea) will have the same detoxifying effect as pulling with oil ...
Instructions: how oil (or water) pulling is done
In the morning before breakfast (i.e. on an empty stomach), take one tablespoon into the mouth (don’t swallow it).
Move the fluid slowly around your mouth, as you would when rinsing your teeth. While keeping your mouth closed,
slosh the fluid around your oral cavity, pulling it through your teeth, sucking it etc. Do this for fifteen to twenty
minutes. “Chewing” in this manner draws a lot of saliva and gradually dilutes the oil which becomes thoroughly
mixed with saliva in the process. Swishing is said to activate the enzymes, with the enzymes drawing toxins out of
the blood. As you continue this process, the oil-saliva mix gradually becomes more and more liquid and thin and
acquires a whitish look (if the oil remains yellowish, it has not been pulled long enough).
The watery oil/saliva mix is then spat out. It must not be swallowed
Best time to do the oil pulling routine is said to be in the morning before breakfast
oil pulling can be repeated three times a day (always before meals on an empty stomach) but it also says that only
the patient himself can answer this question depending on how he feels which tells him if he needs more or less
applications of the oil pulling routine.
Patients suffering from more than one disease can experience a worsening of their situation in the beginning.
Dr. Karach - like other naturopaths - believes that an apparent worsening of one’s state of health is a propitious
sign (often referred to as healing crisis) indicating that your disease is disappearing. This includes healing fever.
He advises not to interrupt the treatment when one’s state gets worse.
One author (perhaps more) warns against oil pulling for people who carry amalgam fillings, claiming that even
more mercury than “normal” will/could be released by this practice.
Erika Herbst reports in her book "Die Heilkunst von Morgen" a number of healings due to oil pulling. These
include one or more cases of tinnitus, colitis, sleeplessness, excess mucus, blood in urine, tiredness incl. after
meals, arthritic stiffness, major pain in hands, a leg that had already turned blue from diabetes, headaches,
coughing, bronchitis, chronic sinusitis, head cleared, firmer skin, hot flashes gone, initial worsening of symptoms
followed by healing, no more colds or flu, better evacuation, better sleep, acne gone, glaucoma improved, migraine
gone, no more hayfever, general rejuvenation, prostatitis healed, diarrhea, nausea, lack of appetite, even varicose
veins disappeared after oil pulling.
The third case involves a woman who developed a malignant tumor larger than a tennis ball on her jawbone (this
patient is also on homeopathic medicines). After a month of oil pulling, pus was discharged from a hole that formed
in the tumor on the jawbone. Three weeks later, the flow of pus stopped, the hole closed and the tumor reduced in
size to be almost undetectable."
1.118 Antineoplaston therapy (Burzynski clinic)
Post from a news group:
"I underwent 17 months of ANP after 3 years of aggressive chemo and radiation and an autologus BMT. Upon my
third relapse during this aggressive conventional treatment I was told that "nothing more could be done for me."
While on ANP my bone lesions shrank and disappeared. I have been cancer free since the conclusion of ANP
therapy- in '99.
http://peoplebeatingcancer.org/discuss/david-emerson-diagnosed-multiple-myeloma-394"
Dr Burzynski movie
BBC Panorama investigates the Burzynski clinic
(against it; naturally no cancer treatment is 100% effective)
1.119 Hyperbaric oxygen therapy
The case for hyperbaric oxygen therapy
MS, Brain Injury (including stroke), Autism, Dementia, Lyme disease, seizures, surgery, during chemo therapy,
before radiation therapy, burns, wounds (incl fracture healing)
1.120. Calcium Fructoborate / Boron
Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy.
"Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer.
CF has been identified as Ca ( (C6H10O6)2B)2o4H2O and is a natural product from plants (can be produced by
chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and
osteoarthritis.
CF showed inhibitory effects on MDA-MB-231 breast cancer cells as well, and enters the cell (most likely) by a
co-transport mechanism via a sugar transporter. Inside cells CF acts as an antioxidant and induces the
overexpression of apoptosis-related proteins and eventually apoptosis."
Calcium fructoborate--potential anti-inflammatory agent.
"The studies on animals and humans with a dose range of 1-7 mg calcium fructoborate (0.025-0.175 mg elemental
boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible
adverse effect on humans."
Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
Oral resveratrol and calcium fructoborate supplementation in subjectswith stable angina pectoris: Effects on
lipid profiles, inflammation markers,and quality of life
"From the literature, the highest dose of CF administered was 37.5 mg/kg. No toxicity was noted at this
dosage [28]. Resveratrol presents a low toxicity [29]."
"Orally ingested boron has been observed to be well absorbed (>90%) from the gastrointestinal tract in humans,
rats, and rabbits. Boron as borate is readily and almost completely absorbed (>90%) from the human gut [30,31].
About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, the oral bioavailabilityof
resveratrol is low because it is rapidly metabolized in the intestines and liver into conjugated forms, i.e.,
glucuronateand sulfonate. Only trace amounts (<5 ng/mL) of unchanged resveratrol have been detected in the
blood after a 25-mg oral dose [9].
Boron supplements have been reported to lower the platelet count and potentially decrease the risk of thrombosis
[32], and experimental evidence has been obtained for the likely usefulness of boron-containing thrombin
inhibitors in the treatment of cardiovascular disorders [33]. Recent studies in animal models have suggested that
boron deprivation increases the concentrations of plasma homocysteine [34] and insulin [35], which have been
suggested as risk factors for heart disease. For this trial, we chose this combination of CF and resveratrol because
previous research has suggested that CF stabilizes resveratrol degradation in the digestive tract [17], CF has been
shown to be an important anti-inflammatory agent [11,15], and resveratrol has been found to have antioxidant
properties [36]. CF also is an antioxidant [11]."
dose used for this study:
Calcium Fructoborate = 112[mg/day];
Resveratrol = 20[mg/day]
1.121. Temporary anti-cancer & anti-pain effects of mechanical stimulation of any one of 3 front teeth (1st incisor, 2nd
incisor, & canine) of right & left side of upper & lower jaws and their possible mechanism, & relatively long term
disappearance of pain & cancer parameters by one optimal dose of DHEA, Astragalus, Boswellia Serrata, often
with press needle stimulation of True ST. 36.
"One minute downward pressure on the tip of any one of the front 3 teeth ... by a wooden toothpick induced
temporary disappearance ... of abnormally increased pain parameters ... and cancer parameters ... of Astrocytoma,
Glioblastoma, squamous cell carcinoma of esophagus, adenocarcinoma of lung, breast cancer, adenocarcinoma of
colon, prostate cancer).
The effect included temporary disappearance of headache, toothache, chest and abdominal pain, and backache,
often with improved memory & concentration.
...Repeated daily press needle stimulation of True ST. 36 increased NC telomere 450-700 ng BDORT units.
One optimal dose of DHEA increased NC telomere 525 ng DBORT units and eliminated the pain and abnormally
increased cancer parameters; effect of one optimal dose lasted 0.5-11 months.
One optimal dose of Boswellia Serrata or Astragalus not only increased NC telomere 650 ng BDORT units,
eliminating pain and cancer parameters, but also reduced the size of the Astrocytoma grade I by 10-20% and the
Glioblastoma by 15-90% in less than 2-6 months in some patients, as long as high NC telomere is maintained."
1.122. Pomegranate
Cytotoxicity of Pomegranate Polyphenolics in Breast Cancer Cells in Vitro and Vivo - Potential Role of
miRNA-27a and miRNA-155 in Cell Survival and Inflammation
"Pomegranate (Punica granatum L.) is rich in polyphenols. The predominant and therapeutically relevant
compounds are ellagic acid, ellagitannins, flavonoids, and 3-glucosides/3,5-diglucosides of the anthocyanins
delphinidin, cyanidin, and pelargonidin [18], that exert antioxidant, anti-inflammatory, and anticarcinogenic
activities in vitro and vivo [19–21]. Polyphenolics from pomegranate juice and peels inhibited aromatase activity
relevant to the prevention of breast cancer [2, 22], exhibited cytotoxic activities in hepatocellular carcinomas in
rats [23], and suppressed chemical-induced colon cancer in rats [10, 24]. The inhibition of NF-?B and other
inflammatory markers by pomegranate polyphenolics have been reported for breast [2, 5], lung [3, 4] and
prostate cancer cell lines ...
Treatment with Pg (0.8mg GAE (galvanic acid equivalent)/kg/day/) (for 35 days) significantly decreased tumor
volume and weight ...
Pg decreased breast cancer cell growth, and tumor volume and activated caspase-3 ... induce apoptosis in cancer
cell lines including breast, prostrate, liver, lung and skin cancer involving multiple pathways and inducing
apoptosis involving caspase-3 [2–4, 23, 46, 52]. Previous studies have observed resistance of non-cancer cells to
the effects of polyphenolics observed in this study (Fig 2a) has been previously reported with delphinidin
(anthocyanin) from pomegranate extracts [2, 53, 54]. The effects of Pg extract on inhibition of tumor growth
in anthymic nude mice bearing BT474 cells as xenografts (Fig. 7a) has also been observed in nude mice bearing
prostrate, pancreatic and breast cancer cells"
Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in
vivo efficacy of docetaxel chemotherapy.
"We demonstrated that POMx exhibited potent in vitro cytotoxicity in metastatic castration-resistant PCa cells. ...
The in vivo administration of POMx treatment effectively inhibited survivin, induced apoptosis, retarded C4-2
tumor growth in skeleton and significantly enhanced the efficacy of docetaxel in athymic nude mice."
Anticancer activities of pomegranate extracts and genistein in human breast cancer cells.
"Both pomegranate extracts and genistein had significant (dose- and time-dependent) cytotoxic and growth
inhibition effects on MCF-7 cancer cells. Both growth inhibition and cytotoxicity were significantly higher (P < .01)
in the combination treatments than in the single treatments with either agent."
Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells.
"Fatty acids from pomegranate, tung, and catalpa were cytotoxic to human monocytic leukemia cells at
concentrations exceeding 5 microM for pomegranate and tung and 10 microM for catalpa, but fatty acids from pot
marigold oil had no effect at concentrations ranging up to 163 microM."
Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic
agents for leukemia.
"We investigated the potential effect of PJE on induction of apoptosis and inhibition of cellular proliferation in 8
leukemia cell lines (4 lymphoid and 4 myeloid) and nontumor hematopoietic stem cells (control cells) ... PJE
significantly induced apoptosis in all cell lines, including nontumor control cells, although lymphoid cells and 2 of
the myeloid cell lines were more sensitive."
Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.
"Thus, our data show that PFE significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a
chemopreventive agent for human lung cancer."
Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence
"Recent research has shown that pomegranate extracts selectively inhibit the growth of breast, prostate, colon and
lung cancer cells in culture. In preclinical animal studies, oral consumption of pomegranate extract inhibited
growth of lung, skin, colon and prostate tumors. ...
The antioxidant activity of flavonoids obtained from pomegranate juice (PJ) was observed to be close to that of
butylated hydroxyanisole, green tea, and significantly greater than red wine (2,3). Commercially available
pomegranate juices ... showed antioxidant activity ... three times higher than those of red wine and green tea ...
Cancer Type Pomegranate Fraction
Breast Juice, seed-oil, fermented juice polyphenols, extract
Prostate Seed-oil, fermented juice polyphenols, extract, juice
Lung Fruit extract
Colon Seed-oil, juice
Skin Seed-oil, fruit extract
Leukemia Fresh and fermented juice"
Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model.
"equivalent to 250 and 500 ml of pomegranate juice ...
Compared with respective water-fed groups, none of the mice in PFE-supplemented groups exhibited metastases
to any of the distant organs at 20 weeks and only 20% mice exhibited metastasis at 34 weeks of age. Many of the
PFE-supplemented animals had multiple foci of well-differentiated carcinoma but no evidence of poorly
differentiated carcinoma."
1.123. Carnivora
Carnivora (extract from a venus flytrap plant)
Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer
"... chemopreventive and therapeutic compounds ... from food plants... flavonoids (carrots) including chalcones,
isothiocyanates (cabbage), lycopene (tomatoes), indoles, organosulfides (garlic), and polyphenols (curcumin) ...
compounds can also be found in food preparations ... resveratrol ... catechins and procyanidins and polyphenols
from cocoa ... quercetin and kaempferol from honey
... carnivorous plants ... traditional medicine ... butterworts (Pinguicula vulgaris, Pinguicula alpina) were used for
the treatment of wounds. Decoctions of butterworts and sundew (Drosera rotundifolia) ... respiratory diseases like
pertussis, bronchitis, and asthma ... stomach pain and tuberculosis. ... ability to promote delivery. ... syrups to treat
coughs. ... local application on warts or bunions
... purple pitcher plant Sarracenia purpurea ... diuretic and laxative properties and also to treat fever, cough, and diabetes. ... scarlet fever, smallpox, and measles. ... ease labor, to prevent sickness after childbirth and to treat
absence of menstrual cycle
... pitcher plant Nepenthes khasiana ... stomach pain and eye troubles (pain, cataract, night blindness), urinary
troubles but also skin diseases. ... malaria, leprosy, and cholera patients
Plumbagin
... anti-bacterial, anti-fungal, anti-inflammatory, and anti-cancer properties. ... present in others plants like
Limonium axillare or walnut trees (Juglans sp.) ... other carnivorous plants like N. khasiana, Nepenthes gracilis,
or Drosera binata (64, 137, 138). ... cardiotonic, neuroprotective, and hepatoprotective properties ...
... breast cancer ... melanoma ... lung cancer ... inhibits the growth of tumors and the number of metastasis ...
ovarian and prostate-cancer cells ... plumbagin has an oral bioavailability of about 40% in conscious freely
moving rat models and that plumbagin is detected in a micromolar range 1 h after administration
Phenolic acids
Ellagic acid
... many other plants such as pomegranate (Punica granatum), Terminalia chebula fruit (yellow myrobalan), berry
fruits (blueberry, blackberry, and strawberry), Vitis rotundifolia (Muscadine grapevine), or black walnut (Juglans
nigra) .. digestibility-reducing compounds .. anti-bacterial agent ... chemopreventive agent ... pancreatic cancer ...
prostate carcinoma ... colon cancer ... breast cancer ...
Gallic acid
... bitter orange tree flowers (Citrus aurantium), Marrubium persicum, yellow myrobalan fruit (T. chebula),
Acalypha australis, Pleurotus sp., Vitis sp. seeds, rose myrtle (Rhodomyrtus tomentosa), Mysore raspberry
(Rubus niveus), white sorghum, or carrot ... anti-bacterial and anti-fungal properties ...
... anti-cancer ... leukemia ... gastric carcinoma ... prostate-cancer ... osteosarcoma ...
Vanillin
... inhibits growth of mammary adenocarcinoma ... reduces the number of lung metastasis ... lung cancer ...
colorectal cancer ... vanillin has a relatively good bioavailability (7.6%). ...
Protocatechuic acid
... in plants like True roselle (Hibiscus sabdariffa), Rhizoma homalomenae, Spatholobus suberectus, and Alpinia
oxyphylla ... inhibits AGS (human stomach adenocarcinoma) ... melanoma ... hepatocellular carcinoma ... pre-
treatment of HepG2 with N-acetyl-l-cysteine (NAC) blocks the cytotoxic effect of protocatechuic acid ... leukemia
cells ...
Caffeic acid
Present in Vitis sp. seeds, pomegranate (P. granatum), coffee beans, honey, common daisy (Bellis perennis), and
hyssop (Hyssopus officinalis), ... anti-bacterial and anti-fungal ... human fibrosarcoma ... colon cancer ... breast
cancer ...
Chlorogenic acid
... plants like prune (Prunus domestica), japanese honeysuckle (Lonicera japonica), apple, plum, Eucommia
ulmodies, and coffee beans ... Human adenocarcinoma ... leukemia cells ... lung cancer ...
Chlorogenic acid has a very low bioavailability but is always present in the small intestine...
Ferulic acid
... in seeds like Vitis sp. seeds brown rice, but also wheat flour, pineapple, creosote bush (Larrea divaricata). ...
Ferulic acid pre-treatment protects against ?-radiation-induced DNA damage in hepatocytes and significantly
increases anti-oxidant enzymes, GSH, vitamins A, E, and C (203). ... ferulic acid prevent tumor development ...
prevented skin tumor formation but that topical application does not ... colon cancer ... anti-oxidant that can
reduce DNA strand breaks induced by ?-irradiation in peripheral blood leukocytes and bone marrow ...
Salicylic acid
... treat aches and pains ... willow tree bark ... the main metabolite of acetylsalicylic acid, the active principle of
aspirin. ... Salicylic acid has no effect on CaCo-2 (colon carcinoma cells) proliferation under normoxic conditions
but increases caspase-3/7 activities and increases phosphorylation of ERK 1/2 under hypoxic conditions...
colorectal cancer ... a dose of 75 mg of aspirin per day during several years reduces colorectal cancer incidence
and mortality ...
Flavonoids
... flavonols (quercetin, myricetin, and kaempferol), flavones, flavanones, flavanols, anthocyanins,
dihydroflavonols, isoflavones, and chalcones. ...
Quercetin
... bitter orange tree flowers (Citrus aurantium), Epilebium species, Nepenthes gracilis, Leucaena leucocephala,
S. purpurea, caper (Capparis spinosa), and chili peppers (Capsicum sp.) ...
hepatocellular carcinoma ... Quercetin used in combination with 5-fluorouracil (5-FU) on EC9706 and Eca109
esophageal cancer cells ... cervical cancer ... colon cancer patients treated with quercetin, rutin, or with sulindac
(NCT00003365). ... ovarian cancer refractory to cisplatin ... hepatocellular ... with genistein ... prostate-cancer
patients (NCT01538316). ... quercetin has a very low bioavailability. ...
Myricetin
... present in many plants ... Limonium axillare, Jatropha curcas, Japanese cypress (Chamaecyparis obtusa),
Leucaena leucocephala, and many berries ...
anti-bacterial ... anti-cancer ... pancreatic cancer ... bladder carcinoma ... leukemia ... colon carcinoma ...
regression of tumor growth and a decrease of metastasis ... increase bioavailability of tamoxifen, a drug used to
treat breast cancer. Similar results were observed for doxorubicin ...
Kaempferol
... in many plants like Nepenthes gracilis, chili peppers, Gynura medica, Bracken (Pteridium aquilinum), Ginkgo
biloba ... anti-cancer properties ... oral cancer ... ovarian cancer ... kaempferol enhances the effect of cisplatin in
ovarian cancer ...
Conclusion
... more than 15 compounds ... Currently only several compounds like quercetin, salicylic acid, and kaempferol
have moved to pharmacokinetic studies and clinical trials ... these compounds have a very poor bioavailability ...
it has been shown that co-treatment of two natural molecules like quercetin and kaempferol and a
chemotherapeutic drug like cisplatin or etoposide is more efficient than a single treatment ... Low bioavailability
and incompletely absorbed compounds are ineffective against metastatic and invasive cancers.
Clinical trials involving natural compounds present in Dionaea muscipula Solander ex Ellis.
One of the most promising anti-cancer compounds is probably plumbagin. ...
Most natural compounds isolated from D. muscipula like plumbagin, quercetin, myricetin, ellagic acid, or vanillin
have multiple effects and act as anti-cancer drugs with multiple targets on different types of cancers. ..."
1.124. Quercetin and other bioflavonoids
Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and
cyanidin in primary cultures of human retinal pigment epithelial cells.
"Vegetable polyphenols (bioflavonoids) have been suggested to represent promising drugs for treating cancer and
retinal diseases. We compared the effects of various bioflavonoids (epigallocatechin-3-gallate [EGCG], luteolin,
apigenin, myricetin, quercetin, and cyanidin) on the physiological properties and viability of cultured human retinal
pigment epithelial (RPE) cells. ...
The intake of luteolin, apigenin, myricetin, and quercetin as supplemental cancer therapy or in treating retinal
diseases should be accompanied by careful monitoring of the retinal function. The possible beneficial effects of EGCG
and cyanidin, which had little effect on RPE cell viability, in treating retinal diseases should be examined in further
investigations"
Quercetin
Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell
model systems.
"... phytoestrogens ... mimic the actions of endogenous estrogens. Among these, quercetin ... has been reported as
estrogenic in some occasions. However, quercetin occurs in substantial amounts as glycosides such as
quercetin-3-O-glucoside (isoquercitrin) and quercetin-3-O-rutinoside (rutin) in dietary sources. ...
quercetin-3-O-glucuronide, one of the main human phase II metabolites produced after intake of dietary quercetin,
displays ERa- and ERß-dependent estrogenic activity, the functional consequences of which might be related to the
protective activity of diets rich in quercetin glycosides."
Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin
in rat intestine in vitro.
Liposomal quercetin: evaluating drug delivery in vitro and biodistribution in vivo.
Induction of apoptosis and inhibition of angiogenesis by PEGylated liposomal quercetin in both cisplatin-sensitive
and cisplatin-resistant ovarian cancers.
Isoquercitrin
Isoquercitrin: Pharmacology, toxicology, and metabolism.
"Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in
vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions.
Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is
extensively metabolized in the intestine and the liver. Biotransformation of isoquercitrin includes deglycosylation,
followed by formation of conjugated and methylated derivatives of quercetin or degradation to phenolic acids and
carbon dioxide. The acceptable daily intake of (95%) isoquercitrin and of EMIQ was estimated to be 5.4 and
4.9mg/kg/day, respectively. Adverse effects of higher doses in rats included mostly (benign) chromaturia;
nevertheless some drug interactions may occur due to the modulation of the activity and/or expression of drug
metabolizing/transporting systems."
Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway.
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated
hepatocellular tumor promotion of oxfendazole in rats.
Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than
other quercetin glycosides or aglycone after oral administration in rats.
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin
cellular localization.
Troxerutin (from Sophora Japonica)
Radioprotective effects of troxerutin against gamma irradiation in V79 cells and mice.
Rutin
The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful
peripheral neuropathy.
Flavonoid rutin increases thyroid iodide uptake in rats.
Rutin exerts antitumor effects on nude mice bearing SW480 tumor.
colon cancer
rutin: 3-rhamnosyl-glucosylquercetin; 20[mg/kg]
Myricetin
1.125 Green / Black tea, Coffee
Apoptogenic effects of black tea on Ehrlich’s ascites carcinoma cell
rats were given black tea instead of water.
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
rats were given 0.02% caffeine in drinking water.
Note: 0.02% is approximately the level of caffeine in strong green or black tea.
For strong coffee it is about 0.08%.
1.126 Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435
breast cancer cells in vivo
"Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose
range of 0.8 – 1.6 mg/day ... Conversion to equivalent human intake for future clinical studies using the body
surface area (BSA) normalization method gave a dose of ~370.6 mg/day for a human adult of 60 kg, which can
be supplied by consuming 2 to 3 peach fruit per day or alternatively using a dietary supplement peach polyphenol
extract powder."
1.127 Bee propolis; Bee pollen; Royal jelly
Functional properties of honey, propolis, and royal jelly.
Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk
markers: results of a pilot open-uncontrolled trial.
"Melbrosia may offer a potential alternative to hormone therapy for the treatment of menopausal symptoms. ...
this study's uncontrolled, open-label"
Melbrosia content per 1 capsule:
257 mg of pollen,
150 mg of Perga (fermented pollen),
hydroxypropylmethyl cellulose 95 mg,
33 mg of lyophilized royal mletsitse (royal jelly),
20 mg Acerola extract.
Bee propolis
Notes: content of active ingredients varies depending on region
Caffeic acid phenethyl ester (CAPE) is often studied independently. It does not have effect on estrogen.
Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic
Targets via an Epigenetically Mediated Mechanism of Action.
"... CAPE and propolis, cause an accumulation of acetylated histone proteins in MCF-7 (ER+) and MDA-MB-231
(ER-/PR-/Her2-) cells with associated decreases in ER and PR in MCF-7 cells, and upregulation of ER and decrease
in EGFR in MDA-231 cells. ... Interestingly, propolis, when normalized for CAPE content, appears to be more potent
than CAPE alone similarly to the greater effects of complete foods than isolated components."
Amelioration of renal carcinogenesis by bee propolis: a chemo preventive approach.
Ethanolic Extract of Polish Propolis: Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic
Activity against Prostate Cancer Cells
Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line.
"... human colon cancer cell line HCT-116 ... All tested propolis samples had pronounced cytotoxic and
antioxidative activities."
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro.
Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells.
Anti-tumor effects of water-soluble propolis on a mouse sarcoma cell line in vivo and in vitro.
Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro
tube formation and endothelial cell proliferation.
Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor
in mice.
"Water-soluble derivative of propolis increases macrophage activity and sensitivity of tumor cells to HIPEC and
reduces cisplatin toxicity to normal cells."
Estrogenic effects of ethanol and ether extracts of propolis.
"Animals treated with EEP (ethanol extract of propolis) or REP (ether extract of propolis) for 4 days (500-1000
mg/kg per day, s.c.) exhibited significant dose-dependent increases in uterine wet weight. ... The results suggest
that propolis produces estrogenic effects through activation of estrogen receptors."
Glycemic control and anti-osteopathic effect of propolis in diabetic rats
Effect of propolis on insulin resistance in fructose-drinking rats
"Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma
level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose
and total cholesterol levels, and tended to decrease systolic blood pressure."
Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin
resistance in OLETF rats by intake of propolis extracts.
Effect of propolis on mast cells in wound healing.
"topical application of 30% propolis alcoholic extract"
Therapeutic effects of propolis essential oil on anxiety of restraint-stressed mice.
"propolis essential oil (PEO) could significantly reverse the anxiety-like behavior of restraint-stressed mice, and
has no effect on locomotor activity. Furthermore, PEO significantly decreased the plasma levels of cortisol
(CORT), adrenocorticotropic hormone (ACTH) and malondialdehyde (MDA), whereas it increased the activity
of superoxide dismutase (SOD) in restraint-stressed mice. These results strongly suggest that PEO has therapeutic
effects on anxiety through antagonizing the hyperfunction of hypothalamic-pituitary-adrenal (HPA) axis and
improving the ability of antioxidation in brain tissue."
Royal Jelly
Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells.
"Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the
proliferation of cells in the absence of BPA."
GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and
breast cancer cells.
"GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane,
Lycopene and Royal jelly.
... high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3 (prostate cancer), MCF7
(breast cancer), and SW480 (colon cancer)), as well as on the EA.hy 926 endothelial cell line in a dose-dependent
manner."
Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin.
"RJ elicited a significant protective effect towards liver and kidney ... significantly enhanced apoptotic cell
numbers and degenerative changes by cisplatin, but these histological changes were lower in the liver and kidney
tissues of RJ + CDDP group. Besides, treatment with RJ lead to an increase in antiapoptotic activity hepatocytes
and tubular epithelium. In conclusion, RJ may be used in combination with cisplatin in chemotherapy to improve
cisplatin-induced oxidative stress parameters and apoptotic activity."
Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a
randomized clinical trial.
"1,000 mg royal jelly soft gel ... for 8 weeks. ... the mean fasting blood glucose decreased remarkably ... significant
reduction in the mean serum glycosylated hemoglobin levels ... significant elevation in the mean insulin
concentration"
Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines.
Royal jelly has estrogenic effects in vitro and in vivo.
Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly,
in stress-inducible depression-like mouse model.
"10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against
the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the
stress loading. ... RJ given by the oral route was less effective. "
Contribution of lipids in honeybee (Apis mellifera) royal jelly to health.
"Lipids in RJ are useful as preventive and supportive medicines with functionalities that include potential inhibitors
of cancer growth, immune system modulators, alternative therapies for menopause, skin-aging protectors,
neurogenesis inducers, and more."
Bee Pollen
Antiestrogenic and antigenotoxic activity of bee pollen from Cystus incanus and Salix alba as evaluated by the
yeast estrogen screen and the micronucleus assay in human lymphocytes.
"At least one preparation from each species showed a marked antigenotoxic effect against the action of the
anticancer drugs mytomicin C, bleomycin, and vincristine. Bee pollens from C. incanus and S. alba were found to
be neither genotoxic nor estrogenic as well as effective estrogen inhibitors, and able to reduce the chromosome
damage induced by the three cancer drugs used, thus supporting their use as a safe food supplement and future
chemoprotective/chemopreventive agents."
Probable interaction between warfarin and bee pollen.
1.128. Mushrooms
Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26
colon cancer-tansplanted mice.
Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom
with amazing health benefits.
"hepatopathy, chronic hepatitis, nephritis, hypertension, hyperlipemia, arthritis, neurasthenia, insomnia,
bronchitis, asthma, gastric ulcers, atherosclerosis, leukopenia, diabetes, anorexia, and cancer"
Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.
"Severe combined immunodeficient mice injected with IBC cells treated with Reishi for 13 weeks show reduced
tumor growth and weight by ~50%"
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of
Coriolus versicolor and Ganoderma lucidum.
"chemopreventive potential of I'm-Yunity (trade name for Trametes versicolor) may be enhanced by adding
Ganoderma lucidum"
Antihepatoma activity of the acid and neutral components from Ganoderma lucidum.
"The supercritical fluid extracts of Ganoderma lucidum (total component, TC) and its acid component (AC) and
neutral component (NC), were evaluated in vitro and in vivo for their antihepatoma activities. The NC showed a
conspicuous inhibitory effect on tumor growth of Heps-bearing mice, whereas AC was less effective."
Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
"We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma
lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly
acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated
subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited
stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other
rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. ... Thus, our results suggest that GLme
might be a good candidate for treatment of diverse forms of cancers."
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
"Ganoderic acid T (GA-T), which is a lanostane triterpenoid purified from methanol extract of G. lucidum mycelia,
was found to exert cytotoxicity on various human carcinoma cell lines in a dose-dependent manner, while it was
less toxic to normal human cell lines. Animal experiments in vivo also showed that GA-T suppressed the growth of
human solid tumor in athymic mice. It markedly inhibited the proliferation of a highly metastatic lung cancer cell
line"
1.129 L-Methionine
L-Methionine inhibits growth of human pancreatic cancer cells.
"L-methionine inhibits proliferation of breast, prostate, and colon cancer cells ...
L-methionine inhibits proliferation and interferes with the cell cycle of BXPC-3 and HPAC pancreatic cancer cells;
the effects on apoptosis remarkably persisted after methionine withdrawal"
Methionine
1.130. ProstaCaid
Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.
"contains mycelium from medicinal mushrooms (Ganoderma lucidum, Coriolus versicolor, Phellinus linteus), saw
palmetto berry, pomegranate, pumpkin seed, green tea [40% epigallocatechin-3-gallate (EGCG)], Japanese
knotweed (50% resveratrol), extracts of turmeric root (BCM-95®), grape skin, pygeum bark, sarsaparilla root,
Scutellaria barbata, eleuthero root, Job's tears, astragalus root, skullcap, dandelion, coptis root, broccoli, and
stinging nettle, with purified vitamin C, vitamin D3, selenium, quercetin, citrus bioflavonoid complex,
β sitosterolzinc, lycopene, α lipoic acid, boron, berberine and 3.3'-diinodolymethane (DIM).
We show that PC treatment resulted in the inhibition of cell proliferation of the highly invasive human hormone
refractory (independent) PC-3 prostate cancer cells in a dose- and time-dependent manner ...
In addition, PC also suppresses metastatic behavior of PC-3 by the inhibition of cell adhesion, cell migration and
cell invasion"
1.131. Hypothermia
Increases metastasis if only hypothermia is used!!!
Hypothermia activates adipose tissue to promote malignant lung cancer progression.
Hypothermic microenvironment plays a key role in tumor immune subversion.
Hypothermia affects on the body
Hypothermia can be a result of chemotherapy and it is also observed in some cancer patients in general.
Maybe it is best to use hyperthermia instead of hypothermia during chemo therapy ...?
Hypothermia during chemotherapy for Hodgkin's disease.
Some protective effect during radiation and chemotherapy, but also potential serious side effects
[Radioprotective effect of local hypothermia].
Selective protection of non-cancer cells by hypothermia.
Hypothermia and cancer chemotherapy.
Main use during chemotherapy:
used for protection against hair loss during chemotherapy
Some positive effect if used with hyperthermia (i.e. cold/hot cycles).
Specifically used for treatments of tumors that are accessible (cryo-surgery).
Immunological response induced by alternated cooling and heating of breast tumor.
Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report
Immunological Response Induced by Alternated Cooling and Heating of Breast Tumor
1.132. Diet and Fasting
Fasting improves efficacy of radiation therapy
Up to 48 hour fasting cycles.
Fasting triggers stem cell regeneration of damaged, old immune system
Up to 72 hour fasting prior chemotherapy.
Fasting May Improve Cancer Chemotherapy
"starvation for 48 to 60 hours before chemotherapy"
normal cells go to hibernation mode and remain protected, while cancer cells remain in growth mode and are
sensitive to the drugs.
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
"Cycles of starvation (fasting) were as effective as chemotherapeutic agents in delaying progression of specific
tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In
mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs—but not either treatment alone--
resulted in long-term cancer-free survival. ... These studies suggest that multiple cycles of fasting promote
differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy
of certain toxic chemotherapy drugs in the treatment of various cancers."
Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose
chemotherapy
To Eat or Not to Eat: With Cancer Therapies, That Is the Question
"patients who voluntarily underwent short-term fasting before and/or after cytotoxic chemotherapy infusion.
Patients reported fewer side effects, including fatigue, weakness, and gastrointestinal problems, when they
fasted. ...
fasting renders cancer cells more sensitive to chemotherapy.
Normal cells reduced the expression of genes associated with cell growth and division and diverted their energy to
cellular maintenance pathways that protect normal cells from stressful conditions and repair stress-induced damage.
In contrast, cancer cells reduced the expression of many protective genes, which made them more likely to die ...
Fasting also deprives cancer cells of the glucose and other molecules they need to fuel their endless cell division.
Therefore, fasting adds a second stressor on top of chemotherapy, forcing cancer cells to deal "with two extreme
environments at once," ...
Fasting before administering the drug had a stronger effect ...
In mouse models of metastatic melanoma, breast cancer, and neuroblastoma, fasting combined with high-dose
chemotherapy extended survival ...
patients would refuse a water-only fast, so the international trials will use a substitution diet called Chemolieve"
Note:
Fasting for more than 18 hours depletes the glycogen in the liver forcing the body into ketosis.
This is similar to the ketogenic diet therapy (with 2-DG) [Ref.1.51, 1.52, 3.4].
Also, the effect may be similar for the IPT therapy which relies on bringing the blood sugar low during
drug administration [Ref.1.58].
See also Diet web pages (diet calculator, ketogenic diet, raw vegan diet, Gerson therapy,
fasting and reduced calorie diet, Mediterranean diet).
1.133. Probiotics
Gut Flora Boost Cancer Therapies
Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer
in mice.
Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B₁-induced liver carcinogenesis
in rats.
Kefir
1.134. Essential Oils
Rosemary(oil/extract):
types of cancer affected:
http://www.ncbi.nlm.nih.gov/pubmed/21955093
breast cancer:
http://www.ncbi.nlm.nih.gov/pubmed/24615943
Vit. D3 + rosemary (leukemia):
http://www.ncbi.nlm.nih.gov/pubmed/16395705
nerve growth / glioblastoma:
http://www.ncbi.nlm.nih.gov/pubmed/14600414
colon cancer:
http://www.ncbi.nlm.nih.gov/pubmed/21112365
anti angiogenesis:
http://www.ncbi.nlm.nih.gov/pubmed/22173778
oral application:
http://www.ncbi.nlm.nih.gov/pubmed/24598693
taken as food: 1% dry rosemary extract (mixed with food) and 1 microg Ro25-4020 (D3 derivative) resulted in a
strong cooperative antitumor effect, without inducing hypercalcemia.
http://www.ncbi.nlm.nih.gov/pubmed/16395705
oral application: http://www.ncbi.nlm.nih.gov/pubmed/24598693
same article - full version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943728/
The other 8 mice in the treated group received rosemary extract (100 mg/kg) dissolved in olive oil orally for 22
days. ... slower tumor growth.
Eucalyptus oil:
breast cancer:
http://www.ncbi.nlm.nih.gov/pubmed/18075306
ulcer treatment (effective in 3..4 days):
http://www.ncbi.nlm.nih.gov/pubmed/16785038
improved topical delivery for curcumin:
http://www.ncbi.nlm.nih.gov/pubmed/21297295
strong anti bacterial and anti fungal activity: http://www.ncbi.nlm.nih.gov/pubmed/18075306
- I guess this means that should not be taken orally or should be taken with probiotics.
topical application: http://www.ncbi.nlm.nih.gov/pubmed/16785038
Ginger oil:
toxicity in rats:
http://www.ncbi.nlm.nih.gov/pubmed/21960667
liver cancer:
http://www.ncbi.nlm.nih.gov/pubmed/19061005
oral application - up to 500mg/kg - no toxicity in rats: http://www.ncbi.nlm.nih.gov/pubmed/21960667
test with 100mg/kg: http://www.ncbi.nlm.nih.gov/pubmed/19061005
Mentha oil:
http://www.ncbi.nlm.nih.gov/pubmed/20602517
protection for gamma radiation:
http://www.ncbi.nlm.nih.gov/pubmed/15305314
oral application - 40 micro L/animal (per day for 3 days): http://www.ncbi.nlm.nih.gov/pubmed/15305314
albino mice approximate weight = ~30g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764869/
=> 40 micro L/30 g = 40*10^(-6) / 30 * 10^(-3) [L/kg] = 1.3ml/kg
Lemon balm:
http://www.ncbi.nlm.nih.gov/pubmed/22938456
oral application - 100mg/kg : Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo
or copy paste this link if the one above does not work:
http://www.researchgate.net/publication/230780733_Antitumoral_effects_of_Melissa_officinalis_on_breast_cancer_in_vitro_and_in_vivo/file/3deec52cbeee6bfc11.pdf
Lemon balm (WebMD)
Tea tree:
topical use with DMSO: http://www.ncbi.nlm.nih.gov/pubmed/22727730
http://www.ncbi.nlm.nih.gov/pubmed/20577741
Myrrh:
oral application(?) - 100mg/kg , 200mg/kg: http://www.ncbi.nlm.nih.gov/pubmed/21167270
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796379/
Frankincense:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796379/
Thyme oil:
http://www.ncbi.nlm.nih.gov/pubmed/15339564
http://www.ncbi.nlm.nih.gov/pubmed/23994707
http://www.ncbi.nlm.nih.gov/pubmed/17934650
(applied by intra-tumoral injection)
http://www.ncbi.nlm.nih.gov/pubmed/24218968
http://www.ncbi.nlm.nih.gov/pubmed/21273584
http://www.ncbi.nlm.nih.gov/pubmed/20657472
tested 10 oils for prostate, lung and breast cancer cells
- thyme was best
- most effective for prostate cancer
oral application - 40 g/kg alchohol extract: http://www.ncbi.nlm.nih.gov/pubmed/15339564
injection: http://www.ncbi.nlm.nih.gov/pubmed/17934650
Oregano
http://www.ncbi.nlm.nih.gov/pubmed/21535822
http://www.ncbi.nlm.nih.gov/pubmed/19373612
oral application is OK, dose = ?
Black seed:
oral application is safe, dose ?: http://www.ncbi.nlm.nih.gov/pubmed/22083982
Clove oil:
http://www.ncbi.nlm.nih.gov/pubmed/22292639
use: ?
Aroma therapy + massage for boosting the immune system
http://www.ncbi.nlm.nih.gov/pubmed/23886205
1.135 Spirulina (C-phycocyanin, 9-HpbD-a)
Chemoprevention of rat mammary carcinogenesis by spirulina.
Antidiabetic potential of phycocyanin: effects on KKAy mice.
Antihyperglycemic effect of crude extracts of some Egyptian plants and algae.
The apoptosis pathway of photodynamic therapy using 9-HpbD-a in AMC-HN3 human head and neck cancer cell line
and in vivo.
The effect of hydrolyzed Spirulina by malted barley on forced swimming test in ICR mice.
1.136 Dandelion
Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic
cancer cells.
"Dandelion Root Extract has the potential to induce apoptosis and autophagy in human pancreatic cancer cells with
no significant effect on noncancerous cells."
Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia
(CMML) cells.
Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal
tumorigenesis.
"Green Tea Extract, green tea and Dandelion tea caused decrease in tumor multiplication, tumor size and
tumor volume"
The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.
Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion
root extract.
Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.
