Cancer

Cancer

Others have won this battle ... you can too!

Acknowledgement: Much of the information on this webpage has been collected thanks to the people participating in
Cancercured Alternative Cancer Treatment Yahoo newsgroup.

Disclaimer:
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual.

Other resources:
  LEF
  General Health Info
Textbook of natural medicine
Designing a broad-spectrum integrative approach for cancer prevention and treatment (link, link2)
   Thousand plants against cancer without chemotherapy
Diet and supplements for prostate cancer

1. Supplements
Note: In general all supplements should be started with low doses and increased slowly.
If adverse affects occur, reduce dosage, or stop taking it.
If you are on any medications talk to a health care practitioner if the supplement you want to take can
interfere with your medications.

Note: dose conversion for doses tested on animals to human:
   To scale or not to scale: the principles of dose extrapolation
       Dose translation from animal to human studies revisited
[Km Table]
Human dose [mg/kg] = substance dose tested on animal [mg/kg]
* (animal weight [kg] / human weight [kg]) ^ (0.33)
or
  Human dose [mg/kg] = dose tested on animal [mg/kg] * animal_Km / human_Km
or approximately:
Human dose = dose tested on mice / 12

In general starting dose should be 1/10 of the calculated one and increased slowly monitoring for side effects.

Medical Calculations and Conversions

Supplements for specific cancer types:
Note: This list is by no means complete!

  Leukemia:
  Curcumin, Artemisinin, DIM, Rutin, IV Vit.C, Bromelain, Boswellia, Ivermectin (link)
Ellagic acid + Resveratrol,
Quercetin + Resveratrol
Selenium + Vit. E
Hemp Oil
Curcumin + EGCG
Pomegranate extract; Ellagic acid (?)
Carnivora (?)
Mushrooms (Reishi) (?)
Mifepristone (link)
Andrographis
Dandelion
Methyl Jasmonate

Lymphoma:
  Curcumin, Artemisinin, IV Vit.C, Iscador
ALA/N Protocol
Methyl Jasmonate
s-acetyl-glutathione (?) (link)

  Head and neck cancer:
  Curcumin, Artemisinin, Iscador, Bitter melon
Hemp Oil
Oil pulling (with curcumin and/or green tea/EGCG) for oral cancers.
Curcumin + EGCG
Carnivora (?)
Beta Glucan (Lentinan + S-1 (link))
LDN+D3 (ALA/N ?)
GcMAF

Lung cancer:
  Curcumin, DIM, EGCG, Quercetin, Bromelain, Astragalus+radiation
Hemp Oil
Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin (?)
Calcium Fructoborate (?) + Reseveratrol (?)
Pomegranate extract; Ellagic acid (?)
Carnivora (?)
Mushrooms (Lion's Mane, Reishi)
Andrographis
Artemisinin

Pancreatic cancer:
Curcumin, Artemisinin, DIM, EGCG, Quercetin, Resveratrol, IV Vit.C, Bitter melon, Boswellia
ALA/N Protocol
Curcumin + Omega 3
Pomegranate extract; Ellagic acid (?)
Carnivora (?)
   L-Methionine
Dandelion
IP6
Diclofenac (link)
BICT (link)
- ginseng (Panax ginseng C.A. Mey.),
Herba Agrimonia (Agrimonia pilosa Ledeb.),
White Flower Patrinia Herb (Thlaspi arvense Linn.)
arginine
hyperthermia (local)
Doxycycline (link)

  Gastrointestinal cancer:
Curcumin, Artemisinin, DIM, Astragalus, EGCG, Quercetin, Ellagic acid, IV Vit.C, Boswellia
Ulinastatin + curcumin
Curcumin + resveratrol
Curcumin + Turmerones
(?) Curcumin + hyaluronic acid (see notes on curcumin)
Hemp Oil
Selenium + Vit. E
Diallyl disulphide/garlic oil
Pomegranate extract
Carnivora (?)
Rutin
Bee polen
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly)
Mushrooms (Reishi)
  L-Methionine
Andrographis
IP6
GcMAF
Sodium Butyrate
     Ivermectin (link)

  Liver cancer:
Curcumin, Artemisinin (? liver toxicity ?), Astragalus, IV Vit.C
  Ulinastatin + curcumin
  Curcumin + resveratrol
  Curcumin + taurine
  Curcumin + Embellin
ALA/N Protocol
Hemp Oil
  Milk Thistle
  Pomegranate extract; Ellagic acid (?)
  Carnivora (?)
Quercetin
Melatonin
Black / Green tea / Coffee (Caffeine); EGCG (? liver toxicity ?)
Mushrooms (Reishi)
  Andrographis
IP6
BICT (link)
- ginseng (Panax ginseng C.A. Mey.),
Herba Agrimonia (Agrimonia pilosa Ledeb.),
White Flower Patrinia Herb (Thlaspi arvense Linn.)
arginine
hyperthermia (local)
   Neupogen (?) (link)

Breast cancer:
Curcumin, Artemisinin, Maitake Mushrooms, DIM, EGCG, Bromelain, MSM, Boswellia
Selenium + Vit. E
Hemp Oil
  Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + (Quercetin ?)
  Curcumin + Genistein
  Curcumin + Piperine
  Calcium Fructoborate + Reseveratrol (?)
Pomegranate extract; Ellagic acid (?)
  Pomegranate extract + genistein
  Carnivora (?)
Peaches (fruit)
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly)
Mushrooms (Reishi)
Dandelion
IP6
  L-Methionine
  Mifepristone (link - reducing the effect of progesterone, link2)
  Andrographis
Methyl Jasmonate
GcMAF
Recommendations From Life Extension:
- Diet: low glucemic index food, fish, whey, eggs, nuts, hormone free poultry, hormone free low fat
diary products;
no sugar, white flower, white rice etc.; limit fruit juices; low fat diet (high fat diet increases
estrogen); try to loose weight (fat tissue) to reduce estrogen; reduce dietary "estrogen"
(hormones in meat and dairy; soy etc). Avoid using soft plastic.
   - Testing: monthly tests for complete blood chemistry; liver; serum calcium; prolactin; parathyroid
hormone and CA 27.29 (or CA 15.3) tumor markers.
- Apigenin: 20 .. 50mg
- Astragalus: 2000 .. 4000 mg
- Blueberry extract: 900 .. 1800mg
- Chrysin: 1000 .. 2000mg
- I3C: 80 .. 160mg
- Curcumin (BCM-95): 400mg (3x day)
- Lightly caffeinated green tea extract: 725mg (2x day with meal)
- CLA + guarana: 3000 .. 4000 mg and 300mg guarana early in the day
- Lignans: 75 .. 125mg
- Melatonin: 3 .. 50mg at bed time
- Pomegranate extract: 280 .. 375mg (punicalagins)
- Powders (broccoli, cabbage, other veggies providing sulforaphane: 1 .. 2 tbsp/day
- PSK (from mushroom Coriolus versicolor): 3g
- Pterostilbene: 1.. 3mg
- Quercetin: 1000 .. 3000 mg
- Se-methylselnocysteine: 200 .. 400 mg
- Sulforaphane: 400 .. 1600mg (broccoli extract)
- CoQ10 (ubiquinol): 3x 100mg (maybe counter indicative during chemotherapy)
- EPA/DHA (take with sesame lignans): 2 .. 4 g (take with non fiber meals)
- Vit. D3: 4000 .. 6000 IU (monthly blood testing to monitor for toxicity)
- Water soluble Vit. A: 100,000 .. 300,000 IU (monthly blood testing to monitor for toxicity)
- Vit. E: 1200 IU (tocopheryl succinate)
- Gamma tocopherol: at least 359mg of gamma E-mixed tocopherols daily
- Vit. C: 4000 .. 12,000 mg
- GLA: 299 .. 1495mg
- Whey protein concentrate isolate: 30 .. 60 g/day in divided doses
- Calcium: 1000 .. 1200 mg
- Magnesium: 200 .. 1000 mg
- Vit. K: 10mg
- Silicon: 6mg
- Multi nutrient formula as per label instructions (? not clear, assuming from www.lef.org)
- Recommended drug therapies:
Bisphosphonate (Zometa or Avreda);
aromatase inhibitor therapy (Arimidex, Femara, Aromasin)
An Integrative Approach to Fibroids, Endometriosis, and Breast Cancer Prevention
- testing (toxins, hormones)
- estrogen elimination (exercise, detox foods, omega-3, I3C, probiotics, calcium-D-glucarate)
- decrease estrogen intake (diet, avoid hormone replacement therapy)
- avoid environmental toxins
- improve gut health to reduce estrogen levels
- maintain proper body weight
- maintain proper blood sugar and insulin levels
- reduce inflammation (recommendations include oral health, bromelain, curcumin, quercetin)
Doxycyline (link, link2) + IV Vit C (link)
     Ivermectin (link)

