Thoughts on choosing an anti-cancer protocol
Disclaimer:
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual.
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual.
Cancer presents a wicked problem. We are all unique in every aspect (genetic (including mitochondrial and microbiome), current health problems/medications, immune system (immune system strength, allergies/food/chemical sensitives, previous illnesses, viruses/parasites, inflammation, chronic illnesses, etc.). Therefore, any information and suggestions you are receiving are at worst wrong and at best incomplete! It is all an opinion!
Rules of thumb:
1. "No plan can survive the contact with enemy"!
Treatment must be based and adapted to the individual case and current developments. The worst you can do is stick to something based on a belief regardless of the facts.
2. "If it cannot be measured, it cannot be improved."
Doing lab test is the best, but personal observations are also valuable (less pain, improved symptoms, more mobility, mind clarity, mood, etc.).
3. "When all you have is a hammer, everything starts to look like a nail."
A surgeon will tell you you need to cut the cancer out; a functional medicine practitioner will tell you your cells need to be fixed, the rest will be fixed by itself; a Gerson therapy practitioner will tell you Gerson is the answer ... It all sound very good and simple but fighting cancer only with diet, or only with conventional treatment, or only with ... limits your options and chances for success. It is like fighting with one hand tied behind your back. Consider all options and when you choose a treatment, research what you can do to improve it.
Use specialists according to their strengths - MDs for standard treatment advice and NDs for advice on supplements and diets. Since none of them has graduated from Hogwarts, critical thinking is your best friend.
4. When it comes to choosing anticancer supplements - "follow the money".
Some supplements stand out because many companies try to develop synthetic analogs. In this respect such supplements are better studied/understood and should be more effective. These include curcumin, artemisinin, pacific yew, marijuana ...
On the other hand, some are touted on YouTube as miracle treatments or suppressed by the government are often not supported by PubMed articles. Still, there are some positive case studies for leatrile and essiac tea.
Creating a personalized protocol
1. Buy some extra time
There are diets that have been proven slow down most cancers. You can implement these right away.
2. Deal with the cancer/tumor size/symptoms first
In some cases people choose to do conventional treatment first, especially in critical situations such as tumor pressing on the spinal cord nerve that can cause paralysis. Regardless of the chosen treatment, there are many things you can do to potentially improve the outcome and reduce the side effects.
3. Deal with the causes
The cause for having cancer may be one or more of the following: weak immune system, viral/fungal... infections, inflammation, toxicity (heavy metals or chemicals), nutrient insufficiency, hormonal imbalances, digestive problems, stress, age. Finding out the reason and resolving it takes time and the results are slow to come.
Rules of thumb:
1. "No plan can survive the contact with enemy"!
Treatment must be based and adapted to the individual case and current developments. The worst you can do is stick to something based on a belief regardless of the facts.
2. "If it cannot be measured, it cannot be improved."
Doing lab test is the best, but personal observations are also valuable (less pain, improved symptoms, more mobility, mind clarity, mood, etc.).
3. "When all you have is a hammer, everything starts to look like a nail."
A surgeon will tell you you need to cut the cancer out; a functional medicine practitioner will tell you your cells need to be fixed, the rest will be fixed by itself; a Gerson therapy practitioner will tell you Gerson is the answer ... It all sound very good and simple but fighting cancer only with diet, or only with conventional treatment, or only with ... limits your options and chances for success. It is like fighting with one hand tied behind your back. Consider all options and when you choose a treatment, research what you can do to improve it.
Use specialists according to their strengths - MDs for standard treatment advice and NDs for advice on supplements and diets. Since none of them has graduated from Hogwarts, critical thinking is your best friend.
4. When it comes to choosing anticancer supplements - "follow the money".
Some supplements stand out because many companies try to develop synthetic analogs. In this respect such supplements are better studied/understood and should be more effective. These include curcumin, artemisinin, pacific yew, marijuana ...
On the other hand, some are touted on YouTube as miracle treatments or suppressed by the government are often not supported by PubMed articles. Still, there are some positive case studies for leatrile and essiac tea.
Creating a personalized protocol
1. Buy some extra time
There are diets that have been proven slow down most cancers. You can implement these right away.
2. Deal with the cancer/tumor size/symptoms first
In some cases people choose to do conventional treatment first, especially in critical situations such as tumor pressing on the spinal cord nerve that can cause paralysis. Regardless of the chosen treatment, there are many things you can do to potentially improve the outcome and reduce the side effects.
3. Deal with the causes
The cause for having cancer may be one or more of the following: weak immune system, viral/fungal... infections, inflammation, toxicity (heavy metals or chemicals), nutrient insufficiency, hormonal imbalances, digestive problems, stress, age. Finding out the reason and resolving it takes time and the results are slow to come.
A Universal Anti-Cancer Protocol
There is not such thing.
From what I have read so far, there are several things that most cancers have in common:
1. Most cancers (especially the aggressive ones and these that show on PET scans) need sugar and low oxygen environment (hypoxia). Slow growing ones may rely on using glutamine, proteins or other mechanisms for energy.
2. Most cancers (exception are some types of liver cancer) store excess amount of iron.
3. Most cancers need extra blood supply (angiogenesis).
4. Many cancers are hormone dependent (sex hormones, insulin, vit. D)
Regarding the iron - there are 2 possible ways to exploit this.
1. attack the cancer cell by using the fenton reaction (generation of OH or H2O2 that kills the cancer cell).
2. use iron chelators that have proven anti-cancer properties.
It makes sense to apply the fenton reaction approach prior the iron chelation one.
The fenton reaction approach does not rely on anti oxidants, so in general it should enhance the effectiveness of the conventional treatments.
It is also a protocol that should show relatively quickly if it is effective or not.
Research everything against your current medical conditions, treatments and medications. In general add things one at a time a watch for adverse reactions.
Protocol #1:
1. Achieve (blood ketones : blood sugar) > 1:1; reduce insulin and blood sugar;
4:1 (weight ratio of fat:(carbs-fiber+proteins)) ketogenic diet + 30..40% target for caloric restriction,
metformin, ketone supplementation, MCT oil, butyrate, resveratrol (if not an estrogen sensitive cancer?).
calcium fructo borate (?)
glycolysis inhibitors: metformin, 2-DG, IV Vit. C, DCA?
mTOR inhibitors: itraconazole
Note: It is also possible to apply a vegan or other diets with restricted calories, but the ketogenic diet in particular maintains the blood sugar constant low and suppresses the appetite, so calorie restriction is easier to achieve.