"crude extract of dandelion leaf (DLE) decreased the growth of MCF-7/AZ breast cancer cells in an ERK-dependent
manner, whereas the aqueous extracts of dandelion flower (DFE) and root (DRE) had no effect on the growth of either
cell line. Furthermore, DRE was found to block invasion of MCF-7/AZ breast cancer cells while DLE blocked the
invasion of LNCaP prostate cancer cells, into collagen type I."
Anti-carcinogenic activity of Taraxacum plant. I.
"An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on
the two-stage carcinogenesis of mouse skin tumor"
Anti-carcinogenic activity of Taraxacum plant. II.
"exhibited potent anti-tumor-promoting activity in the two-stage carcinogenesis tests of mouse skin ... showed a
remarkable inhibitory effect on mouse spontaneous mammary tumors"
1.137 IP6 (Inositol hexaphosphate)
Inhibition of skin cancer by IP6 in vivo: initiation-promotion model.
Mammary tumor inhibition by IP6: a review.
IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer
xenotransplanted in nude mice.
"IP6 inhibits the formation of liver cancer and regresses pre-existing human hepatic cancer xenograft; therefore, it
has the potential for clinical use as a preventive and therapeutic agent for hepatocellular carcinoma as well."
Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric
magnetic resonance study.
"oral IP6 supplement blocks growth and angiogenesis of prostate cancer in the TRAMP model in conjunction with
metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting a
practical and translational potential of IP6 treatment in suppressing growth and progression of prostate cancer in
humans."
Phytic acid--anticancer nutriceutic
"There has been observed an inhibition of tumor growth and induction of cell differentiation in the presence of IP6 in
a few cancer cell lines including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma."
Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice.
Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer.
Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells.
Anti-angiogenic activity of inositol hexaphosphate (IP6).
In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like
growth factor binding protein-3 and inhibition of vascular endothelial growth factor.
Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and
invasion of MDA-MB 231 human breast cancer cells.
Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer.
WebMD link
- blood thinner, binds to iron in food, binds to calcium in food
Inositol, IP3 and IP6
(EGCG) "no-observed-adverse-effect–level was greater than 600 mg/kg/day" (in dogs)
"Polyphenon E containing a dose range of 200 to 1200 mg EGCG was well tolerated"
"In a 2003 study, patients with androgen-independent metastatic prostate cancer consumed 6 g of green tea daily for up to 4 months. Among 42 participants, 1 patient exhibited a 50% decrease in serum PSA level compared to baseline, but this response was not sustained beyond 2 months. Green tea was well tolerated by most study participants. However, six episodes of grade 3 toxicity occurred, involving insomnia, confusion, and fatigue. These results suggest that, in patients with advanced prostate cancer, green tea may have limited benefits."
Note: Eat Green Tea
1.2. Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues.
"EGCG plateaued between 500 and 2000 mg/kg" (in mice)
1.3. Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals
"We conclude that it is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8–16 cups of green tea once a day or in divided doses twice a day for 4 weeks. There is a >60% increase in the systemic availability of free EGCG after chronic green tea polyphenol administration at a high daily bolus dose (800 mg EGCG or Polyphenon E once daily)."
1.4. EGCG - potent extract of green tea
Atherosclerosis, Cancer, Bladder cancer, Breast cancer, Colorectal cancer, Lung cancer, Pancreatic cancer, Prostate cancer,
Skin cancer, Stomach cancer, Skin health, Joint health, Inflammatory bowel disease (IBD), Diabetes, Liver disease, Antioxidant properties, Weight loss
1.5. Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo.
" Tumor size in xenograft mice treated with 120 mg/kg of rutin was significantly smaller than that in the untreated-control group. These novel findings indicate that rutin inhibits tumor growth in a xenograft animal model. Rutin may be useful in treating leukemia but certainly much more research is needed."
1.6. Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.
"10 g quercetin/kg diet" ( see [4.1, 4.2, 4.3])
"In conclusion, quercetin, but not rutin, at a high dose reduced colorectal carcinogenesis in AOM-treated rats, which was not reflected by changes in ACF-parameters. The lack of protection by rutin is probably due to its low bioavailability."
1.7. Apoptosis by dietary factors: the suicide solution for delaying cancer growth
"Various studies indicate that dietary constituents, particularly phytochemicals, can modulate the complex multistage process of carcinogenesis (6,7). The promising dietary chemopreventive compounds with demonstrated effects in more than one tumor model include (–)-EGCG in green tea; resveratrol in grapes; lupeol in fruits like mango, strawberry and grape; delphinidin in pigmented fruits like pomegranate and strawberry; curcumin in turmeric; sulforaphane and other isothiocyanates in cruciferous vegetables; organosulfur compounds in garlic; lycopene in tomato; quercetin in onion and tomato; silymarin in milk thistle and genistein in soybeans among many others (8). Table I shows various dietary agents that have been reported to induce apoptosis of cancer cells."
1.8. Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase
"In recent years, many dietary compounds have been recognized as anticancer agents and previous studies indicate that resveratrol suppresses growth of pancreatic cancer cells. However, the molecular mechanisms underlying the effect of resveratrol are unknown. Our results herein show a role for resveratrol as a chemo-preventive and chemotherapeutic agent against pancreatic cancer and strongly suggest that LTA4H is an important target."
"our results indicated that promotion of pancreatic cancer could be delayed or suppressed by resveratrol"
1.9. The Influence of Quercetin on Exercise Performance and Muscle Mitochondria
"quercetin supplementation at doses of 1,000 mg/day"
"Food sources of quercetin include elderberries (42 mg/100 grams), red onions (33 mg/100 grams), hot peppers (15 mg/100 grams), apples (4.7 mg/100 grams), and kale (7.7 mg/100 grams)."
"In vitro animal and human epidemiologic studies suggest a long list of desirable effects result from consuming quercetin in the diet. These include antioxidative, anti-inflammatory, antibacterial, immunomodulatory, anticarcinogenic, and cardioprotective actions. High quercetin intake via diet is associated with decreased rates of colorectal, kidney, pancreatic, prostate, and lung cancer; cardiovascular disease; and diabetes."
"Measurements of long-term supplementation with quercetin yield a wide variance in absorption rates. A 12-week study of 1,000 subjects who received either placebo or 500 mg or 1,000 mg of quercetin per day yielded a range of unpredictable responses in plasma levels. A study of ileostomy patients given single 100 mg doses of quercetin found a mean absorption rate of 24%. Another study found a 52% absorption when the quercetin was administered as a serving of fried onions. Polymorphisms in intestinal enzymes, transporters, and liver enzymes, and effects of coadministered foods (dietary compounds), may explain some of these variances."
"In rat studies, omega-3 fats, vitamin C, vitamin E, and green tea extracts have a synergistic effect on quercetin’s action."
"combination of quercetin, green tea, and fish oil. Quercetin (1,000 mg/day), ... (EGCG; 120 mg), isoquercetin (400 mg), and EPA-DHA (400 mg)
... Plasma quercetin levels of those who took the supplement combination were almost twice as high as in those who took quercetin alone."
"A January 2010 study reports red onion, an excellent source of quercetin, enhances absorption of EGCG from green tea."
"Quercetin’s action of increasing mitochondria may warrant clinical trials to study using it for fatigue associated with cancer treatment. It may increase stamina in these patients while at the same time having anticancer action."
1.10. Quercetin
"Pregnant and breastfeeding women and people with kidney disease should avoid quercetin.
At high doses (greater than 1 g per day), there are some reports of damage to the kidneys."
"Chemotherapy -- Test tube and animal studies suggest that quercetin may enhance the effects of doxorubicin and cisplatin, chemotherapy medications used to treat cancer. In addition, some doctors believe taking antioxidants at the same time as chemotherapy can be harmful, while others believe it can be helpful."
1.11. Curcumin 2000x
Content: 300mg curcumin, 100mg Cayenne pepper, 90IU Vit. E
1.12. Standard Curcumin 95% (low cost)
1.13. Curcumin solubility
(poor absorption when taken orally)
"Solubility:
Soluble in ethanol (10 mg/ml),
DMSO (25 mg/ml), ...
water (< 0.1 mg/ml) ..."
1.14. Sabinsa weighs into curcumin bioavailability debate
5mg - piperine will not enhance the absorption of toxins and drugs
more than 20mg - piperine will enhance absorption of toxins and drugs.
Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice.
"cotreatment with piperine resulted in a C(max) = 31.60 +/- 15.08 nmol/g at 90 min, and levels were maintained
above 20 nmol/g until 180 min. This resulted in a significant increase in the small intestine EGCG AUC
(4621.80 +/- 1958.72 vs. 1686.50 +/- 757.07 (nmol/g.min))."
1.15. Testimony from a news group (Melanoma):
"When I started I was using life extension and yes, it almost bankrupted us. But, I changed brands and started capping my own black pepper to go with it, the protocol continues to work as well. Here is where I get mine, it is much more affordable. http://turmeric-curcumin.com/
I buy 12 bottles at a time, which really brings the cost down. I buy bulk organic black pepper and cap it in 00 caps which I take with it.
Dosage always starts at 1 gram a day for a week, then it raises to 2 grams a day for the next week, then 3 grams a day, etc. This is called ramping up. Just starting in taking 4 grams a day will make most people violently ill. After ramping up to 8 grams a day, I felt really tired and fragile, but it was worth it. The moles began to disintegrate, just falling off my skin. When I dropped my dosage to a gram a day, I noticed the moles on my face that did not fall off, but turned pink again, started to go dark. So I raised my dose to 2 grams a day and I appear to be doing really good at this level."
1.16. The amazing healing powers of cayenne pepper (capsicum)
"Christopher has even documented cases where he helped patients come out of heart attacks using only a teaspoon of cayenne powder in a cup of warm water. He isn't alone; there are several anecdotes of people recovering from serious heart attacks by downing cayenne teas or tinctures."
"Dr. Christopher liked to use warm purified or distilled water to mix in the fine cayenne powder. One-half to a full cup of water can be used for to mix a half or full teaspoon of cayenne that can be quickly gulped. Allowing the heat to permeate is part of cayenne's therapeutic value, which a reason why Dr. Schulze disdains cayenne capsules."
"It is also a valuable aid for digestion and elimination which can ultimately help heal hemorrhoids and ulcers. Both Dr. Christopher and Dr. Schulze assert that ingesting cayenne powder will boost the potency of the other herbs and supplements you're taking.
In cayenne studies, scientists have demonstrated an 80% reduction with prostate cancers in mice and in human prostate cancer cells in cultures. The capsaicin in cayenne actually creates accelerated cancer cell apoptosis, or cellular self destruction.
Cayenne pepper contains many beneficial phytochemicals, extremely bio-available vitamins C & E, and minerals, including the vital heart-health mineral magnesium. It cleans the blood, allowing hormonal signals to make their way unimpeded through your system and enhancing the immune system."
1.17. BCM95 - High bioavailability Curcumin
1.18. Meriva - High bioavailability Curcumin
1.19. Turmeric
"Cancer Prevention
...
Inhibits Cancer Cell Growth and Metastases
...
Turmeric and Onions May Help Prevent Colon Cancer
... cancer in the lower intestine. Similarly, quercetin, an anti-oxidant flavonoid found in a variety of foods including onions, green tea and red wine, has been shown to inhibit growth of colon cancer cell lines in humans and abnormal colorectal cells in animals.
In this study, a decrease in polyp number was observed in four of five patients at three months and four of four patients at six months.
Each patient received curcumin (480 mg) and quercetin (20 mg) orally 3 times a day for 6 months. Although the amount of quercetin was similar to what many people consume daily, the curcumin consumed was more than would be provided in a typical diet because turmeric only contains on average 3-5 % curcumin by weight.
...this research clearly demonstrates that liberal use of turmeric and onions can play a protective role against the development of colorectal cancer. And turmeric doesn't have to only be used in curries. This spice is delicious on healthy sautéed apples, and healthy steamed cauliflower and/or green beans and onions. Or, for a flavor-rich, low-calorie dip, try adding some turmeric and dried onion to creamy yogurt.
...
Turmeric Teams Up with Cauliflower to Halt Prostate Cancer
...
curcumin, along with phenethyl isothiocyanates, a phytochemical abundant in cruciferous vegetables including cauliflower, cabbage, broccoli, Brussels sprouts, kale, kohlrabi and turnips.
... when combined, they significantly reduced both tumor growth and the ability of the prostate cancer cells to spread (metastasize) in the test animals.
...
Reduce Risk of Childhood Leukemia
...
Improved Liver Function"
1.20. Turmeric - A detailed description
"Curcumin also was shown by Mahady et al to inhibit the growth of Helicobacterpylori, a group 1 carcinogen, as a possible explaining mechanism for its role in prevention of gastric and colon cancers in rodents.
Curcumin was administered orally for three months with doses ranging from 500 to 12,000 mg/d. Curcumin was found to be non-toxic in doses of up to 8,000 mg/d orally for three months. The results also showed that one of four patients with C1N and one of seven patients with oral leucoplakia developed frank malignancies in spite of treatment with curcumin. However, histological improvement was seen in one of two patients with bladder cancer, two of seven patients with leucoplakia, one of six patients with intestinal metaplasia, one of four patients with C1N, and two of six patients with Bowen's disease.
Turmeric should be avoided in patients allergic to turmeric or any of its constituents (including curcumin), yellow food colorings, or other members of the Zingiberaceae (ginger) family. It should be avoided in patients with bile duct obstruction or cholelithiasis, and gastric or duodenal ulcers or other hyperacidity disorders. [Reviewer’s note: whole turmeric, not the isolated curcurmin, is in fact, recommended in small amounts in these conditions.]
Turmeric is considered safe for pregnant and lactating women when used as a spice in foods. Turmeric should not be taken in large amounts during pregnancy as it might stimulate menstrual flow and uterine contraction. Animal studies have not shown any teratogenicity. There is insufficient evidence of safety to support use of large amounts of turmeric during lactation. "
1.21. Resveratrol - many actions against cancer
"Resveratrol increased longevity by stimulating the survival defence enzyme Sir, which in turn stimulates the
production of sirtuins , survival defence hormones produced when animals are on restricted calorie diets. And in turn,
this improved insulin sensitivity and reduced IGF-1 levels, increased mitochondrial numbers and activity, and
improved motor function. Moreover it negated the detrimental effects of a high-calorie diet at a genetic level.
However the doseage used was 24 mgs per kilogram of body weight equivalent to 1000 bottles per day of red wine!
Not surprisingly there are also scientific studies that show a restriction of calories can stop tumour growth. Drugs
based on resveratrol are being studied for both anti-ageing and type-2 diabetes.
In a study of gliomas (Brain tumours) using rats (Clin Cancer Res. 2004; Mar) a concentration of resveratrol at
40 mgs per kilogram of body weight per day increased survival rate, by exerting an anti-tumour effect and an anti-
vascular effect. It was concluded that the natural compound is a potent chemotherapy agent."
Resveratrol (Linus Pauling Institute)
"At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on
such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens.
... Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-
sensitive cancers, such as breast, ovarian, and uterine cancers, should avoid resveratrol supplements"
1.22. Taurine & Cancer
"Taking up to 3,000 mg of taurine daily is considered safe"
1.23. Taurine enhances anticancer activity of cisplatin in human cervical cancer cells.
"the results indicated that co-treatment of cisplatin with taurine was more effective than single treatment of cisplatin."
1.24. The Forgotten Longevity Benefits of Taurine
Taurine Prevents Obesity
Taurine Promotes Glucose Control—and Treats Diabetes
Taurine Reverses Cardiovascular Disease Factors
Taurine Provides Potent Retina Protection
Taurine Helps Reverse Tinnitus
Solution for Seizures
Taurine Prevents and Treats Liver Disease
1.25. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.
2 [oz] of Aloe gel increases Vit.C and Vit.E absorption apprximately 3..4 times.
"500 mg of ascorbic acid or 420 mg of vitamin E acetate alone (control), or combined with 2 oz of two different Aloe preparations (a whole leaf extract, or an inner fillet gel)."
"For comparative purposes the control area was 100%. The Aloe Gel area was 304%, and Aloe Whole Leaf 80%. Only Aloe Gel caused a significant increase in plasma ascorbate after 8 and 24 h. For vitamin E, the results for the relative areas were control 100%, Gel 369%, and Leaf (198%). Only the Aloes produced a significant increase in plasma tocopherol after 6 and 8 h. Both Aloes were significantly different from the control after 8 h. Aloe Gel was significantly different from the baseline after 24 h. The Aloes slowed down the absorption of both vitamins with maximum concentrations 2-4 h later than the control. There was no difference between the two types of Aloe. The results indicate that the Aloes improve the absorption of both vitamins C and E. The absorption is slower and the vitamins last longer in the plasma with the Aloes. Aloe is the only known supplement to increase the absorption of both of these vitamins and should be considered as a complement to them."
1.26. pycnogenol side effects, pycnogenol benefits
"Studies have shown that these compounds may have benefits on inflammation, asthma, cancer (tumor), vascular disorders, retinopathy, Alzheimer's disease, diabetes, cholesterol, erectile dysfunction, sperm quality, wound healing, dymenorrhea and aging."
"maximum 200 mg/day"
"50 mg x 3/day for 2 months"
CANCER
"In conclusion, pycnogenol selectively induced death in human mammary cancer cells (MCF-7) and not in normal human mammary MCF-10 cells."
"Pycnogenol benefits - on RETINOPATHY
They also consider that pycnogenol is known to increase capillary resistance. They reviewed couples of old study reports in French and German and found that Pycnogenol retains progression of retinopathy and partly recovers visual acuity. Pycnogenol was shown to improve capillary resistance and reduce leakages into the retina.
With pycnogenol-treatment, the retinal function stopped to deteriorate and visual acuity significantly recovered. They both thought that the mechanism might be related to its free radical (FR) scavenging, anti-inflammatory and capillary protective activities. They considered that pycnogenol might bind to the blood vessel wall proteins and mucopolysaccharides and produce a capillary 'sealing' effect, leading to a reduced capillary permeability and oedema formation."
"the side effect was found to be mild and it was confined to gastric discomfort. While in another study of 58 patients suffered from hypertension (hight blood pressure), the side effects included gastrointestinal problems, vertigo, headache and nausea."
1.27. Pycnogenol
Detailed secription and effect of Pycnogenol on various illnesses.
1.28. New Research Shows Combination Of Pycnogenol®, Vitamin C And Zinc To Be An Effective Natural Approach To Relieve Common Cold Duration And Symptoms
"The trio (100mg Pycnogenol® + 200mg Vitamin C + 30mg Gluconate Zn per day) showed the most success in significantly shortening the duration of symptoms to four days, as compared to the average of seven days."
1.29. Effect of pycnogenol on ascorbic acid (vitamin C)
"Among all of the flavonoids tested in this experiment, which included myricetin, polyphenon and theaflavin, pycnogenol had the greatest effect."
1.30. Living Proof Vitamin C Miracle Cure 60 Minutes Video 3 News
H1N1, Leukemia, coma
[7:00] - IV Vit.C - 2 days - 25,000 [mg/day]
[14:30] - Lypo-spheric Vit. C - 6,000 [mg/day]
1.31. William Li: Can we eat to starve cancer?
Angiogenesis
[3:10] (Excessive Angiogenesis) Cancer, Blinding diseases, Psoriasis, Arthritis, Endometriosis, AIDS Kaposi-Sarcoma, Alzheimer, Obesity, MS, Cerebral malaria, Rosacea
[3:50] - every type of cancer
[6:45] Antiangiogenic therapy - targets only cancer cells
[7:10] Glioma (brain tumor) - 4 weeks treatment
[7:20] Breast cancer - 4 weeks
[7:50] (dog) - malignant neurofibroma - spread to lungs (doctor gave him 3 months to live)
applied mixture in food and cream for topical treatment. - 7 weeks
[8:20] - 60% response rate
[8:40] - (dolphin) - Squamous cells cancer; applied paste on tongue 3 times a week; - 7 months
[9:00] - (horse) angio-sarcoma; applied creme and oral cocktail; - 6 months
[9:45] - drugs that are based on antiangiogenic treatment
[9:55] - patient survival data
[11:30] - 35% of cancer is due to diet
[12:30] - Resveratrol - 60% reduced angiogenesis
Strawberries - very potent
Soy bean extract - very potent
[12:55] - list of foods
some of them are - berries, citrus fruits, red grape, red wine, bok choy, kale, turmeric, lavender, parsley,
licorice, garlic, tomato, olive oil, grape seed oil, dark chocolate
[13:40] - tea combination (food synergy); food list vs drugs
[15:10] - cooked tomatoes (lycopene) - 2..3 servings per week - 50% less risk for cancer
[16:45] - obesity
1.32. Cancer Smart Bomb, Part I: An Idea from Ancient Chinese Medicine
(dogs) Osteosarcoma ... five days of treatment the dog was able to walk normally
lymphosarcoma - immediate reduction in tumor size. In all these canine cases, an iron supplement was used.
Prostate Cancer
Pancreatic Cancer
Brain Tumors
Tongue Tumor
"5 cm tongue tumor, being fed through a feeding tube, had her tumor disappear and the feeding tube removed in less than two weeks on artemether."
Breast Cancer
"A woman with stage IV metastatic breast cancer has returned to work after four months of treatment with artemether."
"47-year-old woman with stage-IV breast cancer with metastases to her spine, causing significant pain and limping. Various alternative therapies gave her some symptom relief, but no change was registered on her CT scan until a course of artemisinin was instituted. The other breast cancer case he writes of is a large, oozing cancer that cleared up in a month on artemisinin derivatives."
Lymphoma
"egg-sized tumor on the left side of the man's head, which spontaneously cleared up two weeks after a two-week course of artemisinin derivatives."
Types of Cancers Responding
leukemia, colon cancer, melanoma, breast, ovarian, prostate, renal and central nervous system cancers such as glioblastoma and neuroblastoma.
"the fat-soluble form has superior absorption into the brain."
"Artemether is a semi-synthetic, more fat-soluble form that is the longest lasting in the blood stream. Due to the fat-soluble nature of this compound, it passes more readily through the blood brain barrier. It is also metabolized fairly rapidly to dihydroartemisinin (DHA), and blood tests show that after 6 hours the DHA metabolite has higher plasma concentrations than the parent compound artemether. (see:: www.arenco.be/docu11.htm)"
Various Oral Dosages Used
"1 to 2 mg/kg, once or twice a day."
"3 to 4 mg/kg"
"Higher dosages may be neurotoxic after long-term use or may cause heart problems (read toxicity info below)."
"... combination of a 100 mg capsule of artemisinin, a 60 mg capsule of artesunate and a 40 mg capsule of artemether once a day at bedtime with a glass of milk. He also writes that the correct dosage for a specific person needs to be determined on an individual basis."
artemether - take 2 times a day.
On an Empty Stomach
"need to be taken on an empty stomach away from food, so that it will not interact with the iron in the food. In the evening this would mean at least two or more hours after the last meal."
"take it with a glass of milk "
"take it with cod liver oil and conjugated linoleic acid."
"intestine builds up resistance to absorbing oral artemisinin compounds very quickly, within several days. Resistance is demonstrated by a drop to >30% of the original rate of absorption. Research indicates that this resistance can be overcome very quickly by discontinuing use of the artemisinin compounds for several days to a week; when resumed, their absorption will be at the previous higher level."
"Supplemental antioxidants may be contraindicated with the use of artemisinin though. The nature of the action of artemisinin compounds in the body is the creation of free radicals through interaction with iron in the cancer cell. Anything that protects against that free radical damage may be counterproductive to the effectiveness of the action of the artemisinin derivatives."
1.33. Cancer Smart Bomb: Part II Artemisinin Follow-Up
"dosages from 100 to 600 mg/day"
"brain cancer ... came out of his coma after 21 days of injections of artemether"
"70% reduction in tumor size within a week ... on day one with an oral capsule containing 150 mg of ferrous sulfate along with folic acid (0.5), and from day 1 to day 15, a 60 mg injection (IM) of artesunate was given every evening. Starting on day 16, the patient was switched to an evening oral tablet of artesunate (50 mg), which is being continued on a daily basis."
1.34. ARTEMISININ UPDATE
"American College for Advancement in Medicine, (ACAM list of doctors: 1-888-439-6891 or www.acam.org/dr_search/) who do alternative therapies, usually IV therapies for chelation. They might also be familiar with artemisinin and/or other nutritional support protocols for cancer."
Artemisinin and Cancer
"Dr. Singh reports that a combination of the forms may be the very best treatment due to these different properties
(based on a lab experiment). Thus, he feels the best preparation will contain artemisinin and artemether to provide a
dose of 0.5 – 2 mg/Kg of each form once daily before bed (away from an residual iron left in the stomach after the
evening meal). Dr. Hoang reports that 500 mg twice daily of oral artemisinin by itself is the dosage he has been using
with great success.
The product is best taken on an empty stomach with some natural fat to enhance absorption. Any iron present from
residual food may neutralize the peroxides. Mile is one of the few foods with minimal iron. Whole milk, cottage
cheese or yogurt have ample fat to enhance absorption. Additionally, I believe simultaneous administration of cod
liver oil (for its omega-3 and vitamin D) and conjugated linoleic acid (CLA) will assist absorption, while providing
therapeutic benefits. To date, with the exception of patients very near death, taking artemisinin or derivatives have
stabilized, improved, or remitted every cancer patient I have followed."
Artemisinin And Canine Cancer
Recommended treatment:
1mg/kg Artemether. Calculate Artemix supplement (combination of the 3 types) based on the Artemether content.
Give with Butyrate and Vit.D3. Small quantities of antioxidants can be given (250mg Vit.C, 200IU Vit.E but not given
at the same time as artemisinin). No iron supplements are necessary.
Continue treatment for 8 weeks (every day). If condition improves, start pulsing the Artemisinin and continue for
3..4 months. If condition is not improved change the therapy.
Synergic effects of artemisinin and resveratrol in cancer cells.
Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.
"... artemisinin-type compounds are able to kill cell lines of many different tumor types, e.g. leukemia, lymphoma,
melanoma, brain tumors, carcinoma of the colon, breast, ovary, lung, kidney, and many others...
... Artemisia annuaL. preparations (Luparte®) were obtained from Lupovet GmbH (Müllheim/Baden, Germany).
Using a semiautomated device 450 or 150 mg of the 1:30 extracted and pulverized Herba A. annuae were for
technical reasons enriched with 50 or 17 mg Inulin and enclosed in capsules size “O” or “4”, respectively.
... One female and two male dogs as well as one male cat between 10 and 13 years were diagnosed with
hemangioendothelial sarcoma or fibrosarcoma at the Veterinary Clinic, Müllheim. All four animals suffered from
a grade 3 or 4 tumor at diagnosis ...
... iron was given p.o. b.i.d or intramuscularly every 3 days to mark the iron affine malignant cells. The initial “blind”
dose of orally given iron (e.g. Ferrosanol® capsules 100 mg) was about 100 mg/30 kg b.i.d. or about 100 mg/10 kg
weight Ursoferran i.m. two times a week. The iron application was continued for the entire treatment time, and was
attuned to maintain the iron level at 250 ± 30 µg/dL.
From the fourth day onward, the animals were treated p.o. two to three times daily with one capsule (150 mg in the
cat, 450 mg in the dogs) of Herba A. annuae simultaneously."
Differential Effect of Artemisinin Against Cancer Cell Lines
"The tumor volume increase linearly and significantly in control mice between day 0 and day 6 to reach 1.7 ± 0.08 cm3
compared to the treated animals (1 ± 0.08 cm3). After the 6th day, tumor volumes of untreated mice continue to
growth, which reached at day 20 a mean volume of 2.2 ± 0.1 cm3. Thus, tumor-bearing mice died from progressive
tumors. However, in treated animals, tumor volume began to decrease to attaint 0.26 ± 0.06 cm3 at day 10, and close
to regression (0.003 ± 0.06 cm3) at day 14. This difference was found to be significant between the control and treated
groups (P < 0.05). The tumor volumes of treated animals remained constant between the 14th and 20th day,
suggesting an inhibition of cell growth during this period.
... artemisinin ... at a concentrations able to induce a cytotoxic activity against tumor cells (P815 and BSR), no
cytotoxicity effect on normal cells was observed.
... Furthermore, artesunate, another derivative of artemisinin, was proved to decrease tumor microvessel
density and subsequently reduced tumor growth with no apparent toxicity to the animals at 50 and 100 mg/kg/day,
respectively. The authors described the anti-angiogenic effect of artemisinin analogues ..."
1.35. Garlic Proven to Kill Brain Cancer Cells, Prevent Future Growth
"brain cancer cells, specifically glioblastoma,"
"peel open garlic cloves and exposes them to air for 15 minutes or so to release those compounds. Some even say crush them for more exposure, then consume them raw to get the full benefits."
1.36. The Use of Bee Pollen as a Superfood
"Delay in the Appearance of Palpable Mammary Tumors in C3H Mice Following the Ingestion of PolIenized Food"
"twenty-five women suffering from inoperable uterine cancer. Because surgery was impossible, the women were treated with chemotherapy. The lucky women given bee pollen with their food quickly exhibited a higher concentration of cancer-fighting immune-system cells, increased antibody production, and a markedly improved level of infection-fighting and oxygen carrying red blood cells (hemoglobin). These women suffered less from the awful side effects of chemotherapy as well. Bee pollen lessened the terrible nausea that commonly accompanies the treatment and helped keep hair loss to a minimum. The women also slept better at night."
1.37. How to Take Bee Pollen
"Begin by placing a single granule or a small dosage of the bee pollen supplement on the tip of your tongue. If you are allergic to this product, you will begin to experience an allergic reaction within minutes of the pollen being absorbed by the mucus membranes of your tongue. Any signs of a runny nose, itchy eyes, nose or throat, shortness of breath, hives or other skin problems, or swelling will indicate an allergy to bee pollen."
"Slowly increase your dose every day to make sure that you don't experience an allergic reaction with larger doses. If you begin to experience any side effects with a larger dose, reduce the quantity of bee pollen that you are consuming daily and maintain that smaller quantity for a few weeks. After time has passed, you can begin increasing your dosage once again."
"Most individuals limit themselves to 1 or 2 tablespoons of bee pollen granules each day."
I have sleep improvement at 1/2 teaspoon/day after 2 days. Another site was saying 1 to 6 teaspoons/day.
1.38. MAPLE LEAF HIFU
HIFU - ALTERNATIVE PROSTATE CANCER TREATMENT
info for US patients
1.39. Author Ann Cameron cured her stage 4 cancer with carrot juice, nothing else.
2012, June 6 - surgery for a newly diagnosed Stage 3 colon cancer
November 6 - Stage 4 colon cancer metastasized to the lungs
November 17 - started drinking the juice 5 lbs of carrots / day. No other diet change.
2 weeks after starting the carrots, there was no improvement.
8 weeks after starting the carrots, the tumors had stopped growing and were shrinking.
4 months after starting the carrots, all the lymph nodes in my lungs had returned to normal.
8 months after starting, there was no sign of cancer anywhere in my body.
1.40. Vitamin D Might Be Able to Slash Your Breast Cancer Risk by 90 Percent
sun exposure - 40 percent of your body for approximately 20 minutes between 10 am and 2 pm
oral supplement - D3 - 8,000 [IU] to 10,000 [IU]
K2 - 150 to 200 [micro grams] "Vitamin K2 deficiency is actually what produces the symptoms of vitamin D
toxicity, which includes inappropriate calcification that can lead to hardening of your arteries."
Test Values and Treatment for Vitamin D Deficiency
"50-70[ng/ml] optimal, 70-100[ng/ml] maximum to treat cancer and heart desease."
"multiply by 2.5 to convert to [nmol/L]"
1.41. Questions and Answers About High-Dose Vitamin C
"The anticancer effect of vitamin C in different types of cancer cells involves a chemical reaction that makes hydrogen peroxide, which may kill cancer cells."
"Treatment with high-dose vitamin C slowed the growth and spread of prostate, pancreatic, liver, colon, malignant mesothelioma, neuroblastoma, and other types of cancer cells."
"Combining high-dose vitamin C with certain types of chemotherapy may be more effective than chemotherapy alone."
"Combining dehydroascorbic acid, a particular form of vitamin C, with chemotherapy made it less effective in killing some kinds of cancer cells."
"The study found that patients who received IV vitamin C had better quality of life and fewer side effects than those who did not."
"Vitamin C was shown to be a safe and effective therapy to improve quality of life in these patients, including physical, mental, and emotional functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss."
1.42. Hydrogen peroxide marshals immune system
"the body uses hydrogen peroxide to sound the alarm when a tissue has been injured. As a direct result of this hydrogen-peroxide red alert, white blood cells come to the aid of the wounded site."
"white blood cells *needed* hydrogen peroxide to sense the wound, and move towards it"
1.43. 35% Hydrogen Peroxide Treats cancer
Beat cancer with 35% hydrogen peroxide
Hydrogen Peroxide Cancer Treatment
Alternatives in Cancer Therapy - Hydrogen Peroxide
The One-Minute Cure: The Secret to Healing Virtually All Diseases
Notes:
can be taken in a bath (preferred) or orally.
must use food grade 35%.
if taken orally:
- there must be 3 to 4 hour window of no food and water before taking it.
- must be taken with lots of water (1 to 2 glasses of water).
- dose must be build up slowly.
- maximum dose depends on how you feel!
I know a person (he did not have cancer) who managed to reach 25 drops/day.
Side effect - severe diarrhea, feel sick for a while after drinking it.
He felt very good at 15 drops (excluding the side effects). He did not loose weight despite the diarrhea.
Recommendations if you take it orally:
take probiotics. Hydrogen peroxide will kill good and bad microbes in your intestines.
take vitamins and minerals.
take 1/2 teaspoon/day of naturally dried sea salt or Himalayan salt.
1.44. Nutritional Supplements and Cancer Risk Evidence from Human Trials
[6:15] Vitamin E types:
low dose Alpha is OK; Less than 100[IU] (recommended 60[IU])
Gamma is OK; Gamma is better for Cancer; Alpha suppresses Gamma;
Natural is better than synthetic;
Better when taken with Selenium, CoQ 10 and Vit. C;
[16:45] Beta carotene {from supplements (my comment)} maybe bad for lung cancer.
[17:45] Beta carotene increases the risk of bladder cancer slightly.
[18:00] Astaxanthin instead of Beta carotene.
[25:20] Don't take iron supplements (unless you need it).
[25:45] Curcumin:
[26:30] Curcumin is effective for many diseases; Impact on every stage of cancer;
[27:15] Patient with liver {"pancreatic" on image (my comment)} cancer (failed chemo and radiation):
Curcumin {standard 95% (my comment)} 8,000[mg/day] - cat-scan shows 73% reduction in 2 months.
[29:40] Curcumin supplements and absorption levels:
Meriva - free curcumin not detected in plasma;
detected curcumin break down products (good for inflammation, arthritis);
For Alzheimer's disease you need free curcumin - i.e. Meriva is not good.
BCM-95 - confusing published data
[35:00]
Longvida - the only one that has human trials with good results.
2,000[mg] Longvida supplement reaches 32[ng/ml] (used in the cancer study above with 8,000[mg])
builds up in fatty tissues (including the Brain)
- need 1 [capsule/day] (80[mg] curcumin in 400 [mg] capsule)
- effect after 1 month (to improve brain function).
[39:30] Longvida used for Alzheimer detection via retina scans (visible difference from Dimentia);
shows that Longvida is absorbed and crosses blood brain, blood retina barrier, and binds to the amyloid plaques.
[40:60] Vitamin D; [56:55] - minimum 1,500 [IU/day]
1.45. Antioxidant-Bashing Study is 'Nonsense,' Says Top Doc
"For one thing, all of these types of studies use dl-alpha tocopheryl," he says. Dl-alpha tocopheryl is a synthetic form of vitamin E made from petrochemicals and is not identical to the natural form.
“It's cheaper than d-alpha tocopherol – the natural form. Research has shown that natural vitamin E is twice as effective as synthetic. It's the worst form of vitamin E to use."
"most important failure of the study is that the sick rodents were given just a single antioxidant."
"Studies show that if you give a person or animal a single nutrient like vitamin E, it will oxidize. It is no longer an antioxidant – it becomes an oxidant. You are adding to the oxidant burden, not reducing it," he said.
"Numerous studies have shown that certain antioxidants, such as curcumin, quercetin, resveratrol, and ellagic acid are powerful suppressors of cancer growth and invasion," says Dr. Blaylock.
"I've treated cancer patients with flavonoids and antioxidants for over 20 years and I've never seen them make a cancer grow faster.
1.46. Influence of ellagic acid on prostate cancer cell proliferation: a caspase-dependent pathway.
" It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer."
1.47. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells.
"synergistic interaction for the combinations of ellagic acid with resveratrol and quercetin with resveratrol"
"confirming a synergistic interaction with a combination index of 0.64 for the combination of ellagic acid and resveratrol and 0.68 for quercetin and resveratrol."
"Results indicate that the anticarcinogenic potential of foods containing polyphenols may not be based on the effects of individual compounds, but may involve a synergistic enhancement of the anticancer effects."
1.48. Ellagic acid inhibits migration and invasion by prostate cancer cell lines.
1.49. The Truth About Ellagic Acid and Red Raspberries
"one cup of red raspberries per day (40 mg of ellagitannins)"
"In pure form, ellagic acid is highly insoluble and biologically unavailable...ellagic acid, as it is biosynthesized in plants, occurs in combination with glucose as ellagitannins. These compounds are quite water soluble and biologically available. This means that relatively small amounts of ellagitannins may be more effective in the human diet than large doses of ellagic acid,"
"What is interesting to note is the superior efficacy of eating red raspberries as opposed to taking the individual phytochemicals in the form of dietary supplements. Though we do not yet fully comprehend why this is so, it is clear the nutraceutical whole is greater than the sum of its parts."
"synthetic ellagic acid is too harsh for the human body to accept, and has some potentially serious side effects"
"ellagic acid itself is not naturally present in plants"
"pomegranate. Although not proven in clinical studies, the anecdotal evidence is extremely strong – and the concentration of ellagitannins is much higher in pomegranate than raspberries."
"over 70% of the ellagitannins present in the Meeker red raspberry are found in the seeds."
"One gram of red raspberry seed powder, taken twice a day, provides 40 mg of ellagitannins – equivalent to the amount of ellagitannins found in one cup of fresh red raspberries."
1.50. Alternative and Complementary Therapies in Oncology Care
"Currently, the most interesting results from laboratory and clinical studies involve phytochemicals from fruits and vegetables and berries.
Our group is currently researching the effects of ellagic acid, a simple polyphenol compound—probably a natural insecticide—that is found in raspberries, figs, and red grapes.
Pomegranates, for some reason, have the highest level of ellagic acid we have determined in the laboratory.
We are currently using raspberries as our test substance. Our group studied healthy patients in a clinical research unit and fed them raspberries to determine how much ellagic acid they absorbed; the peak absorption is approximately 5 hours.
We therefore examined ellagic acid and DNA synthesis in our laboratory. For example, DNA synthesis in untreated cervical cancer cells increases rapidly. When we exposed these cancerous cells to ellagic acid in the amount that one gets from eating a cup of raspberries, DNA synthesis basically stops for a period of time, and in our study, a very profound apoptotic cell death occurred among human cervical cancer cells approximately 36 hours after being exposed to ellagic acid.
Our group is currently studying a number of patients, each of whom has been eating 1 cup of raspberries once a day; they are allowing us to perform biopsies of their colons every 3 months. We are using KR67 assays in this study to determine whether the dose of ellagic acid in 1 cup of raspberries returns the rate of cell proliferation back toward normal in patients with hyperactive colon mucosa, colon polyps, and patients who have had colon cancer. "
1.51. Part 2 - Beat Your Own Cancer - Ketogenic Kills Cancer
[1:00] Brain cancer - calorie restricted ketogenic diet
[4:00] tumors cannot metabolize ketones for energy.
(mice test) 40% calorie restriction, 3 days - 65% to 90% tumor reduction
powerful anti-angiogenic effect; pro-apoptonic (kills cancer cells).
[7:15] standard vs ketogenic diet; Fat to (protein + carbohydrates) ratio of 4 to 1.
must be calorie restricted to have therapeutic effect!
added 2-DG (glucolysis inhibitor) - synergy between diet and drug.
[10:00] human study
after standard treatment, 3 days fast, ketogenic diet; tumor disappear completely;
patent gets off ketogenic diet; tumor appears after 2 months;
patent then goes on avastin (chemo drug that actually enhances tumor); patient died;
1.52. Starving Cancer: Ketogenic Diet a Key to Recovery
[0:30] recovery from bone cancer (doctors gave him 3 months to live; 3 different doctors told him that)
cancer disappeared and patent is still OK after 1 year.
