Essential oils
Active ingredients:
Essential oils:
Carriers:
LD50 (for rats -> /6 for approximate human dose):
Toxicity Myths - the Actual Risks of Essential Oils Use
https://www.doterra.com/US/en/essential-oil-safety-and-application-appropriate-dose-internal-GRAS
References:
Exploitation of Cytotoxicity of Some Essential Oils for Translation in Cancer Therapy
The essential oil of turpentine and its major volatile fraction
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.
Anti-tumor effect of α-pinene on human hepatoma cell lines
Turmerones - improved curcumin absorption and additional anticancer effect:
https://www.ncbi.nlm.nih.gov/pubmed/21660443
https://www.ncbi.nlm.nih.gov/pubmed/23847105
https://www.ncbi.nlm.nih.gov/pubmed/23229920
https://www.ncbi.nlm.nih.gov/pubmed/22181075
https://www.ncbi.nlm.nih.gov/pubmed/15254774
https://www.ncbi.nlm.nih.gov/pubmed/20438793
Notes:
Turpentine:
2 protocols (timing and duration varies):
1 drop of water = ~50mg => 9 drops = ~450mg
1 tea spoon => 5ml = 5000mg
Turpentine specific gravity = ~0.87
=> 1 tea spoon of turpentine = 0.87*5000mg = 4350mg
=> 9 drops = ~0.87*450 = 390mg
Turpentine LD50 for rat => 5760mg/kg;
For human estimated LD50 = 5760mg/6.2 = 930mg/kg => 70kg person => 65,100mg => safety factor of 10 => 6510mg
Looking on Amazon there are several turpentine brands that list the type of pine used:
https://www.amazon.com/Pine-Gum-Spirits-Essential-Rectified/dp/B00QK4M206/ref=pd_sbs_201_6?_encoding=UTF8&pd_rd_i=B00QK4M206&pd_rd_r=2J85XDTZV77GHADZ3Y28&pd_rd_w=26He3&pd_rd_wg=YUQpP&refRID=2J85XDTZV77GHADZ3Y28&th=1
https://www.amazon.com/100-Pure-Gum-Spirits-Turpentine/dp/B00KE62DWS/ref=sr_1_sc_1?ie=UTF8&qid=1502852053&sr=8-1-spell&keywords=100%25+pure+gums+of+turpentineoil
http://www.diamondgforestproducts.com/~shop/16oz-100ure-gum-spirits-of-turpentine/186771/?catId=34919
These are derived from pinus elliottii:
https://naldc.nal.usda.gov/download/CAT87201182/PDF (page 95)
a-pinene - 75.6% 61.0% 71%
b-pinene - 21.2 33.7% 3..4%
https://www.amazon.com/Turpentine-Essential-100ml-Pinus-palustris/dp/B01G8ZUGNG/ref=pd_sbs_201_10?_encoding=UTF8&pd_rd_i=B01G8ZUGNG&pd_rd_r=2J85XDTZV77GHADZ3Y28&pd_rd_w=26He3&pd_rd_wg=YUQpP&psc=1&refRID=2J85XDTZV77GHADZ3Y28
https:/www.amazon.com/BlueArrowExpress-Turpentine-essensial-natural-Palustres/dp/B0735Z3YMY/ref=sr_1_sc_2?ie=UTF8&qid=1502852053&sr=8-2-spell&keywords=100%25+pure+gums+of+turpentineoil
These are from pinus palastris:
https://naldc.nal.usda.gov/download/CAT87201182/PDF (page 94)
a-pinene - 64.3%
b-pinene - 31.1%
Frankinsense for comparison contains:
https://www.facebook.com/EssentialOilUniversity/photos/a.10150257060058083.379605.82862428082/10153322755628083/?type=3&theater
a-pinene: 60.35%
Limonene: 6.37%
b-pinene: 6.1%
3-Carene: 6.1%
a-Thujene: 5.36%
Sabinene: 3.14%
para-Cymene: 2.58%
g-Terpinene: 2.32%
a-Phellandrene: 1.42%
Camphene: 1.03%
https://bkbotanicals.com/blogs/essential-oils-gc-ms-analysis/44283845-frankincense-carterii-pure-essential-oil-gc-ms-analysis
α-Pinene 45.4%
b-Caryophyllene 1.24%
β-Pinene 4.2%
Limonene 6.93%
α-Thujene 2.36%
Sabinene 2.34%
Myrcene 2.28%
α-Phellandrene 0.92%
Para-Cymene 0.26%
- 1,8-cineole: tea tree, sage, eucaliptus globulus/radiata, helichrysum gymnocephalum, niaouli, saro, laurel leaf, ravintsara
- a-pinene, alpha-terpinen: tea tree, sage, frankinsense, turpentine
- a-thujone: sage, frankinsense
- b-pinene: frankinsense, turpentine
- b-thujone: sage
- bornyl acetate: sage
- camphor: sage
- camphene: sage
- gama-pinene, gamma-terpinen: tea tree
- humulene: sage
- limonene: sage, bergamot, frankinsense
- linalool: sage
- linalyl acetate: bergamot
- myrcene: frankinsense
- p-cymene: tea tree
- terpinen-4-ol: tea tree
- thymol: thyme
- a-turmerone, r-turmerone: turmeric
Essential oils:
- tea tree
- lemon balm, lemon, lime
- sage
- thyme
- bergamot
- artemisia (wormwood)
- lemon grass
- oregano
- black seed
- pine needles/bark, pure gum spirits of turpentine
- eucaliptus
- frankinsense
- turmeric
Carriers:
- Castor oil
- Coconut oil
- DMSO
- alchohol
- sesame seed, almond oil, olive oil, apricot kernel, jojoba, vit. E cream ... ?