2. Oxygenation and oxidation therapies:
HBOT, O3, IV Vit. C
3. Attacking cells with excess amount of iron:
IV Vit. C, Artemisinin (+ metfromin, butyrate, allicin, resveratrol (if not estrogen sensitive cancer?))
4. Anti-angiogenesis:
Artemisinin, Itraconazole
5. Others things to consider regardless of protocol:
Things to avoid on protocol #1:
1. iron chelators:
2. anti oxidants:
NAC, glutathione, vit.D3 (?), SAMe, GGC, ALA, curcumin, Se, vit. E, some B vitamins, melatonin (?)
3. supplements that can interfere with ketosis: Vandyl sulfate or Hydroxycitrate
4. Others:
Tests:
kidney tests, blood pressure needed for resveratrol:
In some cases tumors swell first (2..4 weeks) before starting to shrink (4..8 weeks after starting artemisinin).
Protocol duration:
6-8 weeks on artemisinin minimum to see if it has an effect.
Basic schedule:
Daily schedule:
morning: coffee (?) + butter+heavy cream+coconut oil; metfromin, andrographis, vitamins (C)
between meals: mineral supplements (taken away from fat intake ?)
launch: meal (iron rich?) + metformin + vit. C
dinner (6..7pm): meal + metformin + vit. C
~8..9pm: LDN
10..11pm (4 hours after dinner): artemisinin + allicin (+ resveratrol ?) + sodium butyrate + fat + water
Weekly schedule:
2 times a week: IV vit.C, O3
2 times a week: HBOT
5 days/week artemisinin for the first 1 month. Dose taken as 1 (i.e. once daily).
IV artesunate can be used instead of oral several times during the first week, (not in consecutive days (?)).
IV artesunate along with IV vit.C.
Note: IV artesunate can be 1 time a week with higher doses used for malaria treatment.(link [50:00 .. 1:20:00])
MBSR classes ?
daily: walks, trampoline, dancing, relaxation, sunlight, (red light?), MBSR/meditation/tai chi...
Monthly shedule:
If artemisinin is helping, maintenance dose is 1 day/week (1/7). If not, change the treatment.
Protocol #2 can be centered around iron chelation supplements such as curcumin and other treatments.
There is not such thing.
From what I have read so far, there are several things that most cancers have in common:
1. Most cancers (especially the aggressive ones and these that show on PET scans) need sugar and low oxygen environment (hypoxia). Slow growing ones may rely on using glutamine, proteins or other mechanisms for energy.
2. Most cancers (exception are some types of liver cancer) store excess amount of iron.
3. Most cancers need extra blood supply (angiogenesis).
4. Many cancers are hormone dependent (sex hormones, insulin, vit. D)
Regarding the iron - there are 2 possible ways to exploit this.
1. attack the cancer cell by using the fenton reaction (generation of OH or H2O2 that kills the cancer cell).
2. use iron chelators that have proven anti-cancer properties.
It makes sense to apply the fenton reaction approach prior the iron chelation one.
The fenton reaction approach does not rely on anti oxidants, so in general it should enhance the effectiveness of the conventional treatments.
It is also a protocol that should show relatively quickly if it is effective or not.
Research everything against your current medical conditions, treatments and medications. In general add things one at a time a watch for adverse reactions.
Protocol #1:
1. Achieve (blood ketones : blood sugar) > 1:1; reduce insulin and blood sugar;
4:1 (weight ratio of fat:(carbs-fiber+proteins)) ketogenic diet + 30..40% target for caloric restriction,
metformin, ketone supplementation, MCT oil, butyrate, resveratrol (if not an estrogen sensitive cancer?).
calcium fructo borate (?)
glycolysis inhibitors: metformin, 2-DG, IV Vit. C, DCA?
mTOR inhibitors: itraconazole
Note: It is also possible to apply a vegan or other diets with restricted calories, but the ketogenic diet in particular maintains the blood sugar constant low and suppresses the appetite, so calorie restriction is easier to achieve.
2. Oxygenation and oxidation therapies:
HBOT, O3, IV Vit. C
3. Attacking cells with excess amount of iron:
IV Vit. C, Artemisinin (+ metfromin, butyrate, allicin, resveratrol (if not estrogen sensitive cancer?))
4. Anti-angiogenesis:
Artemisinin, Itraconazole
5. Others things to consider regardless of protocol:
- probiotics, fermented food - not for people with compromised immune system (i.e. on or after conventional treatment)
- anti-bacterial: doxycycline (or other antibiotics with anti cancer effects) (+IV vit. C - link)
- anti-fungals: ketogenic diet, caprilic acid, olive leaf extract, artemisinin, itraconazole, nystatin, lufenuron
- anti-virals: artemisinin, IV Vit.C
- anti-parasite: artemisinin, black walnut
- immune system boosters: LDN, Andrographis, beta glucans,
- resolve dental issues (amalgam fillings, root canals?) (holistic dentist)
- resolve stress/anxiety issues: MBSR, meditation, light excersizes, EFT, tai chi ...
- good sleep: warm bath before sleep (relaxation), melatonin (will it interfere with the artemisinin?)
- general detox: hyper-thermia / far infra red sauna, coffie enemas, salt baths?; (no herbs/supplements/medications to avoid potential iron chelation and anti oxidant effects)
- some vitamins/minerals: Mg for ketogenic diet constpation, CoQ10 for the metformin; B12 + methyl folate ? for the metfromin, fiber, minerals (epsom salt baths);
things that should be OK to take: lutein, sesamol, ellagic acid - exercise - walks, dancing, trampoline?
- topical treatment: artemisinin creams (DMSO + Artesunate?), tea tree oil, eucaliptus oil, coconut oil, H2O2, curaderm cream
- Hormone balancing: metformin (estrogen reduction), resveratrol (estrogen reduction only at high doses?), infra red sauna, Omega 3, white button mushrooms, olive oil, Vit. D3 (?), chrysin (?)
Things to avoid on protocol #1:
1. iron chelators:
- ALA, Quercetin/Rutin/Myricetin..., Curcumin, EGCG, Phytic acid (IP6, Inositol), Genistein, Pycnogenol, Baicalein, Tetramethylpyrazine, ferulic acid, kaempferol, luteolin, Grape seed extract, green/black tea, soy (?), baicilein, scullcap, luteolin, naringenin, 3-CA, hibiscus, (green) coffee (extract), oils of oregano, thyme, rosemary, sage and clove
- ferrostatin-1 (ferroptosis inhibitor), deferoxamine (iron chelator), Deferasirox (?), Exjade, Janedu, Deferiprone or L1 (Ferriprox)
- Strong iron chelators: luteolin, norwogonin, baicalein, oroxylin A, eupatorin, wogonin, acacetin, genkwanin, quercetagetin, patuletin, myricetin, morin, fisetin, quercetin, kaempferol, isorhamnetin, rhamnetin, isomyricitrin, isoquercitrin, eupatorin, galangin
- weak iron chelators: apigenin, chrysoeriol, sinensetin, chrysin, galangin, spiraeoside, astragalin
2. anti oxidants:
NAC, glutathione, vit.D3 (?), SAMe, GGC, ALA, curcumin, Se, vit. E, some B vitamins, melatonin (?)