[2:00] metabolic therapy.
cancer cells can only survive on glucose; normal cells can use glucose or ketones;
fat and cholesterol are OK, it is sugar that is bad.
[5:45] woman with cancer on salivary gland - went on ketogenic diet and it is OK.
[6:10] ketogenic diet for children with epilepsy; from 100 seizures cured by ketogenic diet;
[7:00] must be high fat
[9:00] MSG comments
[10:00] ketogenic diet makes you loose weight
1.53. The new science of healing, Louis Kuhne (1835 - 1901)
Louis Kuhne: The Origin Of The Detox Bath Method
Main goals:
normalize digestion (no diarrhea or constipation)
restore perspiration (according to him, most sick people don't sweat)
Treatment consist of:
cold water sitting bath (only cooling down the hip/abdomen);
rubbing stomach area with a cloth during the bath;
heat chambers - heating the body (but not the head)
indirect light sunbaths
mostly vegetarian diet (I think milk was OK); solid food (no soup);
patient is left by himself after dinner;
Multiple cases described of people healing themselves using these simple techniques.
Explanations of how the body works and why this treatment helps don't make sense (book is written in 19th century, so
no surprise there). However I do believe that there were people that were healed using his method.
Definitely worth a read or skim through the book skipping his ideas on body physiology.
My opinion on his treatment is:
- cold water sit baths - no idea yet how this could help, but it would have effect on all internal organs and some
lymph nodes. The temperature of the water is ~22 .. 25[oC].
Hypothermia has weakening effect on the immune system. However, when combined with hyperthermia it
appears to strengthen the immune system instead [Ref.1.131].
- rubbing the stomach area with a cloth during the baths:
he describes that sores appear usually (but not always) at the rubbed area.
Sometimes the sores appear at other areas instead (previously injured/ill sites).
I think this is stimulating the immune system.
In addition H2O2 is released when the body is injured stimulating immune response [Ref.1.42], so
I wonder if H2O2 has also direct affect on the cancer, or it is just the immune system.
Also, when the body has constant inflammation due to the sores, it will have raised temperature.
In "The fourfold path to healing" the author is saying that some times tumors shrink if the patient gets
infectious disease and has fever.
- heat chambers - I guess it has general beneficial effect:
restore perspiration/detox;
increased body temperature - "whole body hyperthermia" [Ref.1.109];
also heat is used to treat depression [Ref.3.5], so it should have positive effect hormone and
neurotransmitters balance.
The cooling of the body after the hyperthermia session promotes relaxation and sleep (link).
- relaxing outside on indirect sunlight:
extra Vit. D (?);
some bright light to boost the mood;
relaxation;
- mostly vegetarian diet and non spicy meals; solid food:
This (according to Kuhne) is to maintain proper digestion.
Also, considering the book was written about 100 years ago, everything was organic and pesticide free.
I wonder how many calories/day the patients were taking ... on vegetarian diet, probably not what we take
today. Reduced calories can have effect on cancer (along melatonin and ketogenic diet) [Ref1.68, 1.51].
- patient left alone after dinner:
Again, >100 years ago ... no electric lights, TVs, computers to keep you up at night with bright screens...
This had to boost the melatonin production a lot [Ref.1.68]:
"Food restriction may be related to an increase in melatonin secretion, while blindness leads to the
appearance of free rhythms and a strong melatonin signal. This increase seems to be related to an
improvement in the natural defense mechanisms of the organism. In rats developing breast cancer after
exposure to the carcinogen DMBA, ... afternoon melatonin administration decreased (development of
cancer)."
In addition, for bipolar disorder, many people have positive effects from Darkness Therapy (14..16 hours
(later can be reduced to 8..12) of darkness a day to balance/calm their mood). It was discovered that
actually the blue light is the worst, so if the patent wears yellow glasses the effect is almost the same as
total darkness. I think that probably the effect is related to direct (via the eyes) brain stimulation
(actually lack of stimulation), and also due to stimulating melatonin secretion.
1.54. Aloe
"One study in Italy of 240 patients reported in 2009. It tested aloe vera alongside chemotherapy for people with lung cancer, bowel cancer, or stomach cancer that had spread. Half the patients took aloe arborescens as a liquid 3 times a day during standard chemotherapy treatment. In this study the cancer was controlled or shrank for a time in 67% of patients who had the combined aloe and chemotherapy treatment and in 50% of patients who had chemotherapy alone. In this study the researchers said that patients taking the aloe vera had a better quality of life and that they had fewer chemotherapy side effects such as numb fingers and fatigue.
The researchers also said that there were no ill effects from the aloe vera. More patients who had the aloe vera survived for 3 years than patients who just had chemotherapy."
1.55. The Effect of Curcumin on Breast Cancer Cells
"Moreover, curcumin decreases the toxic effect of mitomycin C"
"Furthermore, curcumin enhanced the efficacy of chemotherapy"
1.56. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-?B and Src protein kinase signaling pathways.
1.57. Fantastic Chemo Response - Was it the Curcumin?
"She was then started on Paclitaxel/Carboplatin (PC) chemo; we persuaded her oncologist to sanction our use of Curcumin at the same time (having read great things about this ingredient of the curry spice, Turmeric, on the internet).
After three rounds of PC a scan showed significant improvement but the remaining tumour was still considered inoperable, so the next 3 rounds of chemo was scheduled to be followed by a one-year course of Avastin. Another scan was taken at the end of the chemo and the Avastin treatment was started.
It turned out that the scan at the end of the 6th chemo showed a remarkable change, so the oncologist got back to the surgical team and they scheduled an operation for optimal debulking and possible bowel resection. They had to wait 6 weeks after the last of the Avastin was given and the surgery took place last week.
A 12 inch section of the colon had to be removed because of damage previously caused by the cancer... but there was no active disease visible on it or anywhere else in the abdomen - even the spleen was completely normal in appearence!
The cancer surgeon told us that he has no doubt that the PC chemo regime, Curcumin & subsequent Avastin have together somehow brought about this fantastic reversal of our situation. "
1.58. Insulin Potentiation Therapy:
from post in a news group:
">if the insulin therapy works for cancer?
Disclosure: I'm on the Advisory Board of BestAnswerForCancer.org, a nonprofit educational integrative cancer
organization that has traditionally focused on IPT.
Insulin potentiation therapy (IPT)/insulin potentiation targeted low dose (IPTLD) is a highly effective cancer
treatment when used by a well-trained IPT doctor on cancers for which it's indicated (as part of an integrative
cancer treatment protocol). It's a strategy for administering a small dose of chemo (or other cancer treatment)
and delivering it to the cancer cells in a concentrated manner. (The ketogenic diet works in a completely different
manner--starving the cancer cells to death by depriving them of sugar over a long period of time; it can also be
very effective.)
>only for some cancers or for all?
IPT is usually most effective w/lymphoma (though high doses are often needed), melanoma, ovarian, breast,
prostate, stomach, small-cell lung cancer (SCLC). It’s also often effective with non-small-cell lung cancer (NSCLC),
colorectal, esophageal, pancreatic, cervical, and uterine cancer, as well as other cancers that are sensitive to chemo.
It’s usually ineffective w/brain cancer, slow-growing/low-grade/indolent cancers, subcutaneous metastases, and
cancers that are resistant to chemo. If the cancer lights up on a PET scan, that may indicate that IPT will be effective.
The Greek chemo-sensitivity test (www.rgcc-genlab.com) adds insulin in their chemo-sensitivity testing, which
assesses the effectiveness of IPT.
Our directory of doctors trained in IPT is at
http://www.ioicp.com/directory
For more info on IPT,
www.ioicp.com (or http://IPTforCancer.com)"
">Some are called German chemo-sensitivity test ... Biofocus (“German Test”)
www.biofocus.de/de/onkologie/ueberblick/ueberblick
>is there any difference?
Yes, it's similar to but (I believe) not as good (and doesn't test as many natural substances) as the Greek test (RGCC)."
Other sources of info on IPT:
Low-dose chemotherapy with insulin (insulin potentiation therapy) in combination with hormone therapy for
treatment of castration-resistant prostate cancer.
Insulin, chemotherapy, and the mechanisms of malignancy: the design and the demise of cancer
IPTLD – Insulin Potentiation Therapy Low Dose for Cancer
DMSO Potentiation Therapy (DPT) DMSO – The Magic Bullet For Cancer (used with IPT)
The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells
Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and
colonic cancer cells.
1.59. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.
"The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia,
sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary
adenocarcinoma."
"With the exception of MB-F10 melanoma, all other tumor-bearing animals had a significantly increased survival
index after bromelain treatment. The largest increase ( approximately 318 %) was attained in mice bearing EAT
ascites and receiving 12.5 mg/kg of bromelain."
1.60. Bromelain
Uses:
- Surgery, Sprains and Strains, and Tendinitis
- Wounds and Burns
- Sinusitis (Sinus inflammation)
- Arthritis
- Infection
How to Take It:
- Don’t give bromelain to a child.
- Adults: 80 - 320 mg 2 - 3 times per day. For specific conditions, higher doses may be prescribed:
Digestive aid: 500 mg per day in divided doses with meals
Injuries: 500 mg 4 times a day on an empty stomach
Arthritis: 500 - 2,000 mg a day in two divided doses
Bromelain is generally recommended for no longer than 8 - 10 days in a row.
Pregnant women, people with bleeding disorders, high blood pressure, liver or kidney disease should not take
bromelain.
Bromelain may increase the risk of bleeding during and after surgery.
You should stop taking bromelain at least 2 weeks before surgery.
Side effects: nausea, vomiting, diarrhea, and excessive menstrual bleeding.
Possible Interactions
- Antibiotics
- Blood-thinners
- Sedatives
- Anti-seizure medications
- Barbiturates
- Benzodiazepines
- Drugs to treat insomnia
- Tricyclic antidepressants
- Alcohol
- herbs with a sedating effect, such as valerian, kava, and catnip.
1.61. Bitter melon extract may have potential to fight head, neck cancer
"In this study, the bitter melon extract treatment suppressed the head and neck cancer cell growth in the mouse model,
reducing the growth of the tumor."
"Ray's initial research found that treatment with this natural substance halted the breast and prostate cancer cell growth,
eventually stopping them from spreading."
1.62. Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells.
"Bitter melon juice (BMJ) against pancreatic carcinoma cells both in culture and nude mice. "
"Results showed that BMJ (2-5% v/v) decreases cell viability in all four pancreatic carcinoma cell lines by inducing
strong apoptotic death. "
"In vivo, oral administration of lyophilized BMJ (5mg in 100 µl water/day/mouse) for 6 weeks inhibited MiaPaCa-2
tumor xenograft growth by 60% (P < 0.01) without noticeable toxicity in nude mice."
1.63. Simple plant kills up to 98% of cancer cells - and stops diabetes
"Bitter melon juice diluted to just 5% in water showed remarkable potency in severely damaging all four pancreatic cancer cell lines researchers tested. The bitter melon reduced the viability of two cancer cell lines by 90%, while it knocked off the other two lines by a staggering 98%. And it did so after just 72 hours of treatment!"
"it also activated a pathway, which shows that it knocks out the cancer cells' metabolism of glucose. In other words, it literally starved them of the sugar they need to survive."
"The animals had a 64% reduction in pancreatic tumor size without side effects! This level of effectiveness beat the most commonly used chemo drugs for this lethal cancer."
"The dose used in mice translates to 6 grams of powder for an average-sized adult (75 kg)."
1.64. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck.
"In 23 cases of carcinoma of the head and neck, the combined use of Somatostatin and/or its analogue Octreotide, prolactin inhibitors, Melatonin, Retinoids, Vitamin E, Vitamin D3, Vitamin C, Calcium, chondroitin-sulphate, and minimal oral doses of cyclophosphamide (50-100 mg/day) led to a decided increase in survival with respect to the median values reported in the literature for the same tumours and stages, together with an evident improvement in the quality of life, partial or complete objective responses and, in some cases, complete and stable cure with functional recovery.
The rationale and the mechanisms of molecular biology of the treatment are discussed, showing that the treatment has a differentiating, apoptotic, antiproliferative, antiangiogenic and antimetastatic effect, and, unlike chemo- and/or radiotherapy, preserves and enhances the trophism and functionality of organs, tissues and immunitary and antitumoral homeostasis.
This result, achieved without toxicity, demonstrates the efficacy of this biological multitherapy (Prof. Luigi Di Bella's method or DBM) and is in agreement with the positive results already published on the use of the DBM in various neoplastic diseases."
1.65. The Di Bella Method (DBM) in the treatment of prostate cancer: a preliminary retrospective study of 16 patients and a review of the literature.
"To evaluate the objective clinical response and the safety of the combined administration of somatostatin, melatonin, retinoids, vitamin D3, dopamine subtype 2 receptor (D2R) agonists and low doses of cyclophosphamide, associated with androgen ablation, in patients with a histological diagnosis of prostate adenocarcinoma (Pac).
16 patients ... Median age: 64 years. Disease stages: 8 patients (50%) were in Stage II. For advanced stages (Stage IV), secondary lesions were located in the bones and lymph nodes.
Taken together, an overall objective response (OR) [Complete response (CR) + Partial Response (PR)] was achieved in 69% of the patients, with 88% of objective clinical benefit [CR+PR+SD]. For local Prostate Cancer group, an OR was achieved in 87.5% of patients (7 cases; 53-98; 95% CI), with CR in 62.5% (5 cases, 31-86; 95% CI). In metastatic disease, the OR was 50% (4 cases; 21-78; 95% CI), with a 20% of CR (2 cases; 7-59; 95% CI) and 75% of clinical benefit.
Conclusions: This preliminary study shows that patients with early and advanced forms of prostate cancer, not previously treated by surgery and/or chemo-radiotherapy, can achieve a more than positive clinical benefit with the protocol foreseen by the Di Bella Method. Further clinical investigations are strongly recommended."
1.66. Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report.
"The current strategies for the treatment of breast cancer are essentially based on surgery, preceded and/or followed by chemotherapy often supplemented by radiotherapy and/or the administration of hormonal therapy and monoclonal antibodies. Their combined use has made it possible to increase an overall survival but they are still penalized by adverse effects and toxicity.
The marked anti-cancer effects of biological molecule such as somatostatin, melatonin, retinoid, vitamin D3 and prolactin inhibitors have been studied and documented for several decades. Their integrated and synergic action have been demonstrated, but only a few studies have as yet been carried out on their combined application in humans. The aim of the present investigation was to evaluate both the objective clinical response and toxicity of the biological multimodal treatment named Di Bella Method (DBM).
... 20 women with a certified diagnosis of breast cancer,defined disease stage, and who independently decided to follow the DBM as first-line treatment, were retrospectively reviewed.
The mean age of the patients was 51 years (min 30; max 73). Twelve (12) patients (60%) presented an early stage disease, while the other 40% had a locally advanced/metastatic stage. An overall clinical benefit was achieved in 75% of cases, with 55% of complete response and 20% of partial response. For metastatic patients, the overall survival rate was 71%. The main toxicity effects included leukopenia, gastrointestinal phenomena and drowsiness.
The preliminary results of this report confirm the positive action of the biological treatment in terms of efficacy and survival, showing a more than favorable profile of tolerability."
Recurrent Glioblastoma Multiforme (grade IV - WHO 2007): a case of complete objective response - concomitant
administration of Somatostatin / Octreotide, Retinoids, Vit E, Vit D3, Vit C, Melatonin, D2 R agonists (Di Bella Method.
1.67. Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells.
"Therefore, we suggest that melatonin is a potential chemotherapeutic agent for treatment of colon cancer, the effects of which are mediated by regulation of both cell death and senescence in cancerous cells with minimized cardiotoxicity."
1.68. Melatonin and Cancer
Therapeutic applications of melatonin
"Many studies have shown that melatonin inhibits the growth of breast cancer cells, cervical cancer cells and ovarian cancer cells."
"In rats, having been exposed to the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA), blindness and food restriction prevent the appearance of breast adenocarcinoma, this result being dependent on the presence of the pineal [Bartsch et al. 1995]. Food restriction may be related to an increase in melatonin secretion, while blindness leads to the appearance of free rhythms and a strong melatonin signal. This increase seems to be related to an improvement in the natural defense mechanisms of the organism. In rats developing breast cancer after exposure to the carcinogen DMBA, pinealectomy increased the frequency of cancer development while afternoon melatonin administration decreased it."
"melatonin was administered along with tamoxifen in women with metastatic breast cancer, which had progressed despite the administration of tamoxifen. It was found that the simultaneous administration of melatonin and tamoxifen may contribute to the objective regression of cancer in women with metastatic breast cancer not responding to tamoxifen alone"
"melatonin with interleukin 2 in patients with distant metastases in non-small cell lung carcinoma, liver carcinoma, bowel carcinoma, stomach carcinoma, pancreatic carcinoma and breast cancer contributes to cancer regression and disease stabilization"
"melatonin was investigated in a group of 1440 patients with progressive solid cancer who received supportive therapy with or without melatonin ...
The objective response of patients to therapy was significantly greater in patients receiving melatonin and chemotherapy than those receiving only chemotherapy. Melatonin decreased the frequency of cachexia, thrombocytopenia, stomatitis, cardiotoxicity and neurotoxicity due to chemotherapy."
"melatonin has been proved to decrease the oxidative damage induced by ionizing radiation. Data show that melatonin may be used as a radioprotective agent in patients with cancer either alone for cancer inhibition or in combination with traditional radiotherapy with the aim of a better effectiveness/toxicity ratio"
"These studies show that melatonin may be used successfully in clinical oncology as supportive therapy in patients with progressive cancer and for the prevention of toxicity induced by chemotherapy and radiotherapy"
"Melatonin is a hormone with multiple actions. It is involved in the regulation of biological rhythms, in sleep regulation, it has potent antioxidant action and protects the organism from carcinogenesis and neurodegenerative disorders. The hormone possesses immune-enhancing activity. Therapeutically, it may be used for the management of insomnia, jet lag, the resynchronization of circadian rhythms, as an adjuvant in cancer therapy and in the inhibition of disease progression in Alzheimer's disease and other neurodegenerative disorders."
1.69. Melatonin - Overview
"melatonin is taken in doses from 0.2 to 20.0 mg"
1.70. Melatonin
"In a study that included a small number of women with breast cancer, melatonin (given 7 days before beginning chemotherapy) prevented the lowering of platelets in the blood. This is a common complication of chemotherapy that can lead to bleeding.
In another small study of women who were taking tamoxifen for breast cancer but seeing no improvement, adding melatonin caused tumors to modestly shrink in more than 28% of the women."
"Studies show that men with prostate cancer have lower melatonin levels than men without the disease. In test tube studies, melatonin blocks the growth of prostate cancer cells. In one small-scale study, melatonin -- combined with conventional medical treatment -- improved survival rates in 9 out of 14 men with metastatic prostate cancer. Interestingly, since meditation may cause melatonin levels to rise it appears to be a valuable addition to the treatment of prostate cancer."
"our bodies normally produce (< 0.3 mg per day)"
Interactions:
Antidepressant medications
In an animal study, melatonin supplements reduced the antidepressant effects of desipramine and fluoxetine (Prozac).
In addition, fluoxetine (a member of a class of drugs called selective serotonin reuptake inhibitors, or SSRIs) can
cause low levels of melatonin in people.
Antipsychotic medications
A common side effect of antipsychotic medications used to treat schizophrenia is a condition called tardive dyskinesia,
which causes involuntary movements. In a study of 22 people with schizophrenia and tardive dyskinesia caused by
antipsychotic medications, those who took melatonin supplements had fewer symptoms compared to those who did
not take the supplements.
Benzodiazepines
The combination of melatonin and triazolam (Halcion) improved sleep quality in one study.
In addition, a few reports have suggested that melatonin supplements may help people stop using long-term
benzodiazepine therapy.
Blood pressure medications
Melatonin may make blood pressure medications like methoxamine (Vasoxyl) and clonidine (Catopres) less effective.
Beta-blockers may lower melatonin levels in the body
Blood-thinning medications
Melatonin may increase the risk of bleeding from anticoagulant medications such as warfarin
Interleukin-2
In one study of 80 cancer patients, use of melatonin along with interleukin-2 led to more tumor regression and
better survival rates than treatment with interleukin-2 alone.
Nonsteroidal anti-inflammatory drugs (Advil, Motrin) may lower levels of melatonin in the blood
Steroids and immunosuppressant medications
Melatonin may cause these medication to lose their effectiveness.
Tamoxifen
Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and melatonin may
benefit some people with breast and other cancers.
1.71. Clinical evaluation of "immunoaugmentative therapy (IAT)": an unconventional cancer treatment.
"No indication of toxicity or effectiveness was found in an uncontrolled, consecutively selected series of 46 cancer patients undergoing IAT treatment. In addition, the therapy did not appear to contribute to improved quality of life in most patients. This study does not justify its continued use."
1.72. Cesium Chloride
Clinical effects of cesium intake.
"total cesium intakes of 6 g/day have been found to produce severe hypokalemia, hypomagnesemia, prolonged QTc interval, episodes of polymorphic ventricular tachycardia, with or without torsade de pointes, and even acute heart arrest."
Life-threatening Torsades de Pointes resulting from "natural" cancer treatment.
Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts.
"CsCl may have a therapeutic effect against prostate cancer, but one cannot overlook the acute toxicities also described."
Fatal cesium chloride toxicity after alternative cancer treatment.
"CsCl is sold as an alternative treatment for cancer. There is no demonstrable efficacy, and clear evidence shows life-threatening toxicity. Reported here is a case of fatal CsCl toxicity after attempted intratumoral injection."
1.73. Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
"administration of AKBA alone (100 mg/kg) significantly inhibited the tumor growth; this activity was enhanced by gemcitabine"
"Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets."
1.74. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.
"BS significantly reduced cerebral edema measured by MRI in the study population. BS could potentially be steroid-sparing for patients receiving brain irradiation."
1.75. Boswellia, Boswellic Acid, Frankincense
Boswellia (Boswellic Acids)
"3000[mg]"
Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By
Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.
"frankincense oil to induce bladder cancer cell death"
Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer
"aroma hand massage on each hand for 5 min for 7 days with blended oil-a mixture of Bergamot, Lavender, and
Frankincense in the ratio of 1:1:1, which was diluted 1.5% with sweet almond carrier oil 50 ml. ...
The aroma hand massage experimental group showed more significant differences in the changes of pain score
and depression than the control group."
A lipoxygenase inhibitor in breast cancer brain metastases.
"The complication of multiple brain metastases in breast cancer patients is a life threatening condition with
limited success following standard therapies. ...
Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were
successfully reversed using this method in a breast cancer patient who had not shown improvement after
standard therapy."
Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.
Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells.
"The aim of the study was to investigate the antitumor and/or preventive effect of BC-4, an isomeric compound
isolated from the plant Boswellia carteri Birdw. containing alpha- and beta-boswellic acid acetate in 1:1,
MW 498.3. ...
In conclusion, if it turns out that BC-4 is a well tolerated substance, exhibiting no significant toxicity or side
effects, being evaluated currently in China, BC-4 is a good candidate for the prevention of primary tumor,
invasion and metastasis."
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.
"Boswellic acids from frankincense ... exert antiproliferative activity toward a variety of malignant cells. ...
tested ... on five leukemia ... and two brain tumor ... The Boswellia serrata extract induced dose-dependent
antiproliferative effects on all human malignant cells tested ..."
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
"Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring
triterpenoids, beta-boswellic acid and its structural related derivatives, has been used as a traditional medicine
for the treatment of inflammatory and arthritic diseases. Topical application of BE to the backs of mice markedly
inhibited ... and tumor promotion in ... mice. Feeding 0.2% of BE in the diet to CF-1 mice for 10-24 weeks reduced
the accumulation of parametrial fat pad weight under the abdomen, ... "
Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human
pancreatic cancer cell death in cultures and in a xenograft murine model
"Both frankincense chemical extracts and essential oil prepared from Boswellia species gum resins exhibit
anti-neoplastic activity, and have been investigated as potential anti-cancer agents....All fractions of frankincense
essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human
pancreatic cancer cell lines.
frankincense ... anti-tumor activity. ... induces apoptosis and prolong survival in a rat glioma model ... inhibits
abnormal skin cell proliferation ... and tumor promotion ... in a mouse ... In a human clinical study ... reduce
cerebral edema and potential anti-cancer activity in patients irradiated for brain tumors ... cultured human
bladder and breast cancer cells are more sensitive to frankincense essential oils prepared from both Boswellia
carteri and Boswellia sacra than their normal counterparts with suppressed proliferation and increased apoptosis
... frankincense essential oil overcomes multicellular resistant and invasive phenotypes of human breast cancer
cells."
Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from
Boswellia serrata.
Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate
cancer cells.
1.76. Brain Tumor
https://www.lef.org/protocols/cancer/brain_tumor_01.htm
Brain tumors and conventional medicine
Brain Tumor Nutritional Protocol
Hormones and Brain Tumors
Vitamin D:
Melatonin:
https://www.lef.org/protocols/cancer/brain_tumor_02.htm
Botanical or Herbal Extracts
Berberine:
Boswellia:
Curcumin:
Quercetin:
Resveratrol:
Green Tea and Coffee:
Sulforaphane:
https://www.lef.org/protocols/cancer/brain_tumor_03.htm
A Diet for Brain Cancer
The Ketogenic Diet:
Caloric Restriction:
1.77. Berberine
Diabetes; Lipids; Liver; Heart; Transplants; Cancer; Mental health; Intestinal Disorders; HIV
1.78. Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
"Cancer cells become resistant to different therapies over time; thus, it is necessary to target multiple signaling points for effective therapy. We have determined that MSM can inhibit STAT3/VEGF and STAT5b/IGF-1R pathways, thereby suppressing the growth of solid tumors. "
"Anti-angiogenic therapy appears to be a too narrow approach for treating patients with cancer. Cancer cells may find compensatory pathways for survival and metastasis. A combinatorial approach should produce better results under such conditions. MSM was found to have high levels of cytotoxic activity (Fig. 8) and anti-angiogenic activity by suppressing VEGF. This compound can halt tumor progression by blocking STAT5b and IGF-1R."
"MSM is an edible natural organic compound present in many food items and is not associated with any toxic effect even at higher concentration [33], [34]. Because of this, we used high concentration of the drug (300 mM) for further studies."
"These results were similar to the ones from a study by Caron et al. on a metastatic murine melanoma cell line. In their report, the authors state that 200 mM MSM exhibits anti-metastatic and anti-cancer activity. This finding was the first report on metastatic anti-cancer effect of MSM [40]. In addition to this, MSM may have dual function with anti-oncogenic effects and active-tumor suppressing effects in the nuclear level of cancer cells (Fig. 4C)."
"Triple-negative hormone receptors are very important in human breast cancer because they can make tumors sensitive or resistant to chemotherapy [15]. The mortality rate of patients with triple-negative breast cancer is very high [55]. These hormonal receptors are usually overexpressed in human breast cancers [56]. Therapy is usually designed based on the receptors responsible for the malignancy. The remarkable ability of MSM is that this compound can manage all types of malignancies associated with hormone receptors. Western blotting studies on hormone responsive breast cancer cells showed that MSM had the ability to down-regulate the expression of triple-negative hormone receptors (Fig. 2)."
1.79. Topical application of curcumin - news group post:
"5 years ago, mom was dissuaded form getting surgery because the tumor was at the base of her tongue and it would disfigured her and we were sure she wouldn't survive it. Besides, we prayed and discerned about it and felt convicted to go natural instead.
Recently we stopped the massive doses of vitamin c. We noticed it made her weaker throughout the six months she had been taking it. Instead we are now trying a turmeric and virgin coconut oil paste on her tongue. It is now the fourth day and there is a tremendous difference in her tongue. Whereas before she had brown, black areas and even green spots on her tongue now they have turned pink and the halitosis has been obliterated. The fight is far from over but we will proceed and hope for the best."
1.80. Alternative Cancer Treatment Clinics in Germany - news group post:
"> My husband who had prostate cancer went to St Georg Klinik in Bad Aibling
> for intraprostate hyperthermia / IV vit C etc.
> Huge success rate – very nice. Intra-prostate hyperthermia was what I was
> after – they take care of many others too –
> They do give chemo when needed yet really focus on nutrition
> etc too.
> My husband psa dropped down to nothing, it was virtually painless & easy
> quick treatments. Absolutely no palp
> Tumors – which is how it was discover. It is soft & pliable – pees like
> a young man. Absolutely no side effects.
> Is coverable by re-imbursement for insurance though really have to chase
> the money. Was total cost around $12k
> for 3 of us to fly there, 2 hospital rooms (son stayed in one) meals, and
> fun things. Total medical costs were around
> $8k. He keeps his manhood and can be repeated. Crazy it isn’t a 1st line
> treatment vs cut & burn methods we offer
> In US. Better than HIFU & other methods we highly researched in my book.
> On supplements alone, his psa began dropping before we went, but I have
> peace of mind knowing it is gone for now.
> Drs here were angry we were going this route – now they are shocked and
> following him closely.
> http://www.klinik-st-georg.de/en/
> I've known many people who've gone to Germany. There are many excellent
> alt. and integrative cancer hospitals there. Overall, my 1st choice would
> be Hufeland Klinik for Holistic Immunotherapy
> Loffeisteizer Str. 1-3, D-97980 Bad Mergentheim, Germany
> 49-7931-7082 or 7931-5360; Fax: 49 7931-8185 or 7931-46244;
> [email protected]_ (mailto:[email protected])
> _www.hufeland.com/english/index.html_
> (http://www.hufeland.com/english/index.html)
> http://germancancerclinics.com/clinics-german-cancer-treatment/hufeland-klinik
> _www.GermanCancerBreakthrough.com_
> (http://www.germancancerbreakthrough.com/)
> Most effective w/melanoma; sarcomas; and brain (particularly GBM), breast,
> prostate, colon, & kidney cancers. Also effective w/ovarian cancer. Least
> effective w/pancreatic cancer.
> "mistletoe...PDT...local and full-body hyperthermia [sometimes w/IPT],
> fever therapy [Coley’s toxins]”, Issels, IV vitamins, autohemotherapy,
> Carnivora, electrogalvanic electricity, pneumatron, autohormone therapy
> (AHT), eumetabolic therapy, light therapy, thyroid peptides, thymus, enzymes,
> oxygen multistep therapy (OMT) (ozone, peroxide), serums, antigens, interferon,
> detox, mind-body therapies, surgery, (rarely) radiation. NFAM.org (2001)
> thought it was the best clinic in Germany--"best protocol, least
> expensive."
> "Moss.... found that [Hufeland]...had excellent documentation to prove
> [their] success with advanced... cancer." "have visited Hufeland clinic
> four times and each time…favorable impression… orientation is the patient’s
> welfare...fees…reasonable…staff keep good records…We rarely hear any
> complaints about [Hufeland]" (Ralph Moss, 2008). Only $3500/wk inpatient (outpatient
> option available)."
1.81. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
"Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. "
"Cell death in 10 cancer and 4 normal cell types was measured by using 1-h exposures. Normal cells were unaffected by 20 mM ascorbate, whereas 5 cancer lines had EC50 values of <4 mM, a concentration easily achievable i.v. Human lymphoma cells were studied in detail because of their sensitivity to ascorbate (EC50 of 0.5 mM) and suitability for addressing mechanisms. Extracellular but not intracellular ascorbate mediated cell death, which occurred by apoptosis and pyknosis/necrosis. Cell death was independent of metal chelators and absolutely dependent on H2O2 formation. Cell death from H2O2 added to cells was identical to that found when H2O2 was generated by ascorbate treatment. H2O2 generation was dependent on ascorbate concentration, incubation time, and the presence of 0.5-10% serum, and displayed a linear relationship with ascorbate radical formation. Although ascorbate addition to medium generated H2O2, ascorbate addition to blood generated no detectable H2O2 and only trace detectable ascorbate radical. Taken together, these data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H2O2, and that blood can be a delivery system of the pro-drug to tissues. These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H2O2 may be beneficial."
"Ascorbic acid (vitamin C, ascorbate) has a controversial history in cancer treatment (1). Observational reports described ascorbate, given in pharmacologic doses of 10 g daily, as effective in treating some cancers and in improving patient well-being (2-4). Subsequently, the same dose had no effect on patient well-being and survival in two double-blind placebo-controlled trials, and ascorbate was discarded as a treatment modality (5, 6). Recent clinical evidence, however, indicates that the role of ascorbate in cancer treatment should be examined anew (7). The originally reported observational studies used i.v. and oral ascorbate, but the subsequent double-blind placebo-controlled studies used only oral ascorbate. It was not recognized that the route of ascorbate administration might produce large differences in plasma concentrations. Recent pharmacokinetics studies in men and women show that 10 g of ascorbate given i.v. is expected to produce plasma concentrations of nearly 6 mM, which are >25-fold higher than those concentrations from the same oral dose (7-9). As much as a 70-fold difference in plasma concentrations is expected between oral and i.v. administration, depending on dose. Despite inconsistencies, some in vitro studies showed that ascorbate killed cancer cells, although mechanisms and physiologic relevance were unclear (10-12). Complementary and alternative medicine practitioners worldwide currently use ascorbate i.v. in some patients, in part because there is no apparent harm (13-15)."
"For five of the nine cancer cell lines, ascorbate concentrations causing a 50% decrease in cell survival (EC50 values) were less than 5 mM, a concentration easily achievable from i.v. infusion (7). All tested normal cells were insensitive to 20 mM ascorbate."
"Ascorbate is transported into cells as such by sodium-dependent transporters, whereas dehydroascorbic acid is transported into cells by glucose transporters and then immediately reduced internally to ascorbate (29). By using either external ascorbate or external dehydroascorbic acid, lymphoma cells were loaded to equal internal concentrations of ascorbate over 1 h (data not shown). Despite similar intracellular ascorbate concentrations under both conditions, cells died only when ascorbate was present externally (Fig. 2D )."
"Because these data implicated H2O2 in cell killing, we added H2O2 to lymphoma cells and studied death patterns using nuclear staining (19, 28). The death patterns found with exogenous H2O2 exposure were similar to those found with ascorbate. For both ascorbate and H2O2, death changed from apoptosis to pyknosis/necrosis as concentrations increased (Fig. 3B )."
"H2O2 generated by ascorbate oxidation and exogenously added H2O2 produced cell death curves that were indistinguishable (Fig. 3C )."
"Ascorbate administered i.v. is likely to be safe in most patients, with virtually no toxicity compared to most currently available cancer chemotherapeutic agents. The occurrence of one predicted complication, oxalate kidney stones, is controversial (13). In patients with glucose-6-phosphate dehydrogenase deficiency, i.v. ascorbate is contraindicated because it causes intravascular hemolysis (13)."
"Old observational animal experiments, although uncontrolled, suggest that i.v. ascorbate is effective in some viral infections (56, 57). This finding is also consistent with in vitro experiments, in which H2O2 is toxic to hepatitis C (58). Use of ascorbate as an H2O2-delivery system against sensitive pathogens, viral or bacterial, has substantial clinical implications that deserve rapid exploration."
1.82. A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy
"At the conclusion of the 12 week treatment period, PSAV decreased and PSADT increased in 13 of 17 patients (p = 0.05). There were no dose-limiting adverse effects. Of the 15 patients who continued on Apatone after 12 weeks, only 1 death occurred after 14 months of treatment.
Apatone showed promise in delaying biochemical progression in this group of end stage prostate cancer patients."
"When VC and VK3 were combined in a ratio of 100:1 (Apatone) and administered to human tumor cell lines, including androgen independent prostate cancer cells (DU145), they exhibited a synergistic inhibition of cell growth and induced cell death by apoptosis at concentrations that were 10 to 50 times lower than for the individual vitamins."
"All patients were treated with Vitamin C: K3 (5,000 mg. of VC and 50 mg. of VK3 each day, Apatone) for a total of 12 weeks."
1.83. Autoschizis: a new cell death induced found in tumour cells induced by oxidative stress mechanism
"One summarizes in this contribution some of the main cytotoxic changes observed in those cancer cells obtained as a result of treatments by VC alone, VK3 alone, combined VC+VK3 [23] as well as in vivo studies in the aim to support the use of this
vitamins’ combination as adjuvant therapy or treatment strategy against some forms cancers [24]. As shown in the
report those vitamins, used against cancer cells, were able to trigger and induce characteristic cell injuries that lead
toward a new form of cell death we have called autoschizic cell death or death by autoschizis, different tham necrotic or
oncotic cell death or apoptotic cell death"
"bladder, prostate, ovarian, etc and other carcinoma cell lines"
1.84. Mistletoe based treatment described in The Fourfold Path to Healing
also check (http://alternativecancertreatmentgerson.com/iscador-therapy/) for more info and instructions
here they combine it with IV vit.C and Gerson Therapy)
---------------------------------------
Phase 1 (6 months minimum, 1..3 years if it has positive effect):
1. Iscador (Weleda - mistletoe extract) treatment according to recommendations
2. measure vitamin D in blood and increment D3 supplement by 1,000IU until blood test reaches 40..60;
Brand used: Carlson;
use calcium lactate (6 tablets/day)
3. Mediherb ganoderma/shiitake - 1 tablet 2..3 times/day
4. Immuplex (by Standard Process) - 1 capsule, 3 times/day
specific protomorphogen of the tissue type from which the cancer originated.
For example - breast cancer - mammary PMG - 1 tablet 3 times/day.
5. individualized herbal therapy:
digestive complaints - turmeric extract (I guess he means curcumin), burdock root, milk thistle
cancers with hormonal implications (breast, prostate) - licorice, saw palmetto
usually add also: poke root extract
-----------------------------------------
Phase 2 (if phase 1 does not stop the cancer growth after 6 months).
In addition to all in Phase 1 add:
1. Melatonin - 20mg
2. Wobezym dygestive enzymes - 3..10 tablets 3..4 times a day between meals
3. Essiac - 2..4 tablets 2..3 times a day
4. specific herbs:
for gastro-intestinal cancer: aloe vera (Mediherb) 1 tablespoon 2 times a day
for melanoma and kidney cancer - Echinacea permium (Mediherb) - 1 tablet 3 times a day
or Astragalus Complex (Mediherb) - 1 tablet 3 times per day
--------------------------------------------
Phase 3:
1. Iscador Special, Mali for women, Quercus for men
-------------------------------------------
Phase 4:
1. IL-2 therapy after stopping Iscador. Dose - 3 million units/day 6 out of 7 days, 4 weeks
-------------------------------------------
In addition he recommend 20,000IU/day vit A from cod liver oil, balanced diet, fermented vegetables (beets),
coconut oil, animal fat, flax seeds/oil, special exercises, meditation.
Specifically says to avoid extreme diets such as all-raw vegetarian
1.85. Mistletoe treatment articles:
The case for mistletoe in the treatment of laryngeal cancer.
"case of a patient with laryngeal carcinoma who made a full recovery following mistletoe therapy, despite failing to
respond to chemoradiotherapy and salvage laryngectomy"
Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines.
"It was concluded that VA extracts have a cytotoxic effect on SCC9 and SCC25 cell lines, but while SCC9 cell line was
more resistant to the action of the drugs, Iscador Qu Spezial and Iscador M have higher cytotoxic potential in both
cell lines compared to Iscador P."
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.
"ISCADOR Q, showing multiple positive effects in the treatment of glioblastoma, may be a candidate for concomitant
treatment of this cancer."
Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two
Case Reports.
"The lymphoma regressed over a period of 12 and 8 months, respectively, and after administration of a cumulative
dose of 12.98 g and 4.63 g mistletoe extract, respectively. The patients are in remission to date, 3.5 years after
commencement of treatment. Neither patient received conventional cancer treatment during the entire observation
period."
Suzanne Somer's Cancer Battle
Mistletoe Extract: Cancer Therapy?
The majority of the mistletoe extracts that are used to treat cancer in patients originate from Europe; they have a
variety of brand names: Iscador (Iscar), Eurixor, Helixor, Isorel (Vysorel), Iscucin, Lektinol (Plenosol) and Abnoba-
viscum.
German researchers performed a meta-analysis in which they reviewed the effects of Iscador, a commonly used form
of mistletoe extract, on survival of cancer patients. The researchers reported that the data they examined showed a
lower risk of mortality.