  Ovarian cancer:
Curcumin, Artemisinin, Apatone
ALA/N Protocol
  Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Reservatrol + (Quercetin ?)
  Carnivora (?)
  Mifepristone (link1, link2 - reducing the effect of progesterone)
Beta Glucan (link)
Andrographis
Diclofenac
   Ivermectin (link)

  Genitourinary cancers (urinary tract, bladder, kidneys, prostate, testicles and penis):
Curcumin, Artemisinin, DIM, EGCG, Quercetin, Ellagic acid, IV Vit.C, Apatone, Boswellia
  D-fraction (Maitake mushroom) + Vit. C
Hemp Oil
Selenium + Vit. E
  Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin (prostate ?)
   Curcumin + melatonin (link)
  Curcumin + PEITC
Liposomal Curcumin + Liposomal Resveratrol
Calcium Fructoborate (?) + Resveratrol (?)
  Pomegranate extract
  Carnivora (?)
Bee propolis (?)
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly)
  L-Methionine
  ProstaCaid
  Andrographis
Dandelion
IP6
Metformin + Vit. D3
Methyl Jasmonate
GcMAF
Doxycyline: http://www.ncbi.nlm.nih.gov/pubmed/9619856?dopt=Abstract

  Skin Cancer:
Curcumin, Artemisinin, EGCG, Bromelain, Boswellia
Tea Tree Oil + DMSO (topical application)
Curcumin + DMSO (topical application) ?
Hemp Oil (topical application)
Pomegranate extract; Ellagic acid (?)
Carnivora (?)
Curaderm Cream (article for both injection and topical application, video) (conflicting info with salves)
Mushrooms (Reishi)
Gerson treatment
Dandelion
IP6
Ingenol mebutate (link, link2, link3, link4, link5, link6, link7, link8, link9, link10, link11, link12, link13,
link14, link15)
Imiquimod cream (link)
Photodynamic therapy (link)
Methyl Jasmonate
GcMAF
Life Extension Suggestions
Polypodium extract: 240 – 480 mg daily (initial dose should be taken 30 minutes prior to sun exposure
and second dose taken following sun exposure)
Red Orange Complex: 100 – 200 mg daily
Melatonin: 0.3 – 5 mg 30 to 60 minutes before bedtime (sometimes up to 10 mg)
Vitamin D: 5000 – 8000 IU daily; depending upon blood levels of 25-OH-vitamin D
Curcumin (as highly absorbed phospholipid blend): 630 mg daily
Green tea extract (std. to 98% polyphenols): 725 mg daily
Grape seed extract: 100 mg daily
Niacin (Vitamin B3): 100 – 500 mg daily
Folate (as L-Methylfolate): 1000 mcg daily
Probiotics: 15 – 30 billion colony forming units (CFUs) daily
Milk thistle extract: providing 240 – 480 mg of silymarin daily
Fish oil (with olive polyphenols and sesame lignans): providing 1400 mg EPA and 1000 mg DHA daily;
or Liquid fish oil: 15 mL twice daily
French maritime pine bark extract: 100 – 200 mg daily
Resveratrol: 250 mg daily
Pterostilbene: 50 – 100 mg daily
Quercetin: 250 – 500 mg daily
Coenzyme Q10 (CoQ10) (as ubiquinol): 100 – 200 mg daily
Rosemary extract (providing carnosinic acid/carnosol): 50 – 100 mg daily
Honokiol extract: 1 – 3 g daily
Modified Citrus Pectin (MCP) (with alginate complex): 3 g daily
Fermented Wheat Germ extract: Per label instructions
Active Hexose Correlated Compound (AHCC): 1 – 3 g daily
Review of Natural Compounds for Potential Skin Cancer Treatment
Apoptosis promoter:
Quercetin, Kaempferol, EGCG, Apigenin, beta-carotene, Fucoxanthin, Vitamin C, Ganoderma lucidum
extract, Coriolus versicolor extract, Resveratrol, Curcumin, Sulforaphane, Melaleuca alternifolia extract,
Zingiber officinale extract, Withaferin A from Withania somnifera, Eupatilin from Artemisia, Galangin
from Alpinia officinarum

Anti-proliferative:
Kaempferol, EGCG, Apigenin, Vitamin A, Vitamin C, Vitamin D, Vitamin E, Ganoderma lucidum
extract, Coriolus versicolor extract, Hypericum perforatum extract, Melaleuca alternifolia extract,
Calendula officinalis extract, Emodin from Aloe, Eupatilin from Artemisia, Alpinia oxyphylla extract,
Alpinia galangal extract

Anti-metastatic:
Amentoflavone, Hinokiflavone, beta-carotene, Fucoxanthin, Vitamin A, Vitamin C, Resveratrol,
Sulforaphane, Withania somnifera extract, Viscum album extract, Calendula officinalis extract,
Carnosol from Rosmarinus officinalis, Ursolic acid from Rosmarinus officinalis

Neurological cancers:
Curcumin, Iscador

Sarcoma:
Artemisinin
Curcumin
Bee propolis (?)
Mushrooms (Reishi)
IP6

Bone cancer:
Curcumin, Artemisinin
Curcumin + Resveratrol + Diallyl Disulfide
Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin (bone metastasis?) Pomegranate extract (bone metastasis); Ellagic acid (?)
Carnivora (?)
Bee propolis (?)
Doxycyline (link)

Brain cancer:
Artemisinin, Resveratrol, Quercetin, Curcumin, Boswellia, Berberine, EGCG, Sulforaphane, Vit. D, Melatonin
Ketogenic Diet + calorie restriction + 2-DG
Hemp Oil
Iscador
Mushrooms (Reishi)
Aloe
IP6
  Mifepristone (link1, link2)
Cimetidine (?) (link)
Diclofenac (link)
  CUSP9 (link, link2)
Recommendations From Life Extension:
- Vit. D3: 5000IU; 50..80 ng/ml 25(OH)D3 serum test
- Melatonin: 10 .. 20mg before bed each night
- Selenium: 200 ug
- Vit. E (alpha tocopherol succinate): 400IU
- Berberine: 500 .. 1000mg
- Boswellia: 500 .. 1000mg
- Curcumin (BCM-95): 400 .. 1200 mg
- Quercetin: 1000mg
- EGCG: 700 .. 2100mg
- Trans-Resverantrol: 500mg
- Sulforaphane: 60 .. 90 mg
- Diet: Ketogenic diet; Caloric Restriction
- Experimental treatment with SSRIs: Clomipramine (+ Dexamethasone)
- Steroids prescribed during treatment may reduce the chemo effectiveness.
Try using Curcumin and Boswellia instead.
Metformin, statins, mebendazole, cimetidine, itraconazole, isotretenoin, doxycycline (link, link2) (?) D3

Other:
   PEMF devices (?) - link, link2

Additional references:
   Life Extension
   Cancer Killers
  http://www.healingfoodreference.com/
  Linus Pauling Institute
  http://doctorsaputo.com/; http://doctorsaputo.com/a/cancer;
  https://www.integrativeonc.org/
  http://www.curezone.org/diseases/cancer/default.asp

  Cancer-Free: Your Guide to Gentle, Non-toxic Healing (?)
Radical Remission Of Cancer; The book