3. supplements that can interfere with ketosis: Vandyl sulfate or Hydroxycitrate
4. Others:
- generally bio-flavonoids may interfere due to iron chelation (?), herbs may interfere !?! use supplements instead
- epival (or other drugs (?) on ketogenic diet) can lead to liver toxicity
- gall bladder problems (inability to process fat) on ketogenic diet
- kidney problem on high protein diet (4:1 ketogenic diet is low protein, so it should not be a problem).
Tests:
- cancer progression tests; liver test; kidney, ketones/blood sugar tests, blood pressure;
- optional: CRP; NO; hormone levels tests for hormone sensitive cancers; iron level test (ideally high normal range);
kidney tests, blood pressure needed for resveratrol:
In some cases tumors swell first (2..4 weeks) before starting to shrink (4..8 weeks after starting artemisinin).
Protocol duration:
6-8 weeks on artemisinin minimum to see if it has an effect.
Basic schedule:
Daily schedule:
morning: coffee (?) + butter+heavy cream+coconut oil; metfromin, andrographis, vitamins (C)
between meals: mineral supplements (taken away from fat intake ?)
launch: meal (iron rich?) + metformin + vit. C
dinner (6..7pm): meal + metformin + vit. C
~8..9pm: LDN
10..11pm (4 hours after dinner): artemisinin + allicin (+ resveratrol ?) + sodium butyrate + fat + water
Weekly schedule:
2 times a week: IV vit.C, O3
2 times a week: HBOT
5 days/week artemisinin for the first 1 month. Dose taken as 1 (i.e. once daily).
IV artesunate can be used instead of oral several times during the first week, (not in consecutive days (?)).
IV artesunate along with IV vit.C.
Note: IV artesunate can be 1 time a week with higher doses used for malaria treatment.(link [50:00 .. 1:20:00])
MBSR classes ?
daily: walks, trampoline, dancing, relaxation, sunlight, (red light?), MBSR/meditation/tai chi...
Monthly shedule:
- initial test - cancer size/markers, liver test
- 1 month after starting artemisinin: liver test. If liver tests are high, reduce the number of days/week for example to 3/7.
- 6..8 weeks after starting artemisinin: cancer progression test (also tumor density estimate (may reduce(?)));
If artemisinin is helping, maintenance dose is 1 day/week (1/7). If not, change the treatment.
Protocol #2 can be centered around iron chelation supplements such as curcumin and other treatments.
- The Metabolic Approach to Cancer
- Designing a broad-spectrum integrative approach for cancer prevention and treatment (link)
Some treatments used by an alternative MD
The doctor (MD) suggesting this is an LDN prescribing doctor.
https://www.ldnscience.org/patients/find-a-doctor
http://www.ldnresearchtrust.org/LDN_Prescribers
The information below is not a complete list of treatments they do.
General guidelines:
1) Repeat ultrasound monthly for 3 months, then decide if therapy is effective.
2) Optional: Maintrac circulating tumour cell count can be used to help monitor response to therapy, and can also give an indication if surgery is likely to be non-curative:
http://www.maintrac.de/diagnostics/faq.php
3) Adjust vitamin D dose to keep blood level of 25-hydroxy vitamin D in the upper end of the normal range (check monthly until level is stable, then cut back). Monitor blood calcium and albumin during the start of high dose vitamin D therapy.
4) Monitor thyroid function while taking LDN, thyroid medication to be adjusted accordingly.
-----------------------------------------
LDN (low dose naltrexone)
-LDN works by boosting natural chemicals in the body called endorphins
-endorphins modulate the immune system, and at least one endorphins (called OGF) has anti-cancer activity
-LDN was used by Dr. Bernard Bihari for treatment of 450 patients with various cancers, and he reported over 60% response
-side effects are minimal (mainly trouble sleeping and vivid dreams)
-opiate pain medications like Tylenol #3, oxycodone, morphine, hydromorphone etc. cannot be taken at the same time
-works best in patients with a small amount of disease (small tumours or microscopic disease only)
-our experience is that LDN is not as powerful as DCA, but it has fewer side effects
-LDN must be stopped 2 days before any planned surgery and may be re-started once postoperative opiate pain medication is stopped
-this medicine comes in capsules or oral liquid
LDN Treatment:
1) LDN 1mg capsules, start 2 capsules (2mg) a day at bedtime for 1 week. If sleep is ok, increase to 3 capsules (3mg) a day at bedtime for 1 week. If sleep is still ok, increase
to 4mg a day at bedtime. If sleep is disturbed, remain at lower dose until improved, then increase, or change to morning dosing. Maximum 4mg per day.
2) Sleeping pill may be used at bedtime if insomnia is a problem.
3) No specific blood tests are required, but general blood tests are recommended once a month:
Complete blood cell count, sodium, potassium, chloride, urea, creatinine, calcium, magnesium, albumin, bilirubin (total+conjugated), AST, ALT, ALKP, GGT, LDH, glucose.
4) Tumour marker(s) should be checked once at the start of treatment and repeated every 4 weeks
-------------------------------------
Metformin
-this diabetes drug can enhance the effects of many chemos and complement the effects of DCA against cancer
-safe to take for non-diabetics
-helps to reduce insulin levels which can reduce cancer growth
-may be combined with chemo to overcome chemo-resistance
-this medicine comes in pills, and a specially compounded intravenous form is available
Metformin Treatment (oral):
1) Start metformin 250mg 3 times a day with meals. If there is no diarrhea, nausea, abdominal cramps or bloating, increase slowly over 2 weeks to 500mg 3 times a day
with meals.