In a review of randomized and non-randomized control trials, the efficacy of a type of mistletoe extract called Viscum
album was assessed to determine whether or not it improved on quality-of-life parameters in patients with cancer.
The researchers reported that the plant improved on quality-of-life measures such as sleep, exhaustion, depression
and anxiety; it also reduced the side effects of chemotherapy and radiation therapy.
In targeted nutritional program for my patients, I focus on several areas:
- Nutrients that lower the 3 main cancer promoters: AP-1, NF-kappa-B, and IGF.
- Nutrients that inhibit the main cancer promoting enzymes; tyrosine kinase, m-TOR, akt and COX-2.
- Nutrients that convert hormones that promote cancer to hormones that protect against cancer.
- Angio-preventative nutrients that inhibit angiogenesis.
- Anti-inflammatory nutrients.
- Reversing hyperinsulinemia through nutrition.
- Nutrients that facilitate apoptosis or programmed cell death, a process which cancer cells have lost.
- Detoxifying cancer-causing toxins with nutrients.
Glutathione, glycine, taurine, black raspberry, garlic, omega-3 and -9 fatty acids, fermented soy products,
isohumalones from hops, and phytosterols are just a few of the nutrients which data show are essential for the above
areas.
1.86. Oligomeric Proanthocyanidins (OPCs)
(Grape Seed Extract, Pine Bark Extract, Procyanidolic Oligomers (PCOs), Pycnogenol)
"Several food sources contain similar chemicals: red wine, cranberries, blueberries, bilberries, tea (green and black),
black currant, onions, legumes, parsley, and the herb hawthorn . However, most OPC supplements are made from
either grape seed or the bark of the maritime pine."
"For the treatment of specific medical conditions, studies have used doses of 150 to 300 mg daily."
Edema After Surgery or Injury:
"Breast cancer surgery often leads to swelling of the arm. A double-blind, placebo-controlled study of 63 post-
operative breast cancer patients found that 600 mg of grape seed OPCs daily for 6 months reduced edema, pain, and
peculiar sensations known as paresthesias. 32 Also, in a double-blind, placebo-controlled study of 32 people who had
received facial surgery, edema disappeared much faster in the group treated with grape seed OPCs. 33"
"Another 10-day, double-blind, placebo-controlled study enrolling 50 participants found that grape seed OPCs
improved the rate at which edema disappeared following sports injuries . 34"
Safety Issues:
"OPCs may have some anticoagulant properties when taken in high doses, and therefore should be used only under
medical supervision by individuals on blood-thinner drugs, such as warfarin (Coumadin), heparin, clopidogrel
(Plavix), ticlopidine (Ticlid), pentoxifylline (Trental), or aspirin."
1.87. Bromelain
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
"However, the viability of MUC1 expressing pancreatic and breast cancer cells are adversely affected by bromelain.
Further, the efficacy of cisplatin and 5-FU are enhanced by adjuvant treatment with bromelain, indicating that the
barrier function of MUC1 may be affected. Other studies have also indicated that there is a greater accumulation of 5-
FU in the cell compartment on treatment with 5-FU and bromelain. Malignant peritoneal mesothelioma (MPM)
expresses MUC1 and initial studies have shown that the viability of MPM cells is adversely affected by exposure to
bromelain. Further, bromelain in combination with either 5-FU or cisplatin, the efficacy of the chemotherapeutic drug
is enhanced. Hence, current evidence indicates that bromelain may have the potential of being developed into an
effective anticancer agent for MPM."
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis.
"we describe its anti-proliferative, anti-inflammatory and subsequent anti-cancer effects in vitro, against human
epidermoid carcinoma-A431 and melanoma-A375 cells. Bromelain exhibited reduction in proliferation of both these
cell-lines and suppressed their potential for anchorage-independent growth. ... Bromelain afforded substantial anti-
cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agent besides only an
additive in chemotherapy."
Bromelain-induced apoptosis in GI-101A breast cancer cells.
"Bromelain has been reported to promote apoptosis, particularly in breast cancer cells"
"Our results indicate an increase in apoptosis-related cell death in breast cancer cells with increasing concentrations
of bromelain."
1.88. Avemar (commercial) / Rejuvelac (home made)
Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases.
"Avemar can inhibit metastatic tumor dissemination and proliferation during and after chemotherapy, surgery, or
radiation. Benefits of Avemar treatment have been shown in various human cancers, in cultures of in vitro grown
cancer cells, in the prevention of chemical carcinogenesis, and also in some autoimmune conditions."
Avemar (wheat germ extract) in cancer prevention and treatment.
"The wide range of biological activity of Avemar probably cannot be explained by only one active ingredient. Since
there are numerous experimental data and the clinical benefit repeatedly confirmed Avemar can be one of the most
potent and best researched food supplements available for cancer patients."
Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of
its activity.
"We found that FWGE (fermented wheat germ extract) exhibited significant antiproliferative effects against 12 human
OVCA cell lines and potentiated cisplatin-induced apoptosis. ... Our findings confirm the value of FWGE as a natural
product with anticancer properties that may also enhance the activity of existing therapeutic agents."
Fermented wheat germ extract--nutritional supplement or anticancer drug?
"FWGE interacts synergistically with a variety of different anticancer drugs and exerted antimetastatic properties in
mouse models. ... Data in the F-344 rat model provide evidence for a colon cancer preventing effect of FWGE.
Clinical data from a randomized phase II trial in melanoma patients indicate a significant benefit for patients treated
with dacarbazine in combination with FWGE in terms of progression free survival (PFS) and overall survival (OS).
Similarly, data from studies in colorectal cancer suggested a benefit of FWGE treatment. Besides extension of OS and
PFS, FWGE improved the quality of life in several studies.
CONCLUSION:
In conclusion, available data so far, justify the use of FWGE as a non-prescription medical nutriment for cancer
patients. Further randomized, controlled and large scale clinical studies are mandatory, to further clarify the value of
FWGE as a drug component of future chemotherapy regimens.
Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines.
Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-
resistant H9 human lymphoma cells through induction of apoptosis.
Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma
patients: a randomized, pilot, phase II clinical study with a 7-year follow-up.
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human
HL-60 promyelocytic leukemia cells.
How to make Rejuvelac (fermented wheat germ juice)
Rejuvelac
"We recommend drinking one quart (1 liter) of rejuvelac per day"
"1. Rinse, then soak in filtered water 3/4 cup of dry grains for 8-12 hours in a jar with a screen tied over the opening.
2. Drain and discard the soak water from the grains, then rinse the grains. Keep the jar upside down at a 45 degree
angle to fully drain and for sprouting.
3. Sprout the grains for 24-36 hours. Rinse the grains two to three times during sprouting.
4. Blend the one cup of sprouted grains with two cups of purified water for about 5 seconds.
Pour contents from the blender into a one gallon container and add enough water to make one gallon.
5. Place a screen on top of the one gallon container and let the rejuvelac ferment for 24 hours in a room temperature
of 68-80 degrees F. Ferment longer if a stronger rejuvelac is desired.
6. Pour rejuvelac through a strainer to strain out the grains and sediment that forms on the bottom.
Discard or compost the grains and sediment."
1.89. Positive thinking
Is there Power in Positive Thinking?
[31:00] starts describing techniques:
MBSR (Mindfulness based stress reduction)
Combined Positive Affect and Self Affirmation Intervention
Cognitive behavioral stress management
Coping effectiveness training
BREATHE:
B - take a deep Breath; be present in the moment; accept what it is; be non judgmental
R - Realistic goals; celebrate when achieving your goals;
E - notice positive moments in Everyday life; recognize when things go right; share with others;
A - Acts of kindness
T - Turn it around; reframe the negative into positive;
H - Honor strengths; acknowledge your strengths;
E - Each day with gratitude; note positive steps and all you are thankful for;
Positive Emotion in the Midst of Stress (similar to "Is there power in Positive thinking")
[37:00] starts describing techniques
The Art of Living Every Minute of Your Life
[31:30] at the end of the day, reflect on your day going backwards (3 times) and ask yourself 1 question:
1. "What surprised me today?"
2. "What touched my heart today?"
3. "What inspired me today?"
write down the 3 answers in your diary.
1.90. Exercises
Healing Through Dance
I think the title is misleading. The main idea is to increase the range of motion and apply mindfulness during the
movement. Pay attention at pain and limitations of the body. Try to avoid (control) pain.
She mention that this can be helpful after surgery.
Demonstration starts at [42:00].
Similar exercises are described in [Ref.1.84].
1.91. Topical Yunnan Baiyao administration as an adjunctive therapy for bleeding complications in adolescents with advanced cancer.
"YNB may be an efficacious agent for uncontrolled bleeding in conjunction with conventional hemostatic agents in
adolescents with advanced cancer. It is well accepted by patients. YNB may be especially valuable in the outpatient
setting to prevent the recurrence of hemorrhage."
In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines.
Yunnan Baiyao and cancer for dogs
The efficacy of Yunnan Baiyao on haemostasis and antiulcer: a systematic review and meta-analysis of randomized
controlled trials.
http://csuvets.colostate.edu/pain/Articlespdf/YunnanPaiyao111206.pdf
1.92. Licorice
The anti-angiogenic activities of glycyrrhizic acid in tumor progression.
" Glycyrrhizic acid (GA) is the bioactive compound of licorice and has been used as a herbal medicine because of its
anti-viral, anti-cancer, and anti-inflammatory properties.
We observed that GA inhibited tumor growth and angiogenesis in mice.
Considering that angiogenesis is highly stimulated in the majority of cancers, GA could offer a potent therapeutic
agent for cancer."
Inhibition of tumor progression by naturally occurring terpenoids.
"Literature survey revealed that triterpenoids, such as glycyrrhizic acid, ursolic acid, oleanolic acid, and nomilin, the
diterpene andrographolide, and the monoterpenoids like limonene and perillic acid had shown immunomodulatory
and antitumor activities. All of them could induce apoptosis in various cancer cells by activating various proapoptotic
signaling cascades. Many of these terpenoids found to inhibit metastatic progression and tumor-induced
angiogenesis."
Licorice - general information
"Licorice is LIKELY SAFE for most people when consumed in amounts found in foods.
It is POSSIBLY SAFE when consumed in larger amounts use as medicine, short-term.
However, it is POSSIBLY UNSAFE when used in large amounts for more than four weeks.
Consuming 30 grams or more of licorice daily for several weeks can cause severe side effects including high
blood pressure, low potassium in the blood, weakness, paralysis, and occasionally brain damage in otherwise
healthy people. In people who eat a lot of salt or have heart disease, kidney disease, or high blood pressure, as
little as 5 grams per day can cause these problems.
Other side effects of licorice use include tiredness, absence of a menstrual period in women, headache, water and
sodium retention, and decreased sexual interest and function in men.
Special precautions & warnings:
Don’t use licorice if you are pregnant or breast-feeding.
Don’t consume large amounts of it if you have high blood pressure.
Don’t consume licorice if you have heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine
fibroids: Licorice might act like estrogen in the body. If you have any condition that might be made worse by exposure
to estrogen, don’t use licorice.
A muscle condition caused by nerve problems (hypertonia): Licorice can cause the level of potassium to drop in the
blood. This can make hypertonia worse. Avoid licorice if you have hypertonia.
Low potassium levels in the blood (hypokalemia): Licorice can lower potassium in the blood. If your potassium is
already low, licorice might make it too low. Don’t use licorice if you have this condition.
Sexual problems in men: Licorice can lower a man’s interest in sex and also worsen erectile dysfunction (ED) by
lowering levels of a hormone called testosterone.
Kidney disease: Overuse of licorice could make kidney disease worse. Don’t use it.
Surgery: Licorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2
weeks before a scheduled surgery."
1.93. Aloe
Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo.
"Aloin (AL), an natural compound derived from Aloe barbadensis Miller leaves, has been shown to possess anti-cancer
potential activities. ...
Our studies provided the first evidence that AL may inhibit tumor angiogenesis and growth via blocking STAT3
activation, with the potential of a drug candidate for cancer therapy."
Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human
U87 malignant glioma cells by aloe emodin.
"Aloe emodin, one of the active compounds found in Aloe vera leaves, plays an important role in the regulation of cell
growth and death. It has been reported to promote the anti-cancer effects in various cancer cells by inducing
apoptosis. ...
Aloe emodin showed a time- and dose-dependent inhibition of U87 cells proliferation and decreased the percentage of
viable U87 cells via the induction of apoptosis."
Reduction of intestinal polyp formation in min mice fed a high-fat diet with aloe vera gel extract.
"Aloe vera gel supercritical CO2 extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat
accumulation, and influence the metabolism of glucose and lipids in animal model experiments.
These results indicate that HAVGE (high dose AVGE = 12.5mg/kg) reduced large-sized intestinal polyps and
ameliorated reduction in plasma HMW adiponectin levels in Min mice fed HFD."
Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial.
"To evaluate an Aloe vera lotion for prevention of radiation-induced dermatitis, all patients with a prescription of
radiotherapy to a minimum dose of 40 Gy were eligible provided that their treatment area could be divided into two
symmetrical halves. Patients were given a lotion of Aloe vera to use on one half of the irradiated area, with no
medication to be used on the other half. ...
Based on these results, we conclude that the prophylactic use of Aloe vera reduces the intensity of radiationinduced
dermatitis."
1.94. Medicinal plants used for cancer treatment
Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.
"The plants that were cited at a higher frequency were Aloe vera, Euphorbia tirucalli, and Tabebuia impetiginosa. ...
We found the following molecules to be the most studied in vitro and in vivo: silibinin, ß-lapachone, plumbagin and
capsaicin."
Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of
ERK1/2-mediated apoptosis.
"Taken together, these findings suggest that euphol selectively induced gastric cancer cells apoptosis by modulation
of ERK signaling, and could thus be of value for cancer therapy."
Preventive and therapeutic euphol treatment attenuates experimental colitis in mice.
"The tetracyclic triterpene euphol is the main constituent found in the sap of Euphorbia tirucalli. This plant is widely
known in Brazilian traditional medicine for its use in the treatment of several kinds of cancer, including leukaemia,
prostate and breast cancers. Here, we investigated the effect of euphol on experimental models of colitis and the
underlying mechanisms involved in its action. ...
Together, these results clearly demonstrated that orally-administered euphol, both preventive or therapeutic
treatment were effective in reducing the severity of colitis in two models of chemically-induced mouse colitis and
suggest this plant-derived compound might be a potential molecule in the management of inflammatory bowel
diseases."
Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya.
"Most commonly cited plant species were Spathodea campanulata P. Beauv. ssp. nilotica (Seem), Microglossa pyrifolia
(Lam.) Kuntze, Harungana madagascariensis Lam. ex poir, Prunus africana (Hook. f.) kalkman, Cyphostemma serpens
(A. Rich), Catharanthus roseus (L.) G. Don and Aloe volkensii Engl."
Complementary and alternative medicine use in patients with chronic lymphocytic leukemia: an Italian multicentric
survey.
"The most common Complementary and alternative medicine therapies were green tea, aloe formulations and high
dose vitamins."
Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer(2).
"The herbs that are traditionally used for anti-cancer treatment and that are anti-angiogenic through multiple
interdependent processes (including effects on gene expression, signal processing, and enzyme activities) include
Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (curcumin), Scutellaria
baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese
magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinalis (ginger),
Panax ginseng, Rabdosia rubescens hora (Rabdosia), and Chinese destagnation herbs."
Botanical medicine and cancer: a review of the safety and efficacy.
"Current evidence suggests that Asian ginseng, garlic, green tea, tomatoes and soy intake as part of the diet may be
useful in preventing various cancers; additional research is needed in order to determine the efficacy of essiac,
evening primrose oil, mistletoe, reishi, shiitake and turmeric as cancer treatments; and ginger may be effective in
treating chemotherapy-induced nausea and vomiting."
Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants
from the island Soqotra.
"Notable cancer cell growth inhibition ... Ballochia atro-virgata, Eureiandra balfourii and Hypoestes pubescens,
... The methanol extracts of Acanthospermum hispidum, Boswellia dioscorides, Boswellia socotrana, Commiphora
ornifolia and Euphorbia socotrana also showed noticeable antiproliferative potency ....
The greatest antimicrobial activity was exhibited by extracts from Acacia pennivenia, Boswellia dioscorides,
Boswellia socotrana, Commiphora ornifolia, Euclea divinorum, Euphorbia socotrana, Leucas samhaensis, Leucas
virgata, Rhus thyrsiflora, and Teucrium sokotranum ...
In addition, the methanolic extracts of Acacia pennivenia, Boswellia dioscorides, Boswellia socotrana and
Commiphora ornifolia showed good antioxidant potential at low concentrations ..."
1.95. Astragalus
Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.
"Astragalus memebranaceus is a traditional Chinese herbal medicine used in treatment of common cold, diarrhea,
fatigue, anorexia and cardiac diseases. Recently, there are growing evidences that Astragalus extract may be a
potential anti-tumorigenic agent. Some research showed that the total saponins obtained from Astragalus
membranaceus possess significant antitumorigenic activity. ...
Total Astragalus saponins inhibited human gastric cancer cell growth, decreased the invasion ability and induced the
apoptosis. "
Does the Couse of Astragalus-Containing Chinese Herbal Prescriptions and Radiotherapy Benefit to Non-Small-Cell
Lung Cancer Treatment: A Meta-Analysis of Randomized Trials.
"Couse of Astragalus-containing Chinese herbal prescriptions and radiotherapy may benefit the patients with non-
small-cell lung cancer via increasing the therapeutic effectiveness and reducing the toxicity of radiotherapy."
Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice.
"In the present study, we investigated the antitumor and immunomodulatory activity of Astragalus membranaceus
polysaccharide (AMP) on liver cancer using murine H22 hepatocarcinoma model. The results showed that AMP (100
and 400 mg/kg) could effectively inhibit the solid tumor growth of H22 hepatocarcinoma transplanted in BALB/c
mice. ...
Taken together, these findings indicate that AMP has antitumor activity in vivo at least partly via improving immune
responses of host organism, and seems to be safe and effective for the use of anti-tumor therapy."
Astragalus
"Medicinal Uses and Indications
Astragalus has been used for the following:
Adaptogen -- protects the body from stress and disease
Anemia -- may improve blood counts in people with aplastic anemia.
Diabetes -- Astragalus appears to lower blood sugar.
Fatigue or lack of appetite from chemotherapy -- Some studies suggest astragalus may help reduce side effects
from chemotherapy.
Hepatitis -- A few studies have used a combination of herbs containing astragalus to treat hepatitis.
Kidney disease -- Preliminary research suggests astragalus may help protect the kidneys and may help treat
kidney disease.
Seasonal allergies -- One study found that astragalus may help reduce symptoms in people who have allergic
rhinitis or hayfever.
How to Take It
Dosage depends on condition being treated, age, and weight. Work with your physician to determine the safest and
most effective dosage for you. Higher doses may suppress the immune system. For best results, use a standardized
astragalus supplement. Recommended doses are as follows:
Standardized extract: 250 - 500 mg, 3 - 4 times a day standardized to 0.4% 4-hydroxy-3-methoxy isoflavone 7-sug.
Decoction (strong boiled tea): 3 - 6 g of dried root per 12 oz water, 3 times per day
Fluid extract (1:1) in 25% ethanol: 2 - 4 mL, 3 times a day
Powdered root: 250 - 500 mg, 3 - 4 times per day
Ointment: 10% astragalus applied to surface of wound. Do not apply to open wound without your doctor's supervision.
Tincture (1:5) in 30% ethanol: 20 - 60 drops, 3 times a day
Possible Interactions
Drugs that suppress the immune system -- Astragalus may interfere with these drugs. If you have an autoimmune
disease such as rheumatoid arthritis or lupus, or take cyclophosphamide, a medication used to reduce the chances of
rejection in transplant recipients, or corticosteroids, do not take astragalus.
Lithium -- Astragalus can make it harder for the body to get rid of lithium, so dangerously high levels of the drug could
build up."
1.96. Integrating Dietary Supplements Into Cancer Care
Curcumin
Curcumin also acts as a chemosensitizer and radiosensitizer for tumors in some cases. Curcumin has also been shown
to protect normal organs such as liver, kidney, oral mucosa, and heart from chemotherapy- and radiotherapy-induced
toxicity.
The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, familial polyposis,
pancreatic cancer, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma,
lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets.
Glutamine
In various cancer patients undergoing chemotherapy and radiation, when glutamine was added to their treatment,
there was decreased rates and severity of mucositis, neuropathy, and intestinal toxicity. Additional benefit was
observed in decreased use of pain medication in patients suffering from stomatitis, with improved nutrition, as a result
of this intervention.
It is commonly used in the powder form to produce oral solution, the dosage in that form is 10 g TID (range = 5-30
g/d).
Vitamin D
Subsequent studies have supported the finding that lower serum 25-hydroxyvitamin D levels are associated with
increased risks of breast and prostate as well as colorectal and possibly other cancers, although the data are considered
inconclusive. An increasing body of evidence suggests that lower serum levels are also related with poorer prognoses in
patients diagnosed with various malignancies.
Maitake Mushrooms
When Maitake D-fraction was given to patients receiving chemotherapy for a number of different cancers, response
rates reportedly increased from 12% to 28%.67 Various chemotherapy side effects were also said to be ameliorated in
patients receiving Maitake D-fraction. In the absence of toxicities, it is felt to be a useful adjuvant to chemotherapy.
There are also reports of synergy when used with vitamin C as suggested by in vitro and animal model studies. A recent
study suggests a direct antitumor effect of Maitake D-fraction with induction of apoptosis observed in breast cancer
cell lines.
Fish Oil
Recent studies in patients with earlier stage cancers, especially those receiving chemotherapy or chemoradiation, have
shown beneficial effects on body weight and quality of life.
Fish oil may increase apoptosis and decrease resistance by suppressing NF-?B.82 Higher rates of response and clinical
benefit with a tendency toward longer survival were observed in lung cancer patients supplemented with fish oil during
chemotherapy, with no increase in dose-limiting toxicities.83 Fish oil improved neutrophil number and function during
chemotherapy, and reduced weight loss.84
Finally, fish oil is used as perioperative immunonutrition—enteral supplements containing fish oil with arginine and
other nutrients have been found to reduce hospital stays and postoperative complications.
Green Tea
Clinical trials in prostate cancer suggest that green tea may be more effective in early than later-stage conditions9;
short-term administration before prostatectomy suggests favorable chemopreventive effects.
Premalignant oral lesions are suppressed by green tea supplements.
Positive effects were shown for a topical preparation in human papilloma virus–infected cervical lesions. Breast cancer
patients drinking green tea had improved high-density lipoprotein cholesterol and nonsignificant improvements in
insulin resistance and weight. Asymptomatic early stage patients with chronic lymphocytic leukemia received high-
dose Polyphenon E in a phase I trial; improvements in absolute lymphocyte count and adenopathy as well as one partial
remission were observed.
Liver enzymes should be monitored in patients taking high-dose green tea supplements.
Milk Thistle
Clinical trials of silymarin have been conducted primarily in patients with either hepatitis or cirrhosis.109 Silymarin is
the only known drug effective in protection from Amanita phalloides toxin, which targets the liver.110,111
Three case reports,112-114 3 pharmacokinetic studies,115-117 and 2 double-blind randomized trials118,119 have been
conducted with varying degrees of scientific rigor. In the only report describing the use of silymarin (450 mg/d) for the
treatment of hepatocellular carcinoma, the authors reported spontaneous regression of the tumor in the absence of
initiation of anticancer therapy.112 In a double-blind, placebo-controlled randomized trial, 50 children who were
undergoing treatment for acute lymphoblastic leukemia and who had chemotherapy-related hepatotoxicity were given
silymarin (80-360 mg/d) for a 30-day period.118 The treatment group had a significantly lower aspartate
aminotransferase and a trend toward a significantly lower alanine aminotransferase. Vidlar et al119 explored the effect
of milk thistle (570 mg) in combination with selenium on quality of life, lipid profile, oxidative stress, and testosterone
levels. Thirty-seven men who underwent radical prostatectomy were randomized to milk thistle and selenium or
placebo for a 6-month period. The authors reported significant improvements in quality of life and lipid panel (total
cholesterol and low-density lipoproteins); however, no effect was observed on measures of oxidative stress or
testosterone levels. No adverse events were reported.
Daily doses ranging from 2 to 13 g are safe.
Astragalus membranaceus
It is used as a supportive agent during cancer treatment, and data from clinical studies suggest that it may be beneficial
when used in conjunction with chemotherapy.1
They also increase phagocytosis and demonstrate hepatoprotective effects on chemical-induced liver injury in
vitro125 and in vivo.126
Astragalus has been reported to have direct anticancer effects: Astragalus extracts inhibit tumor growth,124 delay
chemical-induced hepatocarcinogenesis in rats,126 have antiangiogenic property,127 and may also enhance the effects
of platinum-based chemotherapy.
Melatonin
Probiotics
Chemotherapy relief: Good bugs from probiotics can ease side-effects
Cancer breakthrough: Probiotics may save patients from deadly chemotherapy; antibiotics may cause chemo to be fatal
Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy.
1.97. Diindolilmethane (DIM)
DIM is a phytonutrient (plant nutrient) found in cruciferous vegetables. These include cabbage, broccoli, bok choy,
Brussels sprouts, cauliflower, kale, kohlrabi, mustard, rutabaga, and turnip.
Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects.
200[mg] - maximum effective single dose.
DIM
"Since pure DIM must be provided in an absorption-enhancing formulation, the dose for DIM sometimes specifies the
weight of the absorbable formulation, which is only one-fourth, or 25 percent DIM. In the book, All About DIM, the
suggested dose of 100 to 200 mg per day for women and 200 to 400 mg of DIM per day for men refers to milligrams
of such an absorbable formulation.(15) This dose range for hormonal balance corresponds to 25 to 50 mg per day of
actual DIM for women and 50 to 100 mg of actual DIM for men."
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.
"We report that administration of DIM in a multidose schedule protected rodents against lethal doses of total body
irradiation up to 13 Gy, whether DIM dosing was initiated before or up to 24 h after radiation.
In contrast, DIM did not protect human breast cancer xenograft tumors against radiation under the conditions
tested."
1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a
metastasis model.
Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -
independent prostate cancer cells.
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth.
3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.
Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3'-
diindolylmethene in human breast epithelial cell lines.
3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells.
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic
reticulum stress-dependent upregulation of DR5.
1.98. Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver
metastases via modulating matrix metalloproteinase-9 and E-cadherin expression.
1.99. In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4)
in liver of rats injected with DEN.
"Moreover, curcumin has the potential to be used in a therapy for liver cancer."
Potential therapeutic efficacy of curcumin in liver cancer.
"It is found that Curcumin dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis.
Moreover, Curcumin delayed the growth of liver cancer in a dose-dependent manner in nude mice."
1.100 Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.
"Curcuma aromatica and Polygonum cuspidatum are one of the commonly used paired-herbs for liver cancer
treatment. Curcumin and resveratrol are the major anticancer constituents of Curcuma aromatica and Polygonum
cuspidatum, respectively. Curcumin and resveratrol have been found to exhibit a synergistic anticancer effect in
colon cancer. ...
Combination of curcumin and resveratrol upregulated intracellular reactive oxygen species (ROS) levels in Hepa1-6
cells. The ROS scavenger, NAC, partially attenuated the apoptosis and caspase activation induced by the
combination treatment of curcumin and resveratrol. In addition, the combination of curcumin and resveratrol
downregulated XIAP and survivin expression. These data suggest that the combination treatment of curcumin and
resveratrol is a promising novel anticancer strategy for liver cancer."
Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN
knockout mice.
1.101 Potential impact of curcumin and taurine on human hepatoma cells using Huh-7 cell line.
"Curcumin/taurine in combination formula is better treatment than single therapy ...
Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with
consequent induction of CD8 T-cell responses to lyse tumor cells."
1.102 Integrating Nutrition and Selected Controversial Nutritional Supplements into a Cancer Treatment Program
An excellent article. Some bullet points:
- detoxification; proper digestion; regular bowel movements;
sulforaphane (broccoli sprouts extract) - liver detoxification
- macrobiotic diet; positive results for pancreatic, prostate cancer;
avoid: sugar, white flower, alcohol, caffeine, fluoridated/chlorinated water, food containing bromine,
hydrogenated fats, trans fatty acids, artificial chemicals in food (sweeteners, colors, flavors, preservatives)
GMO, fish with mercury, gluten
non dietary items to avoid: tobacco, recreational drugs, amalgam fillings, exposure to toxic chemicals,
synthetic hair dyes, aluminum containing antiperspirants, cell phones/microwave ovens,
nuclear plants, high voltage transmission power lines (my comment),
tight fitting clothing (bras) which cuts off lymphatic circulation
diet: whole foods, mostly plant based, organic, grass fed animals, juicing vegetables, low glycemic index foods
eat slowly, don't skip breakfast, do not skip meals, avoid malnutrition
boil/poach/stew; avoid frying/broiling/roasting/microwave
- Curcumin, EPA, Vitamin D3, Melatonin, Vit. A, Boswellic acid - affect up to 15 mechanisms of cancer
supplements are about 30 times less potent than drugs and about 21 times less toxic,
supplements work better in combinations
do not interfere and actually enhance chemotherapy and radiation; decrease side effects;
- Jaakkola study supplements:
Retinol Palmitate (Vit.A) - 15,000 .. 40,000[IU]
Beta Carotene - 10,000 .. 20,000[IU]
Vit.E - 300 .. 800[IU]
Thiamin (Vit. B1) - 150 .. 750 [mg]
Vit. B6 - 200 .. 1,140[mg]
Vit. B12 - 30 .. 1,600[ug]
Vit. D - 400 .. 1,000[IU]
Vit. C - 2,000 .. 5,000[mg]
Vit. B5 - 50 .. 300 [mg]
Biotin - 300 .. 1,000[ug]
Essential Fatty Acids - 5 .. 65[g]
Calcium
Magnesium
Zinc
Manganese
Selenium
Copper
Chromium
Vanadium
- The Hoffer protocol
improved diet (see above)
Vit.C - 10 .. 40[g]
Vit.B3 - 300 .. 3,000[mg]
Vit.B6 - 200 .. 300 [mg]
Folic acid - 1 .. 30[mg]
Vit.E - 400 .. 1,200[IU]
mixed carotenoids (such as carrot juice)
multi vitamins and minerals
Co Q10 - 300 .. 600[mg]
Selenium - 200 .. 1,000[ug]
Zinc - 25 .. 10[mg] (with some copper)
Calcium and Magnesium - 2:1 ratio
most supplements given in divided doses 2 .. 3 times daily
- IV Vit.C - 10 .. 120[g]
not giving IV glutathione on the same day as IV Vit.C
typical IV Vit.C includes:
60[g] Vit.C,
10[cc] Calcium Gluconate,
4[cc] Magnesium Chloride,
500[cc] sterile water,
administered over 2 hours
- Iodine - used in Gerson therapy and Hoxsey formula
12.5 .. 50[mg] (about 400 times higher than RDA)
fibrocystic breast disease - could be reversed with 5[mg]; good results with 50[mg] for 3 months
Japanese diet - 13[mg] from seaweed
thyroid gland - iodide form of iodine
breast/ovaries - elemental form of iodine
Lugol (Iodoral) contain both forms
dose must be no more than the body can tolerate in terms of detoxification.
Take with lots of water, unrefined salt, selenium, magnesium and Vit.C
- Mirko Beljanski Products - extracts from Pao Pereira and Rauwolfia Vomitoria
liver, thyroid, brain and breast cancer
- proteolytic enzymes
Vir. D3, Vit. K, Vit. A, phytonutrients (sulforaphane), resveratrol, curcumin, pre/pro biotics
- Salvestrols (resveratrol - max 30[mg])
1.103 Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from
Golden Spice
- anti-inflammatory [3], hypoglycemic [4,5], antioxidant [6], wound healing [7], and antimicrobial activities [8]. It has
been shown to possess chemosensitization, chemotherapeutic and radiosensitization activities as well [9]. Curcumin
has been studied for its chemopreventive potential in a wide variety of cancers, in both preclinical studies and in
clinical trials [10].
1. Oral delivery
Curcumin showed beneficial effects in several types of cancer in patients. Recently it has been reported that oral
curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients
[19]. In animal model oral administration of curcumin inhibited cancer of lung [20], skin [21], head and neck [22],
oral [23], hepatocellular carcinoma [24], mammary tumors, lymphomas, leukemias [25], and familial adenomatous
polyposis [26]. Oral treatment of curcumin found to effective in diabetic condtion. It attenuated high fat diet-
induced glucose intolerance and elevations of oxidative stress in the skeletal muscle [27]. Curcumin also enhanced
wound repair in diabetic impaired healing in mice [28]. Curcumin improves the peripheral neuropathy of R98C mice
by alleviating endoplasmic reticulum stress, reducing the activation of unfolded protein response and promoting
Schwann cell differentiation [29]. It also protects against the pulmonary and cardiovascular effects in mice [30].
2. Subcutaneous delivery
It has been also shown that the microparticle formulation of curcumin showed marked anticancer efficacy in nude
mice
3. Intraperitoneal (IP) delivery
Curcumin, delivered intraperitoneally, has shown inhibitory effect against lipopolysaccharide induced cardiac
hypertrophy in rodents [33]. It also reduced volume of glioma tumor implanted in nude mice, and prolonged the
survival of animals [34]. Another study showed that IP injection of curcumin inhibited tumorigenicity and tumor
growth, decreased the percentages of myeloid-derived suppressor cells in the spleen, blood, and tumor tissues,
reduced IL-6 levels in the serum and tumor tissues in a human gastric cancer xenograft model and a mouse colon
cancer allograft model [35]. It has been also shown that curcumin ameliorates intracerebral hemorrhage damage by
preventing matrix metalloproteinase-mediated blood-brain barrier damage and brain edema, which might provide
therapeutic potential for intracerebral hemorrhage [36]. Beside these, curcumin acts against asthma. ...
Curcumin administered IP inhibited human oral squamous cell carcinoma xenograft tumor in mice, indicating its
therapeutic efficacy in vivo [23]. Interestingly, it has been shown that oral curcumin treatment showed no effect on
important measures of bleomycin-induced injury in mice, whereas IP curcumin administration effectively inhibited
inflammation and collagen deposition along with a trend toward improved survival of animals. IP curcumin also
reduced fibrotic progression even when administered after the acute bleomycin-induced inflammation had subsided.
Intravenous Delivery
Numerous reports have been shown that intravenous injection of curcumin exhibits anticancer property in animal
model. Kim et al. [39] has shown that in curcumin has in antitumor effects in xenograft mouse model of colorectal
cancer. They have also shown that curcumin loaded human serum albumin (HSA) nanoparticles has greater
therapeutic effect than curcumin without inducing toxicity [39]. Several other studies reported that liposomal
curcumin inhibited different type of tumor growth in mouse models. It inhibited the growth of head and neck
squamous cell carcinoma in xenograft mouse .... Liposomal formulation of curcumin also enhanced the effect of
radio and chemotherapy. Shi et al. [41] showed that liposomal curcumin when combined with radiation enhanced
the
inhibition of tumor growth in a murine lung carcinoma (LL/2) model. It has been also reported that intravenous
treatment of liposomal curcumin in combination of cisplatin significantly enhances growth inhibition of xenograft
head and neck tumors in mice.
Another derivative of curcumin conjugated with luteinizing hormone releasing hormone, [DLys(6)]-LHRH-curcumin,
when given intravenously caused a reduction in tumor weights and volumes, and free curcumin given by gavage at an
equal dose failed to cause a significant reduction in tumor weights and volumes in the nude mouse pancreatic cancer
model. This bioconjugate enhanced apoptosis in tumor tissue [43]. The encapsulated curcumin with monomethoxy
poly (ethylene glycol)-poly(e-caprolactone) (MPEG-PCL) micelles also showed stronger anticancer effect than that of
free curcumin. When curcumin/MPEG-PCL micelle applied intravenously inhibited the growth of subcutaneous C-26
colon carcinoma in vivo [44]. The intravenous administration of another curcumin derivative, curcumin-loaded HSA
nanoparticles also showed greater therapeutic effect than curcumin in tumor xenograft HCT116 models without
inducing toxicity [39].
1. Topical delivery
Curcumin has been used topically to study its effect mostly on inflammation on target organ, wound healing, skin
cancer and other.
Beside these when curcumin applied as a noninvasive topical paste to the head and neck squamous cell carcinoma
(HNSCC) xenografts tumors in mice, resulted in inhibition of its growth. Thus, it can be used as an adjuvant or
chemopreventive agent in several cancer [48].
2. Nasal delivery
To increase the bioavailability and also direct nose-to-brain drug transport, nasal delivery of curcumin has been used.
In a study, the pharmacokinetics results showed that the absolute bioavailability of curcumin in the microemulsion-
based in situ ion-sensitive gelling system was 55.82% by intranasal administration. And the distribution of curcumin
in brain versus blood following intranasal administration was higher than that following intravenous administration
[49]. Another study also showed that the drug-targeting efficiencies of the curcumin in the cerebrum, cerebellum,
hippocampus and olfactory bulb after intranasal administration of the curcumin hydrogel were 1.82, 2.05, 2.07, and
1.51 times higher than intravenous administration of the curcumin solution injection, respectively, indicating that the
hydrogel and intranasal administration significantly increased the distribution of curcumin into the rat brain tissue.
In another study intranasal curcumin has been detected in plasma of mice after 15 minutes to 3 hours at
pharmacological dose (5 mg/kg), which has shown antiasthmatic potential by inhibiting bronchoconstriction and
inflammatory cell recruitment to the lungs. Thus, this study indicates that intranasal treatment of curcumin prevents
airway inflammations and bronchoconstrictions in asthma without any side effect [51].
Bioavailability of Curcumin
1. Unformulated curcumin
2. Nanocurcumin
3. Polylactic-co-glycolic acid (PLGA)
4. Liposomal encapsulation
5. Cyclodextrin (CD)
6. Piperine
Biological Activities of Formulated Curcumin
Curcumin liposomes of dimyristoyl phosphatidyl choline and cholesterol inhibit proliferation of prostate cancer cell 10
times more than curcumin [67].
Absorption of Curcumin in Blood, Liver, Brain, Kidney, and Other Organs
Metabolism of Curcumin
1.104 Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C.
"Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available,
the unsatisfactory outcomes demand establishing more effective interventions. D-fraction (PDF), a bioactive
proteoglucan of Maitake mushroom, demonstrates anticancer and immunomodulatory activities, which are also
shown to be potentiated by vitamin C (VC). ...
The present study demonstrates that the combination of PDF and VC can become highly cytotoxic, inducing severe
cell death in ACHN cells. ... Therefore, as PDF and VC may work synergistically to induce apoptotic cell death, they
may have clinical implications in an alternative, improved therapeutic modality for advanced RCC."
1.105 Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells.
"Treatment of cells with liposomal curcumin (5-10 microM) for 24-48 h at 37 degrees C resulted in at least 70-80%
inhibition of cellular proliferation without affecting their viability. On the other hand, free curcumin exhibited similar
inhibition only at 10-fold higher doses (>50 microM). ... We are currently developing liposome formulations with
targeting ability to further improve the efficacy of curcumin in vivo."
Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and
angiogenesis.
"In xenograft tumors in nude mice, liposomal curcumin at 20 mg/kg i.p. three-times a week for four weeks induced
42% suppression of tumor growth compared to untreated controls. ...
These data clearly establish the efficacy of liposomal curcumin in reducing human pancreatic cancer growth in the
examined model. The therapeutic curcumin-based effects, with no limiting side-effects, suggest that liposomal
curcumin may be beneficial in patients with pancreatic cancer."
Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications
Role of Curcumin in Cancer Therapy
1.106. ALA/N Protocol
"The purpose of the program was 3-fold: (1) nutritional support especially through specific antioxidant agents, (2)
comfort and palliation, and (3) immune system modulation via biological response modification. The major
therapeutic agents were intravenous (IV) a-lipoic acid (ALA), 300 to 600 mg, 2 days per week, and low-dose
naltrexone (LDN), 4.5 mg by mouth at bedtime. In addition, a triple antioxidant regimen consisting of oral ALA(600
mg per day), selenium (200 mcg twice daily), and silymarin (300 mg 4 times a day) was started. JA was also placed
on a generally accepted as healthy diet and lifestyle program."
The Long-term Survival of a Patient With Pancreatic Cancer With Metastases to the Liver After Treatment With the
Intravenous Alpha Lipoic Acid/Low-Dose Naltrexone Protocol
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic
pancreatic cancer: a report of 3 new cases.