  25 Cancer Stem Cell Killing Foods Smarter Than Chemo & Radiation


Synergetic combinations:
Curcumin + taurine
Curcumin + resveratrol (both liposomal) + ursolic acid
Curcumin + Ulinastatin
Curcumin + Resveratrol + Diallyl Disulfide
Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin
Curcumin + Genistein
  Curcumin + D3
  Curcumin + Omega 3
  Curcumin + Embellin
  Curcumin + PEITC
  Curcumin + EGCG
  Curcumin + Piperine
  Curcumin + Quercetin
Curcumin + Turmerones
  Curcumin + Diclofenac
Curcumin + melatonin (link)
(?) Curcumin + Hyaluronic acid (see notes on curcumin)
Ellagic acid + Resveratrol
Quercetin + Resveratrol
Quercetin + Omega 3
Apatone: Vit.C + K3
D-fraction (Maitake mushroom) + Vit. C
Vit. C + rutin (?) (link)
Vit.E + Selenium (+ Co Q10 + Vit.C)
Vit.D3 + Vit.K (MK-7)
Ketogenic Diet + calorie restriction + 2-DG
  Diallyl disulphide/garlic oil + (diet) short chain fatty acids/polysaccharides
  Calcium Fructoborate + Resveratrol
  Pomegranate extract + genistein
Rutin + Iodide
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly)
Lymphodran Plus (Quercetin - 500mg, Rutin - 400mg, Bromelain - 125mg, Vit.C - 50mg) (?)
  ProstaCaid:
medicinal mushrooms (Ganoderma lucidum, Coriolus versicolor, Phellinus linteus),
  saw palmetto berry, pomegranate, pumpkin seed, green tea [EGCG], Japanese knotweed (resveratrol),
  curcumin (BCM-95®), grape skin, pygeum bark, sarsaparilla root, Scutellaria barbata, eleuthero root,
  Job's tears, astragalus, skullcap, dandelion, coptis, broccoli, stinging nettle, Vit. C, D3, selenium, quercetin,
  citrus bioflavonoid complex, β sitosterolzinc, lycopene, ALA, boron, berberine, DIM
Lentinan + S-1
Artemisinin + Resverantrol (link)
Artemisinin + Captopril (link)
Artemisinin +Butyrate
LDN+D3
(?) TIC10 / TNF ligands / TRAIL + Hyperthermia (link)
Metformin + Vit. D3
Methyl Jasmonate + 2-DG (link)
BICT (link)
- ginseng (Panax ginseng C.A. Mey.),
Herba Agrimonia (Agrimonia pilosa Ledeb.),
White Flower Patrinia Herb (Thlaspi arvense Linn.)
arginine
hyperthermia (local)
CUSP9 (link, link2)
Metformin, statins, mebendazole, cimetidine, itraconazole, isotretenoin, doxycycline (link, link2) (?) D3
Doxycycline + IV Vit. C (link)

For cachexia: beta-hydroxy-beta-methylbutyrate (3 g/d), L-arginine (14 g/d), and L-glutamine (14 g/d) (link)

Counter productive combinations:
Vit. A - Vit. D
  Potassium supplements can reduce absorption of Vit. B12
Vit. C can destroy dietary vitamin B12. Take vitamin C supplements at least 2 hours after meals.
Warfarin + Bee Pollen (?) [Ref.1.127]
IP6 - with iron and calcium in food/supplements (link) -> take on an empty stomach
Artemisinin + 3CA (iron chelator?) (link)
Artemisinin + Vincrisitine (dose dependent interaction - link)
Metformin + cisplatin (link)
NAC can reduce the effectiveness of some anti cancer supplements
IV Vit C + PEMF (?) (link)
   itraconazole + rituximab (lymphoma) (link)

- Curcumin 95% - up to 8,000 [mg/day] ; taken in 3 to 4 doses throughout the day; max dose 12,000 [mg/day]   [Ref.1.96, 1.99, 1.113, 1.115, 1.116]

Black pepper (piperine) - 5 [mg] (max. 20 [mg]) [Ref. 1.14] with each dose of Curcumin;
freshly grounded in cup of water;

Cayenne pepper - approximately 1/3 of curcumin weight (or 1/2 to 1 teaspoon) in a cup of water [Ref. 1.11, 1.16]

Note:
Some high bio availability curcumin brands are: Longvida, BCM95 + Turmerones, Meriva [Ref.1.17, 1.18, 1.44].
Check actual level of curcumin and multiple by 5 to get an approximate equivalent to 95% curcumin.
For Longvida - 2,000[mg] capsules (400[mg] curcumin) give equivalent 8,000[mg] curcumin [Ref.1.44].
- this may help if high dose of 95% is causing upset stomach and other side effects.
Low cost 95% curcumin is [Ref. 1.12]

  Liposomal, Nano (Theracurcumin) curcumin [Ref.1.105, 1.113]

Turmeric contains additional chemicals that seem to be beneficial [link, link2, turmerones, Golden paste].
Other types of Curcuma plants may also be helpful [link, link, link].

You can also try topical application of curcumin/turmeric [Ref.1.79, 1.103, 1.116] and also turmeric oil.
For topical application you can try DMSO similarly to [Ref. 1.13, 1.108].
  Curcumin is soluble in DMSO at ~25mg/ml and DMSO appears safe at 1g/kg. Therefore for 70kg person the
  Curcumin dose can reach ~1,400mg in 70ml DMSO (80% concentration). Considering that it is local application
  the concentration will be much higher than oral application of curcumin supplements.
Topical application of turmeric (should you add curcumin?!) (link, Golden paste)
1/2 cup turmeric, 1 (1.5) cup water, 1.5 teaspoons ground black pepper, 70ml coconut oil
-> turmeric and water in pan - stir for 5..10 min until thick paste;
add pepper and oil and stir until well mixed.
use internally or topically
topical use (link) add lecithin 1/2 cup (?! link) and maybe use ultrasound to make liposomal for 30%
better absorption through skin (link, home made liposomal supplements):
- apply for 7 days with gauze wrap; air (leave without wrapping) for 1 day; wrap for 2 days

Exposure to light (visible light, UVA) increases the effectiveness [Ref.1.113].
Can be combined with oil pulling [Ref.1.117].
Comprehensive review of new delivery systems and improved availability on Curcumin [Ref.1.103]

  According to [Ref.1.113] curcumin is about 5 times less potent than cisplatin at 10[uM].

For intestinal cancer standard curcumin 95% 8,000[mg] will produce higher concentrations in the intestinal
walls and maybe more effective [Ref.1.116]. It maybe best to combine both standard curcumin and Longvida.

With long term use (2 years?) curcumin at high doses (14,000[mg] ?) may actually be carcinogenic. [Ref.1.113]

Combinations:
ulinastatin + curcumin [Ref.1.98]
  curcumin + resveratrol [Ref.1.100]
  Curcumin + taurine [Ref.1.101]
Curcumin + Resveratrol + Diallyl Disulfide
  Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin [Ref.1.115]
  Curcumin + Genistein [Ref.1.113]
  Curcumin + D3 [Ref.1.113]
  Curcumin + Omega 3 [Ref.1.113]
  Curcumin + Embellin [Ref.1.113]
  Curcumin + PEITC [Ref.1.113]
  Curcumin + EGCG [Ref.1.113]
  Curcumin + Piperine [Ref.1.113]
  Curcumin + Quercetin [Ref.1.113]
Curcumin + Turmerones [link, link]
Curcumin + Diclofenac [link, link2]
(?) Curcumin + Hyaluronic acid (link1, link2(+glucosamine, MSM, white willow bark, ginger, boswellic acid,
cayenne))
Note: Hyaluronic acid may promote or reduce metastasis (link (6.3))
4-MU - reduces metastasis by inhibiting HA (link1, link2, link3, link4, link5, link6,
  link7, link8)
sHA (sulfated Hyaluronic acid) inhibits tumor Hyaluronic acid (link)
HA treatment slows tumor growth post chemotherapy (link)
HYAL1 - tumor promoter or inhibitor based on concentration (link)
WebMD
4-MU - list of articles, Biomonde.org