2) This is a standard prescription that can be obtained from the family doctor
----------------------------------
DMSO
-a natural chemical which is a colourless liquid by-product of paper manufacturing
-DMSO is converted to another natural chemical called MSM in the body
-multiple published studies show that DMSO and MSM have anti-cancer activity
-DMSO quickly penetrates the skin and other biological membranes, making it an effective transportation device to carry small molecules through the skin
-when given intravenously, DMSO can treat cancer, diabetic ulcers, gastritis, herpes, arthritis, and closed head trauma
-can improve brain swelling related to brain tumours, like corticosteroid medications (prednisone, dexamethasone etc), but without the steroid side effects
-can improve cancer pain, quickly in some patients
-main side effect is a strong garlic-like smell and taste, occasional nausea or headache
-this medicine comes in liquid for application to the skin or for injection (intravenous)
------------------------------------
Sodium Phenylbutyrate (PB)
-this is the drug made famous by the Burzynski clinic in Texas, especially for treating brain tumours
-within the body, PB is converted into phenylacetate and phenylacetyl glutamine which have been researched and have anti-cancer activity (Dr. Burzynski named them “antineoplastons”)
http://www.burzynskiclinic.com/scientific-publications.html
-PB appears to work well on brain tumours and on other cancers also
-kills cancer cells or stops their growth by several mechanisms
-may work in a similar way to DCA
-side effects are similar to DCA, but without neuropathy
-our experience with PB indicates it can work on its own, but it is also a powerful chemosensitizer, making chemo much more effective in many cases
-can be given orally 3 times a day or i.v. continuous infusion for 5 days per month, or single high dose i.v. two or 3 times per week
-oral dosing requires 20- 30 large capsules to be taken daily
-this medicine comes in capsules, and liquid for injection (intravenous)
-----------------------------------
DCA
-causes tumor cells to die spontaneously by natural cell suicide (“apoptosis”), and by blocking glucose use in cancer cells, while sparing healthy cells
-not toxic, no immune suppression, unlike chemotherapy drugs
-side effects are generally mild, depend on dose and are higher in older patients
-typically takes about 4 – 6 weeks to begin working (this varies with the type of cancer), requires up to 3 months of therapy to evaluate
-DCA can improve the effects of chemo and radiation in some patients, but can also potentially interfere with chemo (correct timing with chemo will prevent interference)
-we have observed that DCA works for breast, colon, lung, skin (melanoma), prostate, sarcoma, lymphoma, pancreatic, glioblastoma, uterine, bladder, kidney, leukemia (acute and
chronic), various rare cancers and others as well
-this medicine comes in capsules, oral liquid, and liquid for injection (intravenous)
DCA Oral Treatment (no chemo):
1) DCA 500mg capsules, 1 capsule twice a day (=19mg/kg/day) for 2 weeks, then stop for 1 week. This is 1 cycle of DCA treatment. If there are no side effects, DCA may be increased to 1 capsule 3 times a day (=28mg/kg/day).
2) Take R alpha lipoic acid 150mg 3 times a day, benfotiamine 80mg twice a day and acetyl L-carnitine 500mg 3 times a day.
3 cycles of DCA treatment shown:
Week:
1 DCA, Benf, ALA, ALC
2 DCA, Benf, ALA, ALC
3 Benf, ALA, ALC
4 DCA, Benf, ALA, ALC
5 DCA, Benf, ALA, ALC
6 Benf, ALA, ALC
7 DCA, Benf, ALA, ALC
8 DCA, Benf, ALA, ALC
9 Benf, ALA, ALC
DCA = dichloroacetate
Benf = benfotiamine (vitamin B1), 1 cap = 80mg
ALA = R-alpha lipoic acid, 1 cap = 150mg
ALC = acetyl-L-carnitine, 1 cap = 500mg
3) Watch for immediate DCA side effects like fatigue, sleepiness, reduced memory, confusion, hallucinations, depression, anxiety or light headedness. Stop DCA if side effects develop, and then re-start at a reduced dose when the side effects are gone. Also watch for more long-term side effects such numbness or tingling of the fingers or toes (both sides of the body), gradual arm or leg weakness (both sides of the body) or hand tremors. Confirm with doctor if these are likely DCA side effects, then DCA may be stopped temporarily and treatment plan can be revised.
4) Blood tests every 2 weeks to start:
Complete blood cell count, sodium, potassium, chloride, urea, creatinine, calcium, magnesium, phosphate, albumin, bilirubin (total+conjugated), AST, ALT, ALKP, GGT, LDH, glucose. If tests are ok after the first 4, they may be reduced to monthly.
5) Tumour marker(s) should be checked once at the start of treatment and repeated every 4 weeks
6) If DCA causes stomach upset or nausea, take pantoprazole 40mg daily (or similar antacid).
The doctor (MD) suggesting this is an LDN prescribing doctor.
https://www.ldnscience.org/patients/find-a-doctor
http://www.ldnresearchtrust.org/LDN_Prescribers
The information below is not a complete list of treatments they do.
General guidelines:
1) Repeat ultrasound monthly for 3 months, then decide if therapy is effective.
2) Optional: Maintrac circulating tumour cell count can be used to help monitor response to therapy, and can also give an indication if surgery is likely to be non-curative:
http://www.maintrac.de/diagnostics/faq.php
3) Adjust vitamin D dose to keep blood level of 25-hydroxy vitamin D in the upper end of the normal range (check monthly until level is stable, then cut back). Monitor blood calcium and albumin during the start of high dose vitamin D therapy.
4) Monitor thyroid function while taking LDN, thyroid medication to be adjusted accordingly.
-----------------------------------------
LDN (low dose naltrexone)
-LDN works by boosting natural chemicals in the body called endorphins
-endorphins modulate the immune system, and at least one endorphins (called OGF) has anti-cancer activity
-LDN was used by Dr. Bernard Bihari for treatment of 450 patients with various cancers, and he reported over 60% response
-side effects are minimal (mainly trouble sleeping and vivid dreams)
-opiate pain medications like Tylenol #3, oxycodone, morphine, hydromorphone etc. cannot be taken at the same time
-works best in patients with a small amount of disease (small tumours or microscopic disease only)
-our experience is that LDN is not as powerful as DCA, but it has fewer side effects
-LDN must be stopped 2 days before any planned surgery and may be re-started once postoperative opiate pain medication is stopped
-this medicine comes in capsules or oral liquid
LDN Treatment:
1) LDN 1mg capsules, start 2 capsules (2mg) a day at bedtime for 1 week. If sleep is ok, increase to 3 capsules (3mg) a day at bedtime for 1 week. If sleep is still ok, increase
to 4mg a day at bedtime. If sleep is disturbed, remain at lower dose until improved, then increase, or change to morning dosing. Maximum 4mg per day.
2) Sleeping pill may be used at bedtime if insomnia is a problem.