Alpha-Lipoic Acid Plus Low-Dose Naltrexone Reviewed for Cancer Treatment
"Dr. Berkson reported success using ALA to repair liver damage in patients from mushroom poisoning or chronic
infections with hepatitis C virus. He also cited a number of research articles in European medical journals showing
ALA’s beneficial effects on cancer. ...
successful therapy with LDN of both the patient’s cancer and rheumatoid arthritis ...
Dr. Berkson reported uniformly positive responses and low toxicity from the ALA/ LDN regimen for each of the
seven cancer patients ...
Dr. Donahue presented findings from use of LDN in both human ovarian cancer cell cultures and for treating human
ovarian tumors grafted into mice. ...
The Penn State lab has found similar positive responses to LDN in other human cancer cell lines and mouse studies,
including for pancreatic cancer ...
Dr. Donahue has also studied the effects of LDN or OGF in combination with common chemotherapy agents for
cancer, such as taxol and cisplatin. She reported that LDN did not interfere with the tumor reduction effects of those
drugs and, in one case, seemed to enhance the drug’s effect."
Integrative Medical Center of New Mexico
from a post in a news group (cancer type - not specified):
"My recipe for my cancer remission is LDN, ALA, liposomal vitamin C, DCA and fasting two days a week. This
brought me back from hospice in December of 2011."
Dichloroacetate: University of Alberta Doctors Discover A Cure For Cancer
Metabolic treatment of cancer: intermediate results of a prospective case series.
"... lipoic acid at 600 mg i.v. (Thioctacid), hydroxycitrate at 500 mg t.i.d. (Solgar) and low-dose naltrexone at
5 mg (Revia) at bedtime."
Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone and vitamin D3--a case report.
"...These included oral dichloroacetate [14-16] (apoptosis inducer/metabolic therapy), low dose naltrexone,
ammonium tetrathiomolybdate [17-20] (copper chelator / angiogenesis inhibitor), and combination therapy
with radiation. Risks and benefits were discussed.
He was reluctant to have radiotherapy and was interested in medication with low side effects, so LDN was selected.
High dose vitamin D was also added (10,000 IU per day of oral liquid vitamin D3) since it can act as a differentiating
agent, thus potentially enhancing the cancer therapy [21-24]. The target blood level of 25-hydroxy vitamin D was the
upper end of the normal range, as specified by the patient’s local blood lab. The patient was also asked to moderate his
alcohol consumption.
LDN was started at a dose of 3mg orally once a day at bedtime. This reduced dose was selected to ensure that sleep was
not disrupted by insomnia or vivid dreams (known side effects of LDN). Since the LDN was well-tolerated, the dose
was increased to 4 mg daily at bedtime. The patient also added oral vitamin C 2000mg daily for the first 3 months of
therapy.
The patient felt improvement in symptoms with LDN therapy, and decided to continue under the direction of his
family doctor, with periodic re-assessment from his otolaryngologist at the regional cancer hospital. After 3 months
of therapy, blood tests were repeated and demonstrated normalization of most values (Table 2). After one year of
therapy, the 25-hydroxy vitamin D was 268nmol/L (normal range 75-250 nmol/L). Vitamin D was reduced to 5,000 IU
daily. The patient felt well and had no further symptoms from his cancer. Therapy was continued with no dose
changes, and after a total of 2 years of LDN and vitamin D, the MRI was repeated.
There were no complications from the LDN or high dose vitamin D, and no conventional therapy was ever introduced."
Other articles on LDN:
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
"fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. ... anti-inflammatory agent in
the central nervous system, via action on microglial cells.... As a daily oral therapy, LDN is inexpensive and well-
tolerated."
Low-dose naltrexone therapy improves active Crohn's disease.
1.107 Milk Thistle (Silymarin)
Silymarin in the prevention and treatment of liver diseases and primary liver cancer.
"The chemopreventive effect of silymarin on HCC has been established in several studies using in vitro and in vivo
methods; it can exert a beneficial effect on the balance of cell survival and apoptosis by interfering cytokines. In
addition to this, anti-inflammatory activity and inhibitory effect of silymarin on the development of metastases
have also been detected. In some neoplastic diseases silymarin can be administered as adjuvant therapy as well."
1.108 Tea Tree Oil
Tea tree oil might combat melanoma.
"TTO proved to be capable of inhibiting the growth of melanoma cells and of overcoming multidrug resistance
(MDR), as we reported in our previous study. ... The results reported herein indicate that TTO and its main active
component, terpinen-4-ol, can also interfere with the migration and invasion processes of drug-sensitive and drug-
resistant melanoma cells."
Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil.
"Four, daily, topical treatments of 10% TTO/DMSO regressed subcutaneous AE17 mesotheliomas in mice for a
period of 10 days and significantly retarded the growth of subcutaneous B16-F10 melanomas. The antitumour effect
of topical 10% TTO/DMSO was accompanied by skin irritation similar to other topical chemotherapeutic agents, but
unlike other approved topical agents, quickly and completely resolved. Furthermore, we show that topical 10%
TTO/DMSO caused an influx of neutrophils and other immune effector cells in the treated area, with no evidence of
systemic toxicity.
TTO combined with an effective carrier significantly inhibited the growth of aggressive, subcutaneous, chemo-
resistant tumours in immunocompetent mice. Taken together, these findings highlight the potential of topical TTO
as an alternative topical antitumour treatment."
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.
"Melaleuca alternifolia (tea tree) oil (TTO) applied topically in a dilute (10%) dimethyl sulphoxide (DMSO)
formulation exerts a rapid anti-cancer effect after a short treatment protocol. Tumour clearance is associated with
skin irritation mediated by neutrophils which quickly and completely resolves upon treatment cessation. ...
Although topical application of 10% TTO/DMSO appears to activate an immune response, anti-tumour efficacy is
mediated by a direct effect on tumour cells in vivo. The direct cytotoxicity of TTO in vivo appears to be associated
with TTO penetration."
Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and
terpinen-4-ol.
"PURPOSE: To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil (TTO), and its major
active terpene component, terpinen-4-ol, against two aggressive murine tumour cell lines, AE17 mesothelioma and
B16 melanoma.
CONCLUSION: TTO and terpinen-4-ol had significant anti-proliferative activity against two tumour cell lines."
A review of the toxicity of Melaleuca alternifolia (tea tree) oil.
"Anecdotal evidence from almost 80 years of use suggests that the topical use of the oil is relatively safe, and that
adverse events are minor, self-limiting and occasional. Published data indicate that TTO is toxic if ingested in
higher doses and can also cause skin irritation at higher concentrations. Allergic reactions to TTO occur in
predisposed individuals and may be due to the various oxidation products that are formed by exposure of the oil to
light and/or air. Adverse reactions may be minimised by avoiding ingestion, applying only diluted oil topically and
using oil that has been stored correctly. Data from individual components suggest that TTO has the potential to be
developmentally toxic if ingested at higher doses, however, TTO and its components are not genotoxic."
DMSO
The Human Toxicology Of Dimethyl Sulfoxide
"80% DMSO gel at 1 g/kg"
WebMD link
DMSO - living naturally web site
1.109 Hyperthermia
Hyperthermia in Cancer Treatment
Research in hyperthermia treatments
Whole Body Hyperthermia at 43.5-44°C: Dreams or Reality?
Note: Extreme application under general anesthesia.
HYPERTHERMIA at home with Michael and Trish
1.110 Selenium
Super Selenium Complex
contains all 3 forms: Sodium selenite, L-selenomethionine, Selenium-methyl L-selenocysteine
Selenium: What Forms Protect Against Cancer?
The New Recommendations for Dietary Antioxidants
"We also suggest daily supplements of 200 mg of natural vitamin E and 100-200 mcg of selenium, especially for men
at increased risk of prostate cancer. Vitamin E and selenium supplements should not exceed 1,000 mg/day and 400
mcg/day, respectively.
Beta-carotene supplementation is not advisable.
Even very large doses of vitamin C do not exert any adverse health effects."
Dietary selenium supplementation modifies breast tumor growth and metastasis.
"The primary tumor growth, the numbers of cancer cells present in lungs, hearts, livers, kidneys and femurs and
several proinflammatory cytokines were measured. We found that inorganic selenite supplementation provided
only short-term delay of tumor growth, whereas the two organic SeMet and MSA supplements provided more
potent growth inhibition. These diets also affected cancer metastasis differently. Mice fed selenite developed the
most extensive metastasis and had an increased incidence of kidney and bone metastasis. On the other hand, mice
fed the SeMet diet showed the least amount of cancer growth at metastatic sites."
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-
treated colorectal cancer cells.
"Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including
leukemia, prostate cancer and colorectal cancer (CRC) cells."
Selenite enhances and prolongs the efficacy of cisplatin treatment of human ovarian tumor xenografts.
"Selenite increased and prolonged the efficacy of multiple cisplatin treatments, although selenite was not an
effective inhibitor by itself. In the absence of selenite, the effectiveness of cisplatin decreased."
Selenium (University of Maryland)
Selenium (National Institute of Health)
1.111 Hemp Oil
Phoenix tears - Rick Simpson
RUN FROM THE CURE: The Rick Simpson Story
PROOF CANNABIS CURES CANCER - VARIOUS NEWS SOURCES
Hemp oil effectively kills cancer cells
Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows
Spain study confirms hemp oil cures cancer without side effects
Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
"This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the
Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation
therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions
provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally
to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia
chromosome mutation and indications of dose-dependent disease control.
...
These results cannot be explained by any other therapies, as the child was under palliative care and was solely on
cannabinoid treatment when the response was documented by the SickKids Hospital. The toxicology reports ruled
out chemotherapeutic agents, and only showed her to be positive for THC (tetrahydrocannabinol) when she had a
recent massive decrease of WBC from 350,000 to 0.3’ inducing tumor lysis syndrome, as reported by the primary
hematologist/oncologist at the SickKids Hospital."
Me and Cancer-The Cannabis Oil Cure
Case of terminal liver and bowel cancer.
Repositioning therapy for thyroid cancer: new insights on established medications.
"For instance, the derivatives of cannabis and an anti-diabetic agent, metformin, are both able to inhibit extracellular
signal-regulated protein kinase (ERK), which is commonly activated in thyroid cancer cells. We present here several
examples of well-known medications that have the potential to become new therapeutics for patients with thyroid
cancer."
Towards the use of non-psychoactive cannabinoids for prostate cancer.
"... present comprehensive evidence that plant-derived cannabinoids, especially cannabidiol, are potent inhibitors of
prostate carcinoma viability in vitro. They also showed that the extract was active in vivo, either alone or when
administered with drugs commonly used to treat prostate cancer ..."
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and
underlying mechanisms.
"Cannabidiol (CBD) significantly inhibited cell viability."
Cannabinoid-associated cell death mechanisms in tumor models (review).
"Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the
ability of these compounds to induce different pathways of cell death has been highlighted."
1.112 Essiac
Remission of hormone-refractory prostate cancer attributed to Essiac.
"We describe here the case of a 64-year-old man whose hormone-refractory prostate cancer responded well
to Essiac tea."
Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
"Essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a
matter of debate. ...
Essiac effectively scavenged hydroxyl, up to 84% reduction in radical signal at the 50% tea preparation
concentration, and superoxide radicals, up to 82% reduction in radical signal also at the 50% tea preparation
concentration, as well as prevented hydroxyl radical-induced DNA damage. In addition, Essiac inhibited hydroxyl
radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that
Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-
cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac."
Inhibition of prostate cancer-cell proliferation by Essiac.
1.113 Curcumin
Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway.
"In the present study, we found that cell mortality and curcumin concentration were dose dependent. Curcumin of
low concentrations (10 µM) could reduce the level of reactive oxygen species (ROS) in tumor cells, while curcumin
of high concentrations (80 µM) was able to significantly increase the content of ROS. In addition, Western blotting
detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of
Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently
slowing the curcumin-induced apoptosis. Taken together, curcumin further activates the mitochondrial apoptotic
pathway by inducing cells to generate ROS and ultimately promotes the apoptosis of tumor cells."
Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis.
"Through FACS analysis and activated caspase-3 labeling we demonstrate that CUR induces apoptosis of
rabdomyosarcoma and osteosarcoma cells and that this effect is potentiated when CUR is combined with RES or
DADS."
Cytotoxic effects of curcumin on osteosarcoma cell lines.
"In the current study we examined the cytotoxic effect of curcumin on seven osteosarcoma (OS) cell lines with
varying degrees of in vivo metastatic potential. Curcumin inhibited the growth of all OS cell lines tested with half-
maximal inhibitory concentration values ranging from 14.4 to 24.6 microM."
The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro.
"Cisplatin (0.1, 1.0, 10.0 microM) and curcumin (0.1, 1.0, 10.0 microM) induced significant dose-dependent
inhibition in both cell growth as well as cell proliferation. Genistein and quercetin (1.0, 10.0, 100.0 microM) had
biphasic effect, depending on their concentrations, on cell growth as well as cell proliferation. Based on these
findings, it is concluded that curcumin is considerably more potent than genistein and quercetin, but cisplatin is
five fold more potent than curcumin in inhibition of growth and DNA synthesis in SCC-25."
Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
"The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to
curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin
treatment. Therefore, this study showed that at the right concentrations (5 µM to 25 µM), curcumin, along with a
proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells."
Curcumin - The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention
and Treatment
"can act synergistically with ... radiotherapy, chemotherapy and hormonotherapy
... synergistic effect with genistein
... When combined, they are able to reduce the proliferation of the human breast MCF-7 oestrogen-positive cells
induced by environmental pesticides [192].
... curcumin ... D3 (calcitrol) ...
... curcumin and omega-3 fatty acids (fish oil diet) leads to the prevention and treatment of pancreatic tumor ...
... curcumin with embellin, a natural benzoquinone derived from Embelia ribes berries, ... hepatocarcinogenesis
... human prostate cancer PC-3 ... curcumin and b-phenylethyl isothiocyanate (PEITC), a natural compound
issued from cruciferous vegetables.
... curcumin and resveratrol ... colon cancer
... curcumin with epigallocatechin-3-gallate (EGCG), ... premalignant and malignant human oral epithelial cells
... chronic lymphocytic leukemia cells (CLL), synergism between EGCG and curcumin allows to overcome the
stromal-mediated protection of the CLL cells in the case of sequential therapy. By this way, EGCG sensitizes the
cells to curcumin effects and is able to increase strongly cell death in leukemic cells [172].
Curcumin ... piperine, an alkaloid from black pepper, inhibits breast stem cell self-renewal without inducing
toxicity to differentiated cells. This inhibitory effect is mediated by the inhibition of mammosphere formation
and Wnt signaling pathway, but without causing toxicity to differentiated cells [91].
... curcumin with quercetin, ... adenomas in patients with familial adenomatous polyposis without
appreciable toxicity ...
5.2. Synergism with conventional therapy
... curcumin with radiation enhances significantly ...
Curcumin was shown to potentiate the effect of Taxol / paclitaxel-mediated chemotherapy in advanced breast
cancer in vitro and in vivo and is able to inhibit lung metastasis. Such a sensitization of taxol-induced cell death
by curcumin was also observed in cervical HeLa cancer cells.
... enhance ... vinorelbine for the treatment of advanced non-small lung H520 carcinoma cells [204] and of
celecoxib, ..., in pancreatic adenocarcinoma cells
human colon cancer ... curcumin is associated with the antimetabolite 5-fluorouracil (5-FU) chemotherapeutic
agent
... curcumin ... 5-FU associated with oxaliplatin or oxoplatin
... curcumin is also able to circumvent chemoresistance ... platinium (Pt) drugs such as cisplatin and oxaliplatin
... thalidomide and bortezomib ... gemcitabine ... capecitabine
... attenuate the myocardial toxicity usually observed after adriamycin/doxorubicin
... docetaxel, ... highly potent in mice with multidrug-resistant tumors
... sensitize prostate cancer cells for TRAIL-mediated immunotherapy...
6. The “Dark Side” of Curcumin
Moreover, several studies also pointed out that curcumin can exhibit toxicity and carcinogenic effects [12].
In a 2-year study performed on rodents fed with curcumin, an equivocal evidence of curcumin carcinogenic
activity was reported as they observed an increased incidence of hepatocellular and clitoral gland adenoma as
well as carcinomas of the small intestine, due to curcumin ingestion [227]. Curcumin also appeared responsible
for the promotion of lung tumor multiplicity
... curcumin inhibits camptothecin-, mechlorethamine-, and doxorubicin"
The dark side of curcumin
This is the article cited above.
NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component
79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
this is the article referenced in the above one. The test was using turmeric oleoresin with curcumin content up to
85%. Doses were equivalent to ~15,000 to 400,000[mg] (for 70kg person) for the duration of 2 years. Results were
different for male and female rats (maybe indicating effect on hormones). Assuming 10 times lower doses should be
OK, this means that below 2,000[mg] should be OK for long term use.
Curcumin (general info)
Theracurcumin (nano-particles formulation) - 10 to 30 times better effectiveness and ~13 (instead of 6) hours
half-life.
Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
"Curcumin, a dietary pigment from the plant Curcuma longa, inhibits cell proliferation and induces apoptosis in
different cell lines. The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral
application. Therefore, great efforts were undertaken to enhance the effectiveness of curcumin. Recently, it was
demonstrated that curcumin offers the described effects also at low concentrations (0.2–1 µg/ml) when applied in
combination with UVA or visible light."
Curry Compound Fights Cancer in the Clinic
Spicy approach to cancer treatment
1.114 Diallyl Disulphide; Garlic Oil
Diallyl disulphide, a beneficial component of garlic oil, causes a redistribution of cell-cycle growth phases, induces
apoptosis, and enhances butyrate-induced apoptosis in colorectal adenocarcinoma cells (HT-29).
"Garlic oil is a prominent dietary constituent that prevents the development of colorectal cancer. This effect is
believed to be mainly due to diallyl disulphide (DADS), which selectively induces redox stress in cancerous (rather
than normal) cells that leads to apoptotic cell death. ...
Short-chain fatty acids (SCFAs), particularly butyrate (abundantly produced in the gut by bacterial fermentation of
dietary polysaccharides), enhance colonic cell integrity but, in contrast, inhibit colonic cancer cell growth.
Combining DADS with butyrate augmented the apoptotic effect of butyrate on HT-29 cells. These results suggest
that the anticancerous properties of DADS afford greater benefit when supplied with other favorable dietary factors
(short chain fatty acids/polysaccharides) that likewise reduce colonic tumor development."
1.115 Research finds combo of plant nutrients kills breast cancer cells
"The research team tested ten known protective chemical nutrients found in foods like broccoli, grapes, apples,
tofu, and turmeric root (a spice used in Indian curry) before settling upon six – Curcumin known as tumeric,
Isoflavone from soybeans, Indo-3-Carbinol from cruciferous plants, C-phycocyanin from spirulina, Reservatrol
from grapes, and Quercetin, a flavonoid present in fruits, vegetables, and tea.
The researchers administered these six at bioavailable levels to both breast cancer and control cells. They tested
the compounds individually and in combination. They found that the compounds were ineffective individually.
When combined, though, the super cocktail suppressed breast cancer cell growth by more than 80%, inhibited
migration and invasion, caused cell cycle arrest, and triggered the process leading to cell death resulting in the death
of 100% of the breast cancer cells in the sample. The researchers observed no harmful effects on the control cells.
Further analysis also identified several key genes, which could serve as markers to follow the progress of therapy.
Although the cocktail was not tested against BRCA1 and BRAC2, previous studies have shown that they are
molecular targets of four of the six compounds. The researchers also earlier demonstrated that two of the
compounds synergize effectively to kill ovarian cancer cells."
Simultaneous Inhibition of Cell-Cycle, Proliferation, Survival, Metastatic Pathways and Induction of Apoptosis
in Breast Cancer Cells by a Phytochemical Super-Cocktail: Genes That Underpin Its Mode of Action
"The anti-cancer effect of Curcumin ... results from its ability to inhibit tumor growth and metastasis.
Isoflavone (Genistein), a naturally occurring chemical in soybeans, has a protective effect against localized
prostate cancer, non-small cell lung cancer, and estrogen and progesterone receptor positive (ER+, PR+)
breast tumors
Indol-3-Carbinol (I3C), extracted from cruciferous plants, plays an important role in inhibiting carcinogenesis
by protecting cells from oxidative stress ... The chemical derivative of I3C, 1-Benzyl-indole-3-carbinol has a
1000 fold higher activity than I3C in inhibiting the growth of both estrogen-dependent and -independent breast
tumors 20. I3C also plays an important role in sensitizing BC cells to the chemotherapeutic drug tamoxifen 20.
In MDA-MB-231 BC cell line, another member of I3C, 3'-diindolylmethane (DIM) induced apoptosis and
inhibited angiogenesis by suppressing the activity of the Akt/NF-?B signaling pathway. I3C was shown to inhibit
bone metastasis of MDA-MB-231 breast cancer cells in a SCID mouse model.
In a recent study, extract from the blue green algae Spirulina platensis, combined with selenium (an element with
anti-cancer activity), was shown to inhibit the growth of MCF7 BC cell line. ... The active compound of these
extracts, C-phycocyanin (C-PC) is a water-soluble biliprotein that has anti-inflammatory and anti-oxidant effects
and has been reported to induce apoptosis in MCF7 breast cancer cells. Our previous studies have demonstrated
that spirulina inhibited rat liver toxicity and carcinogenesis induced by dibutyl nitrosamine (DMB) precursors
Grape seed extract contains Resveratrol (RE) that inhibits cancer cell proliferation ... induces apoptosis ...
synergizes with Indole 3 Carbinol to inhibit proliferation and survival of ovarian cancer cells
Quercetin induces cell apoptosis
(Curcumin) CUR: 2.25 µg/ml
(Isoflavone / Genistein) GA: 3 µg/ml
(Indol-3-Carbinol) I3C: 4 µg/ml
(C-phycocyanin) PC: 50 µg/ml
(Resveratrol) RE: 0.5 µg/ml
(Quercetin) Qurc:1.5 µg/ml
A moderate effect was observed for each of I3C and Quercetin on MCF7 cell ...
In contrast to the results observed for the individual compounds, a moderate, yet significant decrease of cellular
proliferation was observed in the presence of the combination treatment on the first day of treatment. This effect
continued throughout the treatment reaching maximum level of inhibition by day six with an 8-fold decrease of
cell proliferation.
Similarly, the treatment of MDA-MB-231 metastatic BC cell line with each phytochemical individually resulted
in no detectable effect on the proliferation of the treated cells throughout the course of the experiment, with the
exception of a moderate inhibition with I3C by the third day of treatment. Similar to what was observed with the
MCF7 cells, treatment with the 6-combination on the MDA-MB-231 cells showed a significant suppression in the
number of proliferating cells by day six
When the cells were exposed to the phytochemical combination for 8 days, all the cells were found to detach,
float up and were lost. These data suggest a synergistic mode of action of the individual phytochemicals in the
6-combination treatment for affecting the proliferation of BC cells.
Interestingly, treatment of MCF7 cells with the six phytochemical combination greatly restored the expression
of Wt p53. This induction of Wt p53 would sensitize the primary BC cells for chemotherapy
However previous studies 46-48 have shown that BRCA1 and BRCA2 are molecular targets for four of the six
compounds (Indole-3-carbinol, Resveratrol, Genistein and Curcumin) used in this phytochemical cocktail.
Further, we previously demonstrated that I3C and RE synergize to effectively kill ovarian cancer cells 27, thus
making this super cocktail effective against this cancer also."
1.116 Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
here is the pdf version of the full article.
"1. Indole-3-carbinol (I3C) and diindolylmethane (DIM)
Administered doses of I3C have ranged from 200 to 500mg/day (~ 6-7mg/kg) ...
800 mg/day did not provide additional benefits over 400 mg/day ...
DIM in plasma (2.5µM max at 2 hours, gradually decreasing by 12 hours) or in urine following oral administration
of I3C...
I3C was not detected in plasma or serum following oral doses of 400-1200mg ...
enhanced absorption DIM (BioResponse DIM ®; 108mg/day ...
BioResponse DIM resulted in levels approximately 50% higher than those obtained with unformulated DIM...
I3C was rapidly absorbed and cleared from blood and tissues within an hour, while DIM peaked slightly later and
was more persistent...
assumptions that I3C is not absorbed, but undergoes complete acid-condensation in the stomach. Several studies
have revealed distinct responses to I3C and DIM in animal models [22-26]. Therefore, the in vivo activity of
dietary I3C cannot be attributed completely to the production of DIM, although response due partially to DIM
conversion is probable. ...
I3C dose given to mice would equate to a 20mg/kg dose in humans (1200 mg/day), which yielded the maximal
serum concentration 2.5µM DIM (2 hours), with no I3C detectable after 1 hour ...
BioResponse DIM resulting in 50% higher bioavailability. The dose of BioResponse DIM used in humans was
108mg (~ 1.3-1.9mg/kg) [6], which might be expected to give levels in the range 3-30µM....
Both I3C and DIM clearly inhibit tumour cell growth in vivo in a range of animal models ...
mammary tumours ... liver, small intestine and lungs ...
1.6. Evidence for I3C or DIM acting synergistically/ antagonistically
... melanoma ... in combination with vinblastine
DIM (45µM) increased the drug content of cells by 50% ...
DIM (25µM) plus genistein (5µM) ...
I3C (50 or 100µM) has been shown to cooperate with tamoxifen (1µM) in vitro ...
I3C acid-condensation mixture also enhanced the efficacy of vinblastine in mouse melanoma cells (see above),
while I3C itself had no effect ...
I3C, together with crambene ...
2. Curcumin
8 g/day ... 3.6 g/day ... 10 nM range
3.6 g/day for one week. In the only human study to examine colorectal tissue to date, this oral dose resulted in
levels in the 10 µM range ...
Significant levels of curcumin may also be achieved locally when administered topically to the skin or within the
oral cavity, but the exact dose achieved in these scenarios remains to be confirmed. ...
liposomal preparation of curcumin ... nano-particle ..
Anti-cancer effects of curcumin have been demonstrated in multiple cell types, at concentrations between 5 and
50 µM ...
pancreatic cancer ... gastrointestinal tract, including breast [95], prostate [96], lung [97] and liver ...
2.6. Evidence for curcumin acting synergistically/ antagonistically
curcumin (10 µM) and genistein (25 µM) ...
Curcumin also synergistically potentiated the inhibitory effect of celecoxib on pancreatic carcinoma cells ...
colorectal cancer with celecoxib ...
oral cancer, EGCG ... curcumin ... only the combination decreased the proliferation index of squamous cell
carcinoma ...
prostate cancer cells ... TRAIL (20 ng/ml) ... curcumin (10 µM) ...
colorectal carcinoma lines, ... curcumin ... oxaliplatin ...
curcumin ... gemcitabine and paclitaxel in bladder cancer ... gemcitabine in an orthotopic model of pancreatic
cancer ...
Antagonistic interactions have also been demonstrated, however, with curcumin shown to inhibit chemotherapy-
induced apoptosis in breast tumour lines. Camptothecin-, mechlorethamine-, and doxorubicin-induced apoptosis
in MCF7, MDA-MB-231 and BT-474 cells was inhibited by as much as 70%, following 3h exposure to as little as
1 µM curcumin.
3. Epigallocatechin-3-gallate (EGCG)
Bioavailability in two early studies found plasma levels at 0.2 to 2% of the ingested amount of EGCG (up to 4µM),
but higher plasma concentrations have since been reported in fasting subjects compared to those who consumed
catechins with food ...
topical application to skin of an ointment containing 10% EGCG ...
holding a green tea solution (1.2g/200ml water) in the mouth for one min resulted in salivary EGCG concentrations
(mean) of 27µM, with values up to 48µM recorded, several fold higher than achieved through normal drinking,
and many more times greater than plasma concentrations [114, 115]. But holding the tea in the mouth for 5 min
resulted in salivary concentrations four to five times higher, whilst taking tea solids in capsules resulted in no
detectable salivary catechin levels. ...
liposomes for local (injection) delivery of EGCG, found that a liposomal cocktail containing deoxycholic acid and
ethanol greatly increased the tumour uptake of EGCG, in both melanoma and colon murine tumour models.
However, liposomal delivery was not superior following topical application. ...
piperine from black pepper enhanced the bioavailability of EGCG in mice. Small intestinal levels following
EGCG administration alone resulted in a Cmax of 37.5 ± 2.5 nmol/g at 60 min, decreasing to 5.1 ± 1.7nmol/g
at 90min. Following cotreatment with piperine, the Cmax was 31.6 ± 15.1nmol/g at 90 min, with levels still
above 20nmol/g at 180min. Appearance of EGCG in the colon and faeces was slower in the co-treated mice. ...
bioavailability of EGCG, whether administered as tea or pure compound, is in the range of 0.1-7µM in humans,
with concentrations over 100µM observed in saliva ...
Green tea polyphenols inhibited growth of 4T1 breast cancer cells and their metastasis to lungs in BALB/c mice ...
Topical application of EGCG to SKH-1 hairless mice ... decreased the multiplicity of skin tumours by 44-72%
and increased the apoptotic index by 56-92%,...
liposomal delivery of EGCG resulted in increased tumour uptake, ... increased antiproliferative activity in basal
carcinoma cells in vitro, ...
When green tea extract (400-500mg/cup, 5 cups/day) ...
0.6% green tea inhibited DMBA-induced oral tumour...
green tea in drinking water (1.25% containing 708µg/ml EGCG, giving plasma levels of 0.1 - 0.3µM) ...
EGCG may be a useful in vivo inhibitor of angiogenesis ...
prostate intraepithelial neoplasia, ... 600mg/day green tea compounds in (oral) capsule form,
3.6 Evidence for EGCG acting synergistically/ antagonistically
epicatechin significantly enhanced uptake of labelled EGCG into human lung PC-9 cells ...
whole green tea was a better preventive agent than EGCG alone ...
EGCG were also increased by tamoxifen or sulindac ...
prostate cancer ... 10µM EGCG only resulted in a 12-21% inhibition in cell viability, the addition of 10µM NS-398 ...
EGCG, at 0.1µg/ml (equivalent to serum concentrations), markedly enhanced the growth inhibitory effects of
5-fluorouracil in head and neck squamous carcinoma cells ...
EGCG enhanced the sensitivity of HNSCC (0.1µg/ml) and breast (1.0µg/ml) cells to taxol ...
white tea (1.5%) and sulindac (80ppm),... intestinal tumours ...
EGCG and sulindac was also found to be efficacious in preventing azoxymethane-induced colon cancer in rat ...
4. Resveratrol
0.3-2.4µM following single oral doses of 0.5-5g ...
10-25mg pure resveratrol/70kg ... 1.83-2.06µM at 30 minutes post dose, returning to baseline by 4 hours ...
Aqueous solubility of resveratrol is low ...
The presence of fatty acids increases binding to serum albumin, ... for the delivery of resveratrol to cell
membranes and thus, signalling events. ...
20mg/kg gave a maximal resveratrol plasma content of 3µM, falling to <0.1µM after 1 hour [140], with a
5mg/kg dose showing maximal plasma levels of 1.5µM ...
anti-cancer potential over a range of doses and in a wide variety of tissues, including breast, colon, pancreas,
stomach, prostate, head and neck, ovary, liver, lung and cervix ...
300ml of red wine over a 30 minute period, blood taken up to 2 hours post dose showed significantly raised
serum antioxidant capacity ...
Daily i.p injections of 40mg/kg resveratrol (estimated serum level of 25µM) reduced neuroblastoma growth in
rats and increased survival by 70%. ...
100/mg/kg/day prolonged survival time for rats with intracerebral tumours generated from RT-2 glioma cell ...
4.6. Evidence for resveratrol acting synergistically/antagonistically
Resveratrol sensitized colon cancer cells to CD95 and TRAIL ... sensitized HT29 cells to cisplatin ...
Resveratrol cooperatively enhanced doxorubicin, cytarabine, actinomycin D, taxol and methotrexate ...
neuroblastoma cells [173], and enhanced TRAIL ...
paclitaxel in A549, EBC-1 and Lu65 lung cancer cell lines [175], and of cisplatin and doxorubicin in OVCAR-3
and Ishikawa cells respectively ...
Resveratrol has been used in combination with other phytochemicals such as beta-siterol ...
quercetin/ellagic acid with resveratrol resulted in a synergistic effect ...
resveratrol (0.5µM) or I3C (50µM) to induce non-steroidal anti-inflammatory drug-activated-gene (NAG-1), a
TGF-ß superfamily gene associated with pro-apoptotic and anti-tumorigenic activity. However, when used in
combination, the doses could be reduced to 0.025µM and 1µM respectively. ..."
1.117 Oil Pulling Therapy
"Oil pulling therapy simply consists in thoroughly sloshing certain types of commonly found oil in the mouth for up
to 20 minutes (for details see Instructions: how oil pulling is done). This practice is said to draw toxins & destroy
natural mouth germs while stimulating the body's eliminatory system and increasing metabolism, thus leading to
improved health and the conquering of disease.
In fact, thanks to this double action, oil pulling therapy is claimed (according to Dr. Karach MD as well as others)
to have healed illnesses and complaints as diverse as bronchitis, tooth pain, diseased teeth, headaches & migraines,
eczema, thrombosis, chronic sleeplessness, arthritis & related illnesses, diseases of stomach & intestines (such as
ulcers, gastro-enteritis, peritonitis), kidney, liver, lung and heart disease, blood disorders (such as chronic blood
diseases like leukemia), women’s diseases & hormonal disorders and diseases affecting the nervous system (such
as encephalitis, meningitis, neuro-physiological paralysis). It is also said to prevent the growth of malignant tumors,
to cut and heal them, to be a heart attack preventative, to cure diseases brought on by toxic drugs, and it is credited
with the cure of diabetes.
Additionally, “in terminal diseases such as cancer, Aids and chronic infections, this treatment method has been
shown to successfully replace all others. ... a wide variety of symptoms have unquestionably disappeared without
any side effects
Interestingly, oil pulling is also part of the daily morning routine prescribed in conventional and alternative cancer
treatment researcher Lothar Hirneise’s new cancer treatment center in Germany.
... man who had his saliva tested for eight industrial toxins in the laboratory after oil pulling with sunflower oil.
While the sunflower oil itself (before oil pulling) contained infinitesimal amounts of environmental toxins such as
Lindan, PCB 138, PCB 153, PCB 180, HCB, DDE etc., the saliva-cum-oil-mix contained up to 27 times as much and
even contained toxins that had no detectable levels in the oil prior to pulling. In other words, the body had excreted
these toxins in the process of oil pulling.
... pulling with water (or herbal tea) will have the same detoxifying effect as pulling with oil ...
Instructions: how oil (or water) pulling is done
In the morning before breakfast (i.e. on an empty stomach), take one tablespoon into the mouth (don’t swallow it).
Move the fluid slowly around your mouth, as you would when rinsing your teeth. While keeping your mouth closed,
slosh the fluid around your oral cavity, pulling it through your teeth, sucking it etc. Do this for fifteen to twenty
minutes. “Chewing” in this manner draws a lot of saliva and gradually dilutes the oil which becomes thoroughly
mixed with saliva in the process. Swishing is said to activate the enzymes, with the enzymes drawing toxins out of
the blood. As you continue this process, the oil-saliva mix gradually becomes more and more liquid and thin and
acquires a whitish look (if the oil remains yellowish, it has not been pulled long enough).
The watery oil/saliva mix is then spat out. It must not be swallowed
Best time to do the oil pulling routine is said to be in the morning before breakfast
oil pulling can be repeated three times a day (always before meals on an empty stomach) but it also says that only
the patient himself can answer this question depending on how he feels which tells him if he needs more or less
applications of the oil pulling routine.
Patients suffering from more than one disease can experience a worsening of their situation in the beginning.
Dr. Karach - like other naturopaths - believes that an apparent worsening of one’s state of health is a propitious
sign (often referred to as healing crisis) indicating that your disease is disappearing. This includes healing fever.
He advises not to interrupt the treatment when one’s state gets worse.
One author (perhaps more) warns against oil pulling for people who carry amalgam fillings, claiming that even
more mercury than “normal” will/could be released by this practice.
Erika Herbst reports in her book "Die Heilkunst von Morgen" a number of healings due to oil pulling. These
include one or more cases of tinnitus, colitis, sleeplessness, excess mucus, blood in urine, tiredness incl. after
meals, arthritic stiffness, major pain in hands, a leg that had already turned blue from diabetes, headaches,
coughing, bronchitis, chronic sinusitis, head cleared, firmer skin, hot flashes gone, initial worsening of symptoms
followed by healing, no more colds or flu, better evacuation, better sleep, acne gone, glaucoma improved, migraine
gone, no more hayfever, general rejuvenation, prostatitis healed, diarrhea, nausea, lack of appetite, even varicose
veins disappeared after oil pulling.
The third case involves a woman who developed a malignant tumor larger than a tennis ball on her jawbone (this
patient is also on homeopathic medicines). After a month of oil pulling, pus was discharged from a hole that formed
in the tumor on the jawbone. Three weeks later, the flow of pus stopped, the hole closed and the tumor reduced in
size to be almost undetectable."
1.118 Antineoplaston therapy (Burzynski clinic)
Post from a news group:
"I underwent 17 months of ANP after 3 years of aggressive chemo and radiation and an autologus BMT. Upon my
third relapse during this aggressive conventional treatment I was told that "nothing more could be done for me."
While on ANP my bone lesions shrank and disappeared. I have been cancer free since the conclusion of ANP
therapy- in '99.
http://peoplebeatingcancer.org/discuss/david-emerson-diagnosed-multiple-myeloma-394"
Dr Burzynski movie
BBC Panorama investigates the Burzynski clinic
(against it; naturally no cancer treatment is 100% effective)
1.119 Hyperbaric oxygen therapy
The case for hyperbaric oxygen therapy
MS, Brain Injury (including stroke), Autism, Dementia, Lyme disease, seizures, surgery, during chemo therapy,
before radiation therapy, burns, wounds (incl fracture healing)
1.120. Calcium Fructoborate / Boron
Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy.
"Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer.
CF has been identified as Ca ( (C6H10O6)2B)2o4H2O and is a natural product from plants (can be produced by
chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and
osteoarthritis.
CF showed inhibitory effects on MDA-MB-231 breast cancer cells as well, and enters the cell (most likely) by a
co-transport mechanism via a sugar transporter. Inside cells CF acts as an antioxidant and induces the
overexpression of apoptosis-related proteins and eventually apoptosis."
Calcium fructoborate--potential anti-inflammatory agent.
"The studies on animals and humans with a dose range of 1-7 mg calcium fructoborate (0.025-0.175 mg elemental
boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible
adverse effect on humans."
Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
Oral resveratrol and calcium fructoborate supplementation in subjectswith stable angina pectoris: Effects on
lipid profiles, inflammation markers,and quality of life
"From the literature, the highest dose of CF administered was 37.5 mg/kg. No toxicity was noted at this
dosage [28]. Resveratrol presents a low toxicity [29]."
"Orally ingested boron has been observed to be well absorbed (>90%) from the gastrointestinal tract in humans,
rats, and rabbits. Boron as borate is readily and almost completely absorbed (>90%) from the human gut [30,31].
About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, the oral bioavailabilityof
resveratrol is low because it is rapidly metabolized in the intestines and liver into conjugated forms, i.e.,
glucuronateand sulfonate. Only trace amounts (<5 ng/mL) of unchanged resveratrol have been detected in the
blood after a 25-mg oral dose [9].
Boron supplements have been reported to lower the platelet count and potentially decrease the risk of thrombosis
[32], and experimental evidence has been obtained for the likely usefulness of boron-containing thrombin
inhibitors in the treatment of cardiovascular disorders [33]. Recent studies in animal models have suggested that
boron deprivation increases the concentrations of plasma homocysteine [34] and insulin [35], which have been
suggested as risk factors for heart disease. For this trial, we chose this combination of CF and resveratrol because
previous research has suggested that CF stabilizes resveratrol degradation in the digestive tract [17], CF has been
shown to be an important anti-inflammatory agent [11,15], and resveratrol has been found to have antioxidant
properties [36]. CF also is an antioxidant [11]."
dose used for this study:
Calcium Fructoborate = 112[mg/day];
Resveratrol = 20[mg/day]
1.121. Temporary anti-cancer & anti-pain effects of mechanical stimulation of any one of 3 front teeth (1st incisor, 2nd
incisor, & canine) of right & left side of upper & lower jaws and their possible mechanism, & relatively long term
disappearance of pain & cancer parameters by one optimal dose of DHEA, Astragalus, Boswellia Serrata, often
with press needle stimulation of True ST. 36.