- EGCG - 800 [mg/day] (1 dose) [Ref. 1.1, 1.2, 1.3, 1.31, 1.116, 1.125]
take with piperine [Ref.1.14, 1.116] - 5 .. 20[mg] (see curcumin)
[Ref.1.125] describes tests with mice that were given black tea / caffeine instead of pure water.
Liposomal formulation has better absorption [Ref.1.116]

- Quercetin - 1000 [mg/day] [Ref. 1.9, 1.115, 1.124]
Omega 3 - 400 [mg/day]
Isoquercetin - 400 [mg/day]

Note: quercetin is a phytoestrogen [Ref.1.124]
Isoquercitrin - 5..6 [mg/kg/day] [Ref.1.124]
it is recommended to monitor the retina at high doses [Ref.1.124]
red wine enhances quercetin absorption [Ref.1.124]
Liposomal formulation improves absorption [Ref.1.124]
Can reduce effectiveness of chemo treatment (for hormone sensitive cancers only?) (link)

  Rutin - 5 [mg/kg/day] (400mg for 80 kg person) [Ref. 1.5, 1.124, 2.1];
20[mg/kg] [Ref.1.124]
  Note: Retinopathy is also an angiogenesis disease as is cancer. [Ref. 1.31]
rutin is a phytoestrogen [Ref.1.124]
it is recommended to monitor the retina at high doses [Ref.1.124]

- Resveratrol - 24 [mg/kg/day] (2000 [mg] for 80 [kg] person) [Ref. 1.21, 1.31, 1.102, 1.115, 1.116]
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly) [Ref.1.127]
Liposomal Resveratrol improves absorption.
Note:
Resveratrol may act as an estrogen agonist or antagonist depending on cancer cell types and other factors.
It maybe best to avoid using it for estrogen sensitive cancers [Ref.1.21].

- MSM (Methylsulfonylmethane) - 6,000 [mg] (3,000 [mg] 2 times a day) [Ref. 1.78, 4.12, 4.13]

- Ellagic acid - raspberries - 1 [cup/day] (raspberries, pomegranate, red grape, figs)
Pomegranate (juice/extract)
Carnivora
Note:
0.8mg GAE [mg/kg/day] - dose for test in mice
Pomegranate extract + genistein
[Ref.1.7, 1.46, 1.47, 1.48, 1.49, 1.50, 1.122, 1.123]

- Taurine - 3000 [mg/day] [Ref.1.22, 1.23, 1.24, 1.101, 1.85]

- Vitamin C - 6,000 to 12,000 [mg/day] (preferably Lypo-spheric Vit.C) [Ref. 1.30, 1.81, 4.6, 1.102], (link);
taken in 3..4 doses throughout the day;
take 2 hours after meal or selenium and Vit. B12 supplements.

Intravenous (IV) Vit.C is min 10,000 [mg/day] and can reach 25,000 .. 70,000 [mg/day]
Not for patients with glucose-6-phosphate dehydrogenase deficiency [Ref.1.81].
Note: Some people combine IV Vit.C with oral Vit. K as noted below; maximum dose of K is not defined.
K1 (from plants) or K2 (MK-4, MK-7) most likely will not have the same effect as K3.

Apatone (R) - Vit. C = 6,000[mg] + Vit. K3 = 50[mg] [Ref.1.82, 1.83]
Note: Vit.K3 is toxic and not approved to be sold over the counter in US.

D-fraction (Maitake mushroom) + Vit. C [Ref.1.104]

Note: If you have stomach problems when taking vitamin C - try Ester-C (too much calcium in Ester-C?),
Liposomal Vit. C or timed released Vit.C.
DMSO dissolves well citric acid. I wonder if Vit.C can be used with DMSO topically?

- Vitamin E - maximum 400 [IU] (mixed natural tocopherols + tocopherol succinate) [Ref.4.6, Ref.1.44, 1.45]
Only low dose of Alpha Tocopherols (maximum 100[IU])
Combine with Selenium, CoQ 10 and Vitamin C [Ref. 1.44].

- Aloe Vera gel - 2 [oz] (60 [ml] or ~ 4 spoons) [Ref. 1.25, 4.4, 1.93]
Aloin, Aloe Emodin, Aloe Vera Gel Extract

- Pycnogenol - 150 to 200 [mg/day] - spread over 3 to 4 doses; taken with Vit. C; [Ref. 1.26, 1.27, 1.28, 1.29]

- I3C / DIM - 100 - 200[mg] (400[mg] max) [Ref.1.97, 1.115, 1.116]

- Beta Carotene - 100,000 [IU] [Ref.1.39, 4.6, 1.44]
Note: take only from dietary sources (see section below).
supplements cause negative effect [Ref.1.44].

- Glycyrrhizic acid / licorice [Ref.1.92]
  Note: Possible side effects. Consult with health care practitioner for usage form, dose and duration.
Do not use for breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids [Ref.1.92]

- Fish Oil - 3 to 10 [g] [Ref.4.6, 2.4, 4.18]
Note: cancer is angiogenesis disease as [Ref.2.4].
you can consider using PSCO-524 oil in addition to the standard fish oil.

- Folic Acid - 400 [micro grams] [Ref.4.6]

- Selenium - 400 [micro grams] (l-selenomethionine recommended in Ref.4.6) [Ref.4.6, 1.44, 1.110]
Note: It may be better to use all 3 forms of selenium with total of 400[micro grams] maximum selenium content;
Alternatively, it may be better to take only one or both organic forms or only sodium selenite.

For 400[ug] selenium, the sodium selenite dose is approximately 900[micro grams].
Absorption of sodium selenite is about 60%, so the dose can be a bit higher than 900[micro grams].

Take with Vit.E (natural). High doses of selenium can deplete Vit. E in the body.
Absorption is reduced by Vit. C, so take Vit. C supplements 2 hours after taking selenium.
Selenium level is low in patients with some forms of cancer.
It is best to do a test and determine if supplements are necessary.

- Vit. B12 (Methylcobalamin) - 1 .. 5 [mg] [Ref.4.6, 4.16]
Note: you can take it with lipoic acid [Ref.2.10]

- Vitamin D3 - 4,000 to 10,000 [IU] [Ref.1.40, 1.44, 1.64, 1.65, 1.66, 1.84, 1.102]
It is best to do a test and determine the required supplementation level.
60[ng/ml] is optimal, with maximum of 100[ng/ml].
K2 - 150 to 200 [micro grams]; MK-7 is preferred.

- Spirulina (C-phycocyanin, 9-HpbD-a) [Ref.1.135]

- Bitter melon extract - 6,000[mg] [Ref.1.61, 1.62, 1.63]
Start with low doses and monitor blood sugar or at least watch for hypoglycemic indications.
Juice/Extract maybe better than pills for people with digestive problems.

- Bromelain - 1,000[mg] [Ref. 1.59, 1.60, 1.87]
Take in 2 divided doses (2x 500mg).
Take for 10 days. Stop for 2 weeks.

- Melatonin - maximum 20[mg] [Ref. 1.67, 1.68, 1.69, 1.70, 1.64, 1.65, 1.66, 1.124]

- Boswellia, Frankincense - 3,000[mg] [Ref. 1.73, 1.74, 1.75, 1.121]

- Berberine - [Ref. 1.76, 1.77]

- Iodine - 5 .. 13[mg] [Ref.1.102]
Topical application for skin cancer?