3) No specific blood tests are required, but general blood tests are recommended once a month:
Complete blood cell count, sodium, potassium, chloride, urea, creatinine, calcium, magnesium, albumin, bilirubin (total+conjugated), AST, ALT, ALKP, GGT, LDH, glucose.
4) Tumour marker(s) should be checked once at the start of treatment and repeated every 4 weeks
-------------------------------------
Metformin
-this diabetes drug can enhance the effects of many chemos and complement the effects of DCA against cancer
-safe to take for non-diabetics
-helps to reduce insulin levels which can reduce cancer growth
-may be combined with chemo to overcome chemo-resistance
-this medicine comes in pills, and a specially compounded intravenous form is available
Metformin Treatment (oral):
1) Start metformin 250mg 3 times a day with meals. If there is no diarrhea, nausea, abdominal cramps or bloating, increase slowly over 2 weeks to 500mg 3 times a day
with meals.
2) This is a standard prescription that can be obtained from the family doctor
----------------------------------
DMSO
-a natural chemical which is a colourless liquid by-product of paper manufacturing
-DMSO is converted to another natural chemical called MSM in the body
-multiple published studies show that DMSO and MSM have anti-cancer activity
-DMSO quickly penetrates the skin and other biological membranes, making it an effective transportation device to carry small molecules through the skin
-when given intravenously, DMSO can treat cancer, diabetic ulcers, gastritis, herpes, arthritis, and closed head trauma
-can improve brain swelling related to brain tumours, like corticosteroid medications (prednisone, dexamethasone etc), but without the steroid side effects
-can improve cancer pain, quickly in some patients
-main side effect is a strong garlic-like smell and taste, occasional nausea or headache
-this medicine comes in liquid for application to the skin or for injection (intravenous)
------------------------------------
Sodium Phenylbutyrate (PB)
-this is the drug made famous by the Burzynski clinic in Texas, especially for treating brain tumours
-within the body, PB is converted into phenylacetate and phenylacetyl glutamine which have been researched and have anti-cancer activity (Dr. Burzynski named them “antineoplastons”)
http://www.burzynskiclinic.com/scientific-publications.html
-PB appears to work well on brain tumours and on other cancers also
-kills cancer cells or stops their growth by several mechanisms
-may work in a similar way to DCA
-side effects are similar to DCA, but without neuropathy
-our experience with PB indicates it can work on its own, but it is also a powerful chemosensitizer, making chemo much more effective in many cases
-can be given orally 3 times a day or i.v. continuous infusion for 5 days per month, or single high dose i.v. two or 3 times per week
-oral dosing requires 20- 30 large capsules to be taken daily
-this medicine comes in capsules, and liquid for injection (intravenous)
-----------------------------------
DCA
-causes tumor cells to die spontaneously by natural cell suicide (“apoptosis”), and by blocking glucose use in cancer cells, while sparing healthy cells
-not toxic, no immune suppression, unlike chemotherapy drugs
-side effects are generally mild, depend on dose and are higher in older patients
-typically takes about 4 – 6 weeks to begin working (this varies with the type of cancer), requires up to 3 months of therapy to evaluate
-DCA can improve the effects of chemo and radiation in some patients, but can also potentially interfere with chemo (correct timing with chemo will prevent interference)
-we have observed that DCA works for breast, colon, lung, skin (melanoma), prostate, sarcoma, lymphoma, pancreatic, glioblastoma, uterine, bladder, kidney, leukemia (acute and
chronic), various rare cancers and others as well
-this medicine comes in capsules, oral liquid, and liquid for injection (intravenous)
DCA Oral Treatment (no chemo):
1) DCA 500mg capsules, 1 capsule twice a day (=19mg/kg/day) for 2 weeks, then stop for 1 week. This is 1 cycle of DCA treatment. If there are no side effects, DCA may be increased to 1 capsule 3 times a day (=28mg/kg/day).
2) Take R alpha lipoic acid 150mg 3 times a day, benfotiamine 80mg twice a day and acetyl L-carnitine 500mg 3 times a day.
3 cycles of DCA treatment shown:
Week:
1 DCA, Benf, ALA, ALC
2 DCA, Benf, ALA, ALC
3 Benf, ALA, ALC
4 DCA, Benf, ALA, ALC
5 DCA, Benf, ALA, ALC
6 Benf, ALA, ALC
7 DCA, Benf, ALA, ALC
8 DCA, Benf, ALA, ALC
9 Benf, ALA, ALC
DCA = dichloroacetate
Benf = benfotiamine (vitamin B1), 1 cap = 80mg
ALA = R-alpha lipoic acid, 1 cap = 150mg
ALC = acetyl-L-carnitine, 1 cap = 500mg
3) Watch for immediate DCA side effects like fatigue, sleepiness, reduced memory, confusion, hallucinations, depression, anxiety or light headedness. Stop DCA if side effects develop, and then re-start at a reduced dose when the side effects are gone. Also watch for more long-term side effects such numbness or tingling of the fingers or toes (both sides of the body), gradual arm or leg weakness (both sides of the body) or hand tremors. Confirm with doctor if these are likely DCA side effects, then DCA may be stopped temporarily and treatment plan can be revised.
4) Blood tests every 2 weeks to start:
Complete blood cell count, sodium, potassium, chloride, urea, creatinine, calcium, magnesium, phosphate, albumin, bilirubin (total+conjugated), AST, ALT, ALKP, GGT, LDH, glucose. If tests are ok after the first 4, they may be reduced to monthly.
5) Tumour marker(s) should be checked once at the start of treatment and repeated every 4 weeks
6) If DCA causes stomach upset or nausea, take pantoprazole 40mg daily (or similar antacid).
References:
EcoOncology: Applying the Principles of Ecology to Oncology
https://www.youtube.com/watch?v=2FmBFZ9o64c&list=LLJquMcBsER_eAJbqho3_Liw&index=1
Ketogenic diet:
www.youtube.com/watch?v=PuG5XZSR4vs&index=3&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=0vRr65_6dOE&index=2&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=PuG5XZSR4vs&index=3&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=0vRr65_6dOE&index=2&list=LLJquMcBsER_eAJbqho3_Liw
https://www.youtube.com/watch?v=MsaYYt-zAYY
Books:
"Keto for cancer" https://www.dietarytherapies.com/
Fight cancer with a ketogenic diet
The metabolic approach to cancer
ketogenic diet and cancer stem cells
https://www.youtube.com/watch?v=QK_4Jb_VKiQ&list=LLJquMcBsER_eAJbqho3_Liw&index=2
ketogenic diet + standard treatment
https://www.youtube.com/watch?v=gIKVsHbW1yQ&list=LLJquMcBsER_eAJbqho3_Liw&index=5
discussion on ketogenic diet (for epilepsy) - variations, side effects (management)
https://www.youtube.com/watch?v=1PqjdOz_lUw&list=LLJquMcBsER_eAJbqho3_Liw&index=4
Tackling Brain Cancer with Ketogenics: Presenting Andrew Scarborough
Effects of the ketogenic diet:
- slows down cancer by reducing blood glucose, insulin, IGF, mTOR (low protein).