"One minute downward pressure on the tip of any one of the front 3 teeth ... by a wooden toothpick induced
temporary disappearance ... of abnormally increased pain parameters ... and cancer parameters ... of Astrocytoma,
Glioblastoma, squamous cell carcinoma of esophagus, adenocarcinoma of lung, breast cancer, adenocarcinoma of
colon, prostate cancer).
The effect included temporary disappearance of headache, toothache, chest and abdominal pain, and backache,
often with improved memory & concentration.
...Repeated daily press needle stimulation of True ST. 36 increased NC telomere 450-700 ng BDORT units.
One optimal dose of DHEA increased NC telomere 525 ng DBORT units and eliminated the pain and abnormally
increased cancer parameters; effect of one optimal dose lasted 0.5-11 months.
One optimal dose of Boswellia Serrata or Astragalus not only increased NC telomere 650 ng BDORT units,
eliminating pain and cancer parameters, but also reduced the size of the Astrocytoma grade I by 10-20% and the
Glioblastoma by 15-90% in less than 2-6 months in some patients, as long as high NC telomere is maintained."
1.122. Pomegranate
Cytotoxicity of Pomegranate Polyphenolics in Breast Cancer Cells in Vitro and Vivo - Potential Role of
miRNA-27a and miRNA-155 in Cell Survival and Inflammation
"Pomegranate (Punica granatum L.) is rich in polyphenols. The predominant and therapeutically relevant
compounds are ellagic acid, ellagitannins, flavonoids, and 3-glucosides/3,5-diglucosides of the anthocyanins
delphinidin, cyanidin, and pelargonidin [18], that exert antioxidant, anti-inflammatory, and anticarcinogenic
activities in vitro and vivo [19–21]. Polyphenolics from pomegranate juice and peels inhibited aromatase activity
relevant to the prevention of breast cancer [2, 22], exhibited cytotoxic activities in hepatocellular carcinomas in
rats [23], and suppressed chemical-induced colon cancer in rats [10, 24]. The inhibition of NF-?B and other
inflammatory markers by pomegranate polyphenolics have been reported for breast [2, 5], lung [3, 4] and
prostate cancer cell lines ...
Treatment with Pg (0.8mg GAE (galvanic acid equivalent)/kg/day/) (for 35 days) significantly decreased tumor
volume and weight ...
Pg decreased breast cancer cell growth, and tumor volume and activated caspase-3 ... induce apoptosis in cancer
cell lines including breast, prostrate, liver, lung and skin cancer involving multiple pathways and inducing
apoptosis involving caspase-3 [2–4, 23, 46, 52]. Previous studies have observed resistance of non-cancer cells to
the effects of polyphenolics observed in this study (Fig 2a) has been previously reported with delphinidin
(anthocyanin) from pomegranate extracts [2, 53, 54]. The effects of Pg extract on inhibition of tumor growth
in anthymic nude mice bearing BT474 cells as xenografts (Fig. 7a) has also been observed in nude mice bearing
prostrate, pancreatic and breast cancer cells"
Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in
vivo efficacy of docetaxel chemotherapy.
"We demonstrated that POMx exhibited potent in vitro cytotoxicity in metastatic castration-resistant PCa cells. ...
The in vivo administration of POMx treatment effectively inhibited survivin, induced apoptosis, retarded C4-2
tumor growth in skeleton and significantly enhanced the efficacy of docetaxel in athymic nude mice."
Anticancer activities of pomegranate extracts and genistein in human breast cancer cells.
"Both pomegranate extracts and genistein had significant (dose- and time-dependent) cytotoxic and growth
inhibition effects on MCF-7 cancer cells. Both growth inhibition and cytotoxicity were significantly higher (P < .01)
in the combination treatments than in the single treatments with either agent."
Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells.
"Fatty acids from pomegranate, tung, and catalpa were cytotoxic to human monocytic leukemia cells at
concentrations exceeding 5 microM for pomegranate and tung and 10 microM for catalpa, but fatty acids from pot
marigold oil had no effect at concentrations ranging up to 163 microM."
Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic
agents for leukemia.
"We investigated the potential effect of PJE on induction of apoptosis and inhibition of cellular proliferation in 8
leukemia cell lines (4 lymphoid and 4 myeloid) and nontumor hematopoietic stem cells (control cells) ... PJE
significantly induced apoptosis in all cell lines, including nontumor control cells, although lymphoid cells and 2 of
the myeloid cell lines were more sensitive."
Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.
"Thus, our data show that PFE significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a
chemopreventive agent for human lung cancer."
Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence
"Recent research has shown that pomegranate extracts selectively inhibit the growth of breast, prostate, colon and
lung cancer cells in culture. In preclinical animal studies, oral consumption of pomegranate extract inhibited
growth of lung, skin, colon and prostate tumors. ...
The antioxidant activity of flavonoids obtained from pomegranate juice (PJ) was observed to be close to that of
butylated hydroxyanisole, green tea, and significantly greater than red wine (2,3). Commercially available
pomegranate juices ... showed antioxidant activity ... three times higher than those of red wine and green tea ...
Cancer Type Pomegranate Fraction
Breast Juice, seed-oil, fermented juice polyphenols, extract
Prostate Seed-oil, fermented juice polyphenols, extract, juice
Lung Fruit extract
Colon Seed-oil, juice
Skin Seed-oil, fruit extract
Leukemia Fresh and fermented juice"
Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model.
"equivalent to 250 and 500 ml of pomegranate juice ...
Compared with respective water-fed groups, none of the mice in PFE-supplemented groups exhibited metastases
to any of the distant organs at 20 weeks and only 20% mice exhibited metastasis at 34 weeks of age. Many of the
PFE-supplemented animals had multiple foci of well-differentiated carcinoma but no evidence of poorly
differentiated carcinoma."
1.123. Carnivora
Carnivora (extract from a venus flytrap plant)
Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer
"... chemopreventive and therapeutic compounds ... from food plants... flavonoids (carrots) including chalcones,
isothiocyanates (cabbage), lycopene (tomatoes), indoles, organosulfides (garlic), and polyphenols (curcumin) ...
compounds can also be found in food preparations ... resveratrol ... catechins and procyanidins and polyphenols
from cocoa ... quercetin and kaempferol from honey
... carnivorous plants ... traditional medicine ... butterworts (Pinguicula vulgaris, Pinguicula alpina) were used for
the treatment of wounds. Decoctions of butterworts and sundew (Drosera rotundifolia) ... respiratory diseases like
pertussis, bronchitis, and asthma ... stomach pain and tuberculosis. ... ability to promote delivery. ... syrups to treat
coughs. ... local application on warts or bunions
... purple pitcher plant Sarracenia purpurea ... diuretic and laxative properties and also to treat fever, cough, and diabetes. ... scarlet fever, smallpox, and measles. ... ease labor, to prevent sickness after childbirth and to treat
absence of menstrual cycle
... pitcher plant Nepenthes khasiana ... stomach pain and eye troubles (pain, cataract, night blindness), urinary
troubles but also skin diseases. ... malaria, leprosy, and cholera patients
Plumbagin
... anti-bacterial, anti-fungal, anti-inflammatory, and anti-cancer properties. ... present in others plants like
Limonium axillare or walnut trees (Juglans sp.) ... other carnivorous plants like N. khasiana, Nepenthes gracilis,
or Drosera binata (64, 137, 138). ... cardiotonic, neuroprotective, and hepatoprotective properties ...
... breast cancer ... melanoma ... lung cancer ... inhibits the growth of tumors and the number of metastasis ...
ovarian and prostate-cancer cells ... plumbagin has an oral bioavailability of about 40% in conscious freely
moving rat models and that plumbagin is detected in a micromolar range 1 h after administration
Phenolic acids
Ellagic acid
... many other plants such as pomegranate (Punica granatum), Terminalia chebula fruit (yellow myrobalan), berry
fruits (blueberry, blackberry, and strawberry), Vitis rotundifolia (Muscadine grapevine), or black walnut (Juglans
nigra) .. digestibility-reducing compounds .. anti-bacterial agent ... chemopreventive agent ... pancreatic cancer ...
prostate carcinoma ... colon cancer ... breast cancer ...
Gallic acid
... bitter orange tree flowers (Citrus aurantium), Marrubium persicum, yellow myrobalan fruit (T. chebula),
Acalypha australis, Pleurotus sp., Vitis sp. seeds, rose myrtle (Rhodomyrtus tomentosa), Mysore raspberry
(Rubus niveus), white sorghum, or carrot ... anti-bacterial and anti-fungal properties ...
... anti-cancer ... leukemia ... gastric carcinoma ... prostate-cancer ... osteosarcoma ...
Vanillin
... inhibits growth of mammary adenocarcinoma ... reduces the number of lung metastasis ... lung cancer ...
colorectal cancer ... vanillin has a relatively good bioavailability (7.6%). ...
Protocatechuic acid
... in plants like True roselle (Hibiscus sabdariffa), Rhizoma homalomenae, Spatholobus suberectus, and Alpinia
oxyphylla ... inhibits AGS (human stomach adenocarcinoma) ... melanoma ... hepatocellular carcinoma ... pre-
treatment of HepG2 with N-acetyl-l-cysteine (NAC) blocks the cytotoxic effect of protocatechuic acid ... leukemia
cells ...
Caffeic acid
Present in Vitis sp. seeds, pomegranate (P. granatum), coffee beans, honey, common daisy (Bellis perennis), and
hyssop (Hyssopus officinalis), ... anti-bacterial and anti-fungal ... human fibrosarcoma ... colon cancer ... breast
cancer ...
Chlorogenic acid
... plants like prune (Prunus domestica), japanese honeysuckle (Lonicera japonica), apple, plum, Eucommia
ulmodies, and coffee beans ... Human adenocarcinoma ... leukemia cells ... lung cancer ...
Chlorogenic acid has a very low bioavailability but is always present in the small intestine...
Ferulic acid
... in seeds like Vitis sp. seeds brown rice, but also wheat flour, pineapple, creosote bush (Larrea divaricata). ...
Ferulic acid pre-treatment protects against ?-radiation-induced DNA damage in hepatocytes and significantly
increases anti-oxidant enzymes, GSH, vitamins A, E, and C (203). ... ferulic acid prevent tumor development ...
prevented skin tumor formation but that topical application does not ... colon cancer ... anti-oxidant that can
reduce DNA strand breaks induced by ?-irradiation in peripheral blood leukocytes and bone marrow ...
Salicylic acid
... treat aches and pains ... willow tree bark ... the main metabolite of acetylsalicylic acid, the active principle of
aspirin. ... Salicylic acid has no effect on CaCo-2 (colon carcinoma cells) proliferation under normoxic conditions
but increases caspase-3/7 activities and increases phosphorylation of ERK 1/2 under hypoxic conditions...
colorectal cancer ... a dose of 75 mg of aspirin per day during several years reduces colorectal cancer incidence
and mortality ...
Flavonoids
... flavonols (quercetin, myricetin, and kaempferol), flavones, flavanones, flavanols, anthocyanins,
dihydroflavonols, isoflavones, and chalcones. ...
Quercetin
... bitter orange tree flowers (Citrus aurantium), Epilebium species, Nepenthes gracilis, Leucaena leucocephala,
S. purpurea, caper (Capparis spinosa), and chili peppers (Capsicum sp.) ...
hepatocellular carcinoma ... Quercetin used in combination with 5-fluorouracil (5-FU) on EC9706 and Eca109
esophageal cancer cells ... cervical cancer ... colon cancer patients treated with quercetin, rutin, or with sulindac
(NCT00003365). ... ovarian cancer refractory to cisplatin ... hepatocellular ... with genistein ... prostate-cancer
patients (NCT01538316). ... quercetin has a very low bioavailability. ...
Myricetin
... present in many plants ... Limonium axillare, Jatropha curcas, Japanese cypress (Chamaecyparis obtusa),
Leucaena leucocephala, and many berries ...
anti-bacterial ... anti-cancer ... pancreatic cancer ... bladder carcinoma ... leukemia ... colon carcinoma ...
regression of tumor growth and a decrease of metastasis ... increase bioavailability of tamoxifen, a drug used to
treat breast cancer. Similar results were observed for doxorubicin ...
Kaempferol
... in many plants like Nepenthes gracilis, chili peppers, Gynura medica, Bracken (Pteridium aquilinum), Ginkgo
biloba ... anti-cancer properties ... oral cancer ... ovarian cancer ... kaempferol enhances the effect of cisplatin in
ovarian cancer ...
Conclusion
... more than 15 compounds ... Currently only several compounds like quercetin, salicylic acid, and kaempferol
have moved to pharmacokinetic studies and clinical trials ... these compounds have a very poor bioavailability ...
it has been shown that co-treatment of two natural molecules like quercetin and kaempferol and a
chemotherapeutic drug like cisplatin or etoposide is more efficient than a single treatment ... Low bioavailability
and incompletely absorbed compounds are ineffective against metastatic and invasive cancers.
Clinical trials involving natural compounds present in Dionaea muscipula Solander ex Ellis.
One of the most promising anti-cancer compounds is probably plumbagin. ...
Most natural compounds isolated from D. muscipula like plumbagin, quercetin, myricetin, ellagic acid, or vanillin
have multiple effects and act as anti-cancer drugs with multiple targets on different types of cancers. ..."
1.124. Quercetin and other bioflavonoids
Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and
cyanidin in primary cultures of human retinal pigment epithelial cells.
"Vegetable polyphenols (bioflavonoids) have been suggested to represent promising drugs for treating cancer and
retinal diseases. We compared the effects of various bioflavonoids (epigallocatechin-3-gallate [EGCG], luteolin,
apigenin, myricetin, quercetin, and cyanidin) on the physiological properties and viability of cultured human retinal
pigment epithelial (RPE) cells. ...
The intake of luteolin, apigenin, myricetin, and quercetin as supplemental cancer therapy or in treating retinal
diseases should be accompanied by careful monitoring of the retinal function. The possible beneficial effects of EGCG
and cyanidin, which had little effect on RPE cell viability, in treating retinal diseases should be examined in further
investigations"
Quercetin
Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell
model systems.
"... phytoestrogens ... mimic the actions of endogenous estrogens. Among these, quercetin ... has been reported as
estrogenic in some occasions. However, quercetin occurs in substantial amounts as glycosides such as
quercetin-3-O-glucoside (isoquercitrin) and quercetin-3-O-rutinoside (rutin) in dietary sources. ...
quercetin-3-O-glucuronide, one of the main human phase II metabolites produced after intake of dietary quercetin,
displays ERa- and ERß-dependent estrogenic activity, the functional consequences of which might be related to the
protective activity of diets rich in quercetin glycosides."
Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin
in rat intestine in vitro.
Liposomal quercetin: evaluating drug delivery in vitro and biodistribution in vivo.
Induction of apoptosis and inhibition of angiogenesis by PEGylated liposomal quercetin in both cisplatin-sensitive
and cisplatin-resistant ovarian cancers.
Isoquercitrin
Isoquercitrin: Pharmacology, toxicology, and metabolism.
"Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in
vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions.
Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is
extensively metabolized in the intestine and the liver. Biotransformation of isoquercitrin includes deglycosylation,
followed by formation of conjugated and methylated derivatives of quercetin or degradation to phenolic acids and
carbon dioxide. The acceptable daily intake of (95%) isoquercitrin and of EMIQ was estimated to be 5.4 and
4.9mg/kg/day, respectively. Adverse effects of higher doses in rats included mostly (benign) chromaturia;
nevertheless some drug interactions may occur due to the modulation of the activity and/or expression of drug
metabolizing/transporting systems."
Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway.
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated
hepatocellular tumor promotion of oxfendazole in rats.
Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than
other quercetin glycosides or aglycone after oral administration in rats.
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin
cellular localization.
Troxerutin (from Sophora Japonica)
Radioprotective effects of troxerutin against gamma irradiation in V79 cells and mice.
Rutin
The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful
peripheral neuropathy.
Flavonoid rutin increases thyroid iodide uptake in rats.
Rutin exerts antitumor effects on nude mice bearing SW480 tumor.
colon cancer
rutin: 3-rhamnosyl-glucosylquercetin; 20[mg/kg]
Myricetin
1.125 Green / Black tea, Coffee
Apoptogenic effects of black tea on Ehrlich’s ascites carcinoma cell
rats were given black tea instead of water.
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
rats were given 0.02% caffeine in drinking water.
Note: 0.02% is approximately the level of caffeine in strong green or black tea.
For strong coffee it is about 0.08%.
1.126 Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435
breast cancer cells in vivo
"Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose
range of 0.8 – 1.6 mg/day ... Conversion to equivalent human intake for future clinical studies using the body
surface area (BSA) normalization method gave a dose of ~370.6 mg/day for a human adult of 60 kg, which can
be supplied by consuming 2 to 3 peach fruit per day or alternatively using a dietary supplement peach polyphenol
extract powder."
1.127 Bee propolis; Bee pollen; Royal jelly
Functional properties of honey, propolis, and royal jelly.
Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk
markers: results of a pilot open-uncontrolled trial.
"Melbrosia may offer a potential alternative to hormone therapy for the treatment of menopausal symptoms. ...
this study's uncontrolled, open-label"
Melbrosia content per 1 capsule:
257 mg of pollen,
150 mg of Perga (fermented pollen),
hydroxypropylmethyl cellulose 95 mg,
33 mg of lyophilized royal mletsitse (royal jelly),
20 mg Acerola extract.
Bee propolis
Notes: content of active ingredients varies depending on region
Caffeic acid phenethyl ester (CAPE) is often studied independently. It does not have effect on estrogen.
Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic
Targets via an Epigenetically Mediated Mechanism of Action.
"... CAPE and propolis, cause an accumulation of acetylated histone proteins in MCF-7 (ER+) and MDA-MB-231
(ER-/PR-/Her2-) cells with associated decreases in ER and PR in MCF-7 cells, and upregulation of ER and decrease
in EGFR in MDA-231 cells. ... Interestingly, propolis, when normalized for CAPE content, appears to be more potent
than CAPE alone similarly to the greater effects of complete foods than isolated components."
Amelioration of renal carcinogenesis by bee propolis: a chemo preventive approach.
Ethanolic Extract of Polish Propolis: Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic
Activity against Prostate Cancer Cells
Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line.
"... human colon cancer cell line HCT-116 ... All tested propolis samples had pronounced cytotoxic and
antioxidative activities."
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro.
Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells.
Anti-tumor effects of water-soluble propolis on a mouse sarcoma cell line in vivo and in vitro.
Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro
tube formation and endothelial cell proliferation.
Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor
in mice.
"Water-soluble derivative of propolis increases macrophage activity and sensitivity of tumor cells to HIPEC and
reduces cisplatin toxicity to normal cells."
Estrogenic effects of ethanol and ether extracts of propolis.
"Animals treated with EEP (ethanol extract of propolis) or REP (ether extract of propolis) for 4 days (500-1000
mg/kg per day, s.c.) exhibited significant dose-dependent increases in uterine wet weight. ... The results suggest
that propolis produces estrogenic effects through activation of estrogen receptors."
Glycemic control and anti-osteopathic effect of propolis in diabetic rats
Effect of propolis on insulin resistance in fructose-drinking rats
"Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma
level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose
and total cholesterol levels, and tended to decrease systolic blood pressure."
Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin
resistance in OLETF rats by intake of propolis extracts.
Effect of propolis on mast cells in wound healing.
"topical application of 30% propolis alcoholic extract"
Therapeutic effects of propolis essential oil on anxiety of restraint-stressed mice.
"propolis essential oil (PEO) could significantly reverse the anxiety-like behavior of restraint-stressed mice, and
has no effect on locomotor activity. Furthermore, PEO significantly decreased the plasma levels of cortisol
(CORT), adrenocorticotropic hormone (ACTH) and malondialdehyde (MDA), whereas it increased the activity
of superoxide dismutase (SOD) in restraint-stressed mice. These results strongly suggest that PEO has therapeutic
effects on anxiety through antagonizing the hyperfunction of hypothalamic-pituitary-adrenal (HPA) axis and
improving the ability of antioxidation in brain tissue."
Royal Jelly
Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells.
"Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the
proliferation of cells in the absence of BPA."
GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and
breast cancer cells.
"GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane,
Lycopene and Royal jelly.
... high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3 (prostate cancer), MCF7
(breast cancer), and SW480 (colon cancer)), as well as on the EA.hy 926 endothelial cell line in a dose-dependent
manner."
Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin.
"RJ elicited a significant protective effect towards liver and kidney ... significantly enhanced apoptotic cell
numbers and degenerative changes by cisplatin, but these histological changes were lower in the liver and kidney
tissues of RJ + CDDP group. Besides, treatment with RJ lead to an increase in antiapoptotic activity hepatocytes
and tubular epithelium. In conclusion, RJ may be used in combination with cisplatin in chemotherapy to improve
cisplatin-induced oxidative stress parameters and apoptotic activity."
Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a
randomized clinical trial.
"1,000 mg royal jelly soft gel ... for 8 weeks. ... the mean fasting blood glucose decreased remarkably ... significant
reduction in the mean serum glycosylated hemoglobin levels ... significant elevation in the mean insulin
concentration"
Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines.
Royal jelly has estrogenic effects in vitro and in vivo.
Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly,
in stress-inducible depression-like mouse model.
"10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against
the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the
stress loading. ... RJ given by the oral route was less effective. "
Contribution of lipids in honeybee (Apis mellifera) royal jelly to health.
"Lipids in RJ are useful as preventive and supportive medicines with functionalities that include potential inhibitors
of cancer growth, immune system modulators, alternative therapies for menopause, skin-aging protectors,
neurogenesis inducers, and more."
Bee Pollen
Antiestrogenic and antigenotoxic activity of bee pollen from Cystus incanus and Salix alba as evaluated by the
yeast estrogen screen and the micronucleus assay in human lymphocytes.
"At least one preparation from each species showed a marked antigenotoxic effect against the action of the
anticancer drugs mytomicin C, bleomycin, and vincristine. Bee pollens from C. incanus and S. alba were found to
be neither genotoxic nor estrogenic as well as effective estrogen inhibitors, and able to reduce the chromosome
damage induced by the three cancer drugs used, thus supporting their use as a safe food supplement and future
chemoprotective/chemopreventive agents."
Probable interaction between warfarin and bee pollen.
1.128. Mushrooms
Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26
colon cancer-tansplanted mice.
Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom
with amazing health benefits.
"hepatopathy, chronic hepatitis, nephritis, hypertension, hyperlipemia, arthritis, neurasthenia, insomnia,
bronchitis, asthma, gastric ulcers, atherosclerosis, leukopenia, diabetes, anorexia, and cancer"
Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.
"Severe combined immunodeficient mice injected with IBC cells treated with Reishi for 13 weeks show reduced
tumor growth and weight by ~50%"
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of
Coriolus versicolor and Ganoderma lucidum.
"chemopreventive potential of I'm-Yunity (trade name for Trametes versicolor) may be enhanced by adding
Ganoderma lucidum"
Antihepatoma activity of the acid and neutral components from Ganoderma lucidum.
"The supercritical fluid extracts of Ganoderma lucidum (total component, TC) and its acid component (AC) and
neutral component (NC), were evaluated in vitro and in vivo for their antihepatoma activities. The NC showed a
conspicuous inhibitory effect on tumor growth of Heps-bearing mice, whereas AC was less effective."
Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
"We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma
lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly
acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated
subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited
stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other
rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. ... Thus, our results suggest that GLme
might be a good candidate for treatment of diverse forms of cancers."
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
"Ganoderic acid T (GA-T), which is a lanostane triterpenoid purified from methanol extract of G. lucidum mycelia,
was found to exert cytotoxicity on various human carcinoma cell lines in a dose-dependent manner, while it was
less toxic to normal human cell lines. Animal experiments in vivo also showed that GA-T suppressed the growth of
human solid tumor in athymic mice. It markedly inhibited the proliferation of a highly metastatic lung cancer cell
line"
1.129 L-Methionine
L-Methionine inhibits growth of human pancreatic cancer cells.
"L-methionine inhibits proliferation of breast, prostate, and colon cancer cells ...
L-methionine inhibits proliferation and interferes with the cell cycle of BXPC-3 and HPAC pancreatic cancer cells;
the effects on apoptosis remarkably persisted after methionine withdrawal"
Methionine
1.130. ProstaCaid
Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.
"contains mycelium from medicinal mushrooms (Ganoderma lucidum, Coriolus versicolor, Phellinus linteus), saw
palmetto berry, pomegranate, pumpkin seed, green tea [40% epigallocatechin-3-gallate (EGCG)], Japanese
knotweed (50% resveratrol), extracts of turmeric root (BCM-95®), grape skin, pygeum bark, sarsaparilla root,
Scutellaria barbata, eleuthero root, Job's tears, astragalus root, skullcap, dandelion, coptis root, broccoli, and
stinging nettle, with purified vitamin C, vitamin D3, selenium, quercetin, citrus bioflavonoid complex,
β sitosterolzinc, lycopene, α lipoic acid, boron, berberine and 3.3'-diinodolymethane (DIM).
We show that PC treatment resulted in the inhibition of cell proliferation of the highly invasive human hormone
refractory (independent) PC-3 prostate cancer cells in a dose- and time-dependent manner ...
In addition, PC also suppresses metastatic behavior of PC-3 by the inhibition of cell adhesion, cell migration and
cell invasion"
1.131. Hypothermia
Increases metastasis if only hypothermia is used!!!
Hypothermia activates adipose tissue to promote malignant lung cancer progression.
Hypothermic microenvironment plays a key role in tumor immune subversion.
Hypothermia affects on the body
Hypothermia can be a result of chemotherapy and it is also observed in some cancer patients in general.
Maybe it is best to use hyperthermia instead of hypothermia during chemo therapy ...?
Hypothermia during chemotherapy for Hodgkin's disease.
Some protective effect during radiation and chemotherapy, but also potential serious side effects
[Radioprotective effect of local hypothermia].
Selective protection of non-cancer cells by hypothermia.
Hypothermia and cancer chemotherapy.
Main use during chemotherapy:
used for protection against hair loss during chemotherapy
Some positive effect if used with hyperthermia (i.e. cold/hot cycles).
Specifically used for treatments of tumors that are accessible (cryo-surgery).
Immunological response induced by alternated cooling and heating of breast tumor.
Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report
Immunological Response Induced by Alternated Cooling and Heating of Breast Tumor
1.132. Diet and Fasting
Fasting improves efficacy of radiation therapy
Up to 48 hour fasting cycles.
Fasting triggers stem cell regeneration of damaged, old immune system
Up to 72 hour fasting prior chemotherapy.
Fasting May Improve Cancer Chemotherapy
"starvation for 48 to 60 hours before chemotherapy"
normal cells go to hibernation mode and remain protected, while cancer cells remain in growth mode and are
sensitive to the drugs.
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
"Cycles of starvation (fasting) were as effective as chemotherapeutic agents in delaying progression of specific
tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In
mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs—but not either treatment alone--
resulted in long-term cancer-free survival. ... These studies suggest that multiple cycles of fasting promote
differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy
of certain toxic chemotherapy drugs in the treatment of various cancers."
Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose
chemotherapy
To Eat or Not to Eat: With Cancer Therapies, That Is the Question
"patients who voluntarily underwent short-term fasting before and/or after cytotoxic chemotherapy infusion.
Patients reported fewer side effects, including fatigue, weakness, and gastrointestinal problems, when they
fasted. ...
fasting renders cancer cells more sensitive to chemotherapy.
Normal cells reduced the expression of genes associated with cell growth and division and diverted their energy to
cellular maintenance pathways that protect normal cells from stressful conditions and repair stress-induced damage.
In contrast, cancer cells reduced the expression of many protective genes, which made them more likely to die ...
Fasting also deprives cancer cells of the glucose and other molecules they need to fuel their endless cell division.
Therefore, fasting adds a second stressor on top of chemotherapy, forcing cancer cells to deal "with two extreme
environments at once," ...
Fasting before administering the drug had a stronger effect ...
In mouse models of metastatic melanoma, breast cancer, and neuroblastoma, fasting combined with high-dose
chemotherapy extended survival ...
patients would refuse a water-only fast, so the international trials will use a substitution diet called Chemolieve"
Note:
Fasting for more than 18 hours depletes the glycogen in the liver forcing the body into ketosis.
This is similar to the ketogenic diet therapy (with 2-DG) [Ref.1.51, 1.52, 3.4].
Also, the effect may be similar for the IPT therapy which relies on bringing the blood sugar low during
drug administration [Ref.1.58].
See also Diet web pages (diet calculator, ketogenic diet, raw vegan diet, Gerson therapy,
fasting and reduced calorie diet, Mediterranean diet).
1.133. Probiotics
Gut Flora Boost Cancer Therapies
Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer
in mice.
Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B₁-induced liver carcinogenesis
in rats.
Kefir
1.134. Essential Oils
Rosemary(oil/extract):
types of cancer affected:
http://www.ncbi.nlm.nih.gov/pubmed/21955093
breast cancer:
http://www.ncbi.nlm.nih.gov/pubmed/24615943
Vit. D3 + rosemary (leukemia):
http://www.ncbi.nlm.nih.gov/pubmed/16395705
nerve growth / glioblastoma:
http://www.ncbi.nlm.nih.gov/pubmed/14600414
colon cancer:
http://www.ncbi.nlm.nih.gov/pubmed/21112365
anti angiogenesis:
http://www.ncbi.nlm.nih.gov/pubmed/22173778
oral application:
http://www.ncbi.nlm.nih.gov/pubmed/24598693
taken as food: 1% dry rosemary extract (mixed with food) and 1 microg Ro25-4020 (D3 derivative) resulted in a
strong cooperative antitumor effect, without inducing hypercalcemia.
http://www.ncbi.nlm.nih.gov/pubmed/16395705
oral application: http://www.ncbi.nlm.nih.gov/pubmed/24598693
same article - full version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943728/
The other 8 mice in the treated group received rosemary extract (100 mg/kg) dissolved in olive oil orally for 22
days. ... slower tumor growth.
Eucalyptus oil:
breast cancer:
http://www.ncbi.nlm.nih.gov/pubmed/18075306
ulcer treatment (effective in 3..4 days):
http://www.ncbi.nlm.nih.gov/pubmed/16785038
improved topical delivery for curcumin:
http://www.ncbi.nlm.nih.gov/pubmed/21297295
strong anti bacterial and anti fungal activity: http://www.ncbi.nlm.nih.gov/pubmed/18075306
- I guess this means that should not be taken orally or should be taken with probiotics.
topical application: http://www.ncbi.nlm.nih.gov/pubmed/16785038
Ginger oil:
toxicity in rats:
http://www.ncbi.nlm.nih.gov/pubmed/21960667
liver cancer:
http://www.ncbi.nlm.nih.gov/pubmed/19061005
oral application - up to 500mg/kg - no toxicity in rats: http://www.ncbi.nlm.nih.gov/pubmed/21960667
test with 100mg/kg: http://www.ncbi.nlm.nih.gov/pubmed/19061005
Mentha oil:
http://www.ncbi.nlm.nih.gov/pubmed/20602517
protection for gamma radiation:
http://www.ncbi.nlm.nih.gov/pubmed/15305314
oral application - 40 micro L/animal (per day for 3 days): http://www.ncbi.nlm.nih.gov/pubmed/15305314
albino mice approximate weight = ~30g. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764869/
=> 40 micro L/30 g = 40*10^(-6) / 30 * 10^(-3) [L/kg] = 1.3ml/kg
Lemon balm:
http://www.ncbi.nlm.nih.gov/pubmed/22938456
oral application - 100mg/kg : Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo
or copy paste this link if the one above does not work:
http://www.researchgate.net/publication/230780733_Antitumoral_effects_of_Melissa_officinalis_on_breast_cancer_in_vitro_and_in_vivo/file/3deec52cbeee6bfc11.pdf
Lemon balm (WebMD)
Tea tree:
topical use with DMSO: http://www.ncbi.nlm.nih.gov/pubmed/22727730
http://www.ncbi.nlm.nih.gov/pubmed/20577741
Myrrh:
oral application(?) - 100mg/kg , 200mg/kg: http://www.ncbi.nlm.nih.gov/pubmed/21167270
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796379/
Frankincense:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796379/
Thyme oil:
http://www.ncbi.nlm.nih.gov/pubmed/15339564
http://www.ncbi.nlm.nih.gov/pubmed/23994707
http://www.ncbi.nlm.nih.gov/pubmed/17934650
(applied by intra-tumoral injection)
http://www.ncbi.nlm.nih.gov/pubmed/24218968
http://www.ncbi.nlm.nih.gov/pubmed/21273584
http://www.ncbi.nlm.nih.gov/pubmed/20657472
tested 10 oils for prostate, lung and breast cancer cells
- thyme was best
- most effective for prostate cancer
oral application - 40 g/kg alchohol extract: http://www.ncbi.nlm.nih.gov/pubmed/15339564
injection: http://www.ncbi.nlm.nih.gov/pubmed/17934650
Oregano
http://www.ncbi.nlm.nih.gov/pubmed/21535822
http://www.ncbi.nlm.nih.gov/pubmed/19373612
oral application is OK, dose = ?
Black seed:
oral application is safe, dose ?: http://www.ncbi.nlm.nih.gov/pubmed/22083982
Clove oil:
http://www.ncbi.nlm.nih.gov/pubmed/22292639
use: ?
Aroma therapy + massage for boosting the immune system
http://www.ncbi.nlm.nih.gov/pubmed/23886205
1.135 Spirulina (C-phycocyanin, 9-HpbD-a)
Chemoprevention of rat mammary carcinogenesis by spirulina.
Antidiabetic potential of phycocyanin: effects on KKAy mice.
Antihyperglycemic effect of crude extracts of some Egyptian plants and algae.
The apoptosis pathway of photodynamic therapy using 9-HpbD-a in AMC-HN3 human head and neck cancer cell line
and in vivo.
The effect of hydrolyzed Spirulina by malted barley on forced swimming test in ICR mice.
1.136 Dandelion
Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic
cancer cells.
"Dandelion Root Extract has the potential to induce apoptosis and autophagy in human pancreatic cancer cells with
no significant effect on noncancerous cells."
Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia
(CMML) cells.
Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal
tumorigenesis.
"Green Tea Extract, green tea and Dandelion tea caused decrease in tumor multiplication, tumor size and
tumor volume"
The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.
Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion
root extract.
Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.
"crude extract of dandelion leaf (DLE) decreased the growth of MCF-7/AZ breast cancer cells in an ERK-dependent
manner, whereas the aqueous extracts of dandelion flower (DFE) and root (DRE) had no effect on the growth of either
cell line. Furthermore, DRE was found to block invasion of MCF-7/AZ breast cancer cells while DLE blocked the
invasion of LNCaP prostate cancer cells, into collagen type I."
Anti-carcinogenic activity of Taraxacum plant. I.
"An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on
the two-stage carcinogenesis of mouse skin tumor"
Anti-carcinogenic activity of Taraxacum plant. II.
"exhibited potent anti-tumor-promoting activity in the two-stage carcinogenesis tests of mouse skin ... showed a
remarkable inhibitory effect on mouse spontaneous mammary tumors"
1.137 IP6 (Inositol hexaphosphate)
Inhibition of skin cancer by IP6 in vivo: initiation-promotion model.
Mammary tumor inhibition by IP6: a review.
IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer
xenotransplanted in nude mice.
"IP6 inhibits the formation of liver cancer and regresses pre-existing human hepatic cancer xenograft; therefore, it
has the potential for clinical use as a preventive and therapeutic agent for hepatocellular carcinoma as well."
Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric
magnetic resonance study.
"oral IP6 supplement blocks growth and angiogenesis of prostate cancer in the TRAMP model in conjunction with
metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting a
practical and translational potential of IP6 treatment in suppressing growth and progression of prostate cancer in
humans."
Phytic acid--anticancer nutriceutic
"There has been observed an inhibition of tumor growth and induction of cell differentiation in the presence of IP6 in
a few cancer cell lines including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma."
Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice.
Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer.
Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells.
Anti-angiogenic activity of inositol hexaphosphate (IP6).
In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like
growth factor binding protein-3 and inhibition of vascular endothelial growth factor.
Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and
invasion of MDA-MB 231 human breast cancer cells.
Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer.
WebMD link
- blood thinner, binds to iron in food, binds to calcium in food
Inositol, IP3 and IP6
2. Diabetes and other chronic illneses
2.1. The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
Rutin - 5mg/kg
" In the STZ-induced diabetic rats, blood glucose level was decreased by the antioxidant activities and anti-
inflammatory effects of rutin. Also, the pancreas, heart, liver, kidney, and retina tissues that were related to diabetic
complications were functionally and formatively protected by rutin. Therefore, it is suggested to apply rutin clinically
for the treatment of diabetes and its complications"
2.2. Eye and Vision effects of Blueberry
"fermented bilberry extract (400 mg/day)"
"Feeding the rabbits with blueberries at a dosage of 1.2 or 4.9 g/kg/day for 4 weeks prior to light exposure effectively
reduced photodamage to the retinas."
2.3. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes.
"A 6-hour treatment with fermented juice potentiated glucose uptake by 48% in C2C12 myotubes and by 142% in 3T3-
L1 adipocytes, in the presence or absence of insulin, whereas nonfermented juice had no effect on transport."
"Although the active principles and their mechanisms of action remain to be identified, transformed blueberry juice
may nevertheless represent a novel complementary therapy and a source of novel therapeutic agents against diabetes
mellitus."
2.4. Omega-3 and Retinal Disease.
"Increased use of dietary omega-3 reduces pathologic growth of new blood vessels (angiogenesis) in various eye
diseases. A lower omega-6/omega-3 ratio is protective from angiogenesis. Supplementing with omega-3 may help
prevent the loss of vision in retinopathies such as diabetic retinopathy, retinopathy of prematurity and age-related
macular degeneration."
2.5. Microcirculation of the retina
"In severe ocular pathology such as retinopathies of various type, simple glaucoma and toxic amblyopia, anthocyanin
extract is reported to mitigate the changes at level of retinal vessels or to prevent the alterations in the visual field. The
potential efficacy of Indena 36% anthocyanin bilberry extract in the treatment of diabetic retinopathy was evaluated in
patients with a type 2 diabetes mellitus and non-proliferative retinopathy, which received 480 mg/day 36% bilberry
extract p.o., for 180 days. "
"The Bilberry extract induced a clear improvement in the retinopathy, with marked reduction or disappearance of
retinic haemorrhages."
2.6. Bilberry extract prevents hardening of blood vessels
"One rich in anthocyanin extracted from untreated bilberries, and the other extracted from yeast-fermented bilberries.
After 16 weeks, it was noticed that there was considerable inhibition in development of plaques pertaining to
atherosclerosis in both bilberry groups.
Lead researcher, Aurelie Mauray, said that the yeast-fermented bilberries extract exerts more effective anti-
atherogenic activity than the anthocyanin-rich bilberry extract, which suggests that fermentation generates new
compounds with better health-boosting properties, in comparison to the anthocyanin-rich standaridized extract."
2.7. Pycnogenol
Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy.
The major positive observation of this study is the visual improvement, which was subjectively perceived by 18 out of
24 patients in the Pycnogenol group. Testing of visual acuity using the Snellen chart showed a significant improvement
from baseline 14/20 to 17/20 already, after 2 months treatment, whereas no change was found in the control group.
Pycnogenol taken at this early stage of retinopathy may enhance retinal blood circulation accompanied by regression
of edema, which favorably improves vision of patients.
Pycnogenol for diabetic retinopathy. A review.
All of these studies unequivocally showed that Pycnogenol retains progression of retinopathy and partly recovers
visual acuity. Treatment efficacy of Pycnogenol was at least as good as that of calcium dobesilate. Pycnogenol was
shown to improve capillary resistance and reduce leakages into the retina. Tolerance was generally very good and side
effects were rare, mostly referring to gastric discomfort. In conclusion, treatment with Pycnogenol had a favourable
outcome in the majority of the patients with diabetic retinopathy.
Pycnogenol for diabetic retinopathy
2.8. Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats.
" Our results showed that chronic taurine supplement effectively improved diabetic retinopathy as changes of
histopathology and ultrastructure. ...