LD50 (for rats -> /6 for approximate human dose):
- Castor oil - 6400 mg/kg
- Turpentine - 5760 mg/kg
- Frankinsense oil - ~5000 mg/kg
- Eucaliptus oil - 2480 mg/kg
- Tea tree oil - 2300 mg/kg
- Oregano oil - 1850 mg/kg
- sugar - 30,000 mg/kg
- alcohol - 7060 mg/kg
- salt - 3000 mg/kg; (for human 12,357 mg/kg)
- aspirin - 200 mg/kg
- caffeine - 192 mg/kg; 1 cup of coffee -> 98 mg caffeine
Toxicity Myths - the Actual Risks of Essential Oils Use
https://www.doterra.com/US/en/essential-oil-safety-and-application-appropriate-dose-internal-GRAS
References:
Exploitation of Cytotoxicity of Some Essential Oils for Translation in Cancer Therapy
The essential oil of turpentine and its major volatile fraction
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.
Anti-tumor effect of α-pinene on human hepatoma cell lines
Turmerones - improved curcumin absorption and additional anticancer effect:
https://www.ncbi.nlm.nih.gov/pubmed/21660443
https://www.ncbi.nlm.nih.gov/pubmed/23847105
https://www.ncbi.nlm.nih.gov/pubmed/23229920
https://www.ncbi.nlm.nih.gov/pubmed/22181075
https://www.ncbi.nlm.nih.gov/pubmed/15254774
https://www.ncbi.nlm.nih.gov/pubmed/20438793
Notes:
Turpentine:
2 protocols (timing and duration varies):
- 9 drops / day ?
- 1 tea spoon (2 times a week, 3 bowel movements/day or using castor oil)
1 drop of water = ~50mg => 9 drops = ~450mg
1 tea spoon => 5ml = 5000mg
Turpentine specific gravity = ~0.87
=> 1 tea spoon of turpentine = 0.87*5000mg = 4350mg
=> 9 drops = ~0.87*450 = 390mg
Turpentine LD50 for rat => 5760mg/kg;
For human estimated LD50 = 5760mg/6.2 = 930mg/kg => 70kg person => 65,100mg => safety factor of 10 => 6510mg
Looking on Amazon there are several turpentine brands that list the type of pine used:
https://www.amazon.com/Pine-Gum-Spirits-Essential-Rectified/dp/B00QK4M206/ref=pd_sbs_201_6?_encoding=UTF8&pd_rd_i=B00QK4M206&pd_rd_r=2J85XDTZV77GHADZ3Y28&pd_rd_w=26He3&pd_rd_wg=YUQpP&refRID=2J85XDTZV77GHADZ3Y28&th=1
https://www.amazon.com/100-Pure-Gum-Spirits-Turpentine/dp/B00KE62DWS/ref=sr_1_sc_1?ie=UTF8&qid=1502852053&sr=8-1-spell&keywords=100%25+pure+gums+of+turpentineoil
http://www.diamondgforestproducts.com/~shop/16oz-100ure-gum-spirits-of-turpentine/186771/?catId=34919
These are derived from pinus elliottii:
https://naldc.nal.usda.gov/download/CAT87201182/PDF (page 95)
a-pinene - 75.6% 61.0% 71%
b-pinene - 21.2 33.7% 3..4%
https://www.amazon.com/Turpentine-Essential-100ml-Pinus-palustris/dp/B01G8ZUGNG/ref=pd_sbs_201_10?_encoding=UTF8&pd_rd_i=B01G8ZUGNG&pd_rd_r=2J85XDTZV77GHADZ3Y28&pd_rd_w=26He3&pd_rd_wg=YUQpP&psc=1&refRID=2J85XDTZV77GHADZ3Y28
https:/www.amazon.com/BlueArrowExpress-Turpentine-essensial-natural-Palustres/dp/B0735Z3YMY/ref=sr_1_sc_2?ie=UTF8&qid=1502852053&sr=8-2-spell&keywords=100%25+pure+gums+of+turpentineoil
These are from pinus palastris:
https://naldc.nal.usda.gov/download/CAT87201182/PDF (page 94)
a-pinene - 64.3%
b-pinene - 31.1%
Frankinsense for comparison contains:
https://www.facebook.com/EssentialOilUniversity/photos/a.10150257060058083.379605.82862428082/10153322755628083/?type=3&theater
a-pinene: 60.35%
Limonene: 6.37%
b-pinene: 6.1%
3-Carene: 6.1%
a-Thujene: 5.36%
Sabinene: 3.14%
para-Cymene: 2.58%
g-Terpinene: 2.32%
a-Phellandrene: 1.42%
Camphene: 1.03%
https://bkbotanicals.com/blogs/essential-oils-gc-ms-analysis/44283845-frankincense-carterii-pure-essential-oil-gc-ms-analysis
α-Pinene 45.4%
b-Caryophyllene 1.24%
β-Pinene 4.2%
Limonene 6.93%
α-Thujene 2.36%
Sabinene 2.34%
Myrcene 2.28%
α-Phellandrene 0.92%
Para-Cymene 0.26%