- causes signaling (ketone levels) simulating fasting that trigger multiple effects.
Dr. Amy Savagian - 'Functional Medicine and Ketogenic Nutrition'
[18:00] immune system regulation and inflammation reducing mechanisms (IL1, IL18, CRP, NFkB)
Adrienne C. Scheck, PhD -- The Ketogenic Diet as an Adjuvant to Standard of Care
[20:40] - affects epigenetics, the immune system to reduce tumor immuno-suppression, reduces proliferation,
inflammation, angiogenesis, invasion and metastasis
- changes brain chemistry reducing excitatory and increasing inhibitory neuro transmitters such as GABA.
I suspect that this also affects the immune systems in a positive way similarly to LDN.
- anti fungal effect
Combining the ketogenic diet with other treatments:
Fight Cancer with a Ketogenic Diet presented by Ellen Davis
[15:30] ketone supplements, HBOT, caloric restriction, metformin or berberine, modified citrus pectin,
reishi mushroom extract (i would add any other immune stimulant such as LDN, beta glucans, andrographis).
book
OC Nasha Winters Confounding Cancer with Immune & Metabolic Therapies
[27:30]: mistletoe, IVC, cannabis, hyperthermia
book
notes
Dr. Dawn Lemanne - 'Carbohydrate Restriction in Cancer Therapy'
[30:00] BRAF mutation - cancers that feed on fat/ketones;
hairy-cell leukemia (100%)
melanoma (50%)
colorectal cancer (10%)
prostate cancer (10%)
multiple myeloma (5%)
[34:00] multiple fuel used by cancer cells - difference within the tumor itself.
fructose, lipids, choline, glutamine, cycteine, acetate, lactate
[36:00] - intermittent fasting (13 hours minimum)
Adrienne C. Scheck, PhD -- The Ketogenic Diet as an Adjuvant to Standard of Care
multiple effects of the ketogenic diet:
[20:40] - affects epigenetics, the immune system to reduce tumor immuno-suppression,
reduces proliferation, inflammation, angiogenesis, invasion and metastasis
https://www.youtube.com/watch?v=-nYCzyv-XIw
[18:00] immune system regulation and inflamation reducing mechanisms (IL1, IL18, CRP, NFkB)
Beth Zupec-Kania -- Nutritional Considerations In Managing Ketogenic Diets
formulating ketogenic diets. Mentions vegan ketogenic diet for a woman with breast cancer ("doing very well")
On that note, I recently watched a presentation on Fasting Simulating Diet:
1 avocado + 2 scoop of green drink 2x day. Additional olive oil is OK (I assume coconut oil would be OK too).
Supposed to be done for 5 days, and it seems that it takes about 3..5 days of fasting to increase bHB significantly.
It seems that the research focuses on level of ketones vs blood glucose (> 1 for anti cancer effect). I tried several
things for my own curiosity and I had hard time raising my ketones above 1. The thing that did it was 1 week of stricter ketogenic diet (no fruit) and then 24 hour fast (couple of avocados, coconut oil, 85% dark chocolate). The
result was 4.6mM bHB vs 3.1 mM blood glucose, and I was not hungry.
Brent A. Reynolds, Ph.D. -- The Ketogenic Diet and Targeting Cancer Stem Cells
Brent Reynolds - EcoOncology Applying the Principles of Ecology to Oncology
Other videos from the Epigenix foundation conference: (link)
Artemisinin:
https://depts.washington.edu/bioe/wp-content/uploads/2013/11/Artemisinin-and-Cancer1.pdf
Potential side effects of artemisinin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816047/
(+ captopril 1:1 -> best synergistic effect for anti-angiogenesis)
http://www.cytoluminator.com/cancer-photodynamic-therapy/DHA%20sodium%20butyrate.pdf
(+ sodium butyrate -> 20uM DHA : 1mM(..20mM) sodium butyrate)
Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent.
http://www.ncbi.nlm.nih.gov/pubmed/24987823
Artemisinin–Second Career as Anticancer Drug? (must read !)
http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20150036&year_id=2015&quarter_id=4&falg=1
The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo
http://jeffreydach.com/wp-content/uploads/2016/02/Synergistic-Anticancer-Effect-of-Artesunate-with-Allicin-in-Osteosarcoma-Jiang_2013.pdf
http://www.ncbi.nlm.nih.gov/pubmed/25048878
(artemisinin : resveratrol = 1:2 ratio)
ketogenic diet + calorie restriction + metformin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177919/
https://www.youtube.com/watch?v=SEE-oU8_NSU
(ketone:blood glucose = 1:1 + anti cancer supplements/drugs)
Itraconazole - anti fungal, PI3K, mTOR, anti-angiogenesis, apoptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/ (CUSP9)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406527/ (overview of the anti cancer effects)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529373/
https://www.ncbi.nlm.nih.gov/pubmed/28399898/
https://www.ncbi.nlm.nih.gov/pubmed/28212537/
https://www.ncbi.nlm.nih.gov/pubmed/26823493/
https://www.ncbi.nlm.nih.gov/pubmed/25512128/
https://www.ncbi.nlm.nih.gov/pubmed/24905460/
https://www.ncbi.nlm.nih.gov/pubmed/21969860/
https://www.ncbi.nlm.nih.gov/pubmed/21896639/
Ketogenic diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917518/
(cancer adicted to glutamine)
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336610/
The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774034/
Carbohydrate Restriction, Prostate Cancer Growth, and the Insulin-Like Growth Factor Axis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959866/
https://www.linkedin.com/pulse/nobel-prize-winning-drug-artemisinin-shares-common-mechanism-finley
(metformin vs artemisinin)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330733/
(metformin: immune system effect)
http://www.ncbi.nlm.nih.gov/pubmed/21098880
(metformin: effective for brain tumors ?)