These results demonstrated that chronic taurine supplementation ameliorates diabetic retinopathy via anti-
excitotoxicity of glutamate in rats."
2.9. Curcumin
Curcumin and Diabetes: A Systematic Review
"Curcumin could favorably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycemia,
hyperlipidemia, and islet apoptosis and necrosis.
... prevent the deleterious complications of diabetes. Despite the potential tremendous benefits of this multifaceted
nature product, results from clinical trials of curcumin are only available in using curcumin to treat diabetic
nephropathy, microangiopathy and retinopathy so far."
Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy.
"Diabetes was diagnosed at least 5 years before inclusion and all patients had signs of retinal oedema and of
peripheral microangiopathy. Meriva® was administered at the dosage of 2 tablets/day (each tablet containing
500 mg Meriva® corresponding to 100 mg curcumin) for a period of at least 4 weeks in addition to the standard
management plan, while a comparable group of subjects (n = 39) followed the standard management plan alone.
... At 4 weeks, microcirculatory and clinical evaluations indicated an improvement of microangiopathy. In terms
of peripheral microangiopathy, in the Meriva® group, there was a significant improvement in the venoarteriolar
response (p<0.05) and a decrease in the score of peripheral oedema (p<0.05), a sign typically associated with the
failure of the venoarteriolar response. At the retinal level, high-resolution, duplex scanning, used to measure retinal
flow, showed improvements in the Meriva® treated patients. The evaluation of retinal oedema (Steigerwalt's scale)
showed an improvement associated with improved visual acuity (Snellen scale).
There were no clinical or microcirculatory effects in controls."
2.10. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral
neuropathy
"... daily lipoic acid (300–600 mg i.v.) plus methylcobalamin (500–1000 mg(micro gram?) i.v. or im.) (LA–MC)
with that of methylcobalamin alone (MC) on diabetic peripheral neuropathy (DPN).
... LA–MC combination therapy was significantly superior to MC monotherapy
... treatment with LA–MC for 2–4 weeks is associated with better outcomes in NCV and neuropathic symptoms
relative to MC treatment"
2.11. Manual acupuncture for treatment of diabetic peripheral neuropathy: a systematic review of randomized
controlled trials.
"manual acupuncture had better effect on global symptom improvement compared with mecobalamin , vitamin B1
and B12, and no treatment, and that the combination of manual acupuncture and mecobalamin had better effect
compared with mecobalamin alone on global symptom improvement"
2.12. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.
"Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg);
Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg),
biotin (200 µg), B12 (10 µg) and folic acid (1 mg);
Group P: placebo.
RESULTS:
67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved
from 3.45 to 0.64 (p=0.001) in group MVB,
from 3.96 to 1.0 (p=0.001) in group MV and
from 2.54 to 1.95 in placebo group after 4 months."
Note: List of nutrients in best result group:
Zinc (20 mg),
Magnesium (250 mg),
Vitamin C (200 mg),
E (100 mg),
B1 (10 mg),
B2 (10 mg),
B6 (10 mg),
Biotin (200 µg),
B12 (10 µg),
folic acid (1 mg)
2.13. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic
neuropathy.
"Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident from significant reduction in
motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and increased thermal hyperalgesia.
The 2-week treatment with resveratrol (10 and 20 mg/kg, i.p.) started 6 weeks after diabetes induction
significantly ameliorated the alterations in MNCV, NBF, and hyperalgesia. Resveratrol also attenuated
enhanced levels of malondialdehyde (MDA), peroxynitrite and produced increase in catalase levels in diabetic rats."
2.14. Vitamin D
Effect of large doses of parenteral vitamin D on glycaemic control and calcium/phosphate metabolism in patients
with stable type 2 diabetes mellitus: a randomised, placebo-controlled, prospective pilot study.
"After 6 months of D3 supply, there was a significant intergroup difference in the change in HbA1c levels (relative
change [mean ± standard deviation] +2.9% ± 1.5% in the D3 group vs +6.9% ± 2.1% the in placebo group,
p = 0.041) as HOMA-IR decreased by 12.8% ± 5.6% in the D3 group and increased by 10% ± 5.4% in the placebo
group (intergroup difference, p = 0.032). Twenty-four-hour urinary albumin excretion decreased in the D3 group
from 200 ± 41 to 126 ± 39, p = 0.021)."
Vitamin D Prevents Cancer: Is It True?
Vitamin D and Diabetes-Can We Prevent it?
Repairing the spinal cord with vitamin D: a promising strategy
rat models - up to 500IU/kg/day -> "improved locomotor recovery, a reduced spasticity and a significantly higher rate
of axons crossing the lesion site in treated animals. However, it must be pointed out that the functional improvement
is reduced when vitamin D is provided one week after the trauma."
Overdose of Vit. D3 - 50,000 IU/day for several months (link)
2.15 Scientific American, March 2015
p.28, Shock Medicine, Stimulation of the nervous system could replace drugs for inflammatory and autoimmune
conditions, K.J.Tracey
Bioelectronic medicine - uses electrical stimulus to treat inflammation and other disorders.
p.34,
Potential treatments:
-------------------------
Deep brain stimulation:
- Alzheimer's, Parkinson's, Diabetes, Hypertension
Vagus nerve stimulation:
- Rheumatoid arthritis, inflammatory bowel disease, asthma, diabetes, obesity
Splenic nerve stimulation:
- Chronic fatigue, Rheumatoid arthritis, Lupus
Hepatic/pancreatic stimulation:
- diabetes, hepatitis, cancer
Splanchnic nerve stimulation:
- inflammatory bowel disease, irritable bowel, irritable bladder, cancer
multiple sclerosis (listed on the right bottom side)
p.31
in rats - "Watkins administered .. IL-1 that causes inflammation .. increasing body temperature.
But when she cut the vagus nerve ... no fever occurred. She concluded that the nerve transmitted information
to the brain about the presence of IL-1 and the these neural signals controlled the onset of fever."
p.32
"major organs of the immune system, including thymus, spleen, liver, lymph nodes and lungs are all
innervated with connections that descent from the brain."
p.34
"the vagus nerve ... sends signals from the brain to the spleen, liver, gastrointestinal tract, heart and other organs"
p.35
"middle aged father .. his hands, feet and knees hurt so much that he spent days at a time lying ...
tried and failed .. steroids, methotrexate, and other anti inflammatory drugs...
neurosurgeons implanted a vagus nerve stimulator just under his collarbone ...
within days he was improving, within weeks he was nearly pain free ... playing ping pong, tennis ...
now nearly 4 years after the surgery he remains in remmision, free of dangerous medications ..."
p.35
"of 8 patients with long standing disabling rheumatoid arthritis .."6".. benefited significantly"
Related Links:
http://www.tedpriebe.com/documents/the_inflammatory_reflex.pdf
- mentions meditation, biofeedback and acupuncture at the end to have significant effect on the vagus nerve activity.
http://www.setpointmedical.com/
http://www.feinsteininstitute.org/programs-researchers/featured-programs/bioelectronic-medicine/
http://bioelecmed.org/home
http://en.wikipedia.org/wiki/Inflammatory_reflex
2.16 Low intensity laser therapy
Effects of Light on Osteoarthritis and Cartilage Repair
2.17 The Brain's Way of Healing, Norman Doidge
The book describes cases and methods for treating:
- chronic pain (including spinal injuries)
- brain damage (traumatic brain injury, stroke, surgery, radiation therapy, missing part of the cerebellum)
- paralysis (partial due to stroke)
- cerebral palsy
- Parkinson disease
- blindness due to auto immune disease and surgeries
- MS
- Autism, ADD, ADHD, retardation
- also mentions methods for treating:
knee and hip injuries including cartilage regeneration, depression, some skin cancers, psoriasis,
autism, learning disabilities
Basic ideas:
- "use it or loose it brain"; "learned non use"
- "neurons that fire together wire together"
- neural signals differentiation through small slow movements and mindfulness
Methodology described in the book:
- visualization
Michael H. Moskowitz (book)
- mindful exercises
John Pepper (book)
- low intensity laser therapy
Fred Khan (clinic)
- awareness through movement
Moshe Feldenkrais (web site, book)
- electro tactile stimulation
Yuri Danilov, Paul Bach-y-Rita (University of Wisconsin - article, PubMed article, web site)
PoNS or PoNSTM device (link, link2, article, article, article)
Not descried in the book: Fisher Wallace Stimulator
- Listening therapy
Tomatis
- Neuro feedback
- Magentic and electro stimulation (including for faster fracture healing)
- Matrix (?)
The brain that changes itself, Norman Doidge
Dyslexia and autism - Dr. Merzenich, "Fast ForWord" (link, link), Posit science (link, link)
additioction
Rutin - 5mg/kg
" In the STZ-induced diabetic rats, blood glucose level was decreased by the antioxidant activities and anti-
inflammatory effects of rutin. Also, the pancreas, heart, liver, kidney, and retina tissues that were related to diabetic
complications were functionally and formatively protected by rutin. Therefore, it is suggested to apply rutin clinically
for the treatment of diabetes and its complications"
2.2. Eye and Vision effects of Blueberry
"fermented bilberry extract (400 mg/day)"
"Feeding the rabbits with blueberries at a dosage of 1.2 or 4.9 g/kg/day for 4 weeks prior to light exposure effectively
reduced photodamage to the retinas."
2.3. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes.
"A 6-hour treatment with fermented juice potentiated glucose uptake by 48% in C2C12 myotubes and by 142% in 3T3-
L1 adipocytes, in the presence or absence of insulin, whereas nonfermented juice had no effect on transport."
"Although the active principles and their mechanisms of action remain to be identified, transformed blueberry juice
may nevertheless represent a novel complementary therapy and a source of novel therapeutic agents against diabetes
mellitus."
2.4. Omega-3 and Retinal Disease.
"Increased use of dietary omega-3 reduces pathologic growth of new blood vessels (angiogenesis) in various eye
diseases. A lower omega-6/omega-3 ratio is protective from angiogenesis. Supplementing with omega-3 may help
prevent the loss of vision in retinopathies such as diabetic retinopathy, retinopathy of prematurity and age-related
macular degeneration."
2.5. Microcirculation of the retina
"In severe ocular pathology such as retinopathies of various type, simple glaucoma and toxic amblyopia, anthocyanin
extract is reported to mitigate the changes at level of retinal vessels or to prevent the alterations in the visual field. The
potential efficacy of Indena 36% anthocyanin bilberry extract in the treatment of diabetic retinopathy was evaluated in
patients with a type 2 diabetes mellitus and non-proliferative retinopathy, which received 480 mg/day 36% bilberry
extract p.o., for 180 days. "
"The Bilberry extract induced a clear improvement in the retinopathy, with marked reduction or disappearance of
retinic haemorrhages."
2.6. Bilberry extract prevents hardening of blood vessels
"One rich in anthocyanin extracted from untreated bilberries, and the other extracted from yeast-fermented bilberries.
After 16 weeks, it was noticed that there was considerable inhibition in development of plaques pertaining to
atherosclerosis in both bilberry groups.
Lead researcher, Aurelie Mauray, said that the yeast-fermented bilberries extract exerts more effective anti-
atherogenic activity than the anthocyanin-rich bilberry extract, which suggests that fermentation generates new
compounds with better health-boosting properties, in comparison to the anthocyanin-rich standaridized extract."
2.7. Pycnogenol
Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy.
The major positive observation of this study is the visual improvement, which was subjectively perceived by 18 out of
24 patients in the Pycnogenol group. Testing of visual acuity using the Snellen chart showed a significant improvement
from baseline 14/20 to 17/20 already, after 2 months treatment, whereas no change was found in the control group.
Pycnogenol taken at this early stage of retinopathy may enhance retinal blood circulation accompanied by regression
of edema, which favorably improves vision of patients.
Pycnogenol for diabetic retinopathy. A review.
All of these studies unequivocally showed that Pycnogenol retains progression of retinopathy and partly recovers
visual acuity. Treatment efficacy of Pycnogenol was at least as good as that of calcium dobesilate. Pycnogenol was
shown to improve capillary resistance and reduce leakages into the retina. Tolerance was generally very good and side
effects were rare, mostly referring to gastric discomfort. In conclusion, treatment with Pycnogenol had a favourable
outcome in the majority of the patients with diabetic retinopathy.
Pycnogenol for diabetic retinopathy
2.8. Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats.
" Our results showed that chronic taurine supplement effectively improved diabetic retinopathy as changes of
histopathology and ultrastructure. ...
These results demonstrated that chronic taurine supplementation ameliorates diabetic retinopathy via anti-
excitotoxicity of glutamate in rats."
2.9. Curcumin
Curcumin and Diabetes: A Systematic Review
"Curcumin could favorably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycemia,
hyperlipidemia, and islet apoptosis and necrosis.
... prevent the deleterious complications of diabetes. Despite the potential tremendous benefits of this multifaceted
nature product, results from clinical trials of curcumin are only available in using curcumin to treat diabetic
nephropathy, microangiopathy and retinopathy so far."
Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy.
"Diabetes was diagnosed at least 5 years before inclusion and all patients had signs of retinal oedema and of
peripheral microangiopathy. Meriva® was administered at the dosage of 2 tablets/day (each tablet containing
500 mg Meriva® corresponding to 100 mg curcumin) for a period of at least 4 weeks in addition to the standard
management plan, while a comparable group of subjects (n = 39) followed the standard management plan alone.
... At 4 weeks, microcirculatory and clinical evaluations indicated an improvement of microangiopathy. In terms
of peripheral microangiopathy, in the Meriva® group, there was a significant improvement in the venoarteriolar
response (p<0.05) and a decrease in the score of peripheral oedema (p<0.05), a sign typically associated with the
failure of the venoarteriolar response. At the retinal level, high-resolution, duplex scanning, used to measure retinal
flow, showed improvements in the Meriva® treated patients. The evaluation of retinal oedema (Steigerwalt's scale)
showed an improvement associated with improved visual acuity (Snellen scale).
There were no clinical or microcirculatory effects in controls."
2.10. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral
neuropathy
"... daily lipoic acid (300–600 mg i.v.) plus methylcobalamin (500–1000 mg(micro gram?) i.v. or im.) (LA–MC)
with that of methylcobalamin alone (MC) on diabetic peripheral neuropathy (DPN).
... LA–MC combination therapy was significantly superior to MC monotherapy
... treatment with LA–MC for 2–4 weeks is associated with better outcomes in NCV and neuropathic symptoms
relative to MC treatment"
2.11. Manual acupuncture for treatment of diabetic peripheral neuropathy: a systematic review of randomized
controlled trials.
"manual acupuncture had better effect on global symptom improvement compared with mecobalamin , vitamin B1
and B12, and no treatment, and that the combination of manual acupuncture and mecobalamin had better effect
compared with mecobalamin alone on global symptom improvement"
2.12. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.
"Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg);
Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg),
biotin (200 µg), B12 (10 µg) and folic acid (1 mg);
Group P: placebo.
RESULTS:
67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved
from 3.45 to 0.64 (p=0.001) in group MVB,
from 3.96 to 1.0 (p=0.001) in group MV and
from 2.54 to 1.95 in placebo group after 4 months."
Note: List of nutrients in best result group:
Zinc (20 mg),
Magnesium (250 mg),
Vitamin C (200 mg),
E (100 mg),
B1 (10 mg),
B2 (10 mg),
B6 (10 mg),
Biotin (200 µg),
B12 (10 µg),
folic acid (1 mg)
2.13. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic
neuropathy.
"Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident from significant reduction in
motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and increased thermal hyperalgesia.
The 2-week treatment with resveratrol (10 and 20 mg/kg, i.p.) started 6 weeks after diabetes induction
significantly ameliorated the alterations in MNCV, NBF, and hyperalgesia. Resveratrol also attenuated
enhanced levels of malondialdehyde (MDA), peroxynitrite and produced increase in catalase levels in diabetic rats."
2.14. Vitamin D
Effect of large doses of parenteral vitamin D on glycaemic control and calcium/phosphate metabolism in patients
with stable type 2 diabetes mellitus: a randomised, placebo-controlled, prospective pilot study.
"After 6 months of D3 supply, there was a significant intergroup difference in the change in HbA1c levels (relative
change [mean ± standard deviation] +2.9% ± 1.5% in the D3 group vs +6.9% ± 2.1% the in placebo group,
p = 0.041) as HOMA-IR decreased by 12.8% ± 5.6% in the D3 group and increased by 10% ± 5.4% in the placebo
group (intergroup difference, p = 0.032). Twenty-four-hour urinary albumin excretion decreased in the D3 group
from 200 ± 41 to 126 ± 39, p = 0.021)."
Vitamin D Prevents Cancer: Is It True?
Vitamin D and Diabetes-Can We Prevent it?
Repairing the spinal cord with vitamin D: a promising strategy
rat models - up to 500IU/kg/day -> "improved locomotor recovery, a reduced spasticity and a significantly higher rate
of axons crossing the lesion site in treated animals. However, it must be pointed out that the functional improvement
is reduced when vitamin D is provided one week after the trauma."
Overdose of Vit. D3 - 50,000 IU/day for several months (link)
2.15 Scientific American, March 2015
p.28, Shock Medicine, Stimulation of the nervous system could replace drugs for inflammatory and autoimmune
conditions, K.J.Tracey
Bioelectronic medicine - uses electrical stimulus to treat inflammation and other disorders.
p.34,
Potential treatments:
-------------------------
Deep brain stimulation:
- Alzheimer's, Parkinson's, Diabetes, Hypertension
Vagus nerve stimulation:
- Rheumatoid arthritis, inflammatory bowel disease, asthma, diabetes, obesity
Splenic nerve stimulation:
- Chronic fatigue, Rheumatoid arthritis, Lupus
Hepatic/pancreatic stimulation:
- diabetes, hepatitis, cancer
Splanchnic nerve stimulation:
- inflammatory bowel disease, irritable bowel, irritable bladder, cancer
multiple sclerosis (listed on the right bottom side)
p.31
in rats - "Watkins administered .. IL-1 that causes inflammation .. increasing body temperature.
But when she cut the vagus nerve ... no fever occurred. She concluded that the nerve transmitted information
to the brain about the presence of IL-1 and the these neural signals controlled the onset of fever."
p.32
"major organs of the immune system, including thymus, spleen, liver, lymph nodes and lungs are all
innervated with connections that descent from the brain."
p.34
"the vagus nerve ... sends signals from the brain to the spleen, liver, gastrointestinal tract, heart and other organs"
p.35
"middle aged father .. his hands, feet and knees hurt so much that he spent days at a time lying ...
tried and failed .. steroids, methotrexate, and other anti inflammatory drugs...
neurosurgeons implanted a vagus nerve stimulator just under his collarbone ...
within days he was improving, within weeks he was nearly pain free ... playing ping pong, tennis ...
now nearly 4 years after the surgery he remains in remmision, free of dangerous medications ..."
p.35
"of 8 patients with long standing disabling rheumatoid arthritis .."6".. benefited significantly"
Related Links:
http://www.tedpriebe.com/documents/the_inflammatory_reflex.pdf
- mentions meditation, biofeedback and acupuncture at the end to have significant effect on the vagus nerve activity.
http://www.setpointmedical.com/
http://www.feinsteininstitute.org/programs-researchers/featured-programs/bioelectronic-medicine/
http://bioelecmed.org/home
http://en.wikipedia.org/wiki/Inflammatory_reflex
2.16 Low intensity laser therapy
Effects of Light on Osteoarthritis and Cartilage Repair
2.17 The Brain's Way of Healing, Norman Doidge
The book describes cases and methods for treating:
- chronic pain (including spinal injuries)
- brain damage (traumatic brain injury, stroke, surgery, radiation therapy, missing part of the cerebellum)
- paralysis (partial due to stroke)
- cerebral palsy
- Parkinson disease
- blindness due to auto immune disease and surgeries
- MS
- Autism, ADD, ADHD, retardation
- also mentions methods for treating:
knee and hip injuries including cartilage regeneration, depression, some skin cancers, psoriasis,
autism, learning disabilities
Basic ideas:
- "use it or loose it brain"; "learned non use"
- "neurons that fire together wire together"
- neural signals differentiation through small slow movements and mindfulness
Methodology described in the book:
- visualization
Michael H. Moskowitz (book)
- mindful exercises
John Pepper (book)
- low intensity laser therapy
Fred Khan (clinic)
- awareness through movement
Moshe Feldenkrais (web site, book)
- electro tactile stimulation
Yuri Danilov, Paul Bach-y-Rita (University of Wisconsin - article, PubMed article, web site)
PoNS or PoNSTM device (link, link2, article, article, article)
Not descried in the book: Fisher Wallace Stimulator
- Listening therapy
Tomatis
- Neuro feedback
- Magentic and electro stimulation (including for faster fracture healing)
- Matrix (?)
The brain that changes itself, Norman Doidge
Dyslexia and autism - Dr. Merzenich, "Fast ForWord" (link, link), Posit science (link, link)
additioction
3. Mental Illnesses
3.1. Coping With Stress - The Truth About Psycho Neuro Immunology
[21:00] Types of immune cells;
Natural killer cells - kills any foreign cells, tumor and cells infected with viruses;
[23:45] Brain effect on immune system - via hormones and directly via nerves.
[29:00] Stress - suppresses immune system;
- thymus gland shrinks;
- suppresses natural killer cells, T cells;
- reactivates latent viruses;
[33:00] Tests for natural killer cells ability to kill tumor cells;
[36:00] chronic stress on vaccine effectiveness - caregivers for Alzheimer patients;
[38:45] effect on wound healing;
[40:20] Brief stress {excitement (my comment)} enhances the immune system
[42:00] jumping out of an airplane study;
- Natural killer cells are higher in quantity and more active;
- The type of stress matters!
[47:00] Your thoughts - they matter!
- control ability (or illusion of control ability) - less immune suppression;
[52:10] Placebo response
- bronchial constriction test in asthma patients;
placebo is 2 times better than no placebo;
placebo has 1/3 effectiveness of the real drug;
[55:00] Social support
[55:20] Loss of social status has negative effect on immune system
[1:02:06] - "It is not about reality. It is about your perception."
[1:04:30] Effect on diseases {cold, flu, AIDS/HIV, tumor/cancer, inflammation, depression}.
[1:09:30] (animal tests) stress increases angiogenesis and tumor growth; (human tests give mixed results);
[1:10:15] inflammation - many diseases, joints;
brief stress also can increase inflammation;
[1:12:15] depression (linked to inflammation)
[1:15:00] Interventions
- Cognitive Behavioral Stress Management
- support groups
- meditation
- 8 weeks Mindfulness Based Stress Reduction - boost immune system;
[1:26:30] Regular Exercise - boost immune system;
3.2. Staying in the Now: Mental Health Through Mindfulness
[06:20] What is mindfulness? (stay in the moment, pay attention non-judgmentally);
[12:30] Applied for multiple diseases
(cancer, anxiety, depression, bipolar, chronic pain, psoriasis, fibromyalgia, eating disorder, addiction ...);
[13:45] study for anxiety - 50% reduction
[15:15] bipolar disorder - 50% reduction of both anxiety and depression
[16:30] Mindfulness Based Stress Reduction -> Mindfulness Based Cognitive Therapy;
- 8 weeks,
- 1 time a week,
- 2h 15min sessions
- 6 .. 14 people
- various everyday life exercises (meditation, mindful eating, train your observation skills, breathing).
[21:00] Your thoughts and feelings are just events ... not facts!
Don't just believe your thoughts! Try to look from other points of view [23:45].
Try to separate the fact from your thoughts (your opinion).
[27:15] Metacognition and Decentering - start recognizing your thoughts for what they are - just thoughts (true or not).
[28:15] Mindfulness Based Cognitive Therapy (MBCT) vs. Cognitive Based Therapy (CBT)
MBCT - no emphasis on positive or negative - just observe (note) the thought and focus on reality
CBT - try to answer (reason) the thoughts. {critical thinking (my comment)}
problem: with depression - person will have lots of evidence why he thinks negatively.
solution: MBCT - do not identify yourself with this negative thought - just note it - don't hang to it.
MBCT was originally called "selective attention training".
[36:45] Major depression (Major Depressive Disorder - MDD).
Over time brain becomes sensitive {learns to respond (my comment)} and requires less stress to become depressed.
[38:00] Study on MDD. 50% less chance of having depressive episodes.
[39:00] MDD - using MBCT and stopping medications.
MBCT (only) performed better than medications (only).
75% stayed off medications after MBCT training.
[43:00] Traditional treatment of MDD
Treatment resistant depression.
Only 43% success (positive effect/response) after 4 different sequential treatments.
Problems - relapse, drug intolerance.
MBCT - about 50% improvement. 30% completely recovered vs. 10% for mediation only.
[46:45] Use what works for you - various techniques are thought in the classes.
Body scan meditation - start with the feet (disconnects from current thoughts).
Meditation is about bringing back your focus (after your mind wonders).
Don't worry that you are not doing it right! Training to bring your focus back is the meditation.
[51:30] Rumination - has tendency to lead to worse mood.
[54:15] Decreased resistance to depression (just notice the thoughts, don't dwell on them) -> reduced suffering;
Adventitious suffering - if animal steps on a thorn it feels pain. That's it! They don't say did I deserve this?
- people just lay thoughts on top (elaboration) and make things worse;
depressed about being depressed ...
[59:00] Self compassion. Be gentle toward yourself. Don't criticize yourself.
[1:01:00] Evidence of physiological changes due to MBCT / MBSR (mindfulness based stress reduction).
fMRI scan, EEG - left frontal cortex (positive mood states region)
Immune system response - improved.
[1:06:00] Neurofeedback - using fMRI to train your brain and stop depression.
3.3. How Meditation Can Reshape Our Brains: Sara Lazar
[1:50] yoga and meditation
decrease stress, anxiety, depression, pain, insomnia;
improve focus and happiness;
[2:45] neuroplasticity; detected with MRI; 3 months of trining are enough;
[4:20] meditation slows down or even prevents brain aging (decline of neocortex)
[5:15] 8 weeks meditation based stress reduction program;
30 to 40 min meditation/day;
neo-cortex improved in areas related to Depression and PTSD;
improvement in empathy and compassion region;
amygdala (fight or flight response) - found reduced gray matter - correlates to reduced stress;
[6:45] mice study - after 10 day stress - amygdala grew (indicating higher stress);
mice were acting stressed out even after external stress was reduced;
3.4. First Do No Harm - ketogenic diet for epilepsy.
Movie based on true story.
3.5. Rethinking How We Understand and Treat Depression
[0:30] Psychiatry view: "All mental disorders are brain disorders." - This is NOT true! They CAN be brain disorder!
[1:15] PTSD
[2:30] Depression:
family; mother treatment effects the child;
smog (pollution) causes depression
pollen, second hand smoking - related to depression;
[6:00] fixing the external factors will treat depression in some cases (better than medications).
[6:30] placebo vs anti-depressants; sometimes anti-depressants make things worse;
[8:00] serotonin; medications are non selective (that's bad) - they affect the whole brain;
different people have different reactions; medication affects also centers that reduce serotonin;
takes time for the brain to settle again (that's why it takes 2..6 weeks for the medication to work);
[9:30] depressed people have fever (2 [oF] higher than healthy person) and they don't sweat.
[10:00] neuro surgery
[10:45] alternative to neurosurgery - heat, light, sound, immune system
using the sense of heat eliminates depression; (also reduces body temperature (see [9:30]))
[12:30] test on people - hyperthermia - 2 hours, 145 [oF] (62 [oC]);
many people have immediate improvement, and within 5 days depression drops to 50%;
[16:00] "Don't over estimate the brain".
3.6. The Mindfulness Clinic in Toronto is using:
The Mindful Way Workbook: An 8-Week Program to Free Yourself from Depression and Emotional Distress
This workbook has theory, exercises notes and a CD with MP3 files for all meditation exercises.
Another recommended book [Ref.3.2] is:
The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)
Specifically for psychosis:
Acceptance and Commitment Therapy and Mindfulness for Psychosis
3.7. The most important lesson from 83,000 brain scans
[3:15] Healthy brain vs brain of a person who had a stroke, Alzheimer, brain injury, drug abuse, OCD, epilepsy.
Today psychiatrists make diagnosis as they did in 1840 (A. Lincoln) - talking to people and looking for symptoms.
Psychiatrist never "look" at the organ they treat.
Mental illnesses such as ADHD, anxiety, depression, addictions are not single or simple disorders in the brain.
They all have multiple types.
[6:00] 2 patients with MDD - different brain activity. How would you know how to treat them without a test?
Treatment needs to be tailored to individuals, not clusters of symptoms.
Brain trauma has symptoms of anxiety, depression etc., so it is mistreated by ordinary psychiatrist.
[7:00] Story of a boy who fell at age of 3 (lost consciousness for a few minutes). Age of 15 - multiple symptoms.
The right treatment is not medications "thrown at him in the dark" or behavioral therapy.
Behavior is an expression of the problem (symptom) - not the problem.
[10:00] You can change your brain and we can prove it.
Study on NFL players. "Brain smart program" - 80% improved (blood flow, memory, mood).
[11:50] Girl with ADHD;
Dementia patient case;
9 year old boy - behavior problem (aggression); Found tumor in the brain; Surgery "cured" his behavior.
3.8. How Your Brain Can Turn Anxiety into Calmness
A lecture on using guided imagery for anxiety.
Note: guided imagery with imagining talking/interacting with people should not be used at all.
The brain is an adaptive / learning system. Be careful what you are teaching it.
Imagining anything that looks like a psychosis symptom should be avoided.
[8:00] Worry
"My imaginations is out to get me". Rumination, often for things in the past or future.
worrying - learned behavior
[17:45] Anxiety
can cause also many physical symptoms
[19:45] Stress
[24:00] The triune brain (simplified model)
neo-cortex - the thinking brain ("know it all")
limbic system - mammals - social behavior,
reptilian brain ("can I eat this, can it eat me, can I mate with it").
[30:00] left vs right hemisphere
[32:00] brain connections and chemical messages (bi-directional)
[33:30] reptilian brain send "look out, look out, look out" ... may not know what is looking out for (i.e. just anxious)
the neo cortex is trying to imagine what it should be looking for ...
chemically sensitive process - medications, diet, nutrients can affect the anxiety
thought sensitive process - thoughts trigger chemical processes in the brain
[35:00] bio feedback data - phobia example.
[38:00] neuro-plasticity
"The brain that changes itself" - example how blind people can see using tactile devices.
"Brain and Mind" - OCD treatment. Takes several months to change your brain, but then you have a new start!
"The female brain" - why men are different than women
[45:00] "if the blind can learn to see, the anxious can learn to relax"
[49:00] Accessing wisdom:
Ask your friends for advice.
"What would (a normal/ordinary person) do?" (my choice in the brackets)
[57:00] reversing negative thinking/worrying by imagining positive outcomes and positive scenarios.
[1:04:00] imagine that you are in a calming place ...
[1:06:00] guided imagery exercise
3.9. The Biology of Depression: The Affects of Stress
[4:45] current theory of depression (norepinephrine, serotonin, dopamine imbalance)
[6:15] there is no test that the doctor can do to tell him what type of depression you have and what medication is best for you
all decisions are based on symptoms;
there is no (yet) coherent theory to allow us to test chemicals in the blood and thus determine
the course of treatment
current treatments are discovered based on experiments rather then understanding biological pathology
the new drugs are not better than the old ones; they have fewer side effects are still based on the same idea;
[10:00] after treatment using 4 anti-depressant drugs (4..8 weeks each) only 2/3 of the patient responded (got better);
this proves that we don't understand depression;
DSM is the only method at the method for diagnosis; there is no biological method;
DSM is based on behavior, but there maybe people with different problems that have the same symptoms ...
the DSM does not work for these people.
The current treatment maybe addresses only certain aspects of the disease;
there is more going on than just serotonin/dopamine imbalance;
if depression is just a mental illness (brain disease) why depressed people are more likely to have other illnesses?
Depression maybe a whole body diseases and the mental issue just one of the symptoms.
Is depression an inflammatory disease? Is it oxidation? Is it DNA damage?
Depression is a physical disease.
[14:30] Primary questions to answer:
Stress and early life events vs genetic makeup;
[19:30] Medications, exercise, and psycho-therapy reduce the risk of other diseases associated with depression;
[20:00] Adrenalin, cortisol - affect on norepinephrine, serotonin, dopamine; DHEA
[26:00] stress hormones can physically damage the brain
[29:30] untreated depression - smaller hippocampus volume;
[31:30] serotonin; how current medications work;
[33:30] how stress contributes to develop depression; not simple and strait forward!
genes make you more susceptible but do not determine if you will develop depression;
[36:00] early life adversity (before puberty (up to 18 years old) - major risk factor for developing depression;
social support reduces risk of depression (regardless of genetic predisposition);
[39:15] early life adversity can trigger changes that become (almost) permanent;
Certain genes are normally dormant and become activated by specific conditions (epigenetic programming).
For example stress during childhood triggers changes that make you "prepared" for more "dangerous" world ...
but you have hyper active stress system (respond to stress with more cortisol).
DNA only changes only if the trauma happens in a specific time window of the person's development;
[43:30] anxiety can turn into depression
[44:30] brain can become sensitized to certain drugs (i.e. respond stronger to the same dose after a while)
[45:30] the effect of early live trauma (loss of parent, divorce, violence, etc.) can be reduced by family
handling it in a better way;
[53:30] brain plasticity - hippocampus;
[56:00] cortisol lowering drugs have some anti-depressant effects
[58:00] cortisol lowering drugs may have anti-psychotic effect
[58:45] cortisol lowering drugs can have anti-anxiety effect
[59:15] Anti cortisol effect of DHEA (only works in rats; not proven in humans?)
helps some people with depression [1:02:00]
DHEA is a potent hormone - it should not be taken without doctor supervision;
it affects estrogen and progesterone;
[1:03:45] Neurotrophic factors
[1:06:45] Antidepressants, electro-convulsion therapy, exercise - increase neurogenesis (and BDNF);
exercise more potent than anti-depressant alone; both together even more potent;
[1:08:30] after successful treatment, people that still had high cortisol level slipped back into depression;
if cortisol dropped during the treatment, then people stayed in remission longer;
[1:10:15] Telomeres and telomerase (repair telomeres)
study on mothers caring about chronically ill children - shorter telomeres (equivalent to about 13 years older)
[1:14:30] what causes short telomeres:
- low telomerase
- high cortisol; stress; early life adversity
- oxidative damage
- inflammation
[1:27:45] if you have 1 episode of major depression and after 1 year you stop medications,
there is 50% chance you will have a second episode;
if you have had 3 episodes, then chances are 80%.
you should stay on medications 6 .. 12 months after you are fully recovered;
3.10. Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
"Oral administration of SP(Serrapeptase) or NK(nattokinase) in a rat model of AD(Alzheimer) daily for 45 days
resulted in a significant decrease in brain AchE activity, TGF-ß, Fas and IL-6 levels. Also, the treatment with these
enzymes produced significant increase in BDNF and IGF-1 levels when compared with the untreated AD-induced rats.
Moreover, both SP and NK could markedly increase the expression levels of ADAM9 and ADAM10 genes in the brain
tissue of the treated rats. ... The present results support our hypothesis that the oral administration of proteolytitc
enzymes, SP and/or NK, would have an effective role in modulating certain factors characterizing AD. Thus, these
enzymes may have a therapeutic application in the treatment of AD."
3.11. Alternative therapies
Complementary and alternative therapies as add-on to pharmacotherapy for mood and anxiety disorders:
a systematic review.
"In unipolar depression, there is Level 2 evidence for adjunctive sleep deprivation (SD) and Free and Easy
Wanderer Plus (FEWP), and Level 3 for exercise, yoga, light therapy (LT), omega-3 fatty acids,
S-adenosylmethionine and tryptophan. In bipolar depression, there is Level 1 evidence for adjunctive omega-3s,
Level 2 for SD, and Level 3 for LT and FEWP. In anxiety conditions, exercise augmentation has Level 3 support in
generalized anxiety disorder and panic disorder."
Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence.
"The use of omega-3 fatty acids has been studied in two controlled studies in bipolar disorder while St. John's wort
(Hypericum perforatum), S-adenosyl-l-methionine (SAMe), and acupuncture have been studied in a series of
randomized controlled trials in patients with major depression. Overall, the best evidence supports the use of
St. John's wort for the treatment of mild to moderate depression. SAMe may also be effective for depression.
However, both of these products have the potential to induce mania; the extent of this risk needs to be quantified.
St. John's wort can also interact with a variety of medications. Evidence regarding the benefits of omega-3 fatty
acids or acupuncture is inconsistent. Data regarding other CAM interventions (e.g., aromatherapy massage,
massage therapy, yoga) are almost entirely lacking. "
Complementary medicines in pediatric bipolar disorder.
"Omega-3 fatty acids and lecithin/ choline have preliminary data indicating potential utility in the CAM treatment
for bipolar disorder while S-adenosyl methionine (SAM-e) and inositol have some data supporting their efficacy in
the treatment of depressive symptoms. Some data for CAM suggest they may be useful adjunctive treatments but
only little data are available to support their use as stand-alone therapy."
Non-Standard Anti-Anxiety Treatment
"I used the herbal extract curcumin to block the NF kappa-B mediated inflammation, taking curcumin in 3 or 4
daily doses of 500 to 1000 mg. You have to take it several times a day to work: say a capsule at breakfast, one at
lunch, one at supper time, and one before bed. This is because the plasma half-life of curcumin is short: 3 to 6
hours, so you need to take it 3 or 4 times a day to keep up your anti-inflammatory blockade.
Another good blocker of NF kappa-B mediated inflammation that can be used in place of curcumin (or in addition,
if you want) is grape seed extract 500 mg daily. High doses of curcumin can occasionally slightly increase anger
and irritability in some people, so keep a watch out for that; grape seed extract does not have this problem.
Other good NF kappa-B blockers that you can use are: ashwagandha (1000 mg), alpha lipoic acid (500 mg -
though some may not be able to take this high dose), sulfasalazine (500 to 1000 mg); sulfasalazine is usually a
well tolerated drug.
You might also want to simultaneously try a second anti-inflammatory: one that targets COX-2 mediated
inflammation. This can further lower your anxiety. For this, take propolis herb, 1000 mg, on the same dosing
schedule (that is, 3 or 4 times a day - not before bed, though, as propolis can keep you awake). Propolis is an
potent COX-2 inhibitor. Cat's claw is another good COX-2 inhibitor, and 1000 mg of cat's claw can be used in
place of propolis (or in addition, if you want)."
3.12. Partial remission, residual symptoms, and relapse in depression
"This review primarily concerns unipolar disorder. However, there is a smaller but growing parallel literature
regarding bipolar disorder. ...
Such treatment may include not only antidepressants and possibly lithium augmentation, but also cognitive
therapy, which has been shown to reduce relapse rates, including in one study which specifically targeted
relapse-prone subjects with residual symptoms. In this study, we found that adding cognitive therapy to
full doses of antidepressant continuation and maintenance lowered relapse rates, and the effect lasted for 3 and
a half years after the end of the cognitive therapy. Residual symptoms at remission also suggest, that maintenance
antidepressant may be required, at least for 2 to 3 years. Such symptoms also indicate that, when treatment is
withdrawn, withdrawal should be slow."
3.13. Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria
for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial.
"At baseline, erythrocyte n-3 PUFA (poly unsaturated fatty acids) levels correlated positively with psychosocial
functioning and negatively with psychopathology. By the end of the intervention, n-3 PUFAs significantly improved
functioning and reduced psychiatric symptoms, compared with placebo."
3.14. Mysteries of the mind week (TVO)
The smarter brain
The future brain
3.15. Dr. Daniel Amen (Amen clinics)
Brain Health Tips from Dr. Daniel Amen - SuperheroYou
Healing Anxiety, Depression, and Bipolar
Daniel Amen, M.D. discussing ADD and ADHD
3.16. Dr. Jeffrey M Schwartz
Dr Jeffrey M Schwartz 'You are not your brain'
3.17. Stanford's Sapolsky On Depression
3.18. The Brain's Way of Healing
[21:00] Types of immune cells;
Natural killer cells - kills any foreign cells, tumor and cells infected with viruses;
[23:45] Brain effect on immune system - via hormones and directly via nerves.