- Astragalus - [Ref.1.95, 1.121]
Standardized extract: 250 - 500 mg, 3 - 4 times a day standardized to 0.4% 4-hydroxy-3-methoxy isoflavone 7-sug.
Decoction (strong boiled tea): 3 - 6 g of dried root per 12 oz water, 3 times per day
Fluid extract (1:1) in 25% ethanol: 2 - 4 mL, 3 times a day
Powdered root: 250 - 500 mg, 3 - 4 times per day
Tincture (1:5) in 30% ethanol: 20 - 60 drops, 3 times a day

- Maitake, Reishi, Lion's Mane Mushrooms [Ref.1.94, 1.96, 1.128]
Combined with Vit.C. [Ref.1.104]
Beta (1-3/1-6) Glucan
Dose: typically 2,000mg/day in 2 divided doses, on empty stomach at least 1 hour before meal;
long term use - at least 1 year.
mushroom derived beta glucan seem to be better for cancer.
Works by stimulating the immune system.
Articles: article 1, article 2, article 3, article 4, article 5, article 6, article 7, article 8, article 9, article 10, article 11
Combinations:
Lentinan + S-1
Maitake D-fraction (or PDF) + (I.V.) Vit. C
  Quercetin, selenium, vitamins A, C, E, or alpha lipoic acid may enhance the antiviral qualities of beta-glucan.
AHCC
article 1, article 2, article 3, article 4, article 5, article 6, WebMD, Wikipedia
Agaricus subrufescens
article 1, Wikipedia

- Immune system boosting supplements with anti cancer properties
  LEF protocol
Beta Glucan (see above)

  Andrographis
Methods: anti-inflammatory, anti-angiogenesis, immune system stimulating effects
Dose: 150mg (LEF suggestion); (4mg/kg tested on mice)
Effective against: leukemia, colorectal, colon, prostate, cervical, breast, liver, lung, multiple myeloma, bile duct
Chemo therapy combinations: 5-FU, adriamycin, cysplatin
Enhances the anti cancer effects of whole body hyperthermia.
Side effects and interactions: WebMD
   Articles: art1, art2, art3, art4, art5, art6, art7, art8, art9, art10, art11

Whey protein

Grape seed extract

- Parthenolide (Feverfew)
Effective against: multiple myeloma
Side effects: WebMD
Articles: art1

- Milk Thistle [Ref.1.107, 1.106]

- Tea Tree Oil + DMSO (topical application) [Ref.1.108]
10% TTO/DMSO applied topically;
Note: Possible allergic reactions.

- Hemp Oil [Ref.1.111]

- Dandelion [Ref.1.136]
using both roots and leafs as extracts or tea.

- IP6 [Ref.1.137]
Note: doses used on mice - 2% in drinking water
LEF dose: 1 .. 3 [g]
other suggestions: 12 .. 18[g] inositol or maximum of 5 .. 7[g] IP6 + 1 .. 2[g] inositol
must be taken on an empty stomach

- Diallyl disulphide/garlic oil [Ref.1.114]

- Calcium Fructoborate [Ref.1.120, link, link2, link3, link4]
Note: Boron supplements; prunes? [Ref.4.17]
Dose: 1 .. 7[mg/kg] (70 .. 500[mg] for 70kg person); max dose 37.5[mg/kg] [Ref.1.120]
Can be combined with with Resveratrol

- Systemic (proteolytic ) enzimes  wobenzime, wobe-mugos - (link1, link2 (multiple myeloma), immuno modulation effect link3, link4, link5)
hystory - link
case of contaminated supplement from Mexico - link
case of allergy - link

- Essiac [Ref.1.112]

- Peaches (fruit) [Ref.1.126]

- Bee propolis; Royal Jelly; Bee Pollen [Ref.1.36, 1.37, 1.127]
Supplements combining several ingredients are:
GE132+Natural (Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene, Royal jelly)
Melbrosia (pollen, royal jelly)

Bee Pollen: 1/2 teaspoon to 2 table spoons/day [Ref.1.36, 1.37, 1.127]
  Note: Bee Pollen may irritate stomach, so dissolve in water and take with food.
Bee Pollen has estrogen reducing effect, while propolis and royal jelly increase estrogen

- L-Methionine [Ref.1.129]

- ProstaCaid [Ref.1.130]

- Probiotics [Ref.1.96, 1.133]

- Sodium Butyrate
(link, link2)

- Essential Oils [Ref. 1.134]
CBD/THC, Tea tree , Thyme, Myrrh, Frankincense, Rosemary, Eucalyptus, Ginger, Mentha,
Lemon balm, Oregano, Black seed, Clove

- Methyl Jasmonate
link, link2, link3, link4, link5, link6, link7,
Note:
for lymphoma, mice treated with 236mg/kg had survival rate of ~45%, vs. ~22%;
translated to human dose this would be ~20mg/kg.
15 drops is 1[ml] (link) which for water is 1000[mg]. Therefore for 70kg person this would be
1400[mg] = 1400/1000*15 = ~20 drops
it was mentioned that the mice did not have adverse affects at 2x the test dose, and considering that drop size
and liquid weight vary, the 20 drops is a very approximate estimate that can be used for guidelines only.
can be combined with 2-DG or chemo drugs (link)

- Methylglyoxal
controversial (both positive and negative effects, dose dependent) - needs knowledgeable person to guide the treatment
therapists that use it: Dr. Manju Ray (link), Vincent Gammil (link)
Articles: link1, link2, link3, link4, link5, link6, link7, link8, link9, link10, link11
affected by diet - both ketogenic and vegan increase it;
manuka honey has high concentration as well as fermented foods.

- GcMAF
link, link2, link3
Note: effective for various cancers including multiple myeloma

- Medications to research and consider
Metformin
Can help or interfere with chemotherapy (link)
Multiple beneficial effects (link)
can be combined with 2-DG (link1, link2)
+ Vit. D3 (link)
2-DG
Cimetidine (link, link2, link3, link4, link5, link6, link7)
LDN (Low Dose Naltrexone)
Dipyridamole (link, link2, link3)
Celecoxib (link) - high risk for heart related problems
Valproic acid / Epival (link)
Aspirin (link, link2, link3, link4)
Diclofenac (+ Curcumin) (link, link2, link3, link4, link5, link6)
3-BP (link, link2, link3) (combine with ketogenic diet, 2-DG, metformin - ?)
CUSP9 (link, link2)
Ivermectin (link)
     Itraconazole - anti fungal, PI3K, mTOR, anti-angiogenesis, apoptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/ (CUSP9)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406527/   (overview of the anti cancer effects)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529373/
https://www.ncbi.nlm.nih.gov/pubmed/28399898/
https://www.ncbi.nlm.nih.gov/pubmed/28212537/
https://www.ncbi.nlm.nih.gov/pubmed/26823493/
https://www.ncbi.nlm.nih.gov/pubmed/25512128/
https://www.ncbi.nlm.nih.gov/pubmed/24905460/
https://www.ncbi.nlm.nih.gov/pubmed/21969860/
https://www.ncbi.nlm.nih.gov/pubmed/21896639/

- Willow bark extract
link,

- Bicarbonate
reduces metastasis, enhances the effect of chemotherapy drugs.
diet (link)
link, link2, link3, link4, link5
maximum quantity per day? salt + bicarbonate quantity per day ?