http://www.ncbi.nlm.nih.gov/pubmed/26959881
(metformin + DCA)
https://www.researchgate.net/publication/297722601_Metformin_Decouples_Phospholipid_Metabolism_in_Breast_Cancer_Cells
http://www.omicsgroup.org/journals/metformin-as-an-anticancer-drug-a-commentary-on-the-potential-therapeuticstrategy-and-underlying-mechanism-of-metformin-in-gastric-2167-7700-1000202.pdf
Metformin and dexamethasone combination therapy may be an option for Multiple Myeloma treatment
http://www.ncbi.nlm.nih.gov/pubmed/25305450
Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro
http://link.springer.com/article/10.1007/s13277-015-3751-1#/page-1
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.
http://www.ncbi.nlm.nih.gov/pubmed/27270450
In vitro and in vivo anti-melanoma action of metformin.
http://www.ncbi.nlm.nih.gov/pubmed/21806981?dopt=Abstract
Oxygen related treatements:
https://www.youtube.com/watch?v=85EPbiABqJs
https://www.youtube.com/watch?v=x5wOX4NSb90
Artemisinin / iron in cancer:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246098/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036554/
http://yaletownnaturopathic.com/how-does-artesunate-kill-cancer/
(IV artesunate + IVC)
https://peerj.com/articles/822/
(artemisinin - calorie restriction)
http://www.omicsonline.org/individualizing-chemotherapy-using-the-antidiabetic-drug-metformin-as-an-adjuvant-1948-5956.1000197.pdf
Glioblastoma (best results) (for other cancer results vary and can be reversed):
atemisinin -> 70%
DCA -> 3%
metformin -> 10%
artemisinin + metformin -> 95%;
DCA + metformin -> 99%
Artemisinin and derivatives thereof as antivirals
https://www.google.com/patents/EP2310393A2?cl=en
The Antiviral Activities of Artemisinin and Artesunate
http://cid.oxfordjournals.org/content/47/6/804.full
http://cid.oxfordjournals.org/content/47/6/804.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/24975030
http://www.readcube.com/articles/10.1002/iub.1284
Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.
"The longevity assay showed 2.7 days, 2 days, and 2.25 days median life span increase with artemisinin, curcumin, and combinatorial treatments, respectively"
i.e. artemisinin sould not be taken with curcumin (!)
Mean tumor size(in 103lm2)176.1, 127.1, 119.2, 107.6 (control, artemisinin, curcumin, both)
Median life span 11 days, 13.7 days, 13 days, 13.25 days
i.e. should not be take together!
They should not be taken together - http://medcraveonline.com/AOVS/AOVS-03-00077.pdf
"Curcumin has been reported to inhibit the generation of hydroxyl radicals (.OH) to an extent of 76% and 70%
and prevent the oxidation of Fe2+ in Fentons reaction which generates .OH radicals [18]"
Equipment:
Blood glucose and ketone monitoring
https://www.amazon.com/Precision-Blood-Glucose-Monitoring-System/dp/B000N64MZA
EcoOncology: Applying the Principles of Ecology to Oncology
https://www.youtube.com/watch?v=2FmBFZ9o64c&list=LLJquMcBsER_eAJbqho3_Liw&index=1
Ketogenic diet:
www.youtube.com/watch?v=PuG5XZSR4vs&index=3&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=0vRr65_6dOE&index=2&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=PuG5XZSR4vs&index=3&list=LLJquMcBsER_eAJbqho3_Liw
www.youtube.com/watch?v=0vRr65_6dOE&index=2&list=LLJquMcBsER_eAJbqho3_Liw
https://www.youtube.com/watch?v=MsaYYt-zAYY
Books:
"Keto for cancer" https://www.dietarytherapies.com/
Fight cancer with a ketogenic diet
The metabolic approach to cancer
ketogenic diet and cancer stem cells
https://www.youtube.com/watch?v=QK_4Jb_VKiQ&list=LLJquMcBsER_eAJbqho3_Liw&index=2
ketogenic diet + standard treatment
https://www.youtube.com/watch?v=gIKVsHbW1yQ&list=LLJquMcBsER_eAJbqho3_Liw&index=5
discussion on ketogenic diet (for epilepsy) - variations, side effects (management)
https://www.youtube.com/watch?v=1PqjdOz_lUw&list=LLJquMcBsER_eAJbqho3_Liw&index=4
Tackling Brain Cancer with Ketogenics: Presenting Andrew Scarborough
Effects of the ketogenic diet:
- slows down cancer by reducing blood glucose, insulin, IGF, mTOR (low protein).
- causes signaling (ketone levels) simulating fasting that trigger multiple effects.
Dr. Amy Savagian - 'Functional Medicine and Ketogenic Nutrition'
[18:00] immune system regulation and inflammation reducing mechanisms (IL1, IL18, CRP, NFkB)
Adrienne C. Scheck, PhD -- The Ketogenic Diet as an Adjuvant to Standard of Care
[20:40] - affects epigenetics, the immune system to reduce tumor immuno-suppression, reduces proliferation,
inflammation, angiogenesis, invasion and metastasis
- changes brain chemistry reducing excitatory and increasing inhibitory neuro transmitters such as GABA.
I suspect that this also affects the immune systems in a positive way similarly to LDN.
- anti fungal effect
Combining the ketogenic diet with other treatments:
Fight Cancer with a Ketogenic Diet presented by Ellen Davis
[15:30] ketone supplements, HBOT, caloric restriction, metformin or berberine, modified citrus pectin,
reishi mushroom extract (i would add any other immune stimulant such as LDN, beta glucans, andrographis).
book
OC Nasha Winters Confounding Cancer with Immune & Metabolic Therapies
[27:30]: mistletoe, IVC, cannabis, hyperthermia
book
notes
Dr. Dawn Lemanne - 'Carbohydrate Restriction in Cancer Therapy'
[30:00] BRAF mutation - cancers that feed on fat/ketones;
hairy-cell leukemia (100%)
melanoma (50%)
colorectal cancer (10%)
prostate cancer (10%)
multiple myeloma (5%)
[34:00] multiple fuel used by cancer cells - difference within the tumor itself.
fructose, lipids, choline, glutamine, cycteine, acetate, lactate
[36:00] - intermittent fasting (13 hours minimum)
Adrienne C. Scheck, PhD -- The Ketogenic Diet as an Adjuvant to Standard of Care
multiple effects of the ketogenic diet:
[20:40] - affects epigenetics, the immune system to reduce tumor immuno-suppression,
reduces proliferation, inflammation, angiogenesis, invasion and metastasis
https://www.youtube.com/watch?v=-nYCzyv-XIw
[18:00] immune system regulation and inflamation reducing mechanisms (IL1, IL18, CRP, NFkB)
Beth Zupec-Kania -- Nutritional Considerations In Managing Ketogenic Diets
formulating ketogenic diets. Mentions vegan ketogenic diet for a woman with breast cancer ("doing very well")
On that note, I recently watched a presentation on Fasting Simulating Diet:
1 avocado + 2 scoop of green drink 2x day. Additional olive oil is OK (I assume coconut oil would be OK too).