[29:00] Stress - suppresses immune system;
- thymus gland shrinks;
- suppresses natural killer cells, T cells;
- reactivates latent viruses;
[33:00] Tests for natural killer cells ability to kill tumor cells;
[36:00] chronic stress on vaccine effectiveness - caregivers for Alzheimer patients;
[38:45] effect on wound healing;
[40:20] Brief stress {excitement (my comment)} enhances the immune system
[42:00] jumping out of an airplane study;
- Natural killer cells are higher in quantity and more active;
- The type of stress matters!
[47:00] Your thoughts - they matter!
- control ability (or illusion of control ability) - less immune suppression;
[52:10] Placebo response
- bronchial constriction test in asthma patients;
placebo is 2 times better than no placebo;
placebo has 1/3 effectiveness of the real drug;
[55:00] Social support
[55:20] Loss of social status has negative effect on immune system
[1:02:06] - "It is not about reality. It is about your perception."
[1:04:30] Effect on diseases {cold, flu, AIDS/HIV, tumor/cancer, inflammation, depression}.
[1:09:30] (animal tests) stress increases angiogenesis and tumor growth; (human tests give mixed results);
[1:10:15] inflammation - many diseases, joints;
brief stress also can increase inflammation;
[1:12:15] depression (linked to inflammation)
[1:15:00] Interventions
- Cognitive Behavioral Stress Management
- support groups
- meditation
- 8 weeks Mindfulness Based Stress Reduction - boost immune system;
[1:26:30] Regular Exercise - boost immune system;
3.2. Staying in the Now: Mental Health Through Mindfulness
[06:20] What is mindfulness? (stay in the moment, pay attention non-judgmentally);
[12:30] Applied for multiple diseases
(cancer, anxiety, depression, bipolar, chronic pain, psoriasis, fibromyalgia, eating disorder, addiction ...);
[13:45] study for anxiety - 50% reduction
[15:15] bipolar disorder - 50% reduction of both anxiety and depression
[16:30] Mindfulness Based Stress Reduction -> Mindfulness Based Cognitive Therapy;
- 8 weeks,
- 1 time a week,
- 2h 15min sessions
- 6 .. 14 people
- various everyday life exercises (meditation, mindful eating, train your observation skills, breathing).
[21:00] Your thoughts and feelings are just events ... not facts!
Don't just believe your thoughts! Try to look from other points of view [23:45].
Try to separate the fact from your thoughts (your opinion).
[27:15] Metacognition and Decentering - start recognizing your thoughts for what they are - just thoughts (true or not).
[28:15] Mindfulness Based Cognitive Therapy (MBCT) vs. Cognitive Based Therapy (CBT)
MBCT - no emphasis on positive or negative - just observe (note) the thought and focus on reality
CBT - try to answer (reason) the thoughts. {critical thinking (my comment)}
problem: with depression - person will have lots of evidence why he thinks negatively.
solution: MBCT - do not identify yourself with this negative thought - just note it - don't hang to it.
MBCT was originally called "selective attention training".
[36:45] Major depression (Major Depressive Disorder - MDD).
Over time brain becomes sensitive {learns to respond (my comment)} and requires less stress to become depressed.
[38:00] Study on MDD. 50% less chance of having depressive episodes.
[39:00] MDD - using MBCT and stopping medications.
MBCT (only) performed better than medications (only).
75% stayed off medications after MBCT training.
[43:00] Traditional treatment of MDD
Treatment resistant depression.
Only 43% success (positive effect/response) after 4 different sequential treatments.
Problems - relapse, drug intolerance.
MBCT - about 50% improvement. 30% completely recovered vs. 10% for mediation only.
[46:45] Use what works for you - various techniques are thought in the classes.
Body scan meditation - start with the feet (disconnects from current thoughts).
Meditation is about bringing back your focus (after your mind wonders).
Don't worry that you are not doing it right! Training to bring your focus back is the meditation.
[51:30] Rumination - has tendency to lead to worse mood.
[54:15] Decreased resistance to depression (just notice the thoughts, don't dwell on them) -> reduced suffering;
Adventitious suffering - if animal steps on a thorn it feels pain. That's it! They don't say did I deserve this?
- people just lay thoughts on top (elaboration) and make things worse;
depressed about being depressed ...
[59:00] Self compassion. Be gentle toward yourself. Don't criticize yourself.
[1:01:00] Evidence of physiological changes due to MBCT / MBSR (mindfulness based stress reduction).
fMRI scan, EEG - left frontal cortex (positive mood states region)
Immune system response - improved.
[1:06:00] Neurofeedback - using fMRI to train your brain and stop depression.
3.3. How Meditation Can Reshape Our Brains: Sara Lazar
[1:50] yoga and meditation
decrease stress, anxiety, depression, pain, insomnia;
improve focus and happiness;
[2:45] neuroplasticity; detected with MRI; 3 months of trining are enough;
[4:20] meditation slows down or even prevents brain aging (decline of neocortex)
[5:15] 8 weeks meditation based stress reduction program;
30 to 40 min meditation/day;
neo-cortex improved in areas related to Depression and PTSD;
improvement in empathy and compassion region;
amygdala (fight or flight response) - found reduced gray matter - correlates to reduced stress;
[6:45] mice study - after 10 day stress - amygdala grew (indicating higher stress);
mice were acting stressed out even after external stress was reduced;
3.4. First Do No Harm - ketogenic diet for epilepsy.
Movie based on true story.
3.5. Rethinking How We Understand and Treat Depression
[0:30] Psychiatry view: "All mental disorders are brain disorders." - This is NOT true! They CAN be brain disorder!
[1:15] PTSD
[2:30] Depression:
family; mother treatment effects the child;
smog (pollution) causes depression
pollen, second hand smoking - related to depression;
[6:00] fixing the external factors will treat depression in some cases (better than medications).
[6:30] placebo vs anti-depressants; sometimes anti-depressants make things worse;
[8:00] serotonin; medications are non selective (that's bad) - they affect the whole brain;
different people have different reactions; medication affects also centers that reduce serotonin;
takes time for the brain to settle again (that's why it takes 2..6 weeks for the medication to work);
[9:30] depressed people have fever (2 [oF] higher than healthy person) and they don't sweat.
[10:00] neuro surgery
[10:45] alternative to neurosurgery - heat, light, sound, immune system
using the sense of heat eliminates depression; (also reduces body temperature (see [9:30]))
[12:30] test on people - hyperthermia - 2 hours, 145 [oF] (62 [oC]);
many people have immediate improvement, and within 5 days depression drops to 50%;
[16:00] "Don't over estimate the brain".
3.6. The Mindfulness Clinic in Toronto is using:
The Mindful Way Workbook: An 8-Week Program to Free Yourself from Depression and Emotional Distress
This workbook has theory, exercises notes and a CD with MP3 files for all meditation exercises.
Another recommended book [Ref.3.2] is:
The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)
Specifically for psychosis:
Acceptance and Commitment Therapy and Mindfulness for Psychosis
3.7. The most important lesson from 83,000 brain scans
[3:15] Healthy brain vs brain of a person who had a stroke, Alzheimer, brain injury, drug abuse, OCD, epilepsy.
Today psychiatrists make diagnosis as they did in 1840 (A. Lincoln) - talking to people and looking for symptoms.
Psychiatrist never "look" at the organ they treat.
Mental illnesses such as ADHD, anxiety, depression, addictions are not single or simple disorders in the brain.
They all have multiple types.
[6:00] 2 patients with MDD - different brain activity. How would you know how to treat them without a test?
Treatment needs to be tailored to individuals, not clusters of symptoms.
Brain trauma has symptoms of anxiety, depression etc., so it is mistreated by ordinary psychiatrist.
[7:00] Story of a boy who fell at age of 3 (lost consciousness for a few minutes). Age of 15 - multiple symptoms.
The right treatment is not medications "thrown at him in the dark" or behavioral therapy.
Behavior is an expression of the problem (symptom) - not the problem.
[10:00] You can change your brain and we can prove it.
Study on NFL players. "Brain smart program" - 80% improved (blood flow, memory, mood).
[11:50] Girl with ADHD;
Dementia patient case;
9 year old boy - behavior problem (aggression); Found tumor in the brain; Surgery "cured" his behavior.
3.8. How Your Brain Can Turn Anxiety into Calmness
A lecture on using guided imagery for anxiety.
Note: guided imagery with imagining talking/interacting with people should not be used at all.
The brain is an adaptive / learning system. Be careful what you are teaching it.
Imagining anything that looks like a psychosis symptom should be avoided.
[8:00] Worry
"My imaginations is out to get me". Rumination, often for things in the past or future.
worrying - learned behavior
[17:45] Anxiety
can cause also many physical symptoms
[19:45] Stress
[24:00] The triune brain (simplified model)
neo-cortex - the thinking brain ("know it all")
limbic system - mammals - social behavior,
reptilian brain ("can I eat this, can it eat me, can I mate with it").
[30:00] left vs right hemisphere
[32:00] brain connections and chemical messages (bi-directional)
[33:30] reptilian brain send "look out, look out, look out" ... may not know what is looking out for (i.e. just anxious)
the neo cortex is trying to imagine what it should be looking for ...
chemically sensitive process - medications, diet, nutrients can affect the anxiety
thought sensitive process - thoughts trigger chemical processes in the brain
[35:00] bio feedback data - phobia example.
[38:00] neuro-plasticity
"The brain that changes itself" - example how blind people can see using tactile devices.
"Brain and Mind" - OCD treatment. Takes several months to change your brain, but then you have a new start!
"The female brain" - why men are different than women
[45:00] "if the blind can learn to see, the anxious can learn to relax"
[49:00] Accessing wisdom:
Ask your friends for advice.
"What would (a normal/ordinary person) do?" (my choice in the brackets)
[57:00] reversing negative thinking/worrying by imagining positive outcomes and positive scenarios.
[1:04:00] imagine that you are in a calming place ...
[1:06:00] guided imagery exercise
3.9. The Biology of Depression: The Affects of Stress
[4:45] current theory of depression (norepinephrine, serotonin, dopamine imbalance)
[6:15] there is no test that the doctor can do to tell him what type of depression you have and what medication is best for you
all decisions are based on symptoms;
there is no (yet) coherent theory to allow us to test chemicals in the blood and thus determine
the course of treatment
current treatments are discovered based on experiments rather then understanding biological pathology
the new drugs are not better than the old ones; they have fewer side effects are still based on the same idea;
[10:00] after treatment using 4 anti-depressant drugs (4..8 weeks each) only 2/3 of the patient responded (got better);
this proves that we don't understand depression;
DSM is the only method at the method for diagnosis; there is no biological method;
DSM is based on behavior, but there maybe people with different problems that have the same symptoms ...
the DSM does not work for these people.
The current treatment maybe addresses only certain aspects of the disease;
there is more going on than just serotonin/dopamine imbalance;
if depression is just a mental illness (brain disease) why depressed people are more likely to have other illnesses?
Depression maybe a whole body diseases and the mental issue just one of the symptoms.
Is depression an inflammatory disease? Is it oxidation? Is it DNA damage?
Depression is a physical disease.
[14:30] Primary questions to answer:
Stress and early life events vs genetic makeup;
[19:30] Medications, exercise, and psycho-therapy reduce the risk of other diseases associated with depression;
[20:00] Adrenalin, cortisol - affect on norepinephrine, serotonin, dopamine; DHEA
[26:00] stress hormones can physically damage the brain
[29:30] untreated depression - smaller hippocampus volume;
[31:30] serotonin; how current medications work;
[33:30] how stress contributes to develop depression; not simple and strait forward!
genes make you more susceptible but do not determine if you will develop depression;
[36:00] early life adversity (before puberty (up to 18 years old) - major risk factor for developing depression;
social support reduces risk of depression (regardless of genetic predisposition);
[39:15] early life adversity can trigger changes that become (almost) permanent;
Certain genes are normally dormant and become activated by specific conditions (epigenetic programming).
For example stress during childhood triggers changes that make you "prepared" for more "dangerous" world ...
but you have hyper active stress system (respond to stress with more cortisol).
DNA only changes only if the trauma happens in a specific time window of the person's development;
[43:30] anxiety can turn into depression
[44:30] brain can become sensitized to certain drugs (i.e. respond stronger to the same dose after a while)
[45:30] the effect of early live trauma (loss of parent, divorce, violence, etc.) can be reduced by family
handling it in a better way;
[53:30] brain plasticity - hippocampus;
[56:00] cortisol lowering drugs have some anti-depressant effects
[58:00] cortisol lowering drugs may have anti-psychotic effect
[58:45] cortisol lowering drugs can have anti-anxiety effect
[59:15] Anti cortisol effect of DHEA (only works in rats; not proven in humans?)
helps some people with depression [1:02:00]
DHEA is a potent hormone - it should not be taken without doctor supervision;
it affects estrogen and progesterone;
[1:03:45] Neurotrophic factors
[1:06:45] Antidepressants, electro-convulsion therapy, exercise - increase neurogenesis (and BDNF);
exercise more potent than anti-depressant alone; both together even more potent;
[1:08:30] after successful treatment, people that still had high cortisol level slipped back into depression;
if cortisol dropped during the treatment, then people stayed in remission longer;
[1:10:15] Telomeres and telomerase (repair telomeres)
study on mothers caring about chronically ill children - shorter telomeres (equivalent to about 13 years older)
[1:14:30] what causes short telomeres:
- low telomerase
- high cortisol; stress; early life adversity
- oxidative damage
- inflammation
[1:27:45] if you have 1 episode of major depression and after 1 year you stop medications,
there is 50% chance you will have a second episode;
if you have had 3 episodes, then chances are 80%.
you should stay on medications 6 .. 12 months after you are fully recovered;
3.10. Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
"Oral administration of SP(Serrapeptase) or NK(nattokinase) in a rat model of AD(Alzheimer) daily for 45 days
resulted in a significant decrease in brain AchE activity, TGF-ß, Fas and IL-6 levels. Also, the treatment with these
enzymes produced significant increase in BDNF and IGF-1 levels when compared with the untreated AD-induced rats.
Moreover, both SP and NK could markedly increase the expression levels of ADAM9 and ADAM10 genes in the brain
tissue of the treated rats. ... The present results support our hypothesis that the oral administration of proteolytitc
enzymes, SP and/or NK, would have an effective role in modulating certain factors characterizing AD. Thus, these
enzymes may have a therapeutic application in the treatment of AD."
3.11. Alternative therapies
Complementary and alternative therapies as add-on to pharmacotherapy for mood and anxiety disorders:
a systematic review.
"In unipolar depression, there is Level 2 evidence for adjunctive sleep deprivation (SD) and Free and Easy
Wanderer Plus (FEWP), and Level 3 for exercise, yoga, light therapy (LT), omega-3 fatty acids,
S-adenosylmethionine and tryptophan. In bipolar depression, there is Level 1 evidence for adjunctive omega-3s,
Level 2 for SD, and Level 3 for LT and FEWP. In anxiety conditions, exercise augmentation has Level 3 support in
generalized anxiety disorder and panic disorder."
Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence.
"The use of omega-3 fatty acids has been studied in two controlled studies in bipolar disorder while St. John's wort
(Hypericum perforatum), S-adenosyl-l-methionine (SAMe), and acupuncture have been studied in a series of
randomized controlled trials in patients with major depression. Overall, the best evidence supports the use of
St. John's wort for the treatment of mild to moderate depression. SAMe may also be effective for depression.
However, both of these products have the potential to induce mania; the extent of this risk needs to be quantified.
St. John's wort can also interact with a variety of medications. Evidence regarding the benefits of omega-3 fatty
acids or acupuncture is inconsistent. Data regarding other CAM interventions (e.g., aromatherapy massage,
massage therapy, yoga) are almost entirely lacking. "
Complementary medicines in pediatric bipolar disorder.
"Omega-3 fatty acids and lecithin/ choline have preliminary data indicating potential utility in the CAM treatment
for bipolar disorder while S-adenosyl methionine (SAM-e) and inositol have some data supporting their efficacy in
the treatment of depressive symptoms. Some data for CAM suggest they may be useful adjunctive treatments but
only little data are available to support their use as stand-alone therapy."
Non-Standard Anti-Anxiety Treatment
"I used the herbal extract curcumin to block the NF kappa-B mediated inflammation, taking curcumin in 3 or 4
daily doses of 500 to 1000 mg. You have to take it several times a day to work: say a capsule at breakfast, one at
lunch, one at supper time, and one before bed. This is because the plasma half-life of curcumin is short: 3 to 6
hours, so you need to take it 3 or 4 times a day to keep up your anti-inflammatory blockade.
Another good blocker of NF kappa-B mediated inflammation that can be used in place of curcumin (or in addition,
if you want) is grape seed extract 500 mg daily. High doses of curcumin can occasionally slightly increase anger
and irritability in some people, so keep a watch out for that; grape seed extract does not have this problem.
Other good NF kappa-B blockers that you can use are: ashwagandha (1000 mg), alpha lipoic acid (500 mg -
though some may not be able to take this high dose), sulfasalazine (500 to 1000 mg); sulfasalazine is usually a
well tolerated drug.
You might also want to simultaneously try a second anti-inflammatory: one that targets COX-2 mediated
inflammation. This can further lower your anxiety. For this, take propolis herb, 1000 mg, on the same dosing
schedule (that is, 3 or 4 times a day - not before bed, though, as propolis can keep you awake). Propolis is an
potent COX-2 inhibitor. Cat's claw is another good COX-2 inhibitor, and 1000 mg of cat's claw can be used in
place of propolis (or in addition, if you want)."
3.12. Partial remission, residual symptoms, and relapse in depression
"This review primarily concerns unipolar disorder. However, there is a smaller but growing parallel literature
regarding bipolar disorder. ...
Such treatment may include not only antidepressants and possibly lithium augmentation, but also cognitive
therapy, which has been shown to reduce relapse rates, including in one study which specifically targeted
relapse-prone subjects with residual symptoms. In this study, we found that adding cognitive therapy to
full doses of antidepressant continuation and maintenance lowered relapse rates, and the effect lasted for 3 and
a half years after the end of the cognitive therapy. Residual symptoms at remission also suggest, that maintenance
antidepressant may be required, at least for 2 to 3 years. Such symptoms also indicate that, when treatment is
withdrawn, withdrawal should be slow."
3.13. Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria
for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial.
"At baseline, erythrocyte n-3 PUFA (poly unsaturated fatty acids) levels correlated positively with psychosocial
functioning and negatively with psychopathology. By the end of the intervention, n-3 PUFAs significantly improved
functioning and reduced psychiatric symptoms, compared with placebo."
3.14. Mysteries of the mind week (TVO)
The smarter brain
The future brain
3.15. Dr. Daniel Amen (Amen clinics)
Brain Health Tips from Dr. Daniel Amen - SuperheroYou
Healing Anxiety, Depression, and Bipolar
Daniel Amen, M.D. discussing ADD and ADHD
3.16. Dr. Jeffrey M Schwartz
Dr Jeffrey M Schwartz 'You are not your brain'
3.17. Stanford's Sapolsky On Depression
3.18. The Brain's Way of Healing
4. Food and Supplements
4.1. What's New and Beneficial About Onions
"For example, a red onion can lose about 20% of its quercetin and almost 75% of its anthocyanins if it is "over peeled.""
"The flavonoid content of onions can vary widely, depending on the exact variety and growing conditions. Although the average onion is likely to contain less than 100 milligrams of quercetin per 3-1/2 ounces, some onions do provide this amount."
(Quercetin in onions = 100mg/100g maximum)
4.2. Quercetin
"red onion => 32mg/100g"
"kale => 23mg/100g"
4.3. Absorption and antioxidant effects of quercetin from onions, in man.
"... aged between 25 and 39 y, ingested 225 g of fried onions.."
"quercetin levels increased from baseline values (28.4 +/- 1.9 ng/ml) to peak after 2 h (248.4 +/- 103.9 ng/ml), decreasing to baseline again after 24 h"
4.4. CO-ADMINISTRATION OF ALOE VERA WITH PIPERINE AND MORINGA OLEIFERA WITH CURCUMIN ATTENUATE BERYLLIUM INDUCED BLOOD BIOCHEMICAL ALTERATIONS IN RAT.
"Female albino rats were administered beryllium nitrate at doses of 1mg/kg i.p. once a day for 90 consecutive days followed by combination therapy of Aloe vera (150mg/kg p.o.) with piperine (2.5mg/kg p.o.) and Moringa oleifera root extract (150mg/kg p.o.) with curcumin (5mg/ kg p.o.) once a day for last 15 days to encounter the characteristic blood biochemical alterations. Exposure of berylliumnitrate induced severe alterations in blood biochemical variables. Beryllium nitrate disturbed liver function test as evidenced by induced leakage of AST, ALT in serum whereas activity of SALP was decreased. Exposure of beryllium nitrate disturbed the kidney function test by increased level of urea, uric acid and creatinine. A significant increase in triglyceride, cholesterol and bilirubin was recorded whereas hemoglobin, albumin and blood sugar was decreased as compare to control. Treatment with therapeutic agents maintained the liver and kidney function test and other blood biochemical variables whereas combination therapy of Aloe vera with piperine was found to be most effective in reversal of blood biochemical variablesmore towards control. By present study, it can be concluded that combination therapy of Aloe vera with piperine is better option in treatment of beryllium toxicity."
4.5. Minding Your Mitochondria: Dr. Terry Wahls at TEDxIowaCity
2001 - diagnosed with MS
2003 - transitioned to secondary progressive MS; took chemo therapy; reclined wheel chair; took drugs;
still the disease progressed;
started reading PubMed on diseases causing the brain to shrink (MS, Huntington, Parkinson, Alzheimer);
in all the mitochondria did not work well;
mitochondria is protected by fish oil, creatine and CoQ 10;
taking the above slowed down the progression of the disease;
[2:15] Institute for functional medicine;
B1, B6, B9, B12, Omega 3, Iodine, Sulfur, Antioxidants;
[4:15] relized that if taking all these from food will provide hundreds of others, not yet discovered/studied.
[7:45] started with hunter gatherer diet - 2 ... 10 times more nutrients than Recommended Daily Allowance;
[9:00] 3 cups of green leafs;
kale, parsley
3 cups of sulfur rich vegetables;
cabbage, broccoli, cauliflower, brussels sprouts, turnips, radishes, kale
onion, garlic, leeks, chives, mushrooms, asparagus
3 cups of bright color;
(3 different colors every day), beets, carrots, peppers, red cabbage, berries, fruit
grass fed meat;
wild fish (salmon, herring)
(organic) organ meat (1 time a week);
seaweed (1 time a week)
[13:00] eat vegetables before bread and other meals
[13:35] food allergies and sensitivities (gluten, dairy)
2007 [14:50] - cannot sit in a normal chair, can walk short distance using 2 canes;
started the diet
3 months later - walk with 1 cane
(2008) 1 month later - walk without a cane
1 month later - ride a bike again
4 month later - peddled 18 miles
2009 trail ride (riding horse)
4.6. Healing with Vitamins
4.7. Swedish Bitters
Claims about healing multiple illnesses.
I personally have experienced great improvements for stomach pain (ulcer), and wound healing (topical application).
One side effect for internal use is diarrhea.
4.8. Directions For Using Green Clay
Note: I follow only the instructions for the first week:
1 teaspoon in 8oz of water, left for 8 hours. Drink the water only.
"Make sure you drink plenty of water so you don’t get constipated."
4.9. Sugar: The Bitter Truth
[16:45] high fructose corn syrup;
[39:20] low fat diet (high carb diet);
[43:00] fructose is not glucose
[51:15] alcohol vs. sugar
[57:45] fructose is poison (only metabolized in the liver); causes gout and high blood pressure; 30% ends up as fat;
insulin resistance; leptin resistance
(cases you to feel tired; lack of energy because the brain "thinks" the body is starving
and issues "command" - save energy)
[1:09:00] alcohol vs sugar - chronic illnesses list
4.10. Supersize ME
(a must see documentary about a man that goes on McDonald's diet for a month)
Note: from time to time they say that it is the high fat diet. Actually it is a high sugar diet + lots of trans-fats.
Saturated fat from natural sources is beneficial.
4.11. Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats
This is far more than a cook book. It is filled with information on vitamins, minerals, studies (Weston Price)
and traditional recipes (including how to make fermented food).
Highly recommended.
4.12. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial12
"Fifty men and women, 40–76 years of age with knee OA pain were enrolled in an outpatient medical center.
Intervention was MSM 3g or placebo twice a day for 12 weeks (6g/day total). "
"Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment
(P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also
produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation
(P<0.05)."
4.13. Toxicity of methylsulfonylmethane in rats
"MSM administered as a daily dose of 1.5 g/kg for 90 days by gavage resulted in no adverse events or mortality.
Necropsy did not reveal any gross pathological lesions or changes in organ weights. Renal histology of treated animals
was normal. It is concluded that MSM is well tolerated in rats at an acute dose of 2 g/kg and at a subacute chronic dose
of 1.5 g/kg."
4.14. Serrapeptase
"Serrapeptase tends to be recommended to be ingested at 10-60mg daily, taken on an empty stomach (30 minutes
before a meal or 2 hours after the last meal) and divided into up to three daily doses; most studies used a protocol where 10mg serrapeptase was taken every 8 hours (starting upon waking)."
"Appears to reduce swelling and inflammation following surgery or trauma, although to a lesser degree than
corticosteroids."
"When a decrease in inflammation occurs post surgery, there appears to be a concomitant reduction in pain;"
"Related to the antiinflammatory effects, swelling and edema post surgery appear to be reduced.4.15."
4.16. B12 Methylcobalamin
"standard dose 1mg (1 tablet) for advanced neurological disorders take 5mg (5 tablets)/day"
" maximum doses of up to 25mg and 50mg have been tested without toxicity"
"used for Multiple sclerosis, Alzheimer, diabetic neuropathy, Bell's palsy"
4.17. Boron
Essentiality of boron for healthy bones and joints.
for osteoarthritis - 6mg/day
Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet
"Nutritional needs for bone health can be met with proper food choices. (Table ?22) However, supplementation of
the average American diet is recommended for vitamin D, calcium, magnesium, silicon, vitamin K, and boron.
Regular exercise is also important for bone health. Modest amounts of zinc supplementation may be appropriate
for vegetarians and for older individuals. However, routine supplementation with zinc, manganese, copper and
other metals is generally unnecessary, and excessive supplementation may be harmful. Supplementation with
strontium should also be questioned until long-term risks and benefits are better understood."
Therapeutic effect of dietary boron supplement on retinoic acid-induced osteoporosis in rats
"The dietary boron supplement can increase the serum content of boron of osteoporotic rats to stimulate bone
formation and inhibit bone resorption, producing therefore obvious therapeutical effect against osteoporosis."
Chemical composition and potential health effects of prunes: a functional food?
"Phenolic compounds in prunes had been found to inhibit human LDL oxidation in vitro, and thus might serve as
preventive agents against chronic diseases, such as heart disease and cancer. Additionally, high potassium content
of prunes (745 mg/100 g) might be beneficial for cardiovascular health. Dried prunes are an important source of
boron, which is postulated to play a role in prevention of osteoporosis. A serving of prunes (100 g) fulfills the daily
requirement for boron (2 to 3 mg)."
Delay of natural bone loss by higher intakes of specific minerals and vitamins.
"Calcium and vitamin D support bone mineral density and are basic components in most preventive strategies.
Magnesium is involved in a number of activities supporting bone strength, preservation, and remodeling.
Fluorine and strontium have bone-forming effects. However, high amounts of both elements may reduce bone
strength.
Boron is especially effective in case of vitamin D, magnesium, and potassium deficiency.
Vitamin K is essential for the activation of osteocalcin.
Vitamin C is an important stimulus for osteoblast-derived proteins."
Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical
properties and corresponding metabolic hormones in rats.
"Analysis between the control with the groups 2 and 3 revealed that vibration in the G2 increased the body weight ...,
with no other major difference in plasma and bone indices. Comparison between the control with the G4-G7 (the oil
groups) revealed that the rats in the G5 had a lower body weight (15 % less) and a significant increase in plasma
levels of Estradiol in the G7 was noted.
In addition, levels of Testosterone in the G4 and G7, and Free Testosterone in the G7 had a remarkable increase.
Similar trend was observed for plasma levels of Vit. D in the G4 and G5.
The stiffness and the breaking strength of the femur in the G7, and the breaking strength of the lumbar in the G7
compared to the control and the G4 and G5 was significantly higher and tended to increase in comparison to the G6.
Better and stronger measurements observed for coconut oil is warranted to further study its effect on biomechanical
properties of bones."
Groups:
G1: regular food and drinking water;
G2: regular food and drinking water + physical activity (Whole body vibration);
G3: regular food and drinking water + physical activity + Calcium, Vit. D, Boron;
G4: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + canola oil;
G5: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + sunflower oil;
G6: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + mixed sunflower and canola oil;
G7: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + coconut oil;
4.18. Fish oil and equivalents
PSCO-524 (Green Lipped Mussel oil, Omega XL, Lyprinol)
Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked
against fish oil, a randomized trial, without placebo control.
"PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil.
There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated
with fish oil showed significantly less improvement and a greater level of physical discomfort during the study."
A randomized controlled trial investigating the effects of PCSO-524(R), a patented oil extract of the New Zealand
green lipped mussel (perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and
adolescents (aged 6--14 years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study
protocol ACTRN12610000978066.
Marine lipid fraction PCSO-524 (lyprinol/omega XL) of the New Zealand green lipped mussel attenuates
hyperpnea-induced bronchoconstriction in asthma.
Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run.
"A marine product from Perna canaliculus (green-lipped New Zealand mussel) has attracted attention because of its
anti-inflammatory activity8 and an unusually wide variety of constituent triglycerides, sterol esters, sterols, polar
lipids, and free fatty acids.
Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel
(Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial.
4.19. The Science of Healthy Aging: Living Better, Not Just Longer
"For example, a red onion can lose about 20% of its quercetin and almost 75% of its anthocyanins if it is "over peeled.""
"The flavonoid content of onions can vary widely, depending on the exact variety and growing conditions. Although the average onion is likely to contain less than 100 milligrams of quercetin per 3-1/2 ounces, some onions do provide this amount."
(Quercetin in onions = 100mg/100g maximum)
4.2. Quercetin
"red onion => 32mg/100g"
"kale => 23mg/100g"
4.3. Absorption and antioxidant effects of quercetin from onions, in man.
"... aged between 25 and 39 y, ingested 225 g of fried onions.."
"quercetin levels increased from baseline values (28.4 +/- 1.9 ng/ml) to peak after 2 h (248.4 +/- 103.9 ng/ml), decreasing to baseline again after 24 h"
4.4. CO-ADMINISTRATION OF ALOE VERA WITH PIPERINE AND MORINGA OLEIFERA WITH CURCUMIN ATTENUATE BERYLLIUM INDUCED BLOOD BIOCHEMICAL ALTERATIONS IN RAT.
"Female albino rats were administered beryllium nitrate at doses of 1mg/kg i.p. once a day for 90 consecutive days followed by combination therapy of Aloe vera (150mg/kg p.o.) with piperine (2.5mg/kg p.o.) and Moringa oleifera root extract (150mg/kg p.o.) with curcumin (5mg/ kg p.o.) once a day for last 15 days to encounter the characteristic blood biochemical alterations. Exposure of berylliumnitrate induced severe alterations in blood biochemical variables. Beryllium nitrate disturbed liver function test as evidenced by induced leakage of AST, ALT in serum whereas activity of SALP was decreased. Exposure of beryllium nitrate disturbed the kidney function test by increased level of urea, uric acid and creatinine. A significant increase in triglyceride, cholesterol and bilirubin was recorded whereas hemoglobin, albumin and blood sugar was decreased as compare to control. Treatment with therapeutic agents maintained the liver and kidney function test and other blood biochemical variables whereas combination therapy of Aloe vera with piperine was found to be most effective in reversal of blood biochemical variablesmore towards control. By present study, it can be concluded that combination therapy of Aloe vera with piperine is better option in treatment of beryllium toxicity."
4.5. Minding Your Mitochondria: Dr. Terry Wahls at TEDxIowaCity
2001 - diagnosed with MS
2003 - transitioned to secondary progressive MS; took chemo therapy; reclined wheel chair; took drugs;
still the disease progressed;
started reading PubMed on diseases causing the brain to shrink (MS, Huntington, Parkinson, Alzheimer);
in all the mitochondria did not work well;
mitochondria is protected by fish oil, creatine and CoQ 10;
taking the above slowed down the progression of the disease;
[2:15] Institute for functional medicine;
B1, B6, B9, B12, Omega 3, Iodine, Sulfur, Antioxidants;
[4:15] relized that if taking all these from food will provide hundreds of others, not yet discovered/studied.
[7:45] started with hunter gatherer diet - 2 ... 10 times more nutrients than Recommended Daily Allowance;
[9:00] 3 cups of green leafs;
kale, parsley
3 cups of sulfur rich vegetables;
cabbage, broccoli, cauliflower, brussels sprouts, turnips, radishes, kale
onion, garlic, leeks, chives, mushrooms, asparagus
3 cups of bright color;
(3 different colors every day), beets, carrots, peppers, red cabbage, berries, fruit
grass fed meat;
wild fish (salmon, herring)
(organic) organ meat (1 time a week);
seaweed (1 time a week)
[13:00] eat vegetables before bread and other meals
[13:35] food allergies and sensitivities (gluten, dairy)
2007 [14:50] - cannot sit in a normal chair, can walk short distance using 2 canes;
started the diet
3 months later - walk with 1 cane
(2008) 1 month later - walk without a cane
1 month later - ride a bike again
4 month later - peddled 18 miles
2009 trail ride (riding horse)
4.6. Healing with Vitamins
4.7. Swedish Bitters
Claims about healing multiple illnesses.
I personally have experienced great improvements for stomach pain (ulcer), and wound healing (topical application).
One side effect for internal use is diarrhea.
4.8. Directions For Using Green Clay
Note: I follow only the instructions for the first week:
1 teaspoon in 8oz of water, left for 8 hours. Drink the water only.
"Make sure you drink plenty of water so you don’t get constipated."
4.9. Sugar: The Bitter Truth
[16:45] high fructose corn syrup;
[39:20] low fat diet (high carb diet);
[43:00] fructose is not glucose
[51:15] alcohol vs. sugar
[57:45] fructose is poison (only metabolized in the liver); causes gout and high blood pressure; 30% ends up as fat;
insulin resistance; leptin resistance
(cases you to feel tired; lack of energy because the brain "thinks" the body is starving
and issues "command" - save energy)
[1:09:00] alcohol vs sugar - chronic illnesses list
4.10. Supersize ME
(a must see documentary about a man that goes on McDonald's diet for a month)
Note: from time to time they say that it is the high fat diet. Actually it is a high sugar diet + lots of trans-fats.
Saturated fat from natural sources is beneficial.
4.11. Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats
This is far more than a cook book. It is filled with information on vitamins, minerals, studies (Weston Price)
and traditional recipes (including how to make fermented food).
Highly recommended.
4.12. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial12
"Fifty men and women, 40–76 years of age with knee OA pain were enrolled in an outpatient medical center.
Intervention was MSM 3g or placebo twice a day for 12 weeks (6g/day total). "
"Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment
(P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also
produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation
(P<0.05)."
4.13. Toxicity of methylsulfonylmethane in rats
"MSM administered as a daily dose of 1.5 g/kg for 90 days by gavage resulted in no adverse events or mortality.
Necropsy did not reveal any gross pathological lesions or changes in organ weights. Renal histology of treated animals
was normal. It is concluded that MSM is well tolerated in rats at an acute dose of 2 g/kg and at a subacute chronic dose
of 1.5 g/kg."
4.14. Serrapeptase
"Serrapeptase tends to be recommended to be ingested at 10-60mg daily, taken on an empty stomach (30 minutes
before a meal or 2 hours after the last meal) and divided into up to three daily doses; most studies used a protocol where 10mg serrapeptase was taken every 8 hours (starting upon waking)."
"Appears to reduce swelling and inflammation following surgery or trauma, although to a lesser degree than
corticosteroids."
"When a decrease in inflammation occurs post surgery, there appears to be a concomitant reduction in pain;"
"Related to the antiinflammatory effects, swelling and edema post surgery appear to be reduced.4.15."
4.16. B12 Methylcobalamin
"standard dose 1mg (1 tablet) for advanced neurological disorders take 5mg (5 tablets)/day"
" maximum doses of up to 25mg and 50mg have been tested without toxicity"
"used for Multiple sclerosis, Alzheimer, diabetic neuropathy, Bell's palsy"
4.17. Boron
Essentiality of boron for healthy bones and joints.
for osteoarthritis - 6mg/day
Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet
"Nutritional needs for bone health can be met with proper food choices. (Table ?22) However, supplementation of
the average American diet is recommended for vitamin D, calcium, magnesium, silicon, vitamin K, and boron.
Regular exercise is also important for bone health. Modest amounts of zinc supplementation may be appropriate
for vegetarians and for older individuals. However, routine supplementation with zinc, manganese, copper and
other metals is generally unnecessary, and excessive supplementation may be harmful. Supplementation with
strontium should also be questioned until long-term risks and benefits are better understood."
Therapeutic effect of dietary boron supplement on retinoic acid-induced osteoporosis in rats
"The dietary boron supplement can increase the serum content of boron of osteoporotic rats to stimulate bone
formation and inhibit bone resorption, producing therefore obvious therapeutical effect against osteoporosis."
Chemical composition and potential health effects of prunes: a functional food?
"Phenolic compounds in prunes had been found to inhibit human LDL oxidation in vitro, and thus might serve as
preventive agents against chronic diseases, such as heart disease and cancer. Additionally, high potassium content
of prunes (745 mg/100 g) might be beneficial for cardiovascular health. Dried prunes are an important source of
boron, which is postulated to play a role in prevention of osteoporosis. A serving of prunes (100 g) fulfills the daily
requirement for boron (2 to 3 mg)."
Delay of natural bone loss by higher intakes of specific minerals and vitamins.
"Calcium and vitamin D support bone mineral density and are basic components in most preventive strategies.
Magnesium is involved in a number of activities supporting bone strength, preservation, and remodeling.
Fluorine and strontium have bone-forming effects. However, high amounts of both elements may reduce bone
strength.
Boron is especially effective in case of vitamin D, magnesium, and potassium deficiency.
Vitamin K is essential for the activation of osteocalcin.
Vitamin C is an important stimulus for osteoblast-derived proteins."
Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical
properties and corresponding metabolic hormones in rats.
"Analysis between the control with the groups 2 and 3 revealed that vibration in the G2 increased the body weight ...,
with no other major difference in plasma and bone indices. Comparison between the control with the G4-G7 (the oil
groups) revealed that the rats in the G5 had a lower body weight (15 % less) and a significant increase in plasma
levels of Estradiol in the G7 was noted.
In addition, levels of Testosterone in the G4 and G7, and Free Testosterone in the G7 had a remarkable increase.
Similar trend was observed for plasma levels of Vit. D in the G4 and G5.
The stiffness and the breaking strength of the femur in the G7, and the breaking strength of the lumbar in the G7
compared to the control and the G4 and G5 was significantly higher and tended to increase in comparison to the G6.
Better and stronger measurements observed for coconut oil is warranted to further study its effect on biomechanical
properties of bones."
Groups:
G1: regular food and drinking water;
G2: regular food and drinking water + physical activity (Whole body vibration);
G3: regular food and drinking water + physical activity + Calcium, Vit. D, Boron;
G4: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + canola oil;
G5: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + sunflower oil;
G6: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + mixed sunflower and canola oil;
G7: regular food and drinking water + physical activity + Calcium, Vit. D, Boron + coconut oil;
4.18. Fish oil and equivalents
PSCO-524 (Green Lipped Mussel oil, Omega XL, Lyprinol)
Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked
against fish oil, a randomized trial, without placebo control.
"PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil.
There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated
with fish oil showed significantly less improvement and a greater level of physical discomfort during the study."
A randomized controlled trial investigating the effects of PCSO-524(R), a patented oil extract of the New Zealand
green lipped mussel (perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and
adolescents (aged 6--14 years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study
protocol ACTRN12610000978066.
Marine lipid fraction PCSO-524 (lyprinol/omega XL) of the New Zealand green lipped mussel attenuates
hyperpnea-induced bronchoconstriction in asthma.
Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run.
"A marine product from Perna canaliculus (green-lipped New Zealand mussel) has attracted attention because of its
anti-inflammatory activity8 and an unusually wide variety of constituent triglycerides, sterol esters, sterols, polar
lipids, and free fatty acids.
Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel
(Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial.
4.19. The Science of Healthy Aging: Living Better, Not Just Longer