- Supplements and herbs to research
Euphol [Ref.1.94]
Mirko Beljanski Products - extracts from Pao Pereira and Rauwolfia Vomitoria [Ref.1.102]
Paw Paw
Scutellaria baicalensis (Chinese skullcap) [Ref.1.94]
Magnolia officinalis (Chinese magnolia tree) [Ref.1.94]
Ginkgo biloba [Ref.1.94]
Poria cocos [Ref.1.94]
Zingiber officinalis (ginger) [Ref.1.94]
Panax ginseng [Ref.1.94]
Rabdosia rubescens hora (Rabdosia) [Ref.1.94]
Chinese destagnation herbs [Ref.1.94]
Ginseng [Ref.1.94]
Evening primrose oil [Ref.1.94]
Ginger [Ref.1.94]
Metformin for thyroid cancer?[Ref.1.111]
  Genistein [Ref.1.113], Jiva, Haelan, SoyLac [link1, link2, link3, link4,link5]
Isoflavone [Ref.1.115]
C-phycocyanin [Ref.1.115]
Vital Yew (Pacific Yew)
Cancer Salves / (indian) black salve (topical use)
Zeolite
Eugenol / Cloves
Red clover
  Squalene / squalamine / shark liver oil
Colloidal silver
Chlorophyll
Glutathione
Cocoa
Caffeine
Theobromine
Rosmarinic acid, Fig latex, Lycopene (Resveratrol, E3G - melanoma)
  Caffeic Acid Phenethyl Ester (CAPE); Thymoquinone (Resveratrol - lung cancer)
  Hydroxycitrate (ALA/N protocol?)
  Devil's club / Oplopanax horridus
AHCC
  Turkey tail, Maitake, Reishi, Agaricus blazei
  Ballochia atro-virgata [Ref.1.94]
  Eureiandra balfourii [Ref.1.94]
  Hypoestes pubescens [Ref.1.94]
  Acanthospermum hispidum [Ref.1.94]
  Commiphora ornifolia [Ref.1.94]
  Euphorbia socotrana [Ref.1.94]
  Acacia pennivenia [Ref.1.94]
DHEA
Spirulina
Pau D'Arco
Homoeopathic treatments (link, go with low dilution - link, link2)
Coconut oil - protection against toxicity (link)

- Swedish Bitters - 1 to 3 [teaspoons/day] [Ref.4.7]
  Note: Some of the supplements can irritate the stomach. The Swedish Bitters can help with that.

- Green Clay - 1 teaspoon in a glass of water. Leave for 8 hours and drink 1 hour before meal. [Ref. 4.8]
Note: Some of the supplements can cause diarrhea. The Green clay can help with that.
Topical application (poultice) may help as well for some problems.

- Vitamin and mineral supplement combinations [Ref.1.102]

- Oil Pulling Therapy [Ref.1.117]
Note: can be done with coconut oil and curcumin or green tea for oral cancers [Ref.1.116, 1.117]

Overview of Alternative Cancer Treatments and their effectiveness:
  Complementary and Alternative Medicine in Present Day Oncology Care: Promises and Pitfalls
  - Homeopathy - some positive results for radio therapy; no anti cancer effect
  - Ayurveda - danger of mercury, lead, arsenic contamination
  + Traditional Chinese/Japanese medicine - promising results;
  + Acupuncture, acupressure, electro-acupuncture- promising results but needs better studies
  + Energy therapies - positive results for Tai Chi, Qi Gong; better studies needed
  + Reiki
  + Electromagnetic based therapies
    magnetic filed tested OK; electric pulses tested on cells is OK but no "in vivo" studies
  + Hypnotherapy, Imagery - positive results on immune system, but not maintained after 3 months
  + Yoga
  + Burzynski - helpful for 22% to 60% of the patients
  + Laetrile - 36 published cases
  - Shark cartilage
  - Di Bella Therapy - 12% of the patients with stable disease; not enough evidence to recommend;
also see [Ref.1.64, 1.65, 1.66, 1.67, 1.68]
  + Metabolic therapy: Gerson
  + Exercise

Alternative approach: Gerson Therapy
case study for melanoma (link)
case studies for 6 patients with metastatic cancers (link)

Alternative approach: Antineoplaston Therapy [Ref.1.118]

Alternative approach: Insulin potentiation therapy (IPT) [Ref. 1.58; 1.132]

Alternative approach: Mistletoe extract based therapy [Ref.1.84, 1.85].
Can be combined with curcumin and other supplements.

Alternative approach: ALA/N protocol [Ref.1.106, link]
Combined with Vit. C and D3.

Alternative approach: Artemisinin [Ref.1.32, 1.33, 1.34, 1.94]
1 to 4 [mg/kg]; divided in 2 doses throughout the day;
(or 100 mg artemisinin, 60 mg artesunate and 40 mg artemether - [per day])
(or injections [Ref.1.32])
  taken on empty stomach (2 hours after meal)
fish oil, conjugated linoleic acid or milk every time when taking Artemisinin
Using Iron supplements (Ref.1.34, link):
- use starting dose for 3 days and maintain iron levels in blood by doing regular blood testing
and using iron supplements during the treatment

  Note: antioxidants may counteract the effects of Artemisinin.
Take with Resveratrol (link).
Artemisinin and butyrate have synergetic effect (link).
Hydroxybutyrate in the blood is increased ~20 times if a person follows ketogenic diet (link).
Artemisinin + Captopril (link)
Effect on multiple myeloma (link)
  CUSP9 (link, link2)

I think Artemisinin should not be used with iron chelators (link):
green/black tea, curcumin, polyphenols (quercetin, rutin, ... pomegranate, cranberry),
pectin, milk thistle, lipoic acid, (acetyl-L, propionyl-L) carnitine
lactoferrin (?)
coffee (?)

Vit. C taken with food increases iron absorption so it should be OK to combine with Artemisinin.
Half life time of Vit. C in the blood is ~30[min]. It should not interfere with Artemisinin taken 2 hours after
meal. Half-Life time of artemisinin is between ~15[min] to ~6..8[hours] depending on the type. Considering
that artemisinin should be spread in 2..3 doses throughout the day, Vit. C can be taken in the morning.

Alternative approach: Ketogenic Diet + reduced calories + 2-DG [Ref.1.51, 1.52, 3.4; 1.132]
Note: Must be done under supervision by health care practitioner.
Must balance vitamins and minerals using supplements;
I think most of the supplements (Curcumin, Resveratrol, Quercetin, EGCG, Rutin, etc.) will not be a
problem when being on ketogenic diet.
In my opinion combining Ketogenic diet (increases butyric acid in the blood) and Artemisinin should be
more effective.
Note that ketogenic diet alone (if blood sugar level do not drop) is not effective against cancer (link). It must be
combined with calorie restriction in order to reduce blood sugar levels to low normal (link).
2-DG and metfomin combination is effective against cancer (link).
Metformin is a calorie restriction mimetic, so it can be used instead of (or with less) calorie restricted diet.
Calcium Fructoborate may be a good supplement to use along the ketogenic diet (link, link2, link3)
Should be combined with HBOT (link, link2).
"Metformin increases oxygen released into the cells" (link)

  ATP targeting (as part of the ketogenic diet?) (link):
"All cells need energy to survive and they obtain it from the food we eat. However there are significant differences between the energy metabolism of malignant cells and normal cells. Cancer cells need to generate significantly more energy in a short period of time in order to rapidly proliferate as synthesizing new molecules requires a lot of energy. Several researchers propose that excessive ATP (universal energy currency of the cells) production may force a cell to a premature cell division which later on may lead to malignancy.

The fundamental differences between healthy cells and malignant cells on their energy production can be targeted and cancer cells can be selectively killed by starving them to death. I believe that the formation and promotion of cancer is taking place per the following route:

1- Mutations, free radical damage, carcinogens etc cause a damage in the energy metabolism regulation of a healthy cells where they produce excessive amounts of ATP that they cannot consume in normal metabolic activities.
2- This excessive ATP forces the cells to a premature cell division bypassing normal controls regulating cell division.
3- At the initial cancer formation stage the excessive ATP is mainly produced by the mitochondria as recent evidence showed that mitochondria can actively initiate cell division.
4- When the cancer cells increase in number they begin to make small spheres (tumors). The inner parts of the tumors cannot get enough oxygen and nutrients and the enzyme Hypoxia Inducible Factor HIF-I is overexpressed in such cancer cells
5- HIF-I causes a switch from mitochondrial oxidative phosphorylation to glycolysis (where ATP is generated in the cytoplasm without the use of oxygen in an inefficient way).
6- The inner cores or the hypoxic (low oxygen) parts of the tumors begin to depend more on glycolysis and become less active but the outer rings of the tumor spheroids continue to rely on the efficient mitochondrial ATP generation to obtain the much needed energy to rapidly proliferate.

In general cancer cells consume much higher amounts of glucose than normal cells, may have enhanced glycolysis even in the presence of oxygen and significantly altered mitochondrial characteristics. These altered features of cancer cells can be selectively targeted. Several agents that are used in clinical trials or in actual treatments to try to deplete the ATP selectively in cancer cells showed promising outcomes including the following molecules:

Acetogenins such as Paw Paw Extracts
Dichloroacetic acid –DCA-
Methyl Jasmonate
Methylglyoxal
2-Deoxyglucose
3-Bromopyruvate
Vitamin E Succinate

Generally these agents are selectively toxic to cancer cells while not affecting healthy cells at much higher concentrations. As tumors may contain both glycolysis and oxidative phophorylation dependent cells, either using multiple agents to block both energy generation routes or using the agents that affect both types of energy production may be needed. Most of these agents showed synergy when used in combination with conventional treatments such as chemotherapy and radiotherapy.

My personal view is that a successful cancer treatment program should contain agents or strategies that target the altered energy metabolism of malignant cells. I have been conducting research in this field for quite sometime and noticed that there is a significant amount of scientific literature pointing out to the efficacy of ATP depleting strategies. The next generation of cancer targeting agents will probably be focusing more on the energy metabolism of cancer cells. It is worthwhile to dig into this area for patients seeking alternative treatments who have exhausted most other options without significant benefits.

...

Additionally several other widely used supplements that target the energy metabolism of cancer cells as part of their toxicity against them are being discussed including but not limited to the following:

Curcumin
Luteolin
Maitake D-Fraction"

Alternative approach: Di Bella's method (DBM) [Ref.1.64, 1.65, 1.66, 1.67, 1.68]

Alternative approach: Hydrogen Peroxide (H2O2) [Ref.1.41, 1.42, 1.43, 1.81]
Note: H2O2 baths should not be a problem to be combined with any of the approaches above;
Notice the link between H2O2 and high dose vitamin C, so you can consider doing IV Vit. C therapy first.

During Chemotherapy:
If you do decide to do chemotherapy or radiation, consider using the followings:
- bee pollen (mytomicin C, bleomycin, and vincristine) [Ref. 1.36, 1.127]
- aloe gel [Ref.1.54]
- curcumin [Ref. 1.55, 1.56, 1.57, 1.96, 1.113, 1.116]
Note: curcumin inhibits camptothecin, mechlorethamine and doxorubicin [Ref.1.113, 1.116]
- taurine [Ref. 1.23]
- melatonin (start 7 days before chemo therapy [Ref. 1.70])
- Berberine [Ref.1.76, 1.77]
- Bromelain [Ref.1.87]
- Avemar/Ave Ultra [Ref.1.88]
- Astragalus [Ref.1.95]
- Fish oil [Ref.1.96]
- Maitake Mushrooms [Ref.1.96]
- Probiotics [Ref.1.96, 1.133]
- I3C / DIM [Ref.1.97, 1.116]
- Vitamin and mineral combinations [Ref.1.102]
- Whole body hyperthermia [Ref. 1.109] (+ Withaferin A)
- Selenium [Ref.1.110]
- Mistletoe extract [Ref.1.85]
- Curcumin + Isoflavone + Indo-3-Carbinol + C-phycocyanin + Resveratrol + Quercetin [Ref.1.115, 1.116]
- EGCG [Ref.1.116]
- Resveratrol [Ref.1.116]
- Hyperbaric oxygen therapy [Ref.1.119]
- Pomegranate extract [Ref.1.122]
- Carnivora [Ref.1.123]
- Quercetin, Rutin [Ref.1.124] (not for hormone sensitive cancers - link)
- Bee propolis, Royal Jelly (cisplatin) [Ref.1.127]
  - Vit. D3 + Calcium (to prevent osteoporosis [link])
  - Mifepristone (?) [link1, link2, link3]
  - Fasting (during chemotherapy for protection; after chemo therapy for immune system recovery) [Ref.1.132]
- Beta Glucan (link, link2, link3), AHCC
- Andrographis
- IP6 (link)
- Cisplatin + 3CA (iron chelator ?) (link)
- Artemisinin (link, link2)
- Methyl Jasmonate (link)
- Vit. C (link)
Note: Chemotherapy weakens the immune system. It is generally recommended to avoid some types of raw food. Discuss your diet with your doctor.

You should research the particular drugs used during the chemo to see if any alternative treatment can interfere.
Search Pubmed or Google Scholar using combinations of the chemo drug and the supplement in question.

During Radiation:
- Curcumin [Ref.1.113]
- DIM [Ref.1.97]
- topical use of aloe during radiation treatment [Ref.1.93]
- iodine [Ref.1.102]
- melatonin [Ref. 1.68]
- Boswellia [Ref.1.74, 1.75]
- Avemar/Ave Ultra [Ref.1.88]
- Glutamine [Ref.1.96]
- Fish oil [Ref.1.96]
- Vitamin and mineral combinations [Ref.1.102]
- Whole body hyperthermia [Ref. 1.109]
- Hyperbaric oxygen therapy [Ref.1.119]
- Carnivora / Ferulic acid [Ref.1.123]
- Troxerutin [Ref.1.124]
  - Fasting [Ref.1.132]
- Beta Glucan (link), AHCC
- Probiotics (1.96)
- Artemisinin (link)
- Vit. C (link)
Note: Radiation weakens the immune system. It is generally recommended to avoid some types of raw food. Discuss your diet with your doctor.

After Radiation:
- IV Vit.C or Mayer's cocktail
- iodine [Ref.1.102]
- Beta Glucan (link), AHCC
- Suzanne Somer's Cancer Battle, Pt 2
- low intensity laser therapy (link)
- Vit. D3 for brain and nerve restoration (link, link2)

After Surgery:
- Grape seed extract - 100 to 600[mg] for 6 months [Ref.1.86]
- Serrapeptase - 10-60[mg] [Ref.4.14]
- light exercises [Ref.1.90]
- fish oil with arginine [Ref.1.96]
- Vit. C - 1,000[mg] [Ref.4.6]
- Beta Carotene - only natural sources - 5,000 [IU] [Ref.4.6]
- Zinc - 15[mg] zinc citrate [Ref.4.6]
- Vit. E - 400[IU] (take with selenium) [Ref.4.6]
- Diet, Vitamin and mineral combinations [Ref.1.102]
- Stem cell breast reconstruction. Suzanne Somer's Cancer Battle, Pt 3
- Hyperbaric oxygen therapy [Ref.1.119]
- Bee propolis (?) [Ref.1.127]
- Beta Glucan (link)
- Enzymes (Wobenzym) (link, link2)
- low intensity laser therapy (link)
- Vit. D3 for brain and nerve restoration (link, link2)

Complications:
- Topical Yunnan Baiyao for bleeding tumors [Ref.1.91]
- Hyperbaric oxygen therapy [Ref.1.119]
- Pain
Acupuncture [Ref. BBC - The Science of Acupuncture].
Visualization, low intensity laser therapy (neuro-plasticity - The Brain's Way of Healing, article, Ref.2.15, 2.16)
Pain control and cancer treatment via teeth mechanical stimulation(?) [Ref.1.121];
- Lymphedema Treatments; Coumarin (benzopyrones); Chi machine(?) (case); Selenium (link);
Wobenzyme (link1, link2, link3)
- Radiation proctitis (link)
"rectal sucralfate, adding metronidazole to the anti-inflammatory regime and heater probes"
"Cryospray Ablation, Radio frequency ablation", laser surgery?
Pycnogenol should help for strengthening the blood vessels. (link)
Acupuncture (links to the same article but some have additional info - link1, link2, link3, link4, link5)
Bio-Dyne cream/suppositories (?) (sold as "Preparation H", but in different countries it may have different ingredients)
Aloe Vera gel (drinking/topical) (?)
Sitz baths (?) and other suggestions (link1, link2), sitz bath with smoke tree (link)
or maybe it is better to keep the area dry (?)
- Nerve damage - nerve cell restoration by Vit. D3 (link)
- Mouth sores
L-glutamine (swish and swallow; throughout the day) - there are articles supporting this, and some that say
that it does not help (but also does not harm). Should be tried.
link, link2, link3, link4, link5, link6, link7, link8, link9, link10
beta-hydroxy-beta-methylbutyrate, L-glutamıne, and L-argınıne (link)
Lysine
mouth wash (without alcohol, avoid mint taste, try diluted solution first) - several times a day
Hyaluronic acid (Hyaluronan) based - Gengigel (gel or mouth wash)
Rincinol P.R.N.
Listerine Zero
Diclofenac based mouth wash (? Glimbax ?) - used for short term only - several days? consult with a dentist?
experimental spray (link) or gel (link) - note: hyaluronan is available as gel or spray too
use small and soft (baby) toothbrush and baby toothpaste (no mint taste)
rinse mouth with salt/backing soda solution
honey (+ baking soda)
coconut oil, aloe, calendula, arnica, cold herbal teat (chamomile) - do not swallow!
clove oil - put with cotton on sores
drink plenty of water!
beta glucans for immune system stimulation
Vit. C and D3 - high doses - D3 of up to 50,000IU for short duration (less than a month); do D3 level test!
zink
other alternative treatments (link)
- hiccups (link)

For cachexia:
beta-hydroxy-beta-methylbutyrate (3 g/d), L-arginine (14 g/d), and L-glutamine (14 g/d) (link)
   ketogenic diet(?), vitamin/mineral supplementation; nutrient dense foods

Not Recommended:
  Immuno Augmentative Therapy (IAT) [Ref.1.71]
Cesium Chloride Therapy [Ref.1.72]
Black Salve for skin cancer (article 1, article 2, article 3, article 4)

2. Comments on Food, Diet and Life style

- Balanced Diet [Ref. 4.5, 1.31, 4.9, 4.10, 4.11, 1.53, 1.102]
Juicing Carrots and Leafy Greens (Kale, Spinach). Approximately 1 to 2[kg/day]. [Ref.1.39]
Drink green tea [Ref. 1.31]
or Eat green tea (no more than 6[g] day) [Ref.1.1]
Diet rich in cancer fighting nutrients [Ref.1.85]
   see also: Diet calculator, Raw Vegan Diet, Ketogenic Diet, Dr. Wahls Diet
Fermented cabbage, blueberries [Ref.2.3, 2.5, 2.6, fermentation]
Avemar (17 g/day) or Rejuvelac (1 liter/day) [Reg.1.88]
Okra (artcle1, artcile 2, artcile 3)
Bitter melon [Ref.1.61, 1.62, 1.63]
Garlic [Ref.1.35, 1.85, 1.114]
Tomato juice/puree; baked tomatoes [Ref. 1.31]

(23) 25 Cancer Stem Cell Killing Foods Smarter Than Chemo & Radiation
Epigallocatechin-3-gallate (EGCG) - Green Tea
   6-Gingerol - Ginger
β-Carotene - Carrot, Leafy Greens
   Baicalein - Chinese Skullcap
   Curcumin - Turmeric
   Delphinidin - Blueberry, raspberrry
   Flavonoids (Genistein) - Soy, red clover, coffee
   Guggulsterone - Commiphora (myrrh tree)
Isothiocyanates - Cruciferous vegetables
   Linalool - Mint
   Lycopene - Grapefruit, tomato
   Parthenolide - Feverfew
   Perylill alcohol - Mint, cherry, lavender
   Piperine - Black pepper
   Placycodon saponin - Playycodon grandifloruim
   Psoralidin - Psoralea corylilyfolia
   Quercetin - Capers, onion
   Resveratrol - Grapes, plums, berries
   Salinomycin - Streptomyces albus
   Silibinin - Milk Thistle
   Ursolic acid - Thyme, basil, oregano
   Vitamin D3 - Fish, egg yolk, beef, cod liver oil
   Withaferin A - Withania somnifera (ashwaganda)

- State of mind
MBSR (Mindfulness Based Stress Reduction) [Ref. 3.1, 3.2, 3.3, 3.6]; It is covered by OHIP (Canada);
General relaxation and relaxation techniques (meditation) [Ref. 3.1, 3.3];
Positive thinking [Ref.1.89, 3.1]; Radical Remission Of Cancer; The book
Visualization techniques for pain management (book, article)
Note: [Ref.2.15] mentions meditation and explains that over active nervous system causes inflammation
and if the nerves are calmed down, then the disease can disappear. Cancer is also listed as a disease
that can potentially benefit from such treatment.

- Spend more time with the people close to you [Ref. 3.1];

- Exercise and excitement [Ref. 3.1],
see also the Exercise page;
Neuromuscular electrical stimulation can used instead of physical exercises (see Dr. Wahls Diet).
30..60 [min/day] walk in the park (before sunset);
deep slow breathing (relaxing);
don't look down (bright light helps lift your mood);

- Enough sleep [Ref. 1.67, 1.68]; Melatonin (see references above);
  recommended minimum 8 .. 8 1/2 hours.
BBC - 10 things you need to know about sleep

- Local and whole body hyperthermia [Ref.1.80, 1.109, 1.53]; (+ Withaferin A),
see also the Hyperthermia page
sweating helps for detox;
Heat treatment reduces depression; [Ref. 3.5];
  sauna, long hot shower, go on the beach (or sun bath in the back yard), heat chamber, electric/heat blanket;
sun light and low intensity laser therapy (link)

Note: Hypothermia [Ref.1.131] has negative effect, but seems effective for tumor treatment when cycled with
hyperthermia. Metastasis in some cases disappear after treating the main tumor, indicating immune system
activation.

- Bright light reduces depression; SAD lamps can help you if you don't have enough sunlight during the day.
Note: If you buy an SAD lamp do not look at it directly. Some lamps have 10,000 [lux] intensity,
and some articles testing medications for retinal diseases use 15,000 [lux] light to damage the retina.
It has been noticed that SAD lights are effective even the person is with closed eyes or the light is on the side.
It is important be close though (30 [cm]) and do it for about 15..30 [min/day].

3. Clincs

- American College for Advancement in Medicine [Ref.1.34]
- Maple Leaf HIFU - Prostate cancer treatment (North America) [Ref.1.38]
- ARE (NanoKnife®); PubMed articles;
- prostate cancer; lungs, kidney, liver, breast, prostate, pancreas;
- Burzynski Clinic [Ref.1.118]
- Alternative Cancer Treatment Clinics in Germany [Ref.1.80]
- The Center for the Study of Natural Oncology
- VIR Chicago
- Integrative Medical Center of New Mexico [Ref.1.106]
- Local Hyperthermia (benign prostatic hyperplasia) (link)
- Kotsanis Institute (IPT, diet, ...)
- www.neoplas.org
- http://www.georgeycwong.com/

4. New treatments

- U.S. scientists successfully turn human cancer cells back to normal in process that could ‘switch off’ disease

- Brain tumor cells decimated by mitochondrial 'smart bomb'
Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug

- Electric/magnetic field therapy:
  https://www.youtube.com/watch?v=1w0_kazbb_U
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845545/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886002/
  https://www.youtube.com/watch?v=td5Ld3nURAI

- Dendritic cell therapy

- MTH1 inhibitors
New general concept for the treatment of cancer
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool ---- (abstract)

- Curcumin Implants
Curcumin Implants, not Curcumin Diet Inhibits Estrogen-Induced Mammary Carcinogenesis in ACI rats.

- Israeli Technology Turns Tumors Into Ice Balls To Cure Cancer
"The technique, which does not require general anesthetic and can be completed in about 15 minutes"
  IceCure’s Treatment That Turns Tumors Into Ice Balls Reports Success In Lung Cancer Trial

- A New Postal Code for Cancer

- CANCER THERAPY THAT BOOSTS IMMUNE SYSTEM READY FOR WIDER TESTING (06/02/2012)

- DCA, ALA/N Protocol [Ref.1.106]

- Cryo-surgery (+ hyperthermia) for tumors [Ref.1.131]

- Provectus (PV-10)

- Attenuated virus vaccine treatment or "radioviro" therapy - art1, art2, art3, art4, art5, art6, art7, art8
multiple myaloma, liver, lung, colorectal, tumors, ovarian, malignant glioma, pancreatic cancer

- lbrutinib - art1, art2
leukemia, lymphoma