Supposed to be done for 5 days, and it seems that it takes about 3..5 days of fasting to increase bHB significantly.
It seems that the research focuses on level of ketones vs blood glucose (> 1 for anti cancer effect). I tried several
things for my own curiosity and I had hard time raising my ketones above 1. The thing that did it was 1 week of stricter ketogenic diet (no fruit) and then 24 hour fast (couple of avocados, coconut oil, 85% dark chocolate). The
result was 4.6mM bHB vs 3.1 mM blood glucose, and I was not hungry.
Brent A. Reynolds, Ph.D. -- The Ketogenic Diet and Targeting Cancer Stem Cells
Brent Reynolds - EcoOncology Applying the Principles of Ecology to Oncology
Other videos from the Epigenix foundation conference: (link)
Artemisinin:
https://depts.washington.edu/bioe/wp-content/uploads/2013/11/Artemisinin-and-Cancer1.pdf
Potential side effects of artemisinin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816047/
(+ captopril 1:1 -> best synergistic effect for anti-angiogenesis)
http://www.cytoluminator.com/cancer-photodynamic-therapy/DHA%20sodium%20butyrate.pdf
(+ sodium butyrate -> 20uM DHA : 1mM(..20mM) sodium butyrate)
Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent.
http://www.ncbi.nlm.nih.gov/pubmed/24987823
Artemisinin–Second Career as Anticancer Drug? (must read !)
http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20150036&year_id=2015&quarter_id=4&falg=1
The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo
http://jeffreydach.com/wp-content/uploads/2016/02/Synergistic-Anticancer-Effect-of-Artesunate-with-Allicin-in-Osteosarcoma-Jiang_2013.pdf
http://www.ncbi.nlm.nih.gov/pubmed/25048878
(artemisinin : resveratrol = 1:2 ratio)
ketogenic diet + calorie restriction + metformin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177919/
https://www.youtube.com/watch?v=SEE-oU8_NSU
(ketone:blood glucose = 1:1 + anti cancer supplements/drugs)
Itraconazole - anti fungal, PI3K, mTOR, anti-angiogenesis, apoptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/ (CUSP9)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406527/ (overview of the anti cancer effects)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529373/
https://www.ncbi.nlm.nih.gov/pubmed/28399898/
https://www.ncbi.nlm.nih.gov/pubmed/28212537/
https://www.ncbi.nlm.nih.gov/pubmed/26823493/
https://www.ncbi.nlm.nih.gov/pubmed/25512128/
https://www.ncbi.nlm.nih.gov/pubmed/24905460/
https://www.ncbi.nlm.nih.gov/pubmed/21969860/
https://www.ncbi.nlm.nih.gov/pubmed/21896639/
Ketogenic diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917518/
(cancer adicted to glutamine)
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336610/
The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774034/
Carbohydrate Restriction, Prostate Cancer Growth, and the Insulin-Like Growth Factor Axis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959866/
https://www.linkedin.com/pulse/nobel-prize-winning-drug-artemisinin-shares-common-mechanism-finley
(metformin vs artemisinin)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330733/
(metformin: immune system effect)
http://www.ncbi.nlm.nih.gov/pubmed/21098880
(metformin: effective for brain tumors ?)
http://www.ncbi.nlm.nih.gov/pubmed/26959881
(metformin + DCA)
https://www.researchgate.net/publication/297722601_Metformin_Decouples_Phospholipid_Metabolism_in_Breast_Cancer_Cells
http://www.omicsgroup.org/journals/metformin-as-an-anticancer-drug-a-commentary-on-the-potential-therapeuticstrategy-and-underlying-mechanism-of-metformin-in-gastric-2167-7700-1000202.pdf
Metformin and dexamethasone combination therapy may be an option for Multiple Myeloma treatment
http://www.ncbi.nlm.nih.gov/pubmed/25305450
Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro
http://link.springer.com/article/10.1007/s13277-015-3751-1#/page-1
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.
http://www.ncbi.nlm.nih.gov/pubmed/27270450
In vitro and in vivo anti-melanoma action of metformin.
http://www.ncbi.nlm.nih.gov/pubmed/21806981?dopt=Abstract
Oxygen related treatements:
https://www.youtube.com/watch?v=85EPbiABqJs
https://www.youtube.com/watch?v=x5wOX4NSb90
Artemisinin / iron in cancer:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246098/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036554/
http://yaletownnaturopathic.com/how-does-artesunate-kill-cancer/
(IV artesunate + IVC)
https://peerj.com/articles/822/
(artemisinin - calorie restriction)
http://www.omicsonline.org/individualizing-chemotherapy-using-the-antidiabetic-drug-metformin-as-an-adjuvant-1948-5956.1000197.pdf
Glioblastoma (best results) (for other cancer results vary and can be reversed):
atemisinin -> 70%
DCA -> 3%
metformin -> 10%
artemisinin + metformin -> 95%;
DCA + metformin -> 99%
Artemisinin and derivatives thereof as antivirals
https://www.google.com/patents/EP2310393A2?cl=en
The Antiviral Activities of Artemisinin and Artesunate
http://cid.oxfordjournals.org/content/47/6/804.full
http://cid.oxfordjournals.org/content/47/6/804.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/24975030
http://www.readcube.com/articles/10.1002/iub.1284
Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.
"The longevity assay showed 2.7 days, 2 days, and 2.25 days median life span increase with artemisinin, curcumin, and combinatorial treatments, respectively"
i.e. artemisinin sould not be taken with curcumin (!)
Mean tumor size(in 103lm2)176.1, 127.1, 119.2, 107.6 (control, artemisinin, curcumin, both)
Median life span 11 days, 13.7 days, 13 days, 13.25 days
i.e. should not be take together!
They should not be taken together - http://medcraveonline.com/AOVS/AOVS-03-00077.pdf
"Curcumin has been reported to inhibit the generation of hydroxyl radicals (.OH) to an extent of 76% and 70%
and prevent the oxidation of Fe2+ in Fentons reaction which generates .OH radicals [18]"
Equipment:
Blood glucose and ketone monitoring
https://www.amazon.com/Precision-Blood-Glucose-Monitoring-System/dp/B000N64